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Search results 1 to 100 out of 874 for Atf4

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Protein Domain
Type: Family
Description: ATF4 belongs to the ATF/cAMP-response element-binding protein family. It is a transcriptional activator that binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters [, ]. It plays a crucial role in the adaptation to stresses by regulating the transcription of many genes [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
GXD Expression
Probe: MGI:5000865
Assay Type: RNA in situ
Annotation Date: 2013-01-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3643723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:5448215
Age: embryonic day 15.5
Image: 4 Atf4
Note: Expression was detected in cortical kidney mesenchyme.
Specimen Label: 4 Atf4
Detected: true
Specimen Num: 1
Publication
First Author: Vallejo M
Year: 1993
Journal: Proc Natl Acad Sci U S A
Title: C/ATF, a member of the activating transcription factor family of DNA-binding proteins, dimerizes with CAAT/enhancer-binding proteins and directs their binding to cAMP response elements.
Volume: 90
Issue: 10
Pages: 4679-83
GXD Expression    
Probe: MGI:5811605
Assay Type: Western blot
Annotation Date: 2016-12-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689420
Stage: TS20
Assay Id: MGI:5811619
Age: embryonic day 12.0
Image: S4
Specimen Label: IP ATF4
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:5811601
Assay Type: Western blot
Annotation Date: 2016-12-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689420
Stage: TS20
Assay Id: MGI:5811620
Age: embryonic day 12.0
Image: S4
Specimen Label: IP ATF4
Detected: true
Specimen Num: 2
Protein
Organism: Mus musculus/domesticus
Length: 153  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 116  
Fragment?: true
Publication
First Author: B'chir W
Year: 2013
Journal: Nucleic Acids Res
Title: The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression.
Volume: 41
Issue: 16
Pages: 7683-99
Publication
First Author: Gachon F
Year: 2002
Journal: Virology
Title: Activation of HTLV-I transcription in the presence of Tax is independent of the acetylation of CREB-2 (ATF-4).
Volume: 299
Issue: 2
Pages: 271-8
Publication
First Author: Wang X
Year: 2013
Journal: Nat Med
Title: miR-214 targets ATF4 to inhibit bone formation.
Volume: 19
Issue: 1
Pages: 93-100
Publication
First Author: Tanaka T
Year: 1998
Journal: Genes Cells
Title: Targeted disruption of ATF4 discloses its essential role in the formation of eye lens fibres.
Volume: 3
Issue: 12
Pages: 801-10
Protein
Organism: Mus musculus/domesticus
Length: 349  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 263  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 349  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 381  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 350  
Fragment?: false
Publication
First Author: Li H
Year: 2011
Journal: Biochem J
Title: ATF4 deficiency protects mice from high-carbohydrate-diet-induced liver steatosis.
Volume: 438
Issue: 2
Pages: 283-9
Publication  
First Author: Sobajima M
Year: 2022
Journal: Biochem Biophys Res Commun
Title: The multifaceted role of ATF4 in regulating glucose-stimulated insulin secretion.
Volume: 611
Pages: 165-171
Publication
First Author: Seo J
Year: 2009
Journal: Diabetes
Title: Atf4 regulates obesity, glucose homeostasis, and energy expenditure.
Volume: 58
Issue: 11
Pages: 2565-73
Publication
First Author: Wang W
Year: 2012
Journal: Development
Title: Chondrocytic Atf4 regulates osteoblast differentiation and function via Ihh.
Volume: 139
Issue: 3
Pages: 601-11
Publication
First Author: Xiao G
Year: 2013
Journal: J Biol Chem
Title: ATF4 protein deficiency protects against high fructose-induced hypertriglyceridemia in mice.
Volume: 288
Issue: 35
Pages: 25350-61
Publication
First Author: Zhang Y
Year: 2019
Journal: J Bone Miner Res
Title: Hop2 Interacts with ATF4 to Promote Osteoblast Differentiation.
