Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This is a family of eukaryotic proteins found in animals, plants, and yeasts that includes Atg7p (YHR171W) from Saccharomyces cerevisiae (Baker's yeast) and ATG7 from Pichia angusta. Members are about 650 to 700 residues in length and include a central domain of about 150 residues shared with the ThiF/MoeB/HesA family of proteins. A low level of similarity toubiquitin-activating enzyme E1 is described in a paper on peroxisome autophagy mediated by ATG7 [], and is the basis of the name ubiquitin activating enzyme E1-like protein. Members of the family are involved in protein lipidation events analogous to ubiquitination and required for membrane fusion events during autophagy.This protein is important for several processes. It plays a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration [], the maintenance of hematopoietic stem cells [], the formation of Paneth cell granules [[cite22291845]], as well as in adipose differentiation []. It is involved in circadian clock regulation in the liver and glucose metabolism through the autophagic degradation of CRY1 (clock repressor) in a time-dependent manner []. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Mortensen M |
Year: |
2011 |
Journal: |
J Exp Med |
Title: |
The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance. |
Volume: |
208 |
Issue: |
3 |
Pages: |
455-67 |
|
•
•
•
•
•
|
Publication |
First Author: |
Komatsu M |
Year: |
2007 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration. |
Volume: |
104 |
Issue: |
36 |
Pages: |
14489-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang Y |
Year: |
2009 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis. |
Volume: |
106 |
Issue: |
47 |
Pages: |
19860-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Toledo M |
Year: |
2018 |
Journal: |
Cell Metab |
Title: |
Autophagy Regulates the Liver Clock and Glucose Metabolism by Degrading CRY1. |
Volume: |
28 |
Issue: |
2 |
Pages: |
268-281.e4 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
698
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
741
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
671
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
698
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
698
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee IH |
Year: |
2012 |
Journal: |
Science |
Title: |
Atg7 modulates p53 activity to regulate cell cycle and survival during metabolic stress. |
Volume: |
336 |
Issue: |
6078 |
Pages: |
225-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wittkopf N |
Year: |
2012 |
Journal: |
Clin Dev Immunol |
Title: |
Lack of intestinal epithelial atg7 affects paneth cell granule formation but does not compromise immune homeostasis in the gut. |
Volume: |
2012 |
|
Pages: |
278059 |
|
•
•
•
•
•
|
Publication |
First Author: |
Meijer WH |
Year: |
2007 |
Journal: |
Autophagy |
Title: |
ATG genes involved in non-selective autophagy are conserved from yeast to man, but the selective Cvt and pexophagy pathways also require organism-specific genes. |
Volume: |
3 |
Issue: |
2 |
Pages: |
106-16 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu H |
Year: |
2023 |
Journal: |
J Cell Biol |
Title: |
Endothelial depletion of Atg7 triggers astrocyte-microvascular disassociation at blood-brain barrier. |
Volume: |
222 |
Issue: |
5 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Pu Q |
Year: |
2017 |
Journal: |
J Immunol |
Title: |
Atg7 Deficiency Intensifies Inflammasome Activation and Pyroptosis in Pseudomonas Sepsis. |
Volume: |
198 |
Issue: |
8 |
Pages: |
3205-3213 |
|
•
•
•
•
•
|
Publication |
First Author: |
Aoki A |
Year: |
2018 |
Journal: |
Am J Pathol |
Title: |
Trophoblast-Specific Conditional Atg7 Knockout Mice Develop Gestational Hypertension. |
Volume: |
188 |
Issue: |
11 |
Pages: |
2474-2486 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kern L |
Year: |
2016 |
Journal: |
Cell Tissue Res |
Title: |
Altered glycogen metabolism causes hepatomegaly following an Atg7 deletion. |
Volume: |
366 |
Issue: |
3 |
Pages: |
651-665 |
|
•
•
•
•
•
|
Publication |
First Author: |
Qiang L |
Year: |
2017 |
Journal: |
Autophagy |
