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Search results 1 to 100 out of 110 for Arpc2

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Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
10109 | ARPC2
Type: gene
Organism: human
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Gene
301511 | Arpc2
Type: gene
Organism: rat
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Gene
459938 | ARPC2
Type: gene
Organism: chimpanzee
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Gene
540838 | ARPC2
Type: gene
Organism: cattle
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Gene
429041 | ARPC2
Type: gene
Organism: chicken
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Gene
327068 | arpc2
Type: gene
Organism: zebrafish
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Gene
700536 | ARPC2
Type: gene
Organism: macaque, rhesus
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Gene
448094 | arpc2
Type: gene
Organism: frog, western clawed
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Gene
478907 | ARPC2
Type: gene
Organism: dog, domestic
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Protein Coding Gene
MGI:1923959 | Arpc2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR007188 | ARPC2
Type: Family
Description: Arp2/3 binds to pre-existing actin filaments and nucleates new daughter filaments, and thus becomes incorporated into the dynamic actin network at the leading edge of motile cells and other actin-based protrusive structures []. In order to nucleate filaments, Arp2/3 must bind to a member of the N-WASp/SCAR family protein []. Arp2 and Arp3 are thought to be brought together after activation, forming an actin-like nucleus for actin monomers to bind and create a new actin filament. In the absence of an activating protein, Arp2/3 shows very little nucleation activity. Recent research has focused on the binding and hydrolysis of ATP by Arp2 and Arp3 [], and crystal structures of the Arp2/3 complex have been solved [].The human complex consists of Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. This family represents the ARPC2/p34-ARC subunit.
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Protein
Q9CVB6
Organism: Mus musculus/domesticus
Length: 300  
Fragment?: false
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Protein
Q3UA52
Organism: Mus musculus/domesticus
Length: 383  
Fragment?: true
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Protein
Q4FZG5
Organism: Mus musculus/domesticus
Length: 276  
Fragment?: true
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Protein
D3YXG6
Organism: Mus musculus/domesticus
Length: 284  
Fragment?: false
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Publication
9889097 | -
First Author: Machesky LM
Year: 1998
Journal: Curr Biol
Title: Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex.
Volume: 8
Issue: 25
Pages: 1347-56
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Publication
15505213 | -
First Author: Nolen BJ
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Crystal structures of actin-related protein 2/3 complex with bound ATP or ADP.
Volume: 101
Issue: 44
Pages: 15627-32
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Publication
9600938 | -
First Author: Mullins RD
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: The interaction of Arp2/3 complex with actin: nucleation, high affinity pointed end capping, and formation of branching networks of filaments.
Volume: 95
Issue: 11
Pages: 6181-6
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Publication
11752435 | -
First Author: Dayel MJ
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Arp2/3 complex requires hydrolyzable ATP for nucleation of new actin filaments.
Volume: 98
Issue: 26
Pages: 14871-6
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Publication
25543281 | J:232692
First Author: Rotty JD
Year: 2015
Journal: Dev Cell
Title: Profilin-1 serves as a gatekeeper for actin assembly by Arp2/3-dependent and -independent pathways.
Volume: 32
Issue: 1
Pages: 54-67
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Protein Coding Gene
MGP_CAROLIEiJ_G0014255 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0016143 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0016126 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0016083 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0016081 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0015912 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1923959 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0016534 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0015496 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0015885 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0015986 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0015989 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0016058 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0016009 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0016581 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0015283 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0015558 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0027493 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0015061 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
28827576 | J:265040
First Author: Zhang Y
Year: 2017
Journal: Sci Rep
Title: Arp2/3 complex controls T cell homeostasis by maintaining surface TCR levels via regulating TCR+ endosome trafficking.
Volume: 7
Issue: 1
Pages: 8952
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GXD Expression
GXD Expression
Probe: MGI:5485340
Assay Type: Immunohistochemistry
Annotation Date: 2013-05-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1679917
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:5485405
Age: embryonic day 10.5
Image: S1 A/B
Note: Expressed at the base of the epithelial cells.
Specimen Label: S1 A/B
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:5485340
Assay Type: Immunohistochemistry
Annotation Date: 2013-05-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1679917
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:5485405
Age: embryonic day 10.5
Image: 3G left
Note: Expressed at both the apex and the base of the epithelial cells.
Specimen Label: 3G left
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:5485340
Assay Type: Immunohistochemistry
Annotation Date: 2013-05-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1679917
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:5485405
Age: embryonic day 10.5
Image: 3G middle
Note: Increased expression at both the apex and the base of the epithelial cells.
Specimen Label: 3G middle
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:5485340
Assay Type: Immunohistochemistry
Annotation Date: 2013-05-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1679917
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:5485405
Age: embryonic day 10.5
Image: 3G right
Note: Reduced expression in the lower half of epithelial cells.
Specimen Label: 3G right
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:7282023
Assay Type: Immunohistochemistry
Annotation Date: 2022-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1783824
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:7282031
Age: embryonic day 16.5
Note: Expression localized to epithelial cell-fiber interface (EFI).
Specimen Label: 4C5
Detected: true
Specimen Num: 1
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Publication
20308062 | J:163894
First Author: Monfregola J
Year: 2010
Journal: J Biol Chem
Title: Functional characterization of Wiskott-Aldrich syndrome protein and scar homolog (WASH), a bi-modular nucleation-promoting factor able to interact with biogenesis of lysosome-related organelle subunit 2 (BLOS2) and gamma-tubulin.
Volume: 285
Issue: 22
Pages: 16951-7
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Publication
22689987 | J:185589
First Author: Maritzen T
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Gadkin negatively regulates cell spreading and motility via sequestration of the actin-nucleating ARP2/3 complex.
Volume: 109
Issue: 26
Pages: 10382-7
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Publication
22492726 | J:185040
First Author: Suraneni P
Year: 2012
Journal: J Cell Biol
Title: The Arp2/3 complex is required for lamellipodia extension and directional fibroblast cell migration.
Volume: 197
Issue: 2
Pages: 239-51
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Publication
22553210 | J:197772
First Author: Baas D
Year: 2012
Journal: J Cell Sci
Title: CKIP-1 regulates mammalian and zebrafish myoblast fusion.
Volume: 125
Issue: Pt 16
Pages: 3790-800
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Publication
16084593 | J:105018
First Author: Moepps B
Year: 2006
Journal: Mol Immunol
Title: A homolog of the human chemokine receptor CXCR1 is expressed in the mouse.
Volume: 43
Issue: 7
Pages: 897-914
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Publication
28867487 | J:245877
First Author: Rotty JD
Year: 2017
Journal: Dev Cell
Title: Arp2/3 Complex Is Required for Macrophage Integrin Functions but Is Dispensable for FcR Phagocytosis and In Vivo Motility.
Volume: 42
Issue: 5
Pages: 498-513.e6
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Publication
35681501 | J:346665
 
