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Search results 1 to 100 out of 368 for Atp2b2

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
491 | ATP2B2
Type: gene
Organism: human
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Gene
100487776 | atp2b2
Type: gene
Organism: frog, western clawed
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Gene
24215 | Atp2b2
Type: gene
Organism: rat
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Gene
476535 | ATP2B2
Type: gene
Organism: dog, domestic
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Gene
460168 | ATP2B2
Type: gene
Organism: chimpanzee
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Gene
613800 | ATP2B2
Type: gene
Organism: cattle
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Gene
415958 | ATP2B2
Type: gene
Organism: chicken
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Gene
557430 | atp2b2
Type: gene
Organism: zebrafish
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Gene
701149 | ATP2B2
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR030322 | ATP2B2
Type: Family
Description: Plasma membrane calcium-transporting ATPase 2 (ATP2B2, also known as PMCA2) belongs to the IIB subfamily of P-type ATPases, whose members are plasma membrane Ca2+ ATPases (PMCAs) that catalyse the hydrolysis of ATP coupled with the transport of calcium []. ATP2B2 has very high calmodulin affinity, however, it is only poorly stimulated by calmodulin [].ATP2B2 is expressed in the developing nervous system, adult cerebellar neurons, uterus, liver, and kidney []. Interestingly, it is expressed in the mammary gland, where it has a role in the enrichment of Ca2+ in milk [, ]. It is also expressed in the hair cells of the Corti organ of the inner ear, and acts as a regulator of the dendritic calcium equilibrium controlling Purkinje cell dendritic growth in brains []. In mice, mutations in the ATP2B2 gene cause deafness []and cerebellar ataxia []. In the retina, it regulates the homeostasis of Ca2+ which controls the transmission of visual signals to the synapses []. Therefore, mutations in the ATP2B2 gene also cause defective synaptic signalling within rod cells []. ATP2B2 has also been linked to the progression of breast cancer [].
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Protein Coding Gene
MGI:105368 | Atp2b2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q6DIB8
Organism: Mus musculus/domesticus
Length: 634  
Fragment?: false
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Publication
20534448 | J:161282
First Author: VanHouten J
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: PMCA2 regulates apoptosis during mammary gland involution and predicts outcome in breast cancer.
Volume: 107
Issue: 25
Pages: 11405-10
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Publication
16822977 | J:110230
First Author: Duncan JL
Year: 2006
Journal: J Neurosci
Title: Scotopic visual signaling in the mouse retina is modulated by high-affinity plasma membrane calcium extrusion.
Volume: 26
Issue: 27
Pages: 7201-11
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Publication
15302868 | J:93962
First Author: Reinhardt TA
Year: 2004
Journal: J Biol Chem
Title: Null mutation in the gene encoding plasma membrane Ca2+-ATPase isoform 2 impairs calcium transport into milk.
Volume: 279
Issue: 41
Pages: 42369-73
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Gene
100874324 | ATP2B2-IT1
Type: gene
Organism: human
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Gene
100874325 | ATP2B2-IT2
Type: gene
Organism: human
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Publication
23826306 | J:199859
First Author: Carpinelli MR
Year: 2013
Journal: PLoS One
Title: Two ENU-induced alleles of Atp2b2 cause deafness in mice.
Volume: 8
Issue: 6
Pages: e67479
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Publication
- | J:77607
     
First Author: Bosom KE
Year: 2002
Journal: MGI Direct Data Submission
Title: A new deaf waddler mutation of the Atp2b2 gene
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Publication
21325754 | J:196569
First Author: Xu L
Year: 2011
Journal: Exp Anim
Title: Identification of a novel point mutation of mouse Atp2b2 induced by N-ethyl-N-nitrosourea mutagenesis.
Volume: 60
Issue: 1
Pages: 71-8
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Publication
23792079 | J:220660
 
First Author: Watson CJ
Year: 2013
Journal: Hear Res
Title: A new Atp2b2 deafwaddler allele, dfw(i5), interacts strongly with Cdh23 and other auditory modifiers.
Volume: 304
Pages: 41-8
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Publication
16675132 | -
First Author: Silverstein RS
Year: 2006
Journal: Neuroscience
Title: Atp2b2, encoding plasma membrane Ca2+-ATPase type 2, (PMCA2) exhibits tissue-specific first exon usage in hair cells, neurons, and mammary glands of mice.
Volume: 141
Issue: 1
Pages: 245-57
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Publication
22047666 | -
First Author: Giacomello M
Year: 2011
Journal: Cell Calcium
Title: Mutations in PMCA2 and hereditary deafness: a molecular analysis of the pump defect.
Volume: 50
Issue: 6
Pages: 569-76
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Publication
24288624 | -
 
