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Search results 1 to 100 out of 124 for Atp8b1

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
5205 | ATP8B1
Type: gene
Organism: human
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Gene
594952 | atp8b1
Type: gene
Organism: frog, western clawed
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Gene
291555 | Atp8b1
Type: gene
Organism: rat
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Gene
476190 | ATP8B1
Type: gene
Organism: dog, domestic
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Gene
455439 | ATP8B1
Type: gene
Organism: chimpanzee
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Gene
541187 | ATP8B1
Type: gene
Organism: cattle
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Gene
426857 | ATP8B1
Type: gene
Organism: chicken
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Gene
100148342 | atp8b1
Type: gene
Organism: zebrafish
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Gene
695994 | ATP8B1
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR030346 | ATP8B1
Type: Family
Description: Phospholipid-transporting ATPase IC (also known as ATP8B1 or ATPIC) belongs to subfamily IV of the P-type ATPases family, whose members transport phospholipids across the membrane. ATP8B1 can bind either CDC50A or CDC50B as its accessory protein for endoplasmic reticulum exit and plasma membrane lipid flippase activity [, , ].In hepatocytes, ATP8B1 localises in the canalicular membrane, where it may maintain the membrane integrity and to the function of ABCB4, an ABC floppase that play a role in bile export []. In the epithelial Caco-2 cells, ATP8B1 is required for apical protein expression and microvillus formation in polarised epithelial cells []. Mutations in ATP8B1 cause two forms of intrahepatic cholestasis, progressive familial intrahepatic cholestasis (PFIC) and benign recurrent intrahepatic cholestasis (BFIC) []. It is involved in the correct apical membrane localization of CDC42, CFTR and SLC10A2 [].
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Protein Coding Gene
MGI:1859665 | Atp8b1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
27301931 | J:251366
First Author: van der Mark VA
Year: 2016
Journal: Biochim Biophys Acta
Title: The phospholipid flippase ATP8B1 mediates apical localization of the cystic fibrosis transmembrane regulator.
Volume: 1863
Issue: 9
Pages: 2280-8
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Gene
100505549 | ATP8B1-AS1
Type: gene
Organism: human
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Publication
19478059 | J:150079
First Author: Stapelbroek JM
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: ATP8B1 is essential for maintaining normal hearing.
Volume: 106
Issue: 24
Pages: 9709-14
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Publication
21820390 | -
First Author: Groen A
Year: 2011
Journal: Gastroenterology
Title: Complementary functions of the flippase ATP8B1 and the floppase ABCB4 in maintaining canalicular membrane integrity.
Volume: 141
Issue: 5
Pages: 1927-37.e1-4
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Publication
17948906 | -
First Author: Paulusma CC
Year: 2008
Journal: Hepatology
Title: ATP8B1 requires an accessory protein for endoplasmic reticulum exit and plasma membrane lipid flippase activity.
Volume: 47
Issue: 1
Pages: 268-78
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Publication
37990006 | J:342962
First Author: Tamura R
Year: 2023
Journal: Nat Commun
Title: Intestinal Atp8b1 dysfunction causes hepatic choline deficiency and steatohepatitis.
Volume: 14
Issue: 1
Pages: 6763
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Publication
27689529 | J:351703
First Author: Soundararajan R
Year: 2016
Journal: Aging (Albany NY)
Title: Global gene profiling of aging lungs in Atp8b1 mutant mice.
Volume: 8
Issue: 9
Pages: 2232-2252
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Protein
Q148W0
Organism: Mus musculus/domesticus
Length: 1251  
Fragment?: false
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Publication
30636723 | J:323092
First Author: Fukumoto J
Year: 2019
Journal: Aging (Albany NY)
Title: Oxidative stress induces club cell proliferation and pulmonary fibrosis in Atp8b1 mutant mice.
Volume: 11
Issue: 1
Pages: 209-229
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Publication
20852622 | J:211244
First Author: Ray NB
Year: 2010
Journal: Nat Med
Title: Dynamic regulation of cardiolipin by the lipid pump Atp8b1 determines the severity of lung injury in experimental pneumonia.
Volume: 16
Issue: 10
Pages: 1120-1127
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Publication
16799980 | J:323089
First Author: Paulusma CC
Year: 2006
Journal: Hepatology
Title: Atp8b1 deficiency in mice reduces resistance of the canalicular membrane to hydrophobic bile salts and impairs bile salt transport.
Volume: 44
Issue: 1
Pages: 195-204
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Publication
14976163 | J:89817
First Author: Pawlikowska L
Year: 2004
Journal: Hum Mol Genet
Title: A mouse genetic model for familial cholestasis caused by ATP8B1 mutations reveals perturbed bile salt homeostasis but no impairment in bile secretion.
Volume: 13
Issue: 8
Pages: 881-92
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Protein
Q923U1
Organism: Mus musculus/domesticus
Length: 103  
Fragment?: true
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Publication
9500542 | -
First Author: Bull LN
Year: 1998
Journal: Nat Genet
Title: A gene encoding a P-type ATPase mutated in two forms of hereditary cholestasis.
Volume: 18
Issue: 3
Pages: 219-24
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Publication
20512993 | -
First Author: Verhulst PM
Year: 2010
Journal: Hepatology
Title: A flippase-independent function of ATP8B1, the protein affected in familial intrahepatic cholestasis type 1, is required for apical protein expression and microvillus formation in polarized epithelial cells.
Volume: 51
Issue: 6
Pages: 2049-60
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Publication
20961850 | -
First Author: Bryde S
Year: 2010
Journal: J Biol Chem
Title: CDC50 proteins are critical components of the human class-1 P4-ATPase transport machinery.
Volume: 285
Issue: 52
Pages: 40562-72
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Publication
20947505 | -
First Author: van der Velden LM
Year: 2010
Journal: J Biol Chem
Title: Heteromeric interactions required for abundance and subcellular localization of human CDC50 proteins and class 1 P4-ATPases.
Volume: 285
Issue: 51
Pages: 40088-96
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Protein
A0A494BB33
Organism: Mus musculus/domesticus
Length: 245  
Fragment?: true
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Publication
35204783 | J:322879
 