First Author: Ronzier E
Year: 2022
Journal: Cells
Title: The Actin Cytoskeleton Responds to Inflammatory Cues and Alters Macrophage Activation.
Volume: 11
Issue: 11
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Publication
33188196 | J:301301
First Author: Nicolai L
Year: 2020
Journal: Nat Commun
Title: Vascular surveillance by haptotactic blood platelets in inflammation and infection.
Volume: 11
Issue: 1
Pages: 5778
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Publication
18289379 | J:164711
 
First Author: Ma T
Year: 2008
Journal: J Mol Signal
Title: Dramatic inhibition of osteoclast sealing ring formation and bone resorption in vitro by a WASP-peptide containing pTyr294 amino acid.
Volume: 3
Pages: 4
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Publication
15572692 | J:95254
First Author: Grove M
Year: 2004
Journal: Mol Cell Biol
Title: ABI2-deficient mice exhibit defective cell migration, aberrant dendritic spine morphogenesis, and deficits in learning and memory.
Volume: 24
Issue: 24
Pages: 10905-22
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Publication
34269176 | J:317350
   
First Author: O'Neil SD
Year: 2021
Journal: Elife
Title: Action potential-coupled Rho GTPase signaling drives presynaptic plasticity.
Volume: 10
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Publication
22021442 | J:180120
First Author: Chauhan BK
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Balanced Rac1 and RhoA activities regulate cell shape and drive invagination morphogenesis in epithelia.
Volume: 108
Issue: 45
Pages: 18289-94
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Publication
12473693 | J:80756
First Author: DeMali KA
Year: 2002
Journal: J Cell Biol
Title: Recruitment of the Arp2/3 complex to vinculin: coupling membrane protrusion to matrix adhesion.
Volume: 159
Issue: 5
Pages: 881-91
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Publication
18836449 | J:141431
First Author: Shiow LR
Year: 2008
Journal: Nat Immunol
Title: The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency.
Volume: 9
Issue: 11
Pages: 1307-15
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Publication
24413018 | J:206458
First Author: Biesemann C
Year: 2014
Journal: EMBO J
Title: Proteomic screening of glutamatergic mouse brain synaptosomes isolated by fluorescence activated sorting.
Volume: 33
Issue: 2
Pages: 157-70
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Publication
27385014 | J:235720
First Author: Wang PS
Year: 2016
Journal: Development
Title: Crucial roles of the Arp2/3 complex during mammalian corticogenesis.
Volume: 143
Issue: 15
Pages: 2741-52
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Publication
26398943 | J:225710
First Author: Tuck E
Year: 2015
Journal: Dis Model Mech
Title: A gene expression resource generated by genome-wide lacZ profiling in the mouse.
Volume: 8
Issue: 11
Pages: 1467-78
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Publication
24721909 | J:209956
 
First Author: Liakath-Ali K
Year: 2014
Journal: Nat Commun
Title: Novel skin phenotypes revealed by a genome-wide mouse reverse genetic screen.
Volume: 5
Pages: 3540
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Publication
- | J:175295
     
First Author: Mouse Genome Informatics and the Wellcome Trust Sanger Institute Mouse Genetics Project (MGP)
Year: 2011
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the Wellcome Trust Sanger Institute (WTSI) Mouse Resources Portal
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Publication
30973865 | J:274872
First Author: Ingham NJ
Year: 2019
Journal: PLoS Biol
Title: Mouse screen reveals multiple new genes underlying mouse and human hearing loss.
Volume: 17
Issue: 4
Pages: e3000194
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Publication
- | J:68100
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: RIKEN Data Curation in Mouse Genome Informatics
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Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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