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Search results 1 to 100 out of 506 for Atrx

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: wallaby, tammar
Gene
Type: gene
Organism: rat
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Clynes D
Year: 2014
Journal: PLoS One
Title: ATRX dysfunction induces replication defects in primary mouse cells.
Volume: 9
Issue: 3
Pages: e92915
Publication
First Author: Wong LH
Year: 2010
Journal: Genome Res
Title: ATRX interacts with H3.3 in maintaining telomere structural integrity in pluripotent embryonic stem cells.
Volume: 20
Issue: 3
Pages: 351-60
Publication
First Author: Kernohan KD
Year: 2010
Journal: Dev Cell
Title: ATRX partners with cohesin and MeCP2 and contributes to developmental silencing of imprinted genes in the brain.
Volume: 18
Issue: 2
Pages: 191-202
Publication
First Author: Picketts DJ
Year: 1998
Journal: Mamm Genome
Title: Comparison of the human and murine ATRX gene identifies highly conserved, functionally important domains.
Volume: 9
Issue: 5
Pages: 400-3
Publication
First Author: Nan X
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation.
Volume: 104
Issue: 8
Pages: 2709-14
Publication
First Author: Lagali PS
Year: 2016
Journal: Hum Mol Genet
Title: Retinal interneuron survival requires non-cell-autonomous Atrx activity.
Volume: 25
Issue: 21
Pages: 4787-4803
Publication
First Author: Solomon LA
Year: 2013
Journal: PLoS One
Title: Loss of ATRX does not confer susceptibility to osteoarthritis.
Volume: 8
Issue: 12
Pages: e85526
Publication
First Author: Goldberg AD
Year: 2010
Journal: Cell
Title: Distinct factors control histone variant H3.3 localization at specific genomic regions.
Volume: 140
Issue: 5
Pages: 678-91
Publication
First Author: Huh MS
Year: 2012
Journal: J Clin Invest
Title: Compromised genomic integrity impedes muscle growth after Atrx inactivation.
Volume: 122
Issue: 12
Pages: 4412-23
Publication
First Author: Bérubé NG
Year: 2002
Journal: Hum Mol Genet
Title: Neurodevelopmental defects resulting from ATRX overexpression in transgenic mice.
Volume: 11
Issue: 3
Pages: 253-61
Publication  
First Author: Marano D
Year: 2019
Journal: Int J Mol Sci
Title: ATRX Contributes to MeCP2-Mediated Pericentric Heterochromatin Organization during Neural Differentiation.
Volume: 20
Issue: 21
Publication
First Author: Rowland ME
Year: 2018
Journal: Aging (Albany NY)
Title: Inactivation of hepatic ATRX in Atrx Foxg1cre mice prevents reversal of aging-like phenotypes by thyroxine.
Volume: 10
Issue: 6
Pages: 1223-1238
Publication  
First Author: Gaspar TB
Year: 2022
Journal: Cancers (Basel)
Title: Characterisation of an Atrx Conditional Knockout Mouse Model: Atrx Loss Causes Endocrine Dysfunction Rather Than Pancreatic Neuroendocrine Tumour.
Volume: 14
Issue: 16
Publication  
First Author: Huh MS
Year: 2016
Journal: Cell Death Dis
Title: Stalled replication forks within heterochromatin require ATRX for protection.
Volume: 7
Pages: e2220
Publication  
First Author: Sun C
Year: 2022
Journal: Dis Model Mech
Title: Context matters - Daxx and Atrx are not robust tumor suppressors in the murine endocrine pancreas.
Volume: 15
Issue: 8
Publication  
First Author: Gaspar TB
Year: 2023
Journal: Cancers (Basel)
Title: Generation of an Obese Diabetic Mouse Model upon Conditional Atrx Disruption.
Volume: 15
Issue: 11
Publication
First Author: Solomon LA
Year: 2009
Journal: PLoS One
Title: Loss of ATRX in chondrocytes has minimal effects on skeletal development.
Volume: 4
Issue: 9
Pages: e7106
Publication
First Author: Sailau ZK
Year: 2017
Journal: Acta Histochem
Title: Nuclear distribution of the chromatin-remodeling protein ATRX in mouse early embryogenesis.
Volume: 119
Issue: 1
Pages: 18-25
Publication
First Author: Koschmann C
Year: 2016
Journal: Sci Transl Med
Title: ATRX loss promotes tumor growth and impairs nonhomologous end joining DNA repair in glioma.
Volume: 8
Issue: 328
Pages: 328ra28
Publication
First Author: Bérubé NG
Year: 2005
Journal: J Clin Invest
Title: The chromatin-remodeling protein ATRX is critical for neuronal survival during corticogenesis.
