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Search results 1 to 100 out of 674 for Atg7

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Domain
Type: Family
Description: This is a family of eukaryotic proteins found in animals, plants, and yeasts that includes Atg7p (YHR171W) from Saccharomyces cerevisiae (Baker's yeast) and ATG7 from Pichia angusta. Members are about 650 to 700 residues in length and include a central domain of about 150 residues shared with the ThiF/MoeB/HesA family of proteins. A low level of similarity toubiquitin-activating enzyme E1 is described in a paper on peroxisome autophagy mediated by ATG7 [], and is the basis of the name ubiquitin activating enzyme E1-like protein. Members of the family are involved in protein lipidation events analogous to ubiquitination and required for membrane fusion events during autophagy.This protein is important for several processes. It plays a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration [], the maintenance of hematopoietic stem cells [], the formation of Paneth cell granules [[cite22291845]], as well as in adipose differentiation []. It is involved in circadian clock regulation in the liver and glucose metabolism through the autophagic degradation of CRY1 (clock repressor) in a time-dependent manner [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Mortensen M
Year: 2011
Journal: J Exp Med
Title: The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance.
Volume: 208
Issue: 3
Pages: 455-67
Publication
First Author: Komatsu M
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration.
Volume: 104
Issue: 36
Pages: 14489-94
Publication
First Author: Zhang Y
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis.
Volume: 106
Issue: 47
Pages: 19860-5
Publication
First Author: Toledo M
Year: 2018
Journal: Cell Metab
Title: Autophagy Regulates the Liver Clock and Glucose Metabolism by Degrading CRY1.
Volume: 28
Issue: 2
Pages: 268-281.e4
Protein
Organism: Mus musculus/domesticus
Length: 698  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 741  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 671  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 698  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 698  
Fragment?: false
Publication
First Author: Lee IH
Year: 2012
Journal: Science
Title: Atg7 modulates p53 activity to regulate cell cycle and survival during metabolic stress.
Volume: 336
Issue: 6078
Pages: 225-8
Publication  
First Author: Wittkopf N
Year: 2012
Journal: Clin Dev Immunol
Title: Lack of intestinal epithelial atg7 affects paneth cell granule formation but does not compromise immune homeostasis in the gut.
Volume: 2012
Pages: 278059
Publication
First Author: Meijer WH
Year: 2007
Journal: Autophagy
Title: ATG genes involved in non-selective autophagy are conserved from yeast to man, but the selective Cvt and pexophagy pathways also require organism-specific genes.
Volume: 3
Issue: 2
Pages: 106-16
Publication
First Author: Pu Q
Year: 2017
Journal: J Immunol
Title: Atg7 Deficiency Intensifies Inflammasome Activation and Pyroptosis in Pseudomonas Sepsis.
Volume: 198
Issue: 8
Pages: 3205-3213
Publication  
First Author: Liu H
Year: 2023
Journal: J Cell Biol
Title: Endothelial depletion of Atg7 triggers astrocyte-microvascular disassociation at blood-brain barrier.
Volume: 222
Issue: 5
Publication
First Author: Aoki A
Year: 2018
Journal: Am J Pathol
Title: Trophoblast-Specific Conditional Atg7 Knockout Mice Develop Gestational Hypertension.
Volume: 188
Issue: 11
Pages: 2474-2486
Publication
First Author: Qiang L
Year: 2017
Journal: Autophagy
Title: Autophagy gene ATG7 regulates ultraviolet radiation-induced inflammation and skin tumorigenesis.
Volume: 13
Issue: 12
Pages: 2086-2103
Publication
First Author: Kern L
Year: 2016
Journal: Cell Tissue Res
Title: Altered glycogen metabolism causes hepatomegaly following an Atg7 deletion.
Volume: 366
Issue: 3
Pages: 651-665
Publication
First Author: Frudd K
Year: 2018
Journal: Nat Commun
Title: Oxidation of Atg3 and Atg7 mediates inhibition of autophagy.
Volume: 9
Issue: 1
Pages: 95
Publication
First Author: Wang H
Year: 2014
Journal: Cell Res
Title: Atg7 is required for acrosome biogenesis during spermatogenesis in mice.