First Author: Westermann-Clark E
Year: 2022
Journal: Biomolecules
Title: Matrix Metalloproteinase 7 Expression and Apical Epithelial Defects in Atp8b1 Mutant Mouse Model of Pulmonary Fibrosis.
Volume: 12
Issue: 2
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Gene
106994522 | ATP8B1-AS1
Type: gene
Organism: macaque, rhesus
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Publication
20126555 | J:157936
First Author: Shah S
Year: 2010
Journal: PLoS One
Title: Strain background modifies phenotypes in the ATP8B1-deficient mouse.
Volume: 5
Issue: 2
Pages: e8984
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Publication
33731871 | J:304845
First Author: Langedijk J
Year: 2021
Journal: Sci Rep
Title: Reduced spontaneous itch in mouse models of cholestasis.
Volume: 11
Issue: 1
Pages: 6127
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Publication
26416959 | J:227543
First Author: Bruurs LJ
Year: 2015
Journal: J Cell Biol
Title: ATP8B1-mediated spatial organization of Cdc42 signaling maintains singularity during enterocyte polarization.
Volume: 210
Issue: 7
Pages: 1055-63
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Publication
36273194 | J:331594
First Author: Yang WJ
Year: 2022
Journal: Cell Death Dis
Title: Acinar ATP8b1/LPC pathway promotes macrophage efferocytosis and clearance of inflammation during chronic pancreatitis development.
Volume: 13
Issue: 10
Pages: 893
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Publication
19228692 | J:149062
First Author: Paulusma CC
Year: 2009
Journal: J Biol Chem
Title: Activity of the bile salt export pump (ABCB11) is critically dependent on canalicular membrane cholesterol content.
Volume: 284
Issue: 15
Pages: 9947-54
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Publication
18466903 | J:136984
First Author: Groen A
Year: 2008
Journal: Gastroenterology
Title: Abcg5/8 independent biliary cholesterol excretion in Atp8b1-deficient mice.
Volume: 134
Issue: 7
Pages: 2091-100
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Protein Coding Gene
MGP_CAROLIEiJ_G0022349 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0024505 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0024472 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0024442 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0024471 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0024239 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1859665 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0024918 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0023712 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0024209 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0024339 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0024305 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0024423 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0024334 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0024965 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0023455 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0023776 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0019078 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0023260 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
20510206 | J:243537
First Author: Muñoz-Martínez F
Year: 2010
Journal: Biochem Pharmacol
Title: CDC50A plays a key role in the uptake of the anticancer drug perifosine in human carcinoma cells.
Volume: 80
Issue: 6
Pages: 793-800
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Publication
26775031 | J:255360
First Author: Bolier R
Year: 2016
Journal: Biochim Biophys Acta
Title: Enteroendocrine cells are a potential source of serum autotaxin in men.
Volume: 1862
Issue: 4
Pages: 696-704
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Publication
31979271 | J:323093
 
First Author: Hohenester S
Year: 2020
Journal: Cells
Title: Glycochenodeoxycholate Promotes Liver Fibrosis in Mice with Hepatocellular Cholestasis.
Volume: 9
Issue: 2
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GXD Expression
GXD Expression
     
