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Search results 1 to 100 out of 525 for Atoh7

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Protein Domain
Type: Family
Description: Transcription factor ATOH7 (previously known as Protein atonal homologue 7, Atoh7, and Math5) is a basic helix-loop-helix transcription factor that is involved in early stages of retinal neurogenesis [, , ]. It is specifically expressed in the embryonic neural retina and is required for the genesis of retinal ganglion cells (RGCs) and optic nerves [].This entry also includes Xenopus atonal homologue 5 (Xath5), which is involved in the differentiation of retinal ganglion cells and olfactory receptor neurons [].The bHLH (basic Helix-Loop-Helix) proteins contain the bHLH domain that is approximately 60 amino acids long and consists of a DNA-binding basic region followed by two a-helices separated by a variable loop region (HLH). The HLH domain promotes dimerisation, allowing the formation of homo- or heterodimeric complexes between different family members. Many bHLH proteins have been shown to act as transcriptional regulators [].
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Ghiasvand NM
Year: 2011
Journal: Nat Neurosci
Title: Deletion of a remote enhancer near ATOH7 disrupts retinal neurogenesis, causing NCRNA disease.
Volume: 14
Issue: 5
Pages: 578-86
Publication
First Author: Prasov L
Year: 2012
Journal: Hum Mol Genet
Title: ATOH7 mutations cause autosomal recessive persistent hyperplasia of the primary vitreous.
Volume: 21
Issue: 16
Pages: 3681-94
Publication
First Author: Brown NL
Year: 1998
Journal: Development
Title: Math5 encodes a murine basic helix-loop-helix transcription factor expressed during early stages of retinal neurogenesis.
Volume: 125
Issue: 23
Pages: 4821-33
Protein
Organism: Mus musculus/domesticus
Length: 149  
Fragment?: false
GXD Expression  
Probe: MGI:6194901
Assay Type: Immunohistochemistry
Annotation Date: 2023-09-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716822
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7525630
Age: embryonic day 14.5
Image: 1F E14.5 ATOH7
Specimen Label: 1F E14.5 ATOH7
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:6194901
Assay Type: Immunohistochemistry
Annotation Date: 2023-09-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716827
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:7525630
Age: postnatal day 0
Image: 1F P0 ATOH7
Specimen Label: 1F P0 ATOH7
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:6194901
Assay Type: Immunohistochemistry
Annotation Date: 2023-09-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716825
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:7525630
Age: embryonic day 17.5
Image: 3A Pou3f1+/- ATOH7
Specimen Label: 3A Pou3f1+/- ATOH7
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:6194901
Assay Type: Immunohistochemistry
Annotation Date: 2023-09-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716825
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:7525630
Age: embryonic day 17.5
Image: 1F E17.5 ATOH7
Specimen Label: 1F E17.5 ATOH7
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:6194901
Assay Type: Immunohistochemistry
Annotation Date: 2023-09-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716825
Pattern: Regionally restricted
Stage: TS25
Assay Id: MGI:7525630
Age: embryonic day 17.5
Image: 3A Pou3f1-/- ATOH7
Note: Increase in propottion of expressing cells in retinal ganglion cell layer in central retina.
Specimen Label: 3A Pou3f1-/- ATOH7
Detected: true
Specimen Num: 7
Publication
First Author: Burns CJ
Year: 2002
Journal: Dev Dyn
Title: Xath5 regulates neurogenesis in the Xenopus olfactory placode.
Volume: 225
Issue: 4
Pages: 536-43
Publication
First Author: Atac D
Year: 2020
Journal: Hum Mol Genet
Title: Atonal homolog 7 (ATOH7) loss-of-function mutations in predominant bilateral optic nerve hypoplasia.
Volume: 29
Issue: 1
Pages: 132-148
Publication  
First Author: Vervoort M
Year: 2001
Journal: ScientificWorldJournal
Title: The evolution of the neural basic Helix-Loop-Helix proteins.
Volume: 1
Pages: 396-426
Publication
First Author: Macgregor S
Year: 2010
Journal: Hum Mol Genet
Title: Genome-wide association identifies ATOH7 as a major gene determining human optic disc size.
