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Search results 1 to 100 out of 362 for Atp2b2

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0.022s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Protein Domain
Type: Family
Description: Plasma membrane calcium-transporting ATPase 2 (ATP2B2, also known as PMCA2) belongs to the IIB subfamily of P-type ATPases, whose members are plasma membrane Ca2+ ATPases (PMCAs) that catalyse the hydrolysis of ATP coupled with the transport of calcium []. ATP2B2 has very high calmodulin affinity, however, it is only poorly stimulated by calmodulin [].ATP2B2 is expressed in the developing nervous system, adult cerebellar neurons, uterus, liver, and kidney []. Interestingly, it is expressed in the mammary gland, where it has a role in the enrichment of Ca2+ in milk [, ]. It is also expressed in the hair cells of the Corti organ of the inner ear, and acts as a regulator of the dendritic calcium equilibrium controlling Purkinje cell dendritic growth in brains []. In mice, mutations in the ATP2B2 gene cause deafness []and cerebellar ataxia []. In the retina, it regulates the homeostasis of Ca2+ which controls the transmission of visual signals to the synapses []. Therefore, mutations in the ATP2B2 gene also cause defective synaptic signalling within rod cells []. ATP2B2 has also been linked to the progression of breast cancer [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 634  
Fragment?: false
Publication
First Author: Reinhardt TA
Year: 2004
Journal: J Biol Chem
Title: Null mutation in the gene encoding plasma membrane Ca2+-ATPase isoform 2 impairs calcium transport into milk.
Volume: 279
Issue: 41
Pages: 42369-73
Publication
First Author: VanHouten J
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: PMCA2 regulates apoptosis during mammary gland involution and predicts outcome in breast cancer.
Volume: 107
Issue: 25
Pages: 11405-10
Publication
First Author: Duncan JL
Year: 2006
Journal: J Neurosci
Title: Scotopic visual signaling in the mouse retina is modulated by high-affinity plasma membrane calcium extrusion.
Volume: 26
Issue: 27
Pages: 7201-11
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Publication
First Author: Carpinelli MR
Year: 2013
Journal: PLoS One
Title: Two ENU-induced alleles of Atp2b2 cause deafness in mice.
Volume: 8
Issue: 6
Pages: e67479
Publication      
First Author: Bosom KE
Year: 2002
Journal: MGI Direct Data Submission
Title: A new deaf waddler mutation of the Atp2b2 gene
Publication
First Author: Xu L
Year: 2011
Journal: Exp Anim
Title: Identification of a novel point mutation of mouse Atp2b2 induced by N-ethyl-N-nitrosourea mutagenesis.
Volume: 60
Issue: 1
Pages: 71-8
Publication  
First Author: Watson CJ
Year: 2013
Journal: Hear Res
Title: A new Atp2b2 deafwaddler allele, dfw(i5), interacts strongly with Cdh23 and other auditory modifiers.
Volume: 304
Pages: 41-8
Publication
First Author: Silverstein RS
Year: 2006
Journal: Neuroscience
Title: Atp2b2, encoding plasma membrane Ca2+-ATPase type 2, (PMCA2) exhibits tissue-specific first exon usage in hair cells, neurons, and mammary glands of mice.
Volume: 141
Issue: 1
Pages: 245-57
Publication
First Author: Giacomello M
Year: 2011
Journal: Cell Calcium
Title: Mutations in PMCA2 and hereditary deafness: a molecular analysis of the pump defect.
Volume: 50
Issue: 6
Pages: 569-76
Publication  
First Author: Sherkhane P
Year: 2013
Journal: Neural Plast
Title: The plasma membrane Ca2+-ATPase2 (PMCA2) is involved in the regulation of Purkinje cell dendritic growth in cerebellar organotypic slice cultures.
Volume: 2013
Pages: 321685
Publication
First Author: Empson RM
Year: 2010
Journal: Funct Neurol
Title: The role of the calcium transporter protein plasma membrane calcium ATPase PMCA2 in cerebellar Purkinje neuron function.