Probe: MGI:4358970
Assay Type: RNA in situ
Annotation Date: 2009-09-24
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1666528
Stage: TS28
Assay Id: MGI:4359077
Age: postnatal day 7
Specimen Label: Table 1 P7
Detected: false
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:4358970
Assay Type: RNA in situ
Annotation Date: 2009-09-24
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1666525
Stage: TS25
Assay Id: MGI:4359077
Age: embryonic day 17.0
Specimen Label: Table 1 E17.5
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:4358970
Assay Type: RNA in situ
Annotation Date: 2009-09-24
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1702328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:4359077
Age: postnatal day 7
Specimen Label: Table 1 P7
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:4358970
Assay Type: RNA in situ
Annotation Date: 2009-09-24
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3290628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:4359077
Age: postnatal day 7
Specimen Label: Table 1 P7
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:4358970
Assay Type: RNA in situ
Annotation Date: 2009-09-24
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1647028
Stage: TS28
Assay Id: MGI:4359077
Age: postnatal day 7
Specimen Label: Table 1 P7
Detected: false
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:4358970
Assay Type: RNA in situ
Annotation Date: 2009-09-24
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1647025
Stage: TS25
Assay Id: MGI:4359077
Age: embryonic day 17.0
Specimen Label: Table 1 E17.5
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:4358970
Assay Type: RNA in situ
Annotation Date: 2009-09-24
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1842625
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:4359077
Age: embryonic day 17.0
Specimen Label: Table 1 E17.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:4358970
Assay Type: RNA in situ
Annotation Date: 2009-09-24
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1842628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:4359077
Age: postnatal day 7
Specimen Label: Table 1 P7
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:4358970
Assay Type: RNA in situ
Annotation Date: 2009-09-24
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1684625
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:4359077
Age: embryonic day 17.0
Specimen Label: Table 1 E17.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:4358970
Assay Type: RNA in situ
Annotation Date: 2009-09-24
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1684628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:4359077
Age: postnatal day 7
Specimen Label: Table 1 P7
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:4358970
Assay Type: RNA in situ
Annotation Date: 2009-09-24
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1893928
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4359077
Age: postnatal day 7
Note: Expression is in the crypts.
Specimen Label: 5A
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4358970
Assay Type: RNA in situ
Annotation Date: 2009-09-24
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1775128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:4359077
Age: postnatal day 7
Specimen Label: Table 1 P7
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:4358970
Assay Type: RNA in situ
Annotation Date: 2009-09-24
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3287328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:4359077
Age: postnatal day 7
Note: Especially in colonic crypts.
Specimen Label: Table 1 P7
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:4358970
Assay Type: RNA in situ
Annotation Date: 2009-09-24
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3287325
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:4359077
Age: embryonic day 17.0
Specimen Label: Table 1 E17.5
Detected: true
Specimen Num: 2
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Publication
- | J:62782
   
First Author: Marra M
Year: 1997
Journal: GenBank Submission
Title: mx20g12.r1 Soares mouse NML Mus musculus cDNA clone IMAGE: 680806 5', mRNA sequence
Pages: AA242626
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Publication
29572910 | J:323091
First Author: Slijepcevic D
Year: 2018
Journal: Hepatology
Title: Na+ -taurocholate cotransporting polypeptide inhibition has hepatoprotective effects in cholestasis in mice.
Volume: 68
Issue: 3
Pages: 1057-1069
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Publication
- | J:62781
   
First Author: Marra M
Year: 1998
Journal: GenBank Submission
Title: vy11g09.r1 Stratagene mouse macrophage (#937306) Mus musculus cDNA clone IMAGE:1295200 5' similar to SW:ATC_YEAST p39524 PROBABLE CALCIUM-TRANSPORTING ATPASE 3;, mRNA sequence
Pages: AA896217
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Publication
25068656 | J:215915
First Author: Kunne C
Year: 2014
Journal: Lab Invest
Title: Hepatic cytochrome P450 deficiency in mouse models for intrahepatic cholestasis predispose to bile salt-induced cholestasis.
Volume: 94
Issue: 10
Pages: 1103-13
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Publication
11015572 | J:59384
First Author: Halleck MS
Year: 1999
Journal: Physiol Genomics
Title: Differential expression of putative transbilayer amphipath transporters.
Volume: 1
Issue: 3
Pages: 139-50
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Publication
24952082 | J:237458
First Author: Street VA
Year: 2014
Journal: J Assoc Res Otolaryngol
Title: Resistance to noise-induced hearing loss in 129S6 and MOLF mice: identification of independent, overlapping, and interacting chromosomal regions.
Volume: 15
Issue: 5
Pages: 721-38
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Publication
11208732 | J:66998
First Author: Lammert F
Year: 2001
Journal: Gastroenterology
Title: Chromosomal organization of candidate genes involved in cholesterol gallstone formation: a murine gallstone map.
Volume: 120
Issue: 1
Pages: 221-38
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Publication
- | J:237616
     
First Author: MGI and IMPC
Year: 2017
Journal: MGI Direct Data Submission
Title: MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:342608
       
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
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Publication
- | J:94790
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Mouse Synonym Curation
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Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
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First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
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First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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