Volume: 19
Issue: 13
Pages: 2716-24
Publication
First Author: Brown NL
Year: 2001
Journal: Development
Title: Math5 is required for retinal ganglion cell and optic nerve formation.
Volume: 128
Issue: 13
Pages: 2497-508
Publication
First Author: Brown NL
Year: 2002
Journal: Mamm Genome
Title: Molecular characterization and mapping of ATOH7, a human atonal homolog with a predicted role in retinal ganglion cell development.
Volume: 13
Issue: 2
Pages: 95-101
Publication  
First Author: Miesfeld JB
Year: 2018
Journal: Gene Expr Patterns
Title: The dynamics of native Atoh7 protein expression during mouse retinal histogenesis, revealed with a new antibody.
Volume: 27
Pages: 114-121
Publication
First Author: Maurer KA
Year: 2014
Journal: Development
Title: Notch signaling differentially regulates Atoh7 and Neurog2 in the distal mouse retina.
Volume: 141
Issue: 16
Pages: 3243-54
Publication
First Author: Skowronska-Krawczyk D
Year: 2009
Journal: Development
Title: Conserved regulatory sequences in Atoh7 mediate non-conserved regulatory responses in retina ontogenesis.
Volume: 136
Issue: 22
Pages: 3767-77
Publication
First Author: Gao Z
Year: 2014
Journal: Dev Neurobiol
Title: Transcriptome of Atoh7 retinal progenitor cells identifies new Atoh7-dependent regulatory genes for retinal ganglion cell formation.
Volume: 74
Issue: 11
Pages: 1123-40
Publication
First Author: Miesfeld JB
Year: 2018
Journal: Sci Rep
Title: Rbpj direct regulation of Atoh7 transcription in the embryonic mouse retina.
Volume: 8
Issue: 1
Pages: 10195
Publication  
First Author: Hufnagel RB
Year: 2013
Journal: Mol Cell Neurosci
Title: Heterochronic misexpression of Ascl1 in the Atoh7 retinal cell lineage blocks cell cycle exit.
Volume: 54
Pages: 108-20
Publication  
First Author: Brodie-Kommit J
Year: 2021
Journal: Sci Adv
Title: Atoh7-independent specification of retinal ganglion cell identity.
Volume: 7
Issue: 11
Publication
First Author: Wee R
Year: 2002
Journal: J Neurosci
Title: Loss of photic entrainment and altered free-running circadian rhythms in math5-/- mice.
Volume: 22
Issue: 23
Pages: 10427-33
GXD Expression    
Probe: MGI:6194901
Assay Type: Western blot
Annotation Date: 2018-08-21
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1716825
Stage: TS25
Assay Id: MGI:6195174
Age: embryonic day 17.0
Image: 2
Specimen Label: 2B Atoh7 -/-
Detected: false
Specimen Num: 1
Publication
First Author: Wang SW
Year: 2001
Journal: Genes Dev
Title: Requirement for math5 in the development of retinal ganglion cells.
Volume: 15
Issue: 1
Pages: 24-9
Publication
First Author: Prasov L
Year: 2010
Journal: PLoS One
Title: A critical analysis of Atoh7 (Math5) mRNA splicing in the developing mouse retina.
Volume: 5
Issue: 8
Pages: e12315
GXD Expression    
Probe: MGI:6167928
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6189824
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Atoh7
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6167928
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6189824
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Atoh7
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6167928
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6189824
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Atoh7
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6167928
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189824
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Atoh7
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6167928
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189824
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Atoh7
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:6167928
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6189824
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Atoh7
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6167928
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189824
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Atoh7
Detected: true
Specimen Num: 5
Publication
First Author: Buhr ED
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Neuropsin (OPN5)-mediated photoentrainment of local circadian oscillators in mammalian retina and cornea.
Volume: 112
Issue: 42
Pages: 13093-8
Publication
First Author: Saul SM
Year: 2008
Journal: Mol Cell Neurosci
Title: Math5 expression and function in the central auditory system.
Volume: 37
Issue: 1
Pages: 153-69
GXD Expression
Probe: MGI:6194901
Assay Type: Immunohistochemistry
Annotation Date: 2018-08-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716821
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6195177
Age: embryonic day 13.5
Image: 4D
Note: Tubb3 was coexpressed with Atoh7 in some migrating cells apical to the ganglion cell layer.