Volume: 24
Issue: 7
Pages: 852-69
Publication
First Author: Lee Y
Year: 2020
Journal: Mol Brain
Title: Cx3cr1CreERT2-driven Atg7 deletion in adult mice induces intestinal adhesion.
Volume: 13
Issue: 1
Pages: 88
Publication
First Author: Komatsu M
Year: 2005
Journal: J Cell Biol
Title: Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice.
Volume: 169
Issue: 3
Pages: 425-34
Publication
First Author: Xie X
Year: 2015
Journal: Cancer Discov
Title: Atg7 Overcomes Senescence and Promotes Growth of BrafV600E-Driven Melanoma.
Volume: 5
Issue: 4
Pages: 410-23
Publication
First Author: Singh R
Year: 2009
Journal: J Clin Invest
Title: Autophagy regulates adipose mass and differentiation in mice.
Volume: 119
Issue: 11
Pages: 3329-39
Publication
First Author: Park SM
Year: 2016
Journal: Mol Cell
Title: U2AF35(S34F) Promotes Transformation by Directing Aberrant ATG7 Pre-mRNA 3' End Formation.
Volume: 62
Issue: 4
Pages: 479-90
Publication
First Author: Zhuang Y
Year: 2016
Journal: PLoS One
Title: Atg7 Knockdown Augments Concanavalin A-Induced Acute Hepatitis through an ROS-Mediated p38/MAPK Pathway.
Volume: 11
Issue: 3
Pages: e0149754
Publication
First Author: Xie C
Year: 2016
Journal: Autophagy
Title: Neuroprotection by selective neuronal deletion of Atg7 in neonatal brain injury.
Volume: 12
Issue: 2
Pages: 410-23
Publication
First Author: Vujić N
Year: 2021
Journal: Autophagy
Title: ATG7 is dispensable for LC3-PE conjugation in thioglycolate-elicited mouse peritoneal macrophages.
Volume: 17
Issue: 11
Pages: 3402-3407
Publication
First Author: Santanam U
Year: 2016
Journal: Genes Dev
Title: Atg7 cooperates with Pten loss to drive prostate cancer tumor growth.
Volume: 30
Issue: 4
Pages: 399-407
Publication
First Author: Fang Y
Year: 2020
Journal: Aging (Albany NY)
Title: Loss of Atg7 causes chaotic nucleosome assembly of mouse bone marrow CD11b+Ly6G- myeloid cells.
Volume: 12
Issue: 24
Pages: 25673-25683
Publication
First Author: Donde A
Year: 2020
Journal: Autophagy
Title: Upregulation of ATG7 attenuates motor neuron dysfunction associated with depletion of TARDBP/TDP-43.
Volume: 16
Issue: 4
Pages: 672-682
Publication  
First Author: Li KC
Year: 2020
Journal: J Surg Res
Title: Loss of Atg7 in Endothelial Cells Enhanced Cutaneous Wound Healing in a Mouse Model.
Volume: 249
Pages: 145-155
Publication  
First Author: Song ZH
Year: 2015
Journal: Cell Death Dis
Title: Germ cell-specific Atg7 knockout results in primary ovarian insufficiency in female mice.
Volume: 6
Pages: e1589
Publication
First Author: Bang S
Year: 2016
Journal: Clin Exp Reprod Med
Title: Vitrification, in vitro fertilization, and development of Atg7 deficient mouse oocytes.
Volume: 43
Issue: 1
Pages: 9-14
Publication
First Author: Chen X
Year: 2023
Journal: Skin Res Technol
Title: Autophagy gene Atg7 regulates the development of radiation-induced skin injury and fibrosis of skin.
Volume: 29
Issue: 6
Pages: e13337
Publication
First Author: Lévy J
Year: 2015
Journal: Nat Cell Biol
Title: Intestinal inhibition of Atg7 prevents tumour initiation through a microbiome-influenced immune response and suppresses tumour growth.
Volume: 17
Issue: 8
Pages: 1062-73
Publication
First Author: Yao H
Year: 2023
Journal: Autophagy
Title: Ablation of endothelial Atg7 inhibits ischemia-induced angiogenesis by upregulating Stat1 that suppresses Hif1a expression.
Volume: 19
Issue: 5
Pages: 1491-1511
Publication
First Author: Long JS
Year: 2022
Journal: Proc Natl Acad Sci U S A
Title: ATG7 is a haploinsufficient repressor of tumor progression and promoter of metastasis.
