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Search results 1 to 100 out of 306 for Asxl1

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Protein Domain
Type: Family
Description: Additional sex combs-like protein 1 (ASXL1) is the vertebrate homologue of Drosophila additional sex combs []. ASXL1 is a polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. ASX is a non-catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, consisting at least of BAP1 and ASX. The PR-DUB complex specifically mediates the removal of monoubiquitin from H2A [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Lee SW
Year: 2010
Journal: J Biol Chem
Title: ASXL1 represses retinoic acid receptor-mediated transcription through associating with HP1 and LSD1.
Volume: 285
Issue: 1
Pages: 18-29
Protein
Organism: Mus musculus/domesticus
Length: 1514  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1513  
Fragment?: false
GXD Expression    
Probe: MGI:5699268
Assay Type: RT-PCR
Annotation Date: 2015-12-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610525
Stage: TS25
Assay Id: MGI:5699440
Age: embryonic day 17.0
Image: 2
Specimen Label: Asxl1 +/+
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5699268
Assay Type: RT-PCR
Annotation Date: 2015-12-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610525
Stage: TS25
Assay Id: MGI:5699440
Age: embryonic day 17.0
Image: 2
Specimen Label: Asxl1 -/-
Detected: true
Specimen Num: 2
Publication
First Author: Liu X
Year: 2022
Journal: Cancer Sci
Title: CHIP-associated mutant ASXL1 in blood cells promotes solid tumor progression.
Volume: 113
Issue: 4
Pages: 1182-1194
Publication
First Author: Yang H
Year: 2018
Journal: Blood
Title: Gain of function of ASXL1 truncating protein in the pathogenesis of myeloid malignancies.
Volume: 131
Issue: 3
Pages: 328-341
Publication
First Author: Fujino T
Year: 2021
Journal: Nat Commun
Title: Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway.
Volume: 12
Issue: 1
Pages: 1826
Publication
First Author: Park UH
Year: 2011
Journal: J Biol Chem
Title: Additional sex comb-like (ASXL) proteins 1 and 2 play opposite roles in adipogenesis via reciprocal regulation of peroxisome proliferator-activated receptor {gamma}.
Volume: 286
Issue: 2
Pages: 1354-63
Publication
First Author: Nagase R
Year: 2018
Journal: J Exp Med
Title: Expression of mutant Asxl1 perturbs hematopoiesis and promotes susceptibility to leukemic transformation.
Volume: 215
Issue: 6
Pages: 1729-1747
Publication
First Author: Wang J
Year: 2014
Journal: Blood
Title: Loss of Asxl1 leads to myelodysplastic syndrome-like disease in mice.
Volume: 123
Issue: 4
Pages: 541-53
Publication
First Author: Rohatgi N
Year: 2018
Journal: Blood Adv
Title: ASXL1 impairs osteoclast formation by epigenetic regulation of NFATc1.
Volume: 2
Issue: 19
Pages: 2467-2477
Publication
First Author: Inoue D
Year: 2013
Journal: J Clin Invest
Title: Myelodysplastic syndromes are induced by histone methylation–altering ASXL1 mutations.
Volume: 123
Issue: 11
Pages: 4627-40
Publication
First Author: Guo Y
Year: 2019
Journal: Leukemia
Title: ASXL1 alteration cooperates with JAK2V617F to accelerate myelofibrosis.
Volume: 33
Issue: 5
Pages: 1287-1291
Publication
First Author: Braun TP
Year: 2023
Journal: Leukemia
Title: Asxl1 deletion disrupts MYC and RNA polymerase II function in granulocyte progenitors.
Volume: 37
Issue: 2
Pages: 478-487
Publication  
First Author: Balasubramani A
Year: 2015
Journal: Nat Commun
Title: Cancer-associated ASXL1 mutations may act as gain-of-function mutations of the ASXL1-BAP1 complex.
Volume: 6
Pages: 7307
Publication  
First Author: Fisher CL
Year: 2003
Journal: Gene
Title: A human homolog of Additional sex combs, ADDITIONAL SEX COMBS-LIKE 1, maps to chromosome 20q11.
Volume: 306
Pages: 115-26
Publication
First Author: Guo Y
Year: 2018
Journal: Leukemia
Title: Reduced BAP1 activity prevents ASXL1 truncation-driven myeloid malignancy in vivo.
Volume: 32
Issue: 8
Pages: 1834-1837
Publication
First Author: Li Z
Year: 2017
Journal: Sci Adv
Title: ASXL1 interacts with the cohesin complex to maintain chromatid separation and gene expression for normal hematopoiesis.
Volume: 3
Issue: 1
Pages: e1601602
Publication
First Author: Uni M
Year: 2019
Journal: Leukemia
Title: Modeling ASXL1 mutation revealed impaired hematopoiesis caused by derepression of p16Ink4a through aberrant PRC1-mediated histone modification.
Volume: 33
Issue: 1
Pages: 191-204
Publication
First Author: An S
Year: 2019
Journal: Biochem Biophys Res Commun
Title: Asxl1 ablation in mouse embryonic stem cells impairs neural differentiation without affecting self-renewal.
