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Search results 1 to 100 out of 805 for Atg5

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Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
9474 | ATG5
Type: gene
Organism: human
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Gene
494180 | atg5
Type: gene
Organism: zebrafish
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Gene
365601 | Atg5
Type: gene
Organism: rat
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Gene
462905 | ATG5
Type: gene
Organism: chimpanzee
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Gene
532686 | ATG5
Type: gene
Organism: cattle
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Gene
421784 | ATG5
Type: gene
Organism: chicken
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Gene
696874 | ATG5
Type: gene
Organism: macaque, rhesus
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Gene
549199 | atg5
Type: gene
Organism: frog, western clawed
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Gene
610868 | ATG5
Type: gene
Organism: dog, domestic
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Protein Domain
IPR007239 | Atg5
Type: Family
Description: Macroautophagy is a bulk degradation process induced by starvation in eukaryotic cells. In yeast, 15 Atg proteins coordinate the formation of autophagosomes. The pre-autophagosomal structure contains at least five Atg proteins: Atg1p, Atg2p, Atg5p, Aut7p/Atg8p and Atg16p, found in the vacuole [, ]. The C-terminal glycine of Atg12p is conjugated to a lysine residue of Atg5p via an isopeptide bond. During autophagy, cytoplasmic components are enclosed in autophagosomes and delivered to lysosomes/vacuoles. Autophagy protein 16 (Atg16) has been shown to bind to Atg5 and is required for the function of the Atg12p-Atg5p conjugate []. Autophagy protein 5 (Atg5) is directly required for the import of aminopeptidase I via the cytoplasm-to-vacuole targeting pathway [].This entry represents autophagy protein 5 (Atg5).
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Protein Coding Gene
MGI:1277186 | Atg5
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
23327930 | J:282702
First Author: Conway KL
Year: 2013
Journal: Autophagy
Title: ATG5 regulates plasma cell differentiation.
Volume: 9
Issue: 4
Pages: 528-37
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Publication
31978760 | J:303370
 
First Author: Wang Z
Year: 2020
Journal: Atherosclerosis
Title: Myeloid atg5 deletion impairs n-3 PUFA-mediated atheroprotection.
Volume: 295
Pages: 8-17
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Publication
10712513 | -
First Author: George MD
Year: 2000
Journal: Mol Biol Cell
Title: Apg5p functions in the sequestration step in the cytoplasm-to-vacuole targeting and macroautophagy pathways.
Volume: 11
Issue: 3
Pages: 969-82
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Publication
10406794 | -
First Author: Mizushima N
Year: 1999
Journal: EMBO J
Title: Apg16p is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway.
Volume: 18
Issue: 14
Pages: 3888-96
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Publication
2306415 | -
First Author: Cuthbert AW
Year: 1990
Journal: Br J Clin Pharmacol
Title: Altered sensitivity to amiloride in cystic fibrosis. Observations using cultured sweat glands.
Volume: 29
Issue: 2
Pages: 227-34
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Protein
Q8CF05
Organism: Mus musculus/domesticus
Length: 97  
Fragment?: true
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Publication
11689437 | -
First Author: Suzuki K
Year: 2001
Journal: EMBO J
Title: The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation.
Volume: 20
Issue: 21
Pages: 5971-81
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Protein
Q99J83
Organism: Mus musculus/domesticus
Length: 275  
Fragment?: false
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Protein
A0A385JBX3
Organism: Mus musculus/domesticus
Length: 243  
Fragment?: true
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Publication
33598715 | J:315089
First Author: Germic N
Year: 2021
Journal: Blood
Title: ATG5 promotes eosinopoiesis but inhibits eosinophil effector functions.
Volume: 137
Issue: 21
Pages: 2958-2969
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Publication
28375544 | J:245229
First Author: Xu F
Year: 2017
Journal: Immunology
Title: Aging-related Atg5 defect impairs neutrophil extracellular traps formation.
Volume: 151
Issue: 4
Pages: 417-432
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Publication
23939249 | J:221225
 