Title: |
Autophagy gene ATG7 regulates ultraviolet radiation-induced inflammation and skin tumorigenesis. |
Volume: |
13 |
Issue: |
12 |
Pages: |
2086-2103 |
|
•
•
•
•
•
|
Publication |
First Author: |
Frudd K |
Year: |
2018 |
Journal: |
Nat Commun |
Title: |
Oxidation of Atg3 and Atg7 mediates inhibition of autophagy. |
Volume: |
9 |
Issue: |
1 |
Pages: |
95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang H |
Year: |
2014 |
Journal: |
Cell Res |
Title: |
Atg7 is required for acrosome biogenesis during spermatogenesis in mice. |
Volume: |
24 |
Issue: |
7 |
Pages: |
852-69 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee Y |
Year: |
2020 |
Journal: |
Mol Brain |
Title: |
Cx3cr1CreERT2-driven Atg7 deletion in adult mice induces intestinal adhesion. |
Volume: |
13 |
Issue: |
1 |
Pages: |
88 |
|
•
•
•
•
•
|
Publication |
First Author: |
Komatsu M |
Year: |
2005 |
Journal: |
J Cell Biol |
Title: |
Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. |
Volume: |
169 |
Issue: |
3 |
Pages: |
425-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xie X |
Year: |
2015 |
Journal: |
Cancer Discov |
Title: |
Atg7 Overcomes Senescence and Promotes Growth of BrafV600E-Driven Melanoma. |
Volume: |
5 |
Issue: |
4 |
Pages: |
410-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Singh R |
Year: |
2009 |
Journal: |
J Clin Invest |
Title: |
Autophagy regulates adipose mass and differentiation in mice. |
Volume: |
119 |
Issue: |
11 |
Pages: |
3329-39 |
|
•
•
•
•
•
|
Publication |
First Author: |
Park SM |
Year: |
2016 |
Journal: |
Mol Cell |
Title: |
U2AF35(S34F) Promotes Transformation by Directing Aberrant ATG7 Pre-mRNA 3' End Formation. |
Volume: |
62 |
Issue: |
4 |
Pages: |
479-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhuang Y |
Year: |
2016 |
Journal: |
PLoS One |
Title: |
Atg7 Knockdown Augments Concanavalin A-Induced Acute Hepatitis through an ROS-Mediated p38/MAPK Pathway. |
Volume: |
11 |
Issue: |
3 |
Pages: |
e0149754 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xie C |
Year: |
2016 |
Journal: |
Autophagy |
Title: |
Neuroprotection by selective neuronal deletion of Atg7 in neonatal brain injury. |
Volume: |
12 |
Issue: |
2 |
Pages: |
410-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vujić N |
Year: |
2021 |
Journal: |
Autophagy |
Title: |
ATG7 is dispensable for LC3-PE conjugation in thioglycolate-elicited mouse peritoneal macrophages. |
Volume: |
17 |
Issue: |
11 |
Pages: |
3402-3407 |
|
•
•
•
•
•
|
Publication |
First Author: |
Santanam U |
Year: |
2016 |
Journal: |
Genes Dev |
Title: |
Atg7 cooperates with Pten loss to drive prostate cancer tumor growth. |
Volume: |
30 |
Issue: |
4 |
Pages: |
399-407 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fang Y |
Year: |
2020 |
Journal: |
Aging (Albany NY) |
Title: |
Loss of Atg7 causes chaotic nucleosome assembly of mouse bone marrow CD11b+Ly6G- myeloid cells. |
Volume: |
12 |
Issue: |
24 |
Pages: |
25673-25683 |
|
•
•
•
•
•
|
Publication |
First Author: |
Donde A |
Year: |
2020 |
Journal: |
Autophagy |
Title: |
Upregulation of ATG7 attenuates motor neuron dysfunction associated with depletion of TARDBP/TDP-43. |
Volume: |
16 |
Issue: |
4 |
Pages: |
672-682 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li KC |
Year: |
2020 |
Journal: |
J Surg Res |
Title: |
Loss of Atg7 in Endothelial Cells Enhanced Cutaneous Wound Healing in a Mouse Model. |
Volume: |
249 |
|
Pages: |
145-155 |
|
•
•
•
•
•
|
Publication |
First Author: |
Song ZH |
Year: |
2015 |
Journal: |
Cell Death Dis |
Title: |
Germ cell-specific Atg7 knockout results in primary ovarian insufficiency in female mice. |
Volume: |
6 |
|
Pages: |
e1589 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bang S |
Year: |
2016 |
Journal: |
Clin Exp Reprod Med |
Title: |
Vitrification, in vitro fertilization, and development of Atg7 deficient mouse oocytes. |
Volume: |
43 |
Issue: |
1 |
Pages: |
9-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen X |
Year: |
2023 |
Journal: |
Skin Res Technol |
Title: |
Autophagy gene Atg7 regulates the development of radiation-induced skin injury and fibrosis of skin. |
Volume: |
29 |
Issue: |
6 |
Pages: |