Volume: 34
Issue: 12
Pages: 2287-2300
Publication
First Author: Ord D
Year: 2003
Journal: Exp Cell Res
Title: Mouse NIPK interacts with ATF4 and affects its transcriptional activity.
Volume: 286
Issue: 2
Pages: 308-20
Publication
First Author: Wang X
Year: 2022
Journal: Circ Res
Title: ATF4 Protects the Heart From Failure by Antagonizing Oxidative Stress.
Volume: 131
Issue: 1
Pages: 91-105
Publication
First Author: Yang X
Year: 2018
Journal: Cell Rep
Title: ATF4 Regulates CD4+ T Cell Immune Responses through Metabolic Reprogramming.
Volume: 23
Issue: 6
Pages: 1754-1766
Publication
First Author: Yue Y
Year: 2019
Journal: J Neuroinflammation
Title: Oligodendrocyte-specific ATF4 inactivation does not influence the development of EAE.
Volume: 16
Issue: 1
Pages: 23
Publication
First Author: Paulo E
Year: 2021
Journal: Cell Rep
Title: Brown adipocyte ATF4 activation improves thermoregulation and systemic metabolism.
Volume: 36
Issue: 12
Pages: 109742
Publication
First Author: Xie MX
Year: 2021
Journal: Nat Commun
Title: ATF4 selectively regulates heat nociception and contributes to kinesin-mediated TRPM3 trafficking.
Volume: 12
Issue: 1
Pages: 1401
Publication    
First Author: Miller MJ
Year: 2023
Journal: Geroscience
Title: The transcription regulator ATF4 is a mediator of skeletal muscle aging.
Pages: 1-19
Publication
First Author: Tameire F
Year: 2019
Journal: Nat Cell Biol
Title: ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression.
Volume: 21
Issue: 7
Pages: 889-899
Publication
First Author: Pasini S
Year: 2015
Journal: Cell Rep
Title: Specific downregulation of hippocampal ATF4 reveals a necessary role in synaptic plasticity and memory.
Volume: 11
Issue: 2
Pages: 183-91
Publication
First Author: Suragani RN
Year: 2012
Journal: Blood
Title: Heme-regulated eIF2α kinase activated Atf4 signaling pathway in oxidative stress and erythropoiesis.
Volume: 119
Issue: 22
Pages: 5276-84
Publication
First Author: Matus S
Year: 2013
Journal: PLoS One
Title: Functional contribution of the transcription factor ATF4 to the pathogenesis of amyotrophic lateral sclerosis.
Volume: 8
Issue: 7
Pages: e66672
Publication
First Author: Horiguchi M
Year: 2012
Journal: Cancer Res
Title: Stress-regulated transcription factor ATF4 promotes neoplastic transformation by suppressing expression of the INK4a/ARF cell senescence factors.
Volume: 72
Issue: 2
Pages: 395-401
Publication
First Author: Wang W
Year: 2009
Journal: Development
Title: Atf4 regulates chondrocyte proliferation and differentiation during endochondral ossification by activating Ihh transcription.
Volume: 136
Issue: 24
Pages: 4143-53
Publication
First Author: Kasetti RB
Year: 2020
Journal: Nat Commun
Title: ATF4 leads to glaucoma by promoting protein synthesis and ER client protein load.
Volume: 11
Issue: 1
Pages: 5594
Publication
First Author: Trinh MA
Year: 2012
Journal: Cell Rep
Title: Brain-specific disruption of the eIF2α kinase PERK decreases ATF4 expression and impairs behavioral flexibility.
Volume: 1
Issue: 6
Pages: 676-88
Publication
First Author: Chen H
Year: 2016
Journal: Biochim Biophys Acta
Title: ATF4 regulates SREBP1c expression to control fatty acids synthesis in 3T3-L1 adipocytes differentiation.
Volume: 1859
Issue: 11
Pages: 1459-1469
Publication
First Author: Lange PS
Year: 2008
Journal: J Exp Med
Title: ATF4 is an oxidative stress-inducible, prodeath transcription factor in neurons in vitro and in vivo.