First Author: Pyo JO
Year: 2013
Journal: Nat Commun
Title: Overexpression of Atg5 in mice activates autophagy and extends lifespan.
Volume: 4
Pages: 2300
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Publication
31070476 | J:292095
First Author: Sprott D
Year: 2019
Journal: Arterioscler Thromb Vasc Biol
Title: Endothelial-Specific Deficiency of ATG5 (Autophagy Protein 5) Attenuates Ischemia-Related Angiogenesis.
Volume: 39
Issue: 6
Pages: 1137-1148
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Publication
26438374 | J:312637
First Author: Bouderlique T
Year: 2016
Journal: Ann Rheum Dis
Title: Targeted deletion of Atg5 in chondrocytes promotes age-related osteoarthritis.
Volume: 75
Issue: 3
Pages: 627-31
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Publication
27693508 | J:236380
First Author: Yoshii SR
Year: 2016
Journal: Dev Cell
Title: Systemic Analysis of Atg5-Null Mice Rescued from Neonatal Lethality by Transgenic ATG5 Expression in Neurons.
Volume: 39
Issue: 1
Pages: 116-130
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Publication
25341032 | J:264465
 
First Author: Lin HH
Year: 2014
Journal: Cell Death Dis
Title: Dynamic involvement of ATG5 in cellular stress responses.
Volume: 5
Pages: e1478
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Publication
22240590 | J:193585
First Author: Vázquez P
Year: 2012
Journal: Autophagy
Title: Atg5 and Ambra1 differentially modulate neurogenesis in neural stem cells.
Volume: 8
Issue: 2
Pages: 187-99
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Publication
17709747 | J:124905
First Author: Jounai N
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: The Atg5 Atg12 conjugate associates with innate antiviral immune responses.
Volume: 104
Issue: 35
Pages: 14050-5
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Publication
27210760 | J:235957
First Author: O'Sullivan TE
Year: 2016
Journal: Cell Rep
Title: Atg5 Is Essential for the Development and Survival of Innate Lymphocytes.
Volume: 15
Issue: 9
Pages: 1910-9
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Publication
25109817 | J:212532
 
First Author: Lv X
Year: 2014
Journal: Sci Rep
Title: The crucial role of Atg5 in cortical neurogenesis during early brain development.
Volume: 4
Pages: 6010
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Publication
18188005 | J:222383
First Author: Miller BC
Year: 2008
Journal: Autophagy
Title: The autophagy gene ATG5 plays an essential role in B lymphocyte development.
Volume: 4
Issue: 3
Pages: 309-14
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Publication
33522362 | J:329184
First Author: Srimat Kandadai K
Year: 2021
Journal: Autophagy
Title: ATG5 in microglia does not contribute vitally to autoimmune neuroinflammation in mice.
Volume: 17
Issue: 11
Pages: 3566-3576
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Publication
30196744 | J:278116
First Author: Arbogast F
Year: 2019
Journal: Autophagy
Title: ATG5 is required for B cell polarization and presentation of particulate antigens.
Volume: 15
Issue: 2
Pages: 280-294
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Publication
17190837 | J:125311
First Author: Pua HH
Year: 2007
Journal: J Exp Med
Title: A critical role for the autophagy gene Atg5 in T cell survival and proliferation.
Volume: 204
Issue: 1
Pages: 25-31
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Publication
18996346 | J:254585
First Author: Zhao Z
Year: 2008
Journal: Cell Host Microbe
Title: Autophagosome-independent essential function for the autophagy protein Atg5 in cellular immunity to intracellular pathogens.
Volume: 4
Issue: 5
Pages: 458-69
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Publication
26649827 | J:228300
First Author: Kimmey JM
Year: 2015
Journal: Nature
Title: Unique role for ATG5 in neutrophil-mediated immunopathology during M. tuberculosis infection.
Volume: 528
Issue: 7583
Pages: 565-9
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Publication
26975471 | J:234819
First Author: Chandra M
Year: 2016
Journal: Biochem Biophys Res Commun
Title: Deciphering the role of Atg5 in nucleotide dependent interaction of Rab33B with the dimeric complex, Atg5-Atg16L1.
Volume: 473
Issue: 1
Pages: 8-16
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Publication
25484072 | J:319961
First Author: Kim JH
Year: 2015
Journal: Autophagy
Title: Insights into autophagosome maturation revealed by the structures of ATG5 with its interacting partners.
Volume: 11
Issue: 1
Pages: 75-87
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Publication
30900506 | J:295240
First Author: Oh DS
Year: 2019
Journal: Autophagy
Title: Autophagy protein ATG5 regulates CD36 expression and anti-tumor MHC class II antigen presentation in dendritic cells.
Volume: 15
Issue: 12
Pages: 2091-2106
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Publication
24418158 | J:211940
 