First Author: Sherkhane P
Year: 2013
Journal: Neural Plast
Title: The plasma membrane Ca2+-ATPase2 (PMCA2) is involved in the regulation of Purkinje cell dendritic growth in cerebellar organotypic slice cultures.
Volume: 2013
Pages: 321685
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Publication
21232211 | -
First Author: Empson RM
Year: 2010
Journal: Funct Neurol
Title: The role of the calcium transporter protein plasma membrane calcium ATPase PMCA2 in cerebellar Purkinje neuron function.
Volume: 25
Issue: 3
Pages: 153-8
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Publication
23041476 | -
First Author: Giacomello M
Year: 2013
Journal: Int J Biochem Cell Biol
Title: Plasma membrane calcium ATPases and related disorders.
Volume: 45
Issue: 3
Pages: 753-62
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Protein
A0A1W2P7R3
Organism: Mus musculus/domesticus
Length: 212  
Fragment?: true
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Protein
Q9R0K7
Organism: Mus musculus/domesticus
Length: 1198  
Fragment?: false
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Protein
F8WHB1
Organism: Mus musculus/domesticus
Length: 1243  
Fragment?: false
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Protein
S4R1C4
Organism: Mus musculus/domesticus
Length: 1154  
Fragment?: false
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Protein
D5L240
Organism: Mus musculus/domesticus
Length: 1243  
Fragment?: false
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Protein
Q3UHH0
Organism: Mus musculus/domesticus
Length: 1194  
Fragment?: false
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Protein
Q3UHJ3
Organism: Mus musculus/domesticus
Length: 1198  
Fragment?: false
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Publication
37582836 | J:357427
First Author: Tao Y
Year: 2023
Journal: Nat Commun
Title: Treatment of monogenic and digenic dominant genetic hearing loss by CRISPR-Cas9 ribonucleoprotein delivery in vivo.
Volume: 14
Issue: 1
Pages: 4928
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Publication
18974863 | J:151733
First Author: Spiden SL
Year: 2008
Journal: PLoS Genet
Title: The novel mouse mutation Oblivion inactivates the PMCA2 pump and causes progressive hearing loss.
Volume: 4
Issue: 10
Pages: e1000238
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Publication
9697703 | J:48969
First Author: Street VA
Year: 1998
Journal: Nat Genet
Title: Mutations in a plasma membrane Ca2+-ATPase gene cause deafness in deafwaddler mice.
Volume: 19
Issue: 4
Pages: 390-4
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Publication
16579977 | J:110459
First Author: Johnson KR
Year: 2006
Journal: Brain Res
Title: Strain background effects and genetic modifiers of hearing in mice.
Volume: 1091
Issue: 1
Pages: 79-88
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Protein Coding Gene
MGP_CAROLIEiJ_G0028741 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0031138 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0031107 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0031038 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0031118 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0030590 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_105368 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0031577 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0030225 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0030804 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0030957 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0030911 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0031037 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0030945 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0031604 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0029941 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0030309 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0022492 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0029769 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
7537672 | J:24482
First Author: Modolell M
Year: 1995
Journal: Eur J Immunol
Title: Reciprocal regulation of the nitric oxide synthase/arginase balance in mouse bone marrow-derived macrophages by TH1 and TH2 cytokines.
Volume: 25
Issue: 4
Pages: 1101-4
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Publication
11985881 | J:102783
First Author: Ueno T
Year: 2002
Journal: Neurosci Res
Title: A mouse with a point mutation in plasma membrane Ca2+-ATPase isoform 2 gene showed the reduced Ca2+ influx in cerebellar neurons.
Volume: 42
Issue: 4
Pages: 287-97
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Publication
9668038 | J:48863
First Author: Kozel PJ
Year: 1998
Journal: J Biol Chem
Title: Balance and hearing deficits in mice with a null mutation in the gene encoding plasma membrane Ca2+-ATPase isoform 2.
Volume: 273
Issue: 30
Pages: 18693-6
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Publication
17409239 | J:121220
First Author: Empson RM
Year: 2007
Journal: J Neurosci
Title: Plasma membrane Ca2+ ATPase 2 contributes to short-term synapse plasticity at the parallel fiber to Purkinje neuron synapse.
Volume: 27
Issue: 14
Pages: 3753-8
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Publication
17234811 | J:119503
First Author: Ficarella R
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: A functional study of plasma-membrane calcium-pump isoform 2 mutants causing digenic deafness.
Volume: 104
Issue: 5
Pages: 1516-21
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Publication
20083513 | J:176779
First Author: Empson RM
Year: 2010
Journal: J Physiol
Title: Reduced expression of the Ca(2+) transporter protein PMCA2 slows Ca(2+) dynamics in mouse cerebellar Purkinje neurones and alters the precision of motor coordination.
Volume: 588
Issue: Pt 6
Pages: 907-22
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Publication
18280673 | J:132712
First Author: Sun XY
Year: 2008
Journal: Gene
Title: Insertion of an intracisternal A particle retrotransposon element in plasma membrane calcium ATPase 2 gene attenuates its expression and produces an ataxic phenotype in joggle mutant mice.
Volume: 411
Issue: 1-2
Pages: 94-102
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Publication
15350283 | J:92390
First Author: McCullough BJ
Year: 2004
Journal: Hear Res