Volume: 205
Issue: 5
Pages: 1227-42
Publication
First Author: Wang X
Year: 2013
Journal: Invest Ophthalmol Vis Sci
Title: Modulation of angiogenesis by genetic manipulation of ATF4 in mouse model of oxygen-induced retinopathy [corrected].
Volume: 54
Issue: 9
Pages: 5995-6002
Publication
First Author: Wang C
Year: 2013
Journal: Metabolism
Title: Effects of ATF4 on PGC1α expression in brown adipose tissue and metabolic responses to cold stress.
Volume: 62
Issue: 2
Pages: 282-9
Publication
First Author: Li K
Year: 2016
Journal: J Biol Chem
Title: Liver-specific Gene Inactivation of the Transcription Factor ATF4 Alleviates Alcoholic Liver Steatosis in Mice.
Volume: 291
Issue: 35
Pages: 18536-46
Publication
First Author: Quirós PM
Year: 2017
Journal: J Cell Biol
Title: Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals.
Volume: 216
Issue: 7
Pages: 2027-2045
GXD Expression    
Probe: MGI:6167890
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6189822
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Atf4
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6167890
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6189822
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Atf4
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6167890
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6189822
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Atf4
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6167890
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6189822
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Atf4
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6167890
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189822
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Atf4
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6167890
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189822
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Atf4
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6167890
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189822
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Atf4
Detected: true
Specimen Num: 7
Publication
First Author: Kode A
Year: 2012
Journal: J Biol Chem
Title: FoxO1 protein cooperates with ATF4 protein in osteoblasts to control glucose homeostasis.
Volume: 287
Issue: 12
Pages: 8757-68
Publication
First Author: Yoshizawa T
Year: 2009
Journal: J Clin Invest
Title: The transcription factor ATF4 regulates glucose metabolism in mice through its expression in osteoblasts.
Volume: 119
Issue: 9
Pages: 2807-17
Publication
First Author: Deng J
Year: 2017
Journal: Diabetes
Title: Deletion of ATF4 in AgRP Neurons Promotes Fat Loss Mainly via Increasing Energy Expenditure.
Volume: 66
Issue: 3
Pages: 640-650
Publication
First Author: Bjorkman SH
Year: 2024
Journal: Sci Rep
Title: ATF4 expression in thermogenic adipocytes is required for cold-induced thermogenesis in mice via FGF21-independent mechanisms.
Volume: 14
Issue: 1
Pages: 1563
Publication
First Author: Wang C
Year: 2014
Journal: J Cell Mol Med
Title: ATF4 deficiency protects hepatocytes from oxidative stress via inhibiting CYP2E1 expression.
Volume: 18
Issue: 1
Pages: 80-90
Publication
First Author: Chérasse Y
Year: 2007
Journal: Nucleic Acids Res
Title: The p300/CBP-associated factor (PCAF) is a cofactor of ATF4 for amino acid-regulated transcription of CHOP.
Volume: 35
Issue: 17
Pages: 5954-65
Publication
First Author: Li W
Year: 2015
Journal: J Gerontol A Biol Sci Med Sci
Title: Elevated ATF4 function in fibroblasts and liver of slow-aging mutant mice.
Volume: 70
Issue: 3
Pages: 263-72
Publication
First Author: Yu VW
Year: 2009
Journal: Gene Expr Patterns
Title: FIAT is co-expressed with its dimerization target ATF4 in early osteoblasts, but not in osteocytes.
Volume: 9
Issue: 5
Pages: 335-40
Publication  
First Author: Byles V
Year: 2021
Journal: Mol Metab
Title: Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin.
Volume: 53
Pages: 101309
Publication
First Author: Fox DK
Year: 2014
Journal: Am J Physiol Endocrinol Metab
Title: p53 and ATF4 mediate distinct and additive pathways to skeletal muscle atrophy during limb immobilization.