e13337 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lévy J |
Year: |
2015 |
Journal: |
Nat Cell Biol |
Title: |
Intestinal inhibition of Atg7 prevents tumour initiation through a microbiome-influenced immune response and suppresses tumour growth. |
Volume: |
17 |
Issue: |
8 |
Pages: |
1062-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Trentesaux C |
Year: |
2020 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Essential role for autophagy protein ATG7 in the maintenance of intestinal stem cell integrity. |
Volume: |
117 |
Issue: |
20 |
Pages: |
11136-11146 |
|
•
•
•
•
•
|
Publication |
First Author: |
Long JS |
Year: |
2022 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
ATG7 is a haploinsufficient repressor of tumor progression and promoter of metastasis. |
Volume: |
119 |
Issue: |
28 |
Pages: |
e2113465119 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cadwell K |
Year: |
2009 |
Journal: |
Autophagy |
Title: |
A common role for Atg16L1, Atg5 and Atg7 in small intestinal Paneth cells and Crohn disease. |
Volume: |
5 |
Issue: |
2 |
Pages: |
250-2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yao H |
Year: |
2023 |
Journal: |
Autophagy |
Title: |
Ablation of endothelial Atg7 inhibits ischemia-induced angiogenesis by upregulating Stat1 that suppresses Hif1a expression. |
Volume: |
19 |
Issue: |
5 |
Pages: |
1491-1511 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sukseree S |
Year: |
2020 |
Journal: |
Autophagy |
Title: |
ATG7 is essential for secretion of iron from ameloblasts and normal growth of murine incisors during aging. |
Volume: |
16 |
Issue: |
10 |
Pages: |
1851-1857 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ye Y |
Year: |
2014 |
Journal: |
Am J Physiol Lung Cell Mol Physiol |
Title: |
Atg7 deficiency impairs host defense against Klebsiella pneumoniae by impacting bacterial clearance, survival and inflammatory responses in mice. |
Volume: |
307 |
Issue: |
5 |
Pages: |
L355-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vuppalapati KK |
Year: |
2015 |
Journal: |
J Bone Miner Res |
Title: |
Targeted Deletion of Autophagy Genes Atg5 or Atg7 in the Chondrocytes Promotes Caspase-Dependent Cell Death and Leads to Mild Growth Retardation. |
Volume: |
30 |
Issue: |
12 |
Pages: |
2249-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang J |
Year: |
2009 |
Journal: |
Blood |
Title: |
Mitochondrial clearance is regulated by Atg7-dependent and -independent mechanisms during reticulocyte maturation. |
Volume: |
114 |
Issue: |
1 |
Pages: |
157-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sukseree S |
Year: |
2016 |
Journal: |
PLoS One |
Title: |
Tyrosinase-Cre-Mediated Deletion of the Autophagy Gene Atg7 Leads to Accumulation of the RPE65 Variant M450 in the Retinal Pigment Epithelium of C57BL/6 Mice. |
Volume: |
11 |
Issue: |
8 |
Pages: |
e0161640 |
|
•
•
•
•
•
|
Publication |
First Author: |
Radoshevich L |
Year: |
2010 |
Journal: |
Cell |
Title: |
ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death. |
Volume: |
142 |
Issue: |
4 |
Pages: |
590-600 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mizushima N |
Year: |
2002 |
Journal: |
FEBS Lett |
Title: |
Mouse Apg10 as an Apg12-conjugating enzyme: analysis by the conjugation-mediated yeast two-hybrid method. |
Volume: |
532 |
Issue: |
3 |
Pages: |
450-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tanida I |
Year: |
2002 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Murine Apg12p has a substrate preference for murine Apg7p over three Apg8p homologs. |
Volume: |
292 |
Issue: |
1 |
Pages: |
256-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nakamura J |
Year: |
2022 |
Journal: |
MicroPubl Biol |
Title: |
Cold shock protein RBM3 is upregulated in the autophagy-deficient brain. |
Volume: |
2022 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Ebato C |
Year: |
2008 |
Journal: |
Cell Metab |
Title: |
Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet. |
Volume: |
8 |
Issue: |
4 |
Pages: |
325-32 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jung HS |
Year: |
2008 |
Journal: |
Cell Metab |
Title: |
Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia. |