Volume: 25
Issue: 3
Pages: 153-8
Publication
First Author: Giacomello M
Year: 2013
Journal: Int J Biochem Cell Biol
Title: Plasma membrane calcium ATPases and related disorders.
Volume: 45
Issue: 3
Pages: 753-62
Protein
Organism: Mus musculus/domesticus
Length: 212  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 1198  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1243  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1154  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1243  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1194  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1198  
Fragment?: false
Publication
First Author: Spiden SL
Year: 2008
Journal: PLoS Genet
Title: The novel mouse mutation Oblivion inactivates the PMCA2 pump and causes progressive hearing loss.
Volume: 4
Issue: 10
Pages: e1000238
Publication
First Author: Street VA
Year: 1998
Journal: Nat Genet
Title: Mutations in a plasma membrane Ca2+-ATPase gene cause deafness in deafwaddler mice.
Volume: 19
Issue: 4
Pages: 390-4
Publication
First Author: Johnson KR
Year: 2006
Journal: Brain Res
Title: Strain background effects and genetic modifiers of hearing in mice.
Volume: 1091
Issue: 1
Pages: 79-88
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Modolell M
Year: 1995
Journal: Eur J Immunol
Title: Reciprocal regulation of the nitric oxide synthase/arginase balance in mouse bone marrow-derived macrophages by TH1 and TH2 cytokines.
Volume: 25
Issue: 4
Pages: 1101-4
Publication
First Author: Ueno T
Year: 2002
Journal: Neurosci Res
Title: A mouse with a point mutation in plasma membrane Ca2+-ATPase isoform 2 gene showed the reduced Ca2+ influx in cerebellar neurons.
Volume: 42
Issue: 4
Pages: 287-97
Publication
First Author: Kozel PJ
Year: 1998
Journal: J Biol Chem
Title: Balance and hearing deficits in mice with a null mutation in the gene encoding plasma membrane Ca2+-ATPase isoform 2.
Volume: 273
Issue: 30
Pages: 18693-6
Publication
First Author: Empson RM
Year: 2007
Journal: J Neurosci
Title: Plasma membrane Ca2+ ATPase 2 contributes to short-term synapse plasticity at the parallel fiber to Purkinje neuron synapse.
Volume: 27
Issue: 14
Pages: 3753-8
Publication
First Author: Ficarella R
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: A functional study of plasma-membrane calcium-pump isoform 2 mutants causing digenic deafness.
Volume: 104
Issue: 5
Pages: 1516-21
Publication
First Author: Empson RM
Year: 2010
Journal: J Physiol
Title: Reduced expression of the Ca(2+) transporter protein PMCA2 slows Ca(2+) dynamics in mouse cerebellar Purkinje neurones and alters the precision of motor coordination.
Volume: 588
Issue: Pt 6
Pages: 907-22
Publication
First Author: Sun XY
Year: 2008
Journal: Gene
Title: Insertion of an intracisternal A particle retrotransposon element in plasma membrane calcium ATPase 2 gene attenuates its expression and produces an ataxic phenotype in joggle mutant mice.
Volume: 411
Issue: 1-2
Pages: 94-102
Publication
First Author: Khariv V
Year: 2018
Journal: Sci Rep
Title: A link between plasma membrane calcium ATPase 2 (PMCA2), estrogen and estrogen receptor α signaling in mechanical pain.
Volume: 8
Issue: 1
Pages: 17260
Publication
First Author: Pachera N
Year: 2015
Journal: Diabetologia
Title: Heterozygous inactivation of plasma membrane Ca(2+)-ATPase in mice increases glucose-induced insulin release and beta cell proliferation, mass and viability.
Volume: 58
Issue: 12
Pages: 2843-50
Publication
First Author: Khariv V
Year: 2017
Journal: FASEB J
Title: Impaired sensitivity to pain stimuli in plasma membrane calcium ATPase 2 (PMCA2) heterozygous mice: a possible modality- and sex-specific role for PMCA2 in nociception.