Volume: 307
Issue: 3
Pages: E245-61
Publication
First Author: Elefteriou F
Year: 2006
Journal: Cell Metab
Title: ATF4 mediation of NF1 functions in osteoblast reveals a nutritional basis for congenital skeletal dysplasiae.
Volume: 4
Issue: 6
Pages: 441-51
Publication
First Author: Chen A
Year: 2003
Journal: Neuron
Title: Inducible enhancement of memory storage and synaptic plasticity in transgenic mice expressing an inhibitor of ATF4 (CREB-2) and C/EBP proteins.
Volume: 39
Issue: 4
Pages: 655-69
Publication
First Author: Ambivero CT
Year: 2012
Journal: Biochim Biophys Acta
Title: ATF4 interacts with Abro1/KIAA0157 scaffold protein and participates in a cytoprotective pathway.
Volume: 1823
Issue: 12
Pages: 2149-56
Publication
First Author: Horiguchi M
Year: 2013
Journal: Cancer Res
Title: Rhythmic control of the ARF-MDM2 pathway by ATF4 underlies circadian accumulation of p53 in malignant cells.
Volume: 73
Issue: 8
Pages: 2639-49
Publication
First Author: Yang X
Year: 2004
Journal: Cell
Title: ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome.
Volume: 117
Issue: 3
Pages: 387-98
Publication
First Author: Zhu K
Year: 2013
Journal: J Bone Miner Res
Title: ATF4 promotes bone angiogenesis by increasing VEGF expression and release in the bone environment.
Volume: 28
Issue: 9
Pages: 1870-1884
Publication  
First Author: Xiang J
Year: 2023
Journal: Cells
Title: ATF4 May Be Essential for Adaption of the Ocular Lens to Its Avascular Environment.
Volume: 12
Issue: 22
Publication
First Author: Zhao Y
Year: 2015
Journal: Blood
Title: ATF4 plays a pivotal role in the development of functional hematopoietic stem cells in mouse fetal liver.
Volume: 126
Issue: 21
Pages: 2383-91
Publication
First Author: Liew CW
Year: 2010
Journal: J Clin Invest
Title: The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse beta cells.
Volume: 120
Issue: 8
Pages: 2876-88
Publication
First Author: Hu X
Year: 2019
Journal: Gastroenterology
Title: ATF4 Deficiency Promotes Intestinal Inflammation in Mice by Reducing Uptake of Glutamine and Expression of Antimicrobial Peptides.
Volume: 156
Issue: 4
Pages: 1098-1111
Publication
First Author: Gao Y
Year: 2023
Journal: Sci Rep
Title: Opposite modulation of functional recovery following contusive spinal cord injury in mice with oligodendrocyte-selective deletions of Atf4 and Chop/Ddit3.
Volume: 13
Issue: 1
Pages: 9193
Publication
First Author: Oyabu M
Year: 2022
Journal: FASEB J
Title: FOXO1 cooperates with C/EBPδ and ATF4 to regulate skeletal muscle atrophy transcriptional program during fasting.
Volume: 36
Issue: 2
Pages: e22152
Publication
First Author: Fusakio ME
Year: 2016
Journal: Mol Biol Cell
Title: Transcription factor ATF4 directs basal and stress-induced gene expression in the unfolded protein response and cholesterol metabolism in the liver.
Volume: 27
Issue: 9
Pages: 1536-51
Publication
First Author: Bhootada Y
Year: 2016
Journal: PLoS One
Title: Limited ATF4 Expression in Degenerating Retinas with Ongoing ER Stress Promotes Photoreceptor Survival in a Mouse Model of Autosomal Dominant Retinitis Pigmentosa.
Volume: 11
Issue: 5
Pages: e0154779
Publication
First Author: Ritter B
Year: 2004
Journal: Brain Res Dev Brain Res
Title: The GABA(B) receptor subunits R1 and R2 interact differentially with the activation transcription factor ATF4 in mouse brain during the postnatal development.