First Author: Zhao W
Year: 2014
Journal: Free Radic Biol Med
Title: Atg5 deficiency-mediated mitophagy aggravates cardiac inflammation and injury in response to angiotensin II.
Volume: 69
Pages: 108-15
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Publication
36342387 | J:334653
First Author: Yu S
Year: 2022
Journal: FASEB J
Title: Loss of ATG5 in KRT14(+) cells leads to accumulated functional impairments of salivary glands via pyroptosis.
Volume: 36
Issue: 12
Pages: e22631
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Publication
23211599 | J:193865
First Author: Sukseree S
Year: 2013
Journal: Biochem Biophys Res Commun
Title: Targeted deletion of Atg5 reveals differential roles of autophagy in keratin K5-expressing epithelia.
Volume: 430
Issue: 2
Pages: 689-94
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Publication
34374750 | J:329183
First Author: Merkley SD
Year: 2022
Journal: J Crohns Colitis
Title: Non-autophagy Role of Atg5 and NBR1 in Unconventional Secretion of IL-12 Prevents Gut Dysbiosis and Inflammation.
Volume: 16
Issue: 2
Pages: 259-274
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Publication
37054706 | J:335454
First Author: Wang F
Year: 2023
Journal: Dev Cell
Title: ATG5 provides host protection acting as a switch in the atg8ylation cascade between autophagy and secretion.
Volume: 58
Issue: 10
Pages: 866-884.e8
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Publication
25227738 | J:217554
First Author: Wang S
Year: 2014
Journal: EMBO Rep
Title: Autophagy-related gene Atg5 is essential for astrocyte differentiation in the developing mouse cortex.
Volume: 15
Issue: 10
Pages: 1053-61
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Publication
23884556 | J:229522
First Author: Morgan-Bathke M
Year: 2013
Journal: J Dent Res
Title: Deletion of ATG5 shows a role of autophagy in salivary homeostatic control.
Volume: 92
Issue: 10
Pages: 911-7
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Publication
26938300 | J:329127
 
First Author: Xi Y
Year: 2016
Journal: Cell Death Dis
Title: Knockout of Atg5 delays the maturation and reduces the survival of adult-generated neurons in the hippocampus.
Volume: 7
Pages: e2127
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Publication
22491424 | J:185717
First Author: Ni HM
Year: 2012
Journal: Toxicol Sci
Title: Liver-specific loss of Atg5 causes persistent activation of Nrf2 and protects against acetaminophen-induced liver injury.
Volume: 127
Issue: 2
Pages: 438-50
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Publication
23831471 | J:210782
First Author: Inomata M
Year: 2013
Journal: Biochem Biophys Res Commun
Title: Atg5 regulates formation of MyD88 condensed structures and MyD88-dependent signal transduction.
Volume: 437
Issue: 4
Pages: 509-14
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Publication
26965188 | J:236562
 
First Author: Acharya M
Year: 2016
Journal: Nat Commun
Title: αv Integrins combine with LC3 and atg5 to regulate Toll-like receptor signalling in B cells.
Volume: 7
Pages: 10917
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Publication
19139628 | J:329129
First Author: Cadwell K
Year: 2009
Journal: Autophagy
Title: A common role for Atg16L1, Atg5 and Atg7 in small intestinal Paneth cells and Crohn disease.
Volume: 5
Issue: 2
Pages: 250-2
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Publication
32462028 | J:304241
 
First Author: Liu CJ
Year: 2020
Journal: Biomed Res Int
Title: In Vivo Suppression of Autophagy via Lentiviral shRNA Targeting Atg5 Improves Lupus-Like Syndrome.
Volume: 2020
Pages: 8959726
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Publication
36187114 | J:329448
 