Volume: 115
Issue: 2
Pages: 258-67
Publication  
First Author: Huyhn K
Year: 2011
Journal: BMC Dev Biol
Title: ATRX has a critical and conserved role in mammalian sexual differentiation.
Volume: 11
Pages: 39
Publication
First Author: Rowland ME
Year: 2023
Journal: Nat Commun
Title: Systemic and intrinsic functions of ATRX in glial cell fate and CNS myelination in male mice.
Volume: 14
Issue: 1
Pages: 7090
Publication
First Author: Conte D
Year: 2012
Journal: PLoS One
Title: Loss of Atrx sensitizes cells to DNA damaging agents through p53-mediated death pathways.
Volume: 7
Issue: 12
Pages: e52167
Publication
First Author: Nogami T
Year: 2011
Journal: Hippocampus
Title: Reduced expression of the ATRX gene, a chromatin-remodeling factor, causes hippocampal dysfunction in mice.
Volume: 21
Issue: 6
Pages: 678-87
Publication
First Author: Tamming RJ
Year: 2017
Journal: Dis Model Mech
Title: Mosaic expression of Atrx in the mouse central nervous system causes memory deficits.
Volume: 10
Issue: 2
Pages: 119-126
GXD Expression
Probe: MGI:6259658
Assay Type: RNA in situ
Annotation Date: 2018-12-10
Strength: Present
Sex: Female
Emaps: EMAPS:3187710
Pattern: Not Specified
Stage: TS10
Assay Id: MGI:6259659
Age: embryonic day 7.0
Image: S1E
Note: Biallelic Atrx expression was shown.
Specimen Label: S1E
Detected: true
Specimen Num: 5
Publication  
First Author: Levy MA
Year: 2008
Journal: BMC Genomics
Title: The SWI/SNF protein ATRX co-regulates pseudoautosomal genes that have translocated to autosomes in the mouse genome.
Volume: 9
Pages: 468
Publication
First Author: Danussi C
Year: 2018
Journal: Nat Commun
Title: Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling.
Volume: 9
Issue: 1
Pages: 1057
Publication
First Author: Lovejoy CA
Year: 2020
Journal: PLoS Biol
Title: ATRX affects the repair of telomeric DSBs by promoting cohesion and a DAXX-dependent activity.
Volume: 18
Issue: 1
Pages: e3000594
Publication  
First Author: Bartholf DeWitt S
Year: 2022
Journal: JCI Insight
Title: Loss of ATRX promotes aggressive features of osteosarcoma with increased NF-κB signaling and integrin binding.
Volume: 7
Issue: 17
Publication
First Author: Watson LA
Year: 2013
Journal: J Clin Invest
Title: Atrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span.
Volume: 123
Issue: 5
Pages: 2049-63
Publication
First Author: Tamming RJ
Year: 2020
Journal: Cell Rep
Title: Atrx Deletion in Neurons Leads to Sexually Dimorphic Dysregulation of miR-137 and Spatial Learning and Memory Deficits.
Volume: 31
Issue: 13
Pages: 107838
Publication
First Author: Huh MS
Year: 2017
Journal: PLoS One
Title: Recovery from impaired muscle growth arises from prolonged postnatal accretion of myonuclei in Atrx mutant mice.
Volume: 12
Issue: 11
Pages: e0186989
Publication
First Author: Levy MA
Year: 2015
Journal: Hum Mol Genet
Title: ATRX promotes gene expression by facilitating transcriptional elongation through guanine-rich coding regions.
Volume: 24
Issue: 7
Pages: 1824-35
Publication
First Author: Garrick D
Year: 2006
Journal: PLoS Genet
Title: Loss of Atrx affects trophoblast development and the pattern of X-inactivation in extraembryonic tissues.
Volume: 2
Issue: 4
Pages: e58
Publication
First Author: Baumann C
Year: 2010
Journal: PLoS Genet
Title: Loss of maternal ATRX results in centromere instability and aneuploidy in the mammalian oocyte and pre-implantation embryo.
Volume: 6
Issue: 9
Pages: e1001137
Publication  
First Author: Floyd W
Year: 2023
Journal: J Clin Invest
Title: Atrx deletion impairs CGAS/STING signaling and increases sarcoma response to radiation and oncolytic herpesvirus.
Volume: 133
Issue: 13
Publication
First Author: Ritchie K
Year: 2014
Journal: Biol Open
Title: ATRX is required for maintenance of the neuroprogenitor cell pool in the embryonic mouse brain.
Volume: 3
Issue: 12
Pages: 1158-63
Publication
First Author: Kernohan KD
Year: 2014
Journal: Nucleic Acids Res
Title: Analysis of neonatal brain lacking ATRX or MeCP2 reveals changes in nucleosome density, CTCF binding and chromatin looping.