Volume: 508
Issue: 3
Pages: 907-913
Publication
First Author: Zhang P
Year: 2016
Journal: Stem Cell Reports
Title: Loss of Asxl1 Alters Self-Renewal and Cell Fate of Bone Marrow Stromal Cell, Leading to Bohring-Opitz-like Syndrome in Mice.
Volume: 6
Issue: 6
Pages: 914-925
Publication
First Author: Zhang P
Year: 2018
Journal: J Clin Invest
Title: Chromatin regulator Asxl1 loss and Nf1 haploinsufficiency cooperate to accelerate myeloid malignancy.
Volume: 128
Issue: 12
Pages: 5383-5398
Publication
First Author: Abdel-Wahab O
Year: 2013
Journal: J Exp Med
Title: Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo.
Volume: 210
Issue: 12
Pages: 2641-59
Publication
First Author: Shi Z
Year: 2023
Journal: Haematologica
Title: ASXL1 mutations accelerate bone marrow fibrosis via EGR1-TNFA axis-mediated neoplastic fibrocyte generation in myeloproliferative neoplasms.
Volume: 108
Issue: 5
Pages: 1359-1373
Publication
First Author: Moon S
Year: 2015
Journal: Biochem Biophys Res Commun
Title: Role of Asxl1 in kidney podocyte development via its interaction with Wtip.
Volume: 466
Issue: 3
Pages: 560-6
Protein
Organism: Mus musculus/domesticus
Length: 477  
Fragment?: true
Publication
First Author: Scheuermann JC
Year: 2010
Journal: Nature
Title: Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB.
Volume: 465
Issue: 7295
Pages: 243-7
Protein
Organism: Mus musculus/domesticus
Length: 1514  
Fragment?: false
Publication
First Author: Hsu YC
Year: 2017
Journal: J Hematol Oncol
Title: The distinct biological implications of Asxl1 mutation and its roles in leukemogenesis revealed by a knock-in mouse model.
Volume: 10
Issue: 1
Pages: 139
Publication
First Author: Moon S
Year: 2018
Journal: Cell Death Dis
Title: Asxl1 exerts an antiproliferative effect on mouse lung maturation via epigenetic repression of the E2f1-Nmyc axis.
Volume: 9
Issue: 11
Pages: 1118
Publication
First Author: You X
Year: 2022
Journal: Blood
Title: Asxl1 loss cooperates with oncogenic Nras in mice to reprogram the immune microenvironment and drive leukemic transformation.
Volume: 139
Issue: 7
Pages: 1066-1079
Publication
First Author: Cho YS
Year: 2006
Journal: J Biol Chem
Title: Additional sex comb-like 1 (ASXL1), in cooperation with SRC-1, acts as a ligand-dependent coactivator for retinoic acid receptor.
Volume: 281
Issue: 26
Pages: 17588-98
Publication
First Author: Youn HS
Year: 2017
Journal: Sci Rep
Title: Asxl1 deficiency in embryonic fibroblasts leads to cellular senescence via impairment of the AKT-E2F pathway and Ezh2 inactivation.
Volume: 7
Issue: 1
Pages: 5198
Publication
First Author: Yamamoto K
Year: 2021
Journal: Cell Rep
Title: A histone modifier, ASXL1, interacts with NONO and is involved in paraspeckle formation in hematopoietic cells.
Volume: 36
Issue: 8
Pages: 109576
Publication
First Author: D'Altri T
Year: 2021
Journal: Haematologica
Title: The ASXL1-G643W variant accelerates the development of CEBPA mutant acute myeloid leukemia.
Volume: 106
Issue: 4
Pages: 1000-1007
Publication  
First Author: Micol JB
Year: 2017
Journal: Nat Commun
Title: ASXL2 is essential for haematopoiesis and acts as a haploinsufficient tumour suppressor in leukemia.
Volume: 8
Pages: 15429
Publication  
Year: 2015
Journal: J Biol Chem
Title: ASXL1 represses retinoic acid receptor-mediated transcription through associating with HP1 and LSD1.
Volume: 290
Issue: 10
Pages: 6008
Publication
First Author: Fisher CL
Year: 2010
Journal: Blood
Title: Loss-of-function Additional sex combs like 1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemia.
Volume: 115
Issue: 1
Pages: 38-46
Publication
First Author: Kang M
Year: 2012
Journal: Biochem Biophys Res Commun
Title: Positive regulation of additional sex comb-like 1 gene expression by the pluripotency factor SOX2.
Volume: 421
Issue: 3
Pages: 621-6
Publication  
First Author: Fisher CL
Year: 2006
Journal: Gene
Title: Characterization of Asxl1, a murine homolog of Additional sex combs, and analysis of the Asx-like gene family.
Volume: 369
Pages: 109-18
Publication
First Author: Dey A
Year: 2012
Journal: Science
Title: Loss of the tumor suppressor BAP1 causes myeloid transformation.
Volume: 337
Issue: 6101
Pages: 1541-6
Publication
First Author: Fisher CL
Year: 2010
Journal: Dev Biol
Title: Additional sex combs-like 1 belongs to the enhancer of trithorax and polycomb group and genetically interacts with Cbx2 in mice.