First Author: Hamada K
Year: 2022
Journal: Front Endocrinol (Lausanne)
Title: MIEAP and ATG5 are tumor suppressors in a mouse model of BRAFV600E-positive thyroid cancer.
Volume: 13
Pages: 932754
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Publication
34512629 | J:312741
 
First Author: Plaza-Sirvent C
Year: 2021
Journal: Front Immunol
Title: A Central Role for Atg5 in Microbiota-Dependent Foxp3+ RORγt+ Treg Cell Preservation to Maintain Intestinal Immune Homeostasis.
Volume: 12
Pages: 705436
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Publication
20171125 | J:157911
First Author: Lee HK
Year: 2010
Journal: Immunity
Title: In vivo requirement for Atg5 in antigen presentation by dendritic cells.
Volume: 32
Issue: 2
Pages: 227-39
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Publication
32677505 | J:307712
   
First Author: Huang Q
Year: 2020
Journal: Autophagy
Title: Autophagy core protein ATG5 is required for elongating spermatid development, sperm individualization and normal fertility in male mice.
Pages: 1-15
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Publication
25695667 | J:279692
First Author: Wang L
Year: 2015
Journal: Cancer Biol Ther
Title: Heterozygous deletion of ATG5 in Apc(Min/+) mice promotes intestinal adenoma growth and enhances the antitumor efficacy of interferon-gamma.
Volume: 16
Issue: 3
Pages: 383-91
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Publication
33752242 | J:325638
First Author: Ljubojević-Holzer S
Year: 2022
Journal: Cardiovasc Res
Title: Loss of autophagy protein ATG5 impairs cardiac capacity in mice and humans through diminishing mitochondrial abundance and disrupting Ca2+ cycling.
Volume: 118
Issue: 6
Pages: 1492-1505
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Publication
26077727 | J:315414
First Author: Vuppalapati KK
Year: 2015
Journal: J Bone Miner Res
Title: Targeted Deletion of Autophagy Genes Atg5 or Atg7 in the Chondrocytes Promotes Caspase-Dependent Cell Death and Leads to Mild Growth Retardation.
Volume: 30
Issue: 12
Pages: 2249-61
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Publication
29306553 | J:259690
 
First Author: Shroff A
Year: 2018
Journal: Cell Immunol
Title: Knockout of autophagy gene, ATG5 in mice vaginal cells abrogates cytokine response and pathogen clearance during vaginal infection of Candida albicans.
Volume: 324
Pages: 59-73
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Publication
30297526 | J:329124
 
First Author: Bechelli J
Year: 2019
Journal: Infect Immun
Title: Atg5 Supports Rickettsia australis Infection in Macrophages In Vitro and In Vivo.
Volume: 87
Issue: 1
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Publication
31451060 | J:310717
First Author: Wang X
Year: 2020
Journal: Autophagy
Title: m6A mRNA methylation controls autophagy and adipogenesis by targeting Atg5 and Atg7.
Volume: 16
Issue: 7
Pages: 1221-1235
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Publication
28465655 | J:245130
 