Volume: 42
Issue: 13
Pages: 8356-68
Publication
First Author: Medina CF
Year: 2009
Journal: Hum Mol Genet
Title: Altered visual function and interneuron survival in Atrx knockout mice: inference for the human syndrome.
Volume: 18
Issue: 5
Pages: 966-77
Publication
First Author: Seah C
Year: 2008
Journal: J Neurosci
Title: Neuronal death resulting from targeted disruption of the Snf2 protein ATRX is mediated by p53.
Volume: 28
Issue: 47
Pages: 12570-80
Publication
First Author: Young CC
Year: 2019
Journal: Cell Mol Gastroenterol Hepatol
Title: The Loss of ATRX Increases Susceptibility to Pancreatic Injury and Oncogenic KRAS in Female But Not Male Mice.
Volume: 7
Issue: 1
Pages: 93-113
Publication
First Author: Shioda N
Year: 2011
Journal: J Neurosci
Title: Aberrant calcium/calmodulin-dependent protein kinase II (CaMKII) activity is associated with abnormal dendritic spine morphology in the ATRX mutant mouse brain.
Volume: 31
Issue: 1
Pages: 346-58
Publication
First Author: Lewis PW
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres.
Volume: 107
Issue: 32
Pages: 14075-80
GXD Expression  
Probe: MGI:5609447
Assay Type: Immunohistochemistry
Annotation Date: 2020-07-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160331
Pattern: Not Specified
Stage: TS01
Assay Id: MGI:6438169
Age: embryonic day 0.5
Note: Atrx is a nuclear matrix marker during interphase.
Specimen Label: S2B
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:6259658
Assay Type: RNA in situ
Annotation Date: 2018-12-10
Strength: Present
Sex: Female
Emaps: EMAPS:1604210
Pattern: Regionally restricted
Stage: TS10
Assay Id: MGI:6259659
Age: embryonic day 7.0
Image: S1D
Note: Two nuclei in the chorion - one monoallelic and one biallelic Atrx expression.
Specimen Label: S1D
Detected: true
Specimen Num: 4
GXD Expression
Probe: MGI:5609447
Assay Type: Immunohistochemistry
Annotation Date: 2018-12-10
Strength: Present
Sex: Female
Emaps: EMAPS:3187710
Pattern: Not Specified
Stage: TS10
Assay Id: MGI:6259666
Age: embryonic day 7.0
Image: S1C
Note: Partial overlap of Atrx label with Xist expression domain was noted.
Specimen Label: S1C
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:7384879
Assay Type: Immunohistochemistry
Annotation Date: 2022-11-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Pattern: Regionally restricted
Stage: TS02
Assay Id: MGI:7384974
Age: embryonic day 1.0
Note: Daxx gold particles and Atrx gold particles were noted in separate heterochromatin structures.
Specimen Label: 2c
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7384879
Assay Type: Immunohistochemistry
Annotation Date: 2022-11-18
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:160331
Pattern: Not Specified
Stage: TS01
Assay Id: MGI:7384973
Age: embryonic day 0.5
Note: There was no colocalization of Atrx with Daxx immunolabeling at the late zygote stage.
Specimen Label: 4a
Specimen Num: 1
GXD Expression    
Probe: MGI:7384879
Assay Type: Immunohistochemistry
Annotation Date: 2022-11-18
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:160403
Pattern: Not Specified
Stage: TS03
Assay Id: MGI:7384973
Age: embryonic day 3.0
Note: There was no colocalization of Atrx with Daxx immunolabeling at the morula stage.
Specimen Label: 4c
Specimen Num: 3
GXD Expression  
Probe: MGI:7384879
Assay Type: Immunohistochemistry
Annotation Date: 2022-11-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Pattern: Regionally restricted
Stage: TS02
Assay Id: MGI:7384973
Age: embryonic day 1.0
Note: Daxx and Atrx colocalization in the nucleus of 2-cell mouse embryos.
Specimen Label: 5a
Detected: true
Specimen Num: 4
Publication
First Author: Eustermann S
Year: 2011
Journal: Nat Struct Mol Biol
Title: Combinatorial readout of histone H3 modifications specifies localization of ATRX to heterochromatin.
Volume: 18
Issue: 7
Pages: 777-82
GXD Expression  
Probe: MGI:7384879
Assay Type: Immunohistochemistry
Annotation Date: 2022-11-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Pattern: Regionally restricted
Stage: TS02
Assay Id: MGI:7384974
Age: embryonic day 1.0
Note: Daxx gold particles and Atrx gold particles were noted in a single structure in close proximity to the surface of interchromatin granule cluster.
Specimen Label: 2d
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:5609447
Assay Type: Immunohistochemistry
Annotation Date: 2018-12-10
Strength: Present
Sex: Female
Emaps: EMAPS:1604210
Pattern: Regionally restricted
Stage: TS10
Assay Id: MGI:6259666
Age: embryonic day 7.0
Image: S1B
Note: There was no overlap of the Atrx protein with Xist staining in the two nuclei from chorion shown in the figure. Only 5.8% of chorion nuclei show partial overlap of expression.