Volume: 149
Issue: 1
Pages: 73-7
Publication
First Author: Song H
Year: 2008
Journal: J Biol Chem
Title: Inactivation of G-protein-coupled receptor 48 (Gpr48/Lgr4) impairs definitive erythropoiesis at midgestation through down-regulation of the ATF4 signaling pathway.
Volume: 283
Issue: 52
Pages: 36687-97
Publication
First Author: Luo S
Year: 2003
Journal: J Biol Chem
Title: Induction of Grp78/BiP by translational block: activation of the Grp78 promoter by ATF4 through and upstream ATF/CRE site independent of the endoplasmic reticulum stress elements.
Volume: 278
Issue: 39
Pages: 37375-85
Publication
First Author: Masuoka HC
Year: 2002
Journal: Blood
Title: Targeted disruption of the activating transcription factor 4 gene results in severe fetal anemia in mice.
Volume: 99
Issue: 3
Pages: 736-45
Publication
First Author: Yu VW
Year: 2005
Journal: J Cell Biol
Title: FIAT represses ATF4-mediated transcription to regulate bone mass in transgenic mice.
Volume: 169
Issue: 4
Pages: 591-601
Publication
First Author: MacArthur MR
Year: 2022
Journal: Cell Rep
Title: Multiomics assessment of dietary protein titration reveals altered hepatic glucose utilization.
Volume: 40
Issue: 7
Pages: 111187
Publication
First Author: Yu S
Year: 2009
Journal: PLoS One
Title: Critical role of activating transcription factor 4 in the anabolic actions of parathyroid hormone in bone.
Volume: 4
Issue: 10
Pages: e7583
Publication
First Author: Fan Z
Year: 2021
Journal: Cell Metab
Title: Exercise-induced angiogenesis is dependent on metabolically primed ATF3/4+ endothelial cells.
Volume: 33
Issue: 9
Pages: 1793-1807.e9
Publication
First Author: Jin HO
Year: 2009
Journal: FEBS Lett
Title: SP600125 negatively regulates the mammalian target of rapamycin via ATF4-induced Redd1 expression.
Volume: 583
Issue: 1
Pages: 123-7
Publication  
First Author: Mendes A
Year: 2021
Journal: Life Sci Alliance
Title: Proteostasis in dendritic cells is controlled by the PERK signaling axis independently of ATF4.
Volume: 4
Issue: 2
Publication
First Author: D'Aniello C
Year: 2015
Journal: Cell Death Differ
Title: A novel autoregulatory loop between the Gcn2-Atf4 pathway and (L)-Proline [corrected] metabolism controls stem cell identity.
Volume: 22
Issue: 7
Pages: 1094-105
Publication
First Author: Han J
Year: 2013
Journal: Nat Cell Biol
Title: ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death.
Volume: 15
Issue: 5
Pages: 481-90
Publication    
First Author: Pereira RO
Year: 2021
Journal: Elife
Title: OPA1 deletion in brown adipose tissue improves thermoregulation and systemic metabolism via FGF21.
Volume: 10
Publication
First Author: Masuda M
Year: 2016
Journal: JCI Insight
Title: Activating transcription factor-4 promotes mineralization in vascular smooth muscle cells.
Volume: 1
Issue: 18
Pages: e88646
Publication  
First Author: Stone S
Year: 2019
Journal: JCI Insight
Title: Neuron-specific PERK inactivation exacerbates neurodegeneration during experimental autoimmune encephalomyelitis.
Volume: 4
Issue: 2
Publication
First Author: Cao H
Year: 2010
Journal: J Clin Invest
Title: Activating transcription factor 4 regulates osteoclast differentiation in mice.
Volume: 120
Issue: 8
Pages: 2755-66
Publication
First Author: Chen Y
Year: 2012
Journal: Diabetologia
Title: Activating transcription factor 4 mediates hyperglycaemia-induced endothelial inflammation and retinal vascular leakage through activation of STAT3 in a mouse model of type 1 diabetes.
Volume: 55
Issue: 9
Pages: 2533-45