First Author: Zhang Y
Year: 2017
Journal: Mol Vis
Title: Early AMD-like defects in the RPE and retinal degeneration in aged mice with RPE-specific deletion of Atg5 or Atg7.
Volume: 23
Pages: 228-241
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HT Experiment
E-TABM-815 | Transcription profiling of mouse colonic goblet cells deficient in Atg5
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
34078910 | J:314513
First Author: Yamamoto Y
Year: 2021
Journal: Nat Commun
Title: NEK9 regulates primary cilia formation by acting as a selective autophagy adaptor for MYH9/myosin IIA.
Volume: 12
Issue: 1
Pages: 3292
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Publication
36735498 | J:335881
First Author: Ishii S
Year: 2023
Journal: Mol Biol Cell
Title: CCPG1 recognizes endoplasmic reticulum luminal proteins for selective ER-phagy.
Volume: 34
Issue: 4
Pages: ar29
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Publication
31006538 | J:278382
First Author: Chino H
Year: 2019
Journal: Mol Cell
Title: Intrinsically Disordered Protein TEX264 Mediates ER-phagy.
Volume: 74
Issue: 5
Pages: 909-921.e6
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Publication
18599786 | J:137421
First Author: Tsukamoto S
Year: 2008
Journal: Science
Title: Autophagy is essential for preimplantation development of mouse embryos.
Volume: 321
Issue: 5885
Pages: 117-20
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Publication
29999454 | J:289254
First Author: Cassidy LD
Year: 2018
Journal: Autophagy
Title: A novel Atg5-shRNA mouse model enables temporal control of Autophagy in vivo.
Volume: 14
Issue: 7
Pages: 1256-1266
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Publication
16625204 | J:110050
First Author: Hara T
Year: 2006
Journal: Nature
Title: Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice.
Volume: 441
Issue: 7095
Pages: 885-9
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Publication
33157003 | J:300554
First Author: Kuijpers M
Year: 2021
Journal: Neuron
Title: Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum.
Volume: 109
Issue: 2
Pages: 299-313.e9
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Publication
21493778 | J:179961
First Author: Kimura T
Year: 2011
Journal: J Am Soc Nephrol
Title: Autophagy protects the proximal tubule from degeneration and acute ischemic injury.
Volume: 22
Issue: 5
Pages: 902-13
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Publication
21957292 | J:178543
First Author: Tian Y
Year: 2011
Journal: J Virol
Title: Autophagy required for hepatitis B virus replication in transgenic mice.
Volume: 85
Issue: 24
Pages: 13453-6
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Publication
28492547 | J:258711
First Author: Fujimoto C
Year: 2017
Journal: Cell Death Dis
Title: Autophagy is essential for hearing in mice.
Volume: 8
Issue: 5
Pages: e2780
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Publication
26749442 | J:260382
First Author: Akoumianaki T
Year: 2016
Journal: Cell Host Microbe
Title: Aspergillus Cell Wall Melanin Blocks LC3-Associated Phagocytosis to Promote Pathogenicity.
Volume: 19
Issue: 1
Pages: 79-90
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Publication
22423969 | J:278800
First Author: Alirezaei M
Year: 2012
Journal: Cell Host Microbe
Title: Pancreatic acinar cell-specific autophagy disruption reduces coxsackievirus replication and pathogenesis in vivo.
Volume: 11
Issue: 3
Pages: 298-305
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Publication
21498569 | J:171611
First Author: Takamura A
Year: 2011
Journal: Genes Dev
Title: Autophagy-deficient mice develop multiple liver tumors.
Volume: 25
Issue: 8
Pages: 795-800
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Publication
29358083 | J:273741
First Author: Burger E
Year: 2018
Journal: Cell Host Microbe
Title: Loss of Paneth Cell Autophagy Causes Acute Susceptibility to Toxoplasma gondii-Mediated Inflammation.
Volume: 23
Issue: 2
Pages: 177-190.e4
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Publication
16794605 | J:132345
First Author: Kouroku Y
Year: 2007
Journal: Cell Death Differ
Title: ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation.
Volume: 14
Issue: 2
Pages: 230-9
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Publication
17700057 | J:282479
First Author: Zhao Z
Year: 2007
Journal: Autophagy
Title: Coronavirus replication does not require the autophagy gene ATG5.
Volume: 3
Issue: 6
Pages: 581-5
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Publication
27568548 | J:256735
First Author: Altshuler-Keylin S
Year: 2016
Journal: Cell Metab
Title: Beige Adipocyte Maintenance Is Regulated by Autophagy-Induced Mitochondrial Clearance.
Volume: 24
Issue: 3
Pages: 402-419
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Publication
19571141 | J:150805
First Author: Lee JA
Year: 2009
Journal: J Neurosci
Title: Inhibition of autophagy induction delays neuronal cell loss caused by dysfunctional ESCRT-III in frontotemporal dementia.
Volume: 29
Issue: 26
Pages: 8506-11
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Publication
25585051 | J:232686
First Author: Malhotra R
Year: 2015
Journal: Autophagy
Title: Loss of Atg12, but not Atg5, in pro-opiomelanocortin neurons exacerbates diet-induced obesity.
Volume: 11
Issue: 1
Pages: 145-54
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Publication
38490977 | J:346061
First Author: Liu Y
Year: 2024
Journal: Nat Commun
Title: Autophagy regulates the maturation of hematopoietic precursors in the embryo.
Volume: 15
Issue: 1
Pages: 2255
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Publication
23123158 | J:192272
First Author: Park SJ
Year: 2012
Journal: FEBS Lett
Title: Mitochondrial fragmentation caused by phenanthroline promotes mitophagy.
Volume: 586
Issue: 24
Pages: 4303-10
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Publication
27117419 | J:235386
First Author: Loi M
Year: 2016
Journal: Cell Rep
Title: Macroautophagy Proteins Control MHC Class I Levels on Dendritic Cells and Shape Anti-viral CD8(+) T Cell Responses.
Volume: 15
Issue: 5
Pages: 1076-1087
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Publication
25362489 | J:260630
First Author: Xu X
Year: 2014
Journal: Nat Immunol
Title: Autophagy is essential for effector CD8(+) T cell survival and memory formation.
Volume: 15
Issue: 12
Pages: 1152-61
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Publication
24056772 | J:258721
First Author: Torisu T
Year: 2013
Journal: Nat Med
Title: Autophagy regulates endothelial cell processing, maturation and secretion of von Willebrand factor.
Volume: 19
Issue: 10
Pages: 1281-7
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Publication
35032835 | J:320657
 