Volume: 119
Issue: 28
Pages: e2113465119
Publication
First Author: Trentesaux C
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Essential role for autophagy protein ATG7 in the maintenance of intestinal stem cell integrity.
Volume: 117
Issue: 20
Pages: 11136-11146
Publication
First Author: Cadwell K
Year: 2009
Journal: Autophagy
Title: A common role for Atg16L1, Atg5 and Atg7 in small intestinal Paneth cells and Crohn disease.
Volume: 5
Issue: 2
Pages: 250-2
Publication
First Author: Sukseree S
Year: 2020
Journal: Autophagy
Title: ATG7 is essential for secretion of iron from ameloblasts and normal growth of murine incisors during aging.
Volume: 16
Issue: 10
Pages: 1851-1857
Publication
First Author: Ye Y
Year: 2014
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Atg7 deficiency impairs host defense against Klebsiella pneumoniae by impacting bacterial clearance, survival and inflammatory responses in mice.
Volume: 307
Issue: 5
Pages: L355-63
Publication
First Author: Vuppalapati KK
Year: 2015
Journal: J Bone Miner Res
Title: Targeted Deletion of Autophagy Genes Atg5 or Atg7 in the Chondrocytes Promotes Caspase-Dependent Cell Death and Leads to Mild Growth Retardation.
Volume: 30
Issue: 12
Pages: 2249-61
Publication
First Author: Zhang J
Year: 2009
Journal: Blood
Title: Mitochondrial clearance is regulated by Atg7-dependent and -independent mechanisms during reticulocyte maturation.
Volume: 114
Issue: 1
Pages: 157-64
Gene
Type: gene
Organism: frog, African clawed
Publication
First Author: Sukseree S
Year: 2016
Journal: PLoS One
Title: Tyrosinase-Cre-Mediated Deletion of the Autophagy Gene Atg7 Leads to Accumulation of the RPE65 Variant M450 in the Retinal Pigment Epithelium of C57BL/6 Mice.
Volume: 11
Issue: 8
Pages: e0161640
Publication
First Author: Radoshevich L
Year: 2010
Journal: Cell
Title: ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death.
Volume: 142
Issue: 4
Pages: 590-600
Publication
First Author: Mizushima N
Year: 2002
Journal: FEBS Lett
Title: Mouse Apg10 as an Apg12-conjugating enzyme: analysis by the conjugation-mediated yeast two-hybrid method.
Volume: 532
Issue: 3
Pages: 450-4
Publication
First Author: Tanida I
Year: 2002
Journal: Biochem Biophys Res Commun
Title: Murine Apg12p has a substrate preference for murine Apg7p over three Apg8p homologs.
Volume: 292
Issue: 1
Pages: 256-62
Publication    
First Author: Nakamura J
Year: 2022
Journal: MicroPubl Biol
Title: Cold shock protein RBM3 is upregulated in the autophagy-deficient brain.
Volume: 2022
Publication  
First Author: Piemontese M
Year: 2016
Journal: Sci Rep
Title: Low bone mass and changes in the osteocyte network in mice lacking autophagy in the osteoblast lineage.
Volume: 6
Pages: 24262
Publication
First Author: Leduc-Gaudet JP
Year: 2023
Journal: iScience
Title: Autophagy ablation in skeletal muscles worsens sepsis-induced muscle wasting, impairs whole-body metabolism, and decreases survival.
Volume: 26
Issue: 8
Pages: 107475
Publication
First Author: Inoue J
Year: 2012
Journal: Arch Biochem Biophys
Title: Autophagy in the intestinal epithelium regulates Citrobacter rodentium infection.
Volume: 521
Issue: 1-2
Pages: 95-101
Publication    
First Author: Puleston DJ
Year: 2014
Journal: Elife
Title: Autophagy is a critical regulator of memory CD8(+) T cell formation.
Volume: 3
Publication
First Author: Jung HS
Year: 2008
Journal: Cell Metab
Title: Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia.
Volume: 8
Issue: 4
Pages: 318-24
Publication
First Author: Ebato C
Year: 2008
Journal: Cell Metab
Title: Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet.
Volume: 8
Issue: 4
Pages: 325-32
Publication
First Author: Coupé B
Year: 2012
Journal: Cell Metab
Title: Loss of autophagy in pro-opiomelanocortin neurons perturbs axon growth and causes metabolic dysregulation.