Specimen Label: 4D
Detected: true
Specimen Num: 11
GXD Expression
Probe: MGI:6194901
Assay Type: Immunohistochemistry
Annotation Date: 2018-08-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716821
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6195177
Age: embryonic day 13.5
Image: 4C
Note: Isl1 was transiently expressed with Atoh7 during retinal ganglion cells migration and maintained in the ganglion cell layer.
Specimen Label: 4C
Detected: true
Specimen Num: 10
GXD Expression
Probe: MGI:6194901
Assay Type: Immunohistochemistry
Annotation Date: 2018-08-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716821
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6195177
Age: embryonic day 13.5
Image: 4A
Note: Neurog2 and Atoh7 double positive cells were detected in the neuroblast layer, but not in differentiated retinal ganglion cells.
Specimen Label: 4A
Detected: true
Specimen Num: 8
GXD Expression
Probe: MGI:6194901
Assay Type: Immunohistochemistry
Annotation Date: 2018-08-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716821
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6195177
Age: embryonic day 13.5
Image: 4B
Note: Pou4f1 was transiently expressed with Atoh7 during retinal ganglion cells migration and maintained in the ganglion cell layer.
Specimen Label: 4B
Detected: true
Specimen Num: 9
Publication
First Author: Miesfeld JB
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: The Atoh7 remote enhancer provides transcriptional robustness during retinal ganglion cell development.
Volume: 117
Issue: 35
Pages: 21690-21700
Publication
First Author: Brzezinski JA 4th
Year: 2005
Journal: Invest Ophthalmol Vis Sci
Title: Loss of circadian photoentrainment and abnormal retinal electrophysiology in Math5 mutant mice.
Volume: 46
Issue: 7
Pages: 2540-51
Publication
First Author: Mao CA
Year: 2013
Journal: Development
Title: Reprogramming amacrine and photoreceptor progenitors into retinal ganglion cells by replacing Neurod1 with Atoh7.
Volume: 140
Issue: 3
Pages: 541-51
Publication      
First Author: Ge Y
Year: 2020
Journal: Dev Dyn
Title: Two new genetically modified mouse alleles labeling distinct phases of retinal ganglion cell development by fluorescent proteins.
Publication
First Author: Fries M
Year: 2023
Journal: Cell Rep
Title: Pou3f1 orchestrates a gene regulatory network controlling contralateral retinogeniculate projections.
Volume: 42
Issue: 8
Pages: 112985
Publication
First Author: Hufnagel RB
Year: 2010
Journal: Dev Biol
Title: Neurog2 controls the leading edge of neurogenesis in the mammalian retina.
Volume: 340
Issue: 2
Pages: 490-503
Publication
First Author: Wu F
Year: 2021
Journal: Nat Commun
Title: Single cell transcriptomics reveals lineage trajectory of retinal ganglion cells in wild-type and Atoh7-null retinas.
Volume: 12
Issue: 1
Pages: 1465
Publication
First Author: Whyland KL
Year: 2022
Journal: J Comp Neurol
Title: The parabigeminal nucleus is a source of "retinogeniculate replacement terminals" in mice that lack retinofugal input.
Volume: 530
Issue: 18
Pages: 3179-3192
Publication
First Author: Le TT
Year: 2006
Journal: Dev Biol
Title: Math5 is required for both early retinal neuron differentiation and cell cycle progression.
Volume: 295
Issue: 2
Pages: 764-78
Publication
First Author: Xie BB
Year: 2014
Journal: PLoS One
Title: Differentiation of retinal ganglion cells and photoreceptor precursors from mouse induced pluripotent stem cells carrying an Atoh7/Math5 lineage reporter.
Volume: 9
Issue: 11
Pages: e112175
Publication
First Author: Prasov L
Year: 2012
Journal: Neuroreport
Title: Math5 (Atoh7) gene dosage limits retinal ganglion cell genesis.
Volume: 23
Issue: 10
Pages: 631-4
Publication
First Author: Hufnagel RB
Year: 2007
Journal: Mol Cell Neurosci
Title: Conserved regulation of Math5 and Math1 revealed by Math5-GFP transgenes.