First Author: Matsuda H
Year: 2022
Journal: Biochem Biophys Res Commun
Title: Nickel particles are present in Crohn's disease tissue and exacerbate intestinal inflammation in IBD susceptible mice.
Volume: 592
Pages: 74-80
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Publication
28722508 | J:306953
First Author: Su LY
Year: 2017
Journal: Autophagy
Title: Atg5- and Atg7-dependent autophagy in dopaminergic neurons regulates cellular and behavioral responses to morphine.
Volume: 13
Issue: 9
Pages: 1496-1511
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Publication
17912025 | J:168134
First Author: Nishiyama J
Year: 2007
Journal: Autophagy
Title: Aberrant membranes and double-membrane structures accumulate in the axons of Atg5-null Purkinje cells before neuronal death.
Volume: 3
Issue: 6
Pages: 591-6
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22842577 | J:188034
First Author: Ding WX
Year: 2012
Journal: Biochem Biophys Res Commun
Title: Tumor cells can evade dependence on autophagy through adaptation.
Volume: 425
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Pages: 684-8
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31162728 | J:277707
First Author: Bankston AN
Year: 2019
Journal: Glia
Title: Autophagy is essential for oligodendrocyte differentiation, survival, and proper myelination.
Volume: 67
Issue: 9
Pages: 1745-1759
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35115539 | J:322635
First Author: Kallergi E
Year: 2022
Journal: Nat Commun
Title: Dendritic autophagy degrades postsynaptic proteins and is required for long-term synaptic depression in mice.
Volume: 13
Issue: 1
Pages: 680
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23354484 | J:193479
First Author: Pengo N
Year: 2013
Journal: Nat Immunol
Title: Plasma cells require autophagy for sustainable immunoglobulin production.
Volume: 14
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Pages: 298-305
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32473999 | J:297840
First Author: Xu CN
Year: 2020
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Melatonin ameliorates pressure overload-induced cardiac hypertrophy by attenuating Atg5-dependent autophagy and activating the Akt/mTOR pathway.
Volume: 1866
Issue: 10
Pages: 165848
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First Author: Kubota M
Year: 2019
Journal: PLoS One
Title: Autophagy deficiency exacerbates colitis through excessive oxidative stress and MAPK signaling pathway activation.
Volume: 14
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Pages: e0225066
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First Author: Hahn DR
Year: 2014
Journal: Am J Respir Cell Mol Biol
Title: Reserve autophagic capacity in alveolar epithelia provides a replicative niche for influenza A virus.
Volume: 51
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Pages: 400-12
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31314096 | J:279001
First Author: Kurashige T
Year: 2019
Journal: Endocrinology
Title: Basal Autophagy Deficiency Causes Thyroid Follicular Epithelial Cell Death in Mice.
Volume: 160
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Pages: 2085-2092
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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