Volume: 15
Issue: 2
Pages: 247-55
Publication  
First Author: Wang K
Year: 2015
Journal: Nat Commun
Title: APF lncRNA regulates autophagy and myocardial infarction by targeting miR-188-3p.
Volume: 6
Pages: 6779
Publication
First Author: Zhou H
Year: 2020
Journal: Cell Death Dis
Title: Disruption of Atg7-dependent autophagy causes electromotility disturbances, outer hair cell loss, and deafness in mice.
Volume: 11
Issue: 10
Pages: 913
Publication
First Author: Akatsuka H
Year: 2017
Journal: Biochem Biophys Res Commun
Title: AMBRA1 is involved in T cell receptor-mediated metabolic reprogramming through an ATG7-independent pathway.
Volume: 491
Issue: 4
Pages: 1098-1104
Publication
First Author: Cao Y
Year: 2015
Journal: Exp Hematol
Title: Loss of autophagy leads to failure in megakaryopoiesis, megakaryocyte differentiation, and thrombopoiesis in mice.
Volume: 43
Issue: 6
Pages: 488-94
Publication
First Author: Clarke AJ
Year: 2018
Journal: J Exp Med
Title: B1a B cells require autophagy for metabolic homeostasis and self-renewal.
Volume: 215
Issue: 2
Pages: 399-413
Publication
First Author: Salio M
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Essential role for autophagy during invariant NKT cell development.
Volume: 111
Issue: 52
Pages: E5678-87
Publication
First Author: Lin CW
Year: 2014
Journal: PLoS One
Title: T-cell autophagy deficiency increases mortality and suppresses immune responses after sepsis.
Volume: 9
Issue: 7
Pages: e102066
Publication  
First Author: Suzuki L
Year: 2022
Journal: Biochem Biophys Res Commun
Title: Cumulative autophagy insufficiency in mice leads to progression of β-cell failure.
Volume: 611
Pages: 38-45
Publication
First Author: Sakane S
Year: 2021
Journal: Cell Mol Gastroenterol Hepatol
Title: White Adipose Tissue Autophagy and Adipose-Liver Crosstalk Exacerbate Nonalcoholic Fatty Liver Disease in Mice.
Volume: 12
Issue: 5
Pages: 1683-1699
Publication
First Author: Li H
Year: 2018
Journal: Autophagy
Title: Defective autophagy in osteoblasts induces endoplasmic reticulum stress and causes remarkable bone loss.
Volume: 14
Issue: 10
Pages: 1726-1741
Publication
First Author: Torisu K
Year: 2016
Journal: Aging Cell
Title: Intact endothelial autophagy is required to maintain vascular lipid homeostasis.
Volume: 15
Issue: 1
Pages: 187-91
Publication
First Author: Grootaert MO
Year: 2015
Journal: Autophagy
Title: Defective autophagy in vascular smooth muscle cells accelerates senescence and promotes neointima formation and atherogenesis.
Volume: 11
Issue: 11
Pages: 2014-2032
Publication
First Author: Morales PE
Year: 2021
Journal: FASEB J
Title: Skeletal muscle type-specific mitochondrial adaptation to high-fat diet relies on differential autophagy modulation.
Volume: 35
Issue: 10
Pages: e21933
Publication
First Author: Campos JC
Year: 2020
Journal: FASEB J
Title: β2 -adrenoceptor activation improves skeletal muscle autophagy in neurogenic myopathy.
Volume: 34
Issue: 4
Pages: 5628-5641
Publication
First Author: Li X
Year: 2022
Journal: Int J Biol Sci
Title: The Role of Autophagy in Lamellar Body Formation and Surfactant Production in Type 2 Alveolar Epithelial Cells.
Volume: 18
Issue: 3
Pages: 1107-1119
Publication
First Author: Cheng HC
Year: 2011
Journal: J Neurosci
Title: Akt suppresses retrograde degeneration of dopaminergic axons by inhibition of macroautophagy.
Volume: 31
Issue: 6
Pages: 2125-35
Publication  
First Author: Niu XY
Year: 2016
Journal: Neuroscience
Title: Deletion of autophagy-related gene 7 in dopaminergic neurons prevents their loss induced by MPTP.