Title: Haplo-insufficiency revealed in deafwaddler mice when tested for hearing loss and ataxia.
Volume: 195
Issue: 1-2
Pages: 90-102
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Publication
11124466 | J:108888
First Author: Konrad-Martin D
Year: 2001
Journal: Hear Res
Title: Effects of PMCA2 mutation on DPOAE amplitudes and latencies in deafwaddler mice.
Volume: 151
Issue: 1-2
Pages: 205-220
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Publication
11875276 | J:121326
First Author: Dodson HC
Year: 2001
Journal: J Neurocytol
Title: PMCA2 mutation causes structural changes in the auditory system in deafwaddler mice.
Volume: 30
Issue: 4
Pages: 281-92
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Publication
3038581 | J:19948
First Author: Matsui K
Year: 1987
Journal: Jikken Dobutsu
Title: [Fundamental study on ataxic mice (wriggle mouse Sagami)].
Volume: 36
Issue: 2
Pages: 185-9
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Publication
7948855 | J:22154
First Author: Furukawa K
Year: 1994
Journal: Neuroreport
Title: Amino acid-induced responses in CNS neurons of normal mouse and Wriggle Mouse Sagami.
Volume: 5
Issue: 12
Pages: 1530-2
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Publication
7683393 | J:13355
First Author: Inoue Y
Year: 1993
Journal: Neurosci Res
Title: Abnormal synaptic architecture in the cerebellar cortex of a new dystonic mutant mouse, Wriggle Mouse Sagami.
Volume: 16
Issue: 1
Pages: 39-48
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Publication
2765934 | J:19947
First Author: Ikeda M
Year: 1989
Journal: Brain Res
Title: A neurochemical study of a new mutant mouse presenting myoclonus-like involuntary movement: a possible model of spontaneous serotonergic hyperactivity.
Volume: 495
Issue: 2
Pages: 337-48
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Publication
- | J:1273
First Author: Osawa N
Year: 1992
Journal: Mouse Genome
Title: New neurological mutant "wriggle mouse sagami" with an interesting movement disorder
Volume: 90
Issue: 2
Pages: 223
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Publication
10687933 | J:71283
First Author: Takahashi K
Year: 1999
Journal: Acta Otolaryngol
Title: Evaluation of inner ear histology and auditory brainstem response in Wriggle Mouse Sagami.
Volume: 119
Issue: 7
Pages: 767-72
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Publication
10441500 | J:56737
First Author: Takahashi K
Year: 1999
Journal: Biochem Biophys Res Commun
Title: A point mutation in a plasma membrane Ca(2+)-ATPase gene causes deafness in Wriggle Mouse Sagami.
Volume: 261
Issue: 3
Pages: 773-8
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Publication
15576480 | J:105109
First Author: Kurnellas MP
Year: 2005
Journal: FASEB J
Title: Plasma membrane calcium ATPase deficiency causes neuronal pathology in the spinal cord: a potential mechanism for neurodegeneration in multiple sclerosis and spinal cord injury.
Volume: 19
Issue: 2
Pages: 298-300
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Publication
26729871 | J:229944
First Author: Jeong J
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: PMCA2 regulates HER2 protein kinase localization and signaling and promotes HER2-mediated breast cancer.
Volume: 113
Issue: 3
Pages: E282-90
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Publication
26362865 | J:229039
First Author: Pachera N
Year: 2015
Journal: Diabetologia
Title: Heterozygous inactivation of plasma membrane Ca(2+)-ATPase in mice increases glucose-induced insulin release and beta cell proliferation, mass and viability.
Volume: 58
Issue: 12
Pages: 2843-50
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Publication
17150372 | J:123253
First Author: Kurnellas MP
Year: 2007
Journal: Mol Cell Neurosci
Title: Molecular alterations in the cerebellum of the plasma membrane calcium ATPase 2 (PMCA2)-null mouse indicate abnormalities in Purkinje neurons.
Volume: 34
Issue: 2
Pages: 178-88
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Publication
22789621 | J:203589
First Author: Fakira AK
Year: 2012
Journal: Mol Cell Neurosci
Title: Purkinje cell dysfunction and delayed death in plasma membrane calcium ATPase 2-heterozygous mice.
Volume: 51
Issue: 1-2
Pages: 22-31
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Publication
27702770 | J:322102
First Author: Khariv V
Year: 2017
Journal: FASEB J
Title: Impaired sensitivity to pain stimuli in plasma membrane calcium ATPase 2 (PMCA2) heterozygous mice: a possible modality- and sex-specific role for PMCA2 in nociception.
Volume: 31
Issue: 1
Pages: 224-237
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Publication
30467368 | J:268505
First Author: Khariv V
Year: 2018
Journal: Sci Rep
Title: A link between plasma membrane calcium ATPase 2 (PMCA2), estrogen and estrogen receptor α signaling in mechanical pain.
Volume: 8
Issue: 1
Pages: 17260
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Publication
19304763 | J:226749
First Author: Saidu SP
Year: 2009
Journal: Chem Senses
Title: Role of plasma membrane calcium ATPases in calcium clearance from olfactory sensory neurons.
Volume: 34
Issue: 4
Pages: 349-58
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Publication
11950541 | J:108881
First Author: Kozel PJ
Year: 2002
Journal: Hear Res
Title: Deficiency in plasma membrane calcium ATPase isoform 2 increases susceptibility to noise-induced hearing loss in mice.
Volume: 164
Issue: 1-2
Pages: 231-9
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Publication
18848933 | J:143605
First Author: Souayah N
Year: 2008
Journal: Exp Neurol
Title: Reductions in motor unit number estimates (MUNE) precede motor neuron loss in the plasma membrane calcium ATPase 2 (PMCA2)-heterozygous mice.
Volume: 214
Issue: 2
Pages: 341-346
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Publication
20826782 | J:167344
First Author: Bortolozzi M
Year: 2010
Journal: J Biol Chem
Title: The novel PMCA2 pump mutation Tommy impairs cytosolic calcium clearance in hair cells and links to deafness in mice.
Volume: 285
Issue: 48
Pages: 37693-703
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Publication
16880690 | J:111625
First Author: Chen Z
Year: 2006
Journal: Exp Anim
Title: A novel mutant mouse, joggle, with inherited ataxia.
Volume: 55
Issue: 4
Pages: 411-4
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Publication
- | J:184818
     