Volume: |
8 |
Issue: |
4 |
Pages: |
318-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Inoue J |
Year: |
2012 |
Journal: |
Arch Biochem Biophys |
Title: |
Autophagy in the intestinal epithelium regulates Citrobacter rodentium infection. |
Volume: |
521 |
Issue: |
1-2 |
Pages: |
95-101 |
|
•
•
•
•
•
|
Publication |
First Author: |
Leduc-Gaudet JP |
Year: |
2023 |
Journal: |
iScience |
Title: |
Autophagy ablation in skeletal muscles worsens sepsis-induced muscle wasting, impairs whole-body metabolism, and decreases survival. |
Volume: |
26 |
Issue: |
8 |
Pages: |
107475 |
|
•
•
•
•
•
|
Publication |
First Author: |
Piemontese M |
Year: |
2016 |
Journal: |
Sci Rep |
Title: |
Low bone mass and changes in the osteocyte network in mice lacking autophagy in the osteoblast lineage. |
Volume: |
6 |
|
Pages: |
24262 |
|
•
•
•
•
•
|
Publication |
First Author: |
Puleston DJ |
Year: |
2014 |
Journal: |
Elife |
Title: |
Autophagy is a critical regulator of memory CD8(+) T cell formation. |
Volume: |
3 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Coupé B |
Year: |
2012 |
Journal: |
Cell Metab |
Title: |
Loss of autophagy in pro-opiomelanocortin neurons perturbs axon growth and causes metabolic dysregulation. |
Volume: |
15 |
Issue: |
2 |
Pages: |
247-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang K |
Year: |
2015 |
Journal: |
Nat Commun |
Title: |
APF lncRNA regulates autophagy and myocardial infarction by targeting miR-188-3p. |
Volume: |
6 |
|
Pages: |
6779 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhou H |
Year: |
2020 |
Journal: |
Cell Death Dis |
Title: |
Disruption of Atg7-dependent autophagy causes electromotility disturbances, outer hair cell loss, and deafness in mice. |
Volume: |
11 |
Issue: |
10 |
Pages: |
913 |
|
•
•
•
•
•
|
Publication |
First Author: |
Akatsuka H |
Year: |
2017 |
Journal: |
Biochem Biophys Res Commun |
Title: |
AMBRA1 is involved in T cell receptor-mediated metabolic reprogramming through an ATG7-independent pathway. |
Volume: |
491 |
Issue: |
4 |
Pages: |
1098-1104 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pattison JS |
Year: |
2011 |
Journal: |
Circ Res |
Title: |
Atg7 induces basal autophagy and rescues autophagic deficiency in CryABR120G cardiomyocytes. |
Volume: |
109 |
Issue: |
2 |
Pages: |
151-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cao Y |
Year: |
2015 |
Journal: |
Exp Hematol |
Title: |
Loss of autophagy leads to failure in megakaryopoiesis, megakaryocyte differentiation, and thrombopoiesis in mice. |
Volume: |
43 |
Issue: |
6 |
Pages: |
488-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Clarke AJ |
Year: |
2018 |
Journal: |
J Exp Med |
Title: |
B1a B cells require autophagy for metabolic homeostasis and self-renewal. |
Volume: |
215 |
Issue: |
2 |
Pages: |
399-413 |
|
•
•
•
•
•
|
Publication |
First Author: |
Niu XY |
Year: |
2016 |
Journal: |
Neuroscience |
Title: |
Deletion of autophagy-related gene 7 in dopaminergic neurons prevents their loss induced by MPTP. |
Volume: |
339 |
|
Pages: |
22-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cheng HC |
Year: |
2011 |
Journal: |
J Neurosci |
Title: |
Akt suppresses retrograde degeneration of dopaminergic axons by inhibition of macroautophagy. |
Volume: |
31 |
Issue: |
6 |
Pages: |
2125-35 |
|
•
•
•
•
•
|
Publication |
First Author: |
Komatsu M |
Year: |
2006 |
Journal: |
Nature |
Title: |
Loss of autophagy in the central nervous system causes neurodegeneration in mice. |
Volume: |
441 |
Issue: |
7095 |
Pages: |
880-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li X |
Year: |
2022 |
Journal: |
Int J Biol Sci |
Title: |
The Role of Autophagy in Lamellar Body Formation and Surfactant Production in Type 2 Alveolar Epithelial Cells. |
Volume: |
18 |
Issue: |
3 |
Pages: |
1107-1119 |
|
•
•
•
•
•
|
Publication |
First Author: |
Paré MF |
Year: |
2017 |
Journal: |
Biochim Biophys Acta |
Title: |
Effect of acute and chronic autophagy deficiency on skeletal muscle apoptotic signaling, morphology, and function. |
Volume: |
1864 |
Issue: |
4 |
Pages: |
708-718 |
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75 |
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