Volume: 31
Issue: 1
Pages: 224-237
Publication
First Author: Souayah N
Year: 2008
Journal: Exp Neurol
Title: Reductions in motor unit number estimates (MUNE) precede motor neuron loss in the plasma membrane calcium ATPase 2 (PMCA2)-heterozygous mice.
Volume: 214
Issue: 2
Pages: 341-346
Publication
First Author: Saidu SP
Year: 2009
Journal: Chem Senses
Title: Role of plasma membrane calcium ATPases in calcium clearance from olfactory sensory neurons.
Volume: 34
Issue: 4
Pages: 349-58
Publication
First Author: Kurnellas MP
Year: 2007
Journal: Mol Cell Neurosci
Title: Molecular alterations in the cerebellum of the plasma membrane calcium ATPase 2 (PMCA2)-null mouse indicate abnormalities in Purkinje neurons.
Volume: 34
Issue: 2
Pages: 178-88
Publication
First Author: Kozel PJ
Year: 2002
Journal: Hear Res
Title: Deficiency in plasma membrane calcium ATPase isoform 2 increases susceptibility to noise-induced hearing loss in mice.
Volume: 164
Issue: 1-2
Pages: 231-9
Publication
First Author: Kurnellas MP
Year: 2005
Journal: FASEB J
Title: Plasma membrane calcium ATPase deficiency causes neuronal pathology in the spinal cord: a potential mechanism for neurodegeneration in multiple sclerosis and spinal cord injury.
Volume: 19
Issue: 2
Pages: 298-300
Publication
First Author: Fakira AK
Year: 2012
Journal: Mol Cell Neurosci
Title: Purkinje cell dysfunction and delayed death in plasma membrane calcium ATPase 2-heterozygous mice.
Volume: 51
Issue: 1-2
Pages: 22-31
Publication      
First Author: Takahashi J
Year: 2012
Journal: MGI Direct Data Submission
Title: Direct Data Submission 2012/06/26
Publication
First Author: Bortolozzi M
Year: 2010
Journal: J Biol Chem
Title: The novel PMCA2 pump mutation Tommy impairs cytosolic calcium clearance in hair cells and links to deafness in mice.
Volume: 285
Issue: 48
Pages: 37693-703
Publication
First Author: Takahashi K
Year: 1999
Journal: Acta Otolaryngol
Title: Evaluation of inner ear histology and auditory brainstem response in Wriggle Mouse Sagami.
Volume: 119
Issue: 7
Pages: 767-72
Publication
First Author: Takahashi K
Year: 1999
Journal: Biochem Biophys Res Commun
Title: A point mutation in a plasma membrane Ca(2+)-ATPase gene causes deafness in Wriggle Mouse Sagami.
Volume: 261
Issue: 3
Pages: 773-8
Publication      
First Author: SoRelle J
Year: 2015
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for lohan
Publication
First Author: McCullough BJ
Year: 2004
Journal: Hear Res
Title: Haplo-insufficiency revealed in deafwaddler mice when tested for hearing loss and ataxia.
Volume: 195
Issue: 1-2
Pages: 90-102
Publication
First Author: Jeong J
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: PMCA2 regulates HER2 protein kinase localization and signaling and promotes HER2-mediated breast cancer.
Volume: 113
Issue: 3
Pages: E282-90
Publication
First Author: Matsui K
Year: 1987
Journal: Jikken Dobutsu
Title: [Fundamental study on ataxic mice (wriggle mouse Sagami)].
Volume: 36
Issue: 2
Pages: 185-9
Publication
First Author: Osawa N
Year: 1992
Journal: Mouse Genome
Title: New neurological mutant "wriggle mouse sagami" with an interesting movement disorder
Volume: 90
Issue: 2
Pages: 223
Publication
First Author: Ikeda M
Year: 1989
Journal: Brain Res
Title: A neurochemical study of a new mutant mouse presenting myoclonus-like involuntary movement: a possible model of spontaneous serotonergic hyperactivity.
Volume: 495
Issue: 2
Pages: 337-48
Publication
First Author: Furukawa K
Year: 1994
Journal: Neuroreport
Title: Amino acid-induced responses in CNS neurons of normal mouse and Wriggle Mouse Sagami.