Volume: 36
Issue: 4
Pages: 435-48
Publication
First Author: Riesenberg AN
Year: 2018
Journal: Dev Dyn
Title: Separate and coincident expression of Hes1 and Hes5 in the developing mouse eye.
Volume: 247
Issue: 1
Pages: 212-221
Publication
First Author: Triplett JW
Year: 2009
Journal: Cell
Title: Retinal input instructs alignment of visual topographic maps.
Volume: 139
Issue: 1
Pages: 175-85
Publication
First Author: Triplett JW
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Competition is a driving force in topographic mapping.
Volume: 108
Issue: 47
Pages: 19060-5
Publication
First Author: Zhang Q
Year: 2017
Journal: Development
Title: Regulation of Brn3b by DLX1 and DLX2 is required for retinal ganglion cell differentiation in the vertebrate retina.
Volume: 144
Issue: 9
Pages: 1698-1711
Publication
First Author: Lee HY
Year: 2005
Journal: Dev Biol
Title: Multiple requirements for Hes 1 during early eye formation.
Volume: 284
Issue: 2
Pages: 464-78
Publication
First Author: Su J
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Retinal inputs signal astrocytes to recruit interneurons into visual thalamus.
Volume: 117
Issue: 5
Pages: 2671-2682
Publication
First Author: Brzezinski JA 4th
Year: 2012
Journal: Dev Biol
Title: Math5 defines the ganglion cell competence state in a subpopulation of retinal progenitor cells exiting the cell cycle.
Volume: 365
Issue: 2
Pages: 395-413
Publication
First Author: Wu F
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Two transcription factors, Pou4f2 and Isl1, are sufficient to specify the retinal ganglion cell fate.
Volume: 112
Issue: 13
Pages: E1559-68
Publication
First Author: Hjorth JJ
Year: 2015
Journal: Dev Neurobiol
Title: Quantitative assessment of computational models for retinotopic map formation.
Volume: 75
Issue: 6
Pages: 641-66
UniProt Feature
Begin: 1
Description: Transcription factor Atoh7
Type: chain
End: 149
Publication    
First Author: Monavarfeshani A
Year: 2018
Journal: Elife
Title: LRRTM1 underlies synaptic convergence in visual thalamus.
Volume: 7
Publication
First Author: Sabbagh U
Year: 2018
Journal: J Neurochem
Title: Distribution and development of molecularly distinct perineuronal nets in visual thalamus.
Volume: 147
Issue: 5
Pages: 626-646
Publication
First Author: Kowalchuk AM
Year: 2018
Journal: Dev Biol
Title: Requirements for Neurogenin2 during mouse postnatal retinal neurogenesis.
Volume: 442
Issue: 2
Pages: 220-235
Publication
First Author: O'Koren EG
Year: 2019
Journal: Immunity
Title: Microglial Function Is Distinct in Different Anatomical Locations during Retinal Homeostasis and Degeneration.
Volume: 50
Issue: 3
Pages: 723-737.e7
Publication
First Author: O'Sullivan ML
Year: 2017
Journal: Glia
Title: Astrocytes follow ganglion cell axons to establish an angiogenic template during retinal development.
Volume: 65
Issue: 10
Pages: 1697-1716
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Mu X
Year: 2005
Journal: Dev Biol
Title: A gene network downstream of transcription factor Math5 regulates retinal progenitor cell competence and ganglion cell fate.
Volume: 280
Issue: 2
Pages: 467-81
Publication
First Author: Seabrook TA
Year: 2013
Journal: J Neurosci
Title: Retinal input regulates the timing of corticogeniculate innervation.
Volume: 33
Issue: 24
Pages: 10085-97
Publication
First Author: Charalambakis NE
Year: 2019
Journal: J Neurosci
Title: Developmental Remodeling of Thalamic Interneurons Requires Retinal Signaling.
Volume: 39
Issue: 20
Pages: 3856-3866
Publication
First Author: Edwards MM
Year: 2012
Journal: Exp Eye Res
Title: The deletion of Math5 disrupts retinal blood vessel and glial development in mice.
Volume: 96
Issue: 1
Pages: 147-56