Volume: 339
Pages: 22-31
Publication
First Author: Kim SH
Year: 2017
Journal: Autophagy
Title: Ezetimibe ameliorates steatohepatitis via AMP activated protein kinase-TFEB-mediated activation of autophagy and NLRP3 inflammasome inhibition.
Volume: 13
Issue: 10
Pages: 1767-1781
Publication
First Author: Wang LF
Year: 2015
Journal: PLoS One
Title: Male-Specific Alleviation of Iron-Induced Striatal Injury by Inhibition of Autophagy.
Volume: 10
Issue: 7
Pages: e0131224
Publication
First Author: Wang HJ
Year: 2015
Journal: Autophagy
Title: Chronic HMGCR/HMG-CoA reductase inhibitor treatment contributes to dysglycemia by upregulating hepatic gluconeogenesis through autophagy induction.
Volume: 11
Issue: 11
Pages: 2089-2101
Publication
First Author: Yan B
Year: 2023
Journal: Cell Death Discov
Title: Pharmacological inhibition of MALT1 (mucosa-associated lymphoid tissue lymphoma translocation protein 1) induces ferroptosis in vascular smooth muscle cells.
Volume: 9
Issue: 1
Pages: 456
Publication
First Author: Muralimanoharan S
Year: 2016
Journal: Autophagy
Title: Sexual dimorphism in activation of placental autophagy in obese women with evidence for fetal programming from a placenta-specific mouse model.
Volume: 12
Issue: 5
Pages: 752-69
Publication
First Author: Martinet W
Year: 2012
Journal: Arterioscler Thromb Vasc Biol
Title: Everolimus triggers cytokine release by macrophages: rationale for stents eluting everolimus and a glucocorticoid.
Volume: 32
Issue: 5
Pages: 1228-35
Publication
First Author: Paré MF
Year: 2017
Journal: Biochim Biophys Acta
Title: Effect of acute and chronic autophagy deficiency on skeletal muscle apoptotic signaling, morphology, and function.
Volume: 1864
Issue: 4
Pages: 708-718
Publication
First Author: Yuan Y
Year: 2020
Journal: Aging Cell
Title: Deterioration of hematopoietic autophagy is linked to osteoporosis.
Volume: 19
Issue: 5
Pages: e13114
Publication
First Author: Komatsu M
Year: 2006
Journal: Nature
Title: Loss of autophagy in the central nervous system causes neurodegeneration in mice.
Volume: 441
Issue: 7095
Pages: 880-4
Publication
First Author: Quan W
Year: 2012
Journal: Endocrinology
Title: Role of hypothalamic proopiomelanocortin neuron autophagy in the control of appetite and leptin response.
Volume: 153
Issue: 4
Pages: 1817-26
Publication
First Author: Nam SA
Year: 2019
Journal: Cell Death Dis
Title: Autophagy attenuates tubulointerstital fibrosis through regulating transforming growth factor-β and NLRP3 inflammasome signaling pathway.
Volume: 10
Issue: 2
Pages: 78
Publication  
First Author: Piemontese M
Year: 2015
Journal: Bone
Title: Suppression of autophagy in osteocytes does not modify the adverse effects of glucocorticoids on cortical bone.
Volume: 75
Pages: 18-26
Publication
First Author: Inaba Y
Year: 2016
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Soluble bioactive microbial mediators regulate proteasomal degradation and autophagy to protect against inflammation-induced stress.
Volume: 311
Issue: 4
Pages: G634-G647
Publication  
First Author: Wärri A
Year: 2018
Journal: Cell Death Discov
Title: Autophagy and unfolded protein response (UPR) regulate mammary gland involution by restraining apoptosis-driven irreversible changes.
Volume: 4
Pages: 40
Publication
First Author: Schwartz-Roberts JL
Year: 2015
Journal: Cancer Res
Title: Interferon regulatory factor-1 signaling regulates the switch between autophagy and apoptosis to determine breast cancer cell fate.
Volume: 75
Issue: 6
Pages: 1046-55
Publication
First Author: Sumis A
Year: 2016
Journal: Endocr Relat Cancer
Title: Social isolation induces autophagy in the mouse mammary gland: link to increased mammary cancer risk.
Volume: 23
Issue: 10
Pages: 839-56