Volume: 5
Issue: 12
Pages: 1530-2
Publication
First Author: Inoue Y
Year: 1993
Journal: Neurosci Res
Title: Abnormal synaptic architecture in the cerebellar cortex of a new dystonic mutant mouse, Wriggle Mouse Sagami.
Volume: 16
Issue: 1
Pages: 39-48
Publication
First Author: Chen Z
Year: 2006
Journal: Exp Anim
Title: A novel mutant mouse, joggle, with inherited ataxia.
Volume: 55
Issue: 4
Pages: 411-4
Publication
First Author: Konrad-Martin D
Year: 2001
Journal: Hear Res
Title: Effects of PMCA2 mutation on DPOAE amplitudes and latencies in deafwaddler mice.
Volume: 151
Issue: 1-2
Pages: 205-220
Publication
First Author: Dodson HC
Year: 2001
Journal: J Neurocytol
Title: PMCA2 mutation causes structural changes in the auditory system in deafwaddler mice.
Volume: 30
Issue: 4
Pages: 281-92
Publication      
First Author: Zhang Z
Year: 2019
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for johan.
Publication
First Author: Sun XY
Year: 2007
Journal: Exp Anim
Title: Mapping of jog locus to the region between D6Mit104 and D6Mit336 on mouse chromosome 6.
Volume: 56
Issue: 5
Pages: 389-92
GXD Expression    
Probe: MGI:6434219
Assay Type: RT-PCR
Annotation Date: 2020-06-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3187817
Stage: TS17
Assay Id: MGI:6434489
Age: embryonic day 10.5
Image: S4
Specimen Label: WT
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6434219
Assay Type: RT-PCR
Annotation Date: 2020-06-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3187817
Stage: TS17
Assay Id: MGI:6434489
Age: embryonic day 10.5
Image: S4
Specimen Label: KO
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3663005
Assay Type: Western blot
Annotation Date: 2006-10-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610515
Stage: TS15
Assay Id: MGI:3663007
Age: embryonic day 9.5
Specimen Label: +/-
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3663005
Assay Type: Western blot
Annotation Date: 2006-10-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610515
Stage: TS15
Assay Id: MGI:3663007
Age: embryonic day 9.5
Specimen Label: -/-
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3663005
Assay Type: Western blot
Annotation Date: 2006-10-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610515
Stage: TS15
Assay Id: MGI:3663007
Age: embryonic day 9.5
Specimen Label: +/-
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3663005
Assay Type: Western blot
Annotation Date: 2006-10-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610515
Stage: TS15
Assay Id: MGI:3663007
Age: embryonic day 9.5
Specimen Label: -/-
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3663005
Assay Type: Western blot
Annotation Date: 2006-10-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610515
Stage: TS15
Assay Id: MGI:3663007
Age: embryonic day 9.5
Specimen Label: +/+
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:5816924
Assay Type: RT-PCR
Annotation Date: 2017-01-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684622
Stage: TS22
Assay Id: MGI:5816982
Age: embryonic day 14.5
Image: 6
Specimen Label: +/+
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5816924
Assay Type: RT-PCR
Annotation Date: 2017-01-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684622
Stage: TS22
Assay Id: MGI:5816982
Age: embryonic day 14.5
Image: 6
Specimen Label: +/-
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:5816924
Assay Type: RT-PCR
Annotation Date: 2017-01-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684622
Stage: TS22
Assay Id: MGI:5816982
Age: embryonic day 14.5
Image: 6
Specimen Label: -/-
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:4867237
Assay Type: RT-PCR
Annotation Date: 2011-01-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759725
Stage: TS25
Assay Id: MGI:4867263
Age: embryonic day 17.0
Specimen Label: E17
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:4867237
Assay Type: RT-PCR
Annotation Date: 2011-01-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759726
Stage: TS26
Assay Id: MGI:4867263
Age: embryonic day 18.0
Specimen Label: E18
Detected: true
Specimen Num: 2