First Author: Takahashi J
Year: 2012
Journal: MGI Direct Data Submission
Title: Direct Data Submission 2012/06/26
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Publication
- | J:221473
     
First Author: SoRelle J
Year: 2015
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for lohan
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Publication
- | J:271981
     
First Author: Zhang Z
Year: 2019
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for johan.
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Publication
18075201 | J:141534
First Author: Sun XY
Year: 2007
Journal: Exp Anim
Title: Mapping of jog locus to the region between D6Mit104 and D6Mit336 on mouse chromosome 6.
Volume: 56
Issue: 5
Pages: 389-92
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GXD Expression
GXD Expression
     
Probe: MGI:3663005
Assay Type: Western blot
Annotation Date: 2006-10-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610515
Stage: TS15
Assay Id: MGI:3663007
Age: embryonic day 9.5
Specimen Label: +/-
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:3663005
Assay Type: Western blot
Annotation Date: 2006-10-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610515
Stage: TS15
Assay Id: MGI:3663007
Age: embryonic day 9.5
Specimen Label: -/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:3663005
Assay Type: Western blot
Annotation Date: 2006-10-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610515
Stage: TS15
Assay Id: MGI:3663007
Age: embryonic day 9.5
Specimen Label: +/-
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:3663005
Assay Type: Western blot
Annotation Date: 2006-10-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610515
Stage: TS15
Assay Id: MGI:3663007
Age: embryonic day 9.5
Specimen Label: -/-
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:3663005
Assay Type: Western blot
Annotation Date: 2006-10-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610515
Stage: TS15
Assay Id: MGI:3663007
Age: embryonic day 9.5
Specimen Label: +/+
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:4867237
Assay Type: RT-PCR
Annotation Date: 2011-01-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759725
Stage: TS25
Assay Id: MGI:4867263
Age: embryonic day 17.0
Specimen Label: E17
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:4867237
Assay Type: RT-PCR
Annotation Date: 2011-01-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759726
Stage: TS26
Assay Id: MGI:4867263
Age: embryonic day 18.0
Specimen Label: E18
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:4867237
Assay Type: RT-PCR
Annotation Date: 2011-01-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759727
Stage: TS27
Assay Id: MGI:4867263
Age: postnatal day 0
Specimen Label: P0
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:4867237
Assay Type: RT-PCR
Annotation Date: 2011-01-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759727
Stage: TS27
Assay Id: MGI:4867263
Age: postnatal day 2
Specimen Label: P2
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:4867237
Assay Type: RT-PCR
Annotation Date: 2011-01-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759728
Stage: TS28
Assay Id: MGI:4867263
Age: postnatal day 4
Specimen Label: P4
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:4867237
Assay Type: RT-PCR
Annotation Date: 2011-01-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759728
Stage: TS28
Assay Id: MGI:4867263
Age: postnatal day 6
Specimen Label: P6
Detected: true
Specimen Num: 6
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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