Volume: 337
Issue: 1
Pages: 9-15
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression      
Probe: MGI:3656275
Assay Type: Northern blot
Annotation Date: 2006-10-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3656297
Age: postnatal adult
Specimen Label: kidney
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3656275
Assay Type: Northern blot
Annotation Date: 2006-10-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:3656297
Age: postnatal adult
Specimen Label: lung
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3656275
Assay Type: Northern blot
Annotation Date: 2006-10-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3656297
Age: postnatal adult
Specimen Label: heart
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3656275
Assay Type: Northern blot
Annotation Date: 2006-10-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1775128
Stage: TS28
Assay Id: MGI:3656297
Age: postnatal adult
Specimen Label: salivary gland
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3656275
Assay Type: Northern blot
Annotation Date: 2006-10-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:3656297
Age: postnatal adult
Specimen Label: skeletal muscle
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3656275
Assay Type: Northern blot
Annotation Date: 2006-10-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3656297
Age: postnatal adult
Specimen Label: brain
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:3656286
Assay Type: Northern blot
Annotation Date: 2006-10-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3656301
Age: postnatal adult
Specimen Label: kidney
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3656286
Assay Type: Northern blot
Annotation Date: 2006-10-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:3656301
Age: postnatal adult
Specimen Label: lung
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3656286
Assay Type: Northern blot
Annotation Date: 2006-10-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3656301
Age: postnatal adult
Specimen Label: heart
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3656286
Assay Type: Northern blot
Annotation Date: 2006-10-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1775128
Stage: TS28
Assay Id: MGI:3656301
Age: postnatal adult
Specimen Label: salivary gland
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3656286
Assay Type: Northern blot
Annotation Date: 2006-10-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:3656301
Age: postnatal adult
Specimen Label: skeletal muscle
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3656286
Assay Type: Northern blot
Annotation Date: 2006-10-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3656301
Age: postnatal adult
Specimen Label: brain
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:5699149
Assay Type: RT-PCR
Annotation Date: 2015-12-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610526
Stage: TS26
Assay Id: MGI:5699313
Age: embryonic day 18.5
Image: 1
Specimen Label: Asxl2 +/+
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5699149
Assay Type: RT-PCR
Annotation Date: 2015-12-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610526
Stage: TS26
Assay Id: MGI:5699313
Age: embryonic day 18.5
Image: 1
Specimen Label: Asxl2 -/-
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:7284399
Assay Type: RT-PCR
Annotation Date: 2022-06-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672827
Stage: TS27
Assay Id: MGI:7284423
Age: postnatal day 0
Image: 4
Specimen Label: +/+
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7284399
Assay Type: RT-PCR
Annotation Date: 2022-06-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672827
Stage: TS27
Assay Id: MGI:7284423
Age: postnatal day 0
Image: 4
Specimen Label: -/-
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3656290
Assay Type: RNA in situ
Annotation Date: 2006-10-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:3656374
Age: embryonic day 10.5
Note: Ubiquitous expression.
Specimen Label: 5A
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3656290
Assay Type: RNA in situ
Annotation Date: 2006-10-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603918
Pattern: Not Specified
Stage: TS18
Assay Id: MGI:3656374
Age: embryonic day 11.0
Note: Ubiquitous expression.
Specimen Label: 5B
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3656290
Assay Type: RNA in situ
Annotation Date: 2006-10-02
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1674817
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:3656374
Age: embryonic day 10.5
Specimen Label: 5A
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3656290
Assay Type: RNA in situ
Annotation Date: 2006-10-02
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1640617
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:3656374
Age: embryonic day 10.5
Specimen Label: 5A
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3656290
Assay Type: RNA in situ
Annotation Date: 2006-10-02
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1666817
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:3656374
Age: embryonic day 10.5
Specimen Label: 5A
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3656290
Assay Type: RNA in situ
Annotation Date: 2006-10-02
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1691417
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:3656374
Age: embryonic day 10.5
Specimen Label: 5A
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3656290
Assay Type: RNA in situ
Annotation Date: 2006-10-02
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1677917
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:3656374
Age: embryonic day 10.5
Specimen Label: 5A
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3656290
Assay Type: RNA in situ
Annotation Date: 2006-10-02
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1611717
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:3656374
Age: embryonic day 10.5
Specimen Label: 5A
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3656290
Assay Type: RNA in situ
Annotation Date: 2006-10-02
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1674818
Pattern: Not Specified
Stage: TS18
Assay Id: MGI:3656374
Age: embryonic day 11.0
Specimen Label: 5B
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3656290
Assay Type: RNA in situ
Annotation Date: 2006-10-02
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1640618
Pattern: Not Specified
Stage: TS18
Assay Id: MGI:3656374
Age: embryonic day 11.0
Specimen Label: 5B
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3656290
Assay Type: RNA in situ
Annotation Date: 2006-10-02
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1666818
Pattern: Not Specified
Stage: TS18
Assay Id: MGI:3656374
Age: embryonic day 11.0
Specimen Label: 5B
Detected: true
Specimen Num: 2