Specimen Label: S1B
Detected: true
Specimen Num: 2
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: frog, western clawed
GXD Expression  
Probe: MGI:5609447
Assay Type: Immunohistochemistry
Annotation Date: 2018-02-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Pattern: Not Specified
Stage: TS02
Assay Id: MGI:6117769
Age: embryonic day 1.0
Note: Intense staining were observed at the periphery of the nucleolus precursor bodies, together with a diffuse staining of the nucleoplasm. A colocalization of heterochromatin and ATRX was detected in some areas at the nucleolus precursor body periphery. The presence of heterochromatin areas that do not contain ATRX is clearly seen.
Specimen Label: 4
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:7384879
Assay Type: Immunohistochemistry
Annotation Date: 2022-11-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Pattern: Regionally restricted
Stage: TS02
Assay Id: MGI:7384973
Age: embryonic day 1.0
Note: At late two-cell stage, colocalization of Daxx and ATRX was detectable both in the ring-shaped heterochromatin zones associated with the nucleolus precursor body (NPB) periphery and in NPB-unassociated heterochromatin patches. Some zones of Daxx localization did not overlap with ATRX (and vise versa). ATRX was found in 60% Daxx-positive heterochromatin areas associated with NPBs and in 80% Daxx-positive heterochromatin clumps located outside the NPBs.
Specimen Label: 4b
Detected: true
Specimen Num: 2
Protein
Organism: Mus musculus/domesticus
Length: 2476  
Fragment?: false
Publication
First Author: Le Douarin B
Year: 1996
Journal: EMBO J
Title: A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors.
Volume: 15
Issue: 23
Pages: 6701-15
Publication  
First Author: Yamaguchi K
Year: 2018
Journal: Int J Mol Sci
Title: SA4503, A Potent Sigma-1 Receptor Ligand, Ameliorates Synaptic Abnormalities and Cognitive Dysfunction in a Mouse Model of ATR-X Syndrome.
Volume: 19
Issue: 9
Publication
First Author: Muers MR
Year: 2007
Journal: Am J Hum Genet
Title: Defining the cause of skewed X-chromosome inactivation in X-linked mental retardation by use of a mouse model.
Volume: 80
Issue: 6
Pages: 1138-49
Publication
First Author: Shioda N
Year: 2018
Journal: Nat Med
Title: Targeting G-quadruplex DNA as cognitive function therapy for ATR-X syndrome.
Volume: 24
Issue: 6
Pages: 802-813
Publication
First Author: Kugler J
Year: 2017
Journal: Carcinogenesis
Title: Elevated HMGN4 expression potentiates thyroid tumorigenesis.
Volume: 38
Issue: 4
Pages: 391-401
Publication  
First Author: Lagali PS
Year: 2021
Journal: Neuroscience
Title: Sensory Experience Modulates Atrx-mediated Neuronal Integrity in the Mouse Retina.
Volume: 452
Pages: 169-180
Publication
First Author: Bogolyubova IO
Year: 2019
Journal: Acta Histochem
Title: The dynamics of DAXX protein distribution in the nucleus of mouse early embryos.
Volume: 121
Issue: 4
Pages: 522-529
Publication
First Author: Ishov AM
Year: 2004
Journal: J Cell Sci
Title: Heterochromatin and ND10 are cell-cycle regulated and phosphorylation-dependent alternate nuclear sites of the transcription repressor Daxx and SWI/SNF protein ATRX.
Volume: 117
Issue: Pt 17
Pages: 3807-20
Publication
First Author: Solomon LA
Year: 2013
Journal: Hum Mol Genet
Title: Targeted loss of the ATR-X syndrome protein in the limb mesenchyme of mice causes brachydactyly.
Volume: 22
Issue: 24
Pages: 5015-25
Publication
First Author: Chang FT
Year: 2013
Journal: Nucleic Acids Res
Title: PML bodies provide an important platform for the maintenance of telomeric chromatin integrity in embryonic stem cells.
Volume: 41
Issue: 8
Pages: 4447-58
Publication
First Author: De La Fuente R
Year: 2004
Journal: Dev Biol
Title: ATRX, a member of the SNF2 family of helicase/ATPases, is required for chromosome alignment and meiotic spindle organization in metaphase II stage mouse oocytes.
Volume: 272
Issue: 1
Pages: 1-14
Publication
First Author: Bagheri-Fam S
Year: 2011
Journal: Hum Mol Genet
Title: Defective survival of proliferating Sertoli cells and androgen receptor function in a mouse model of the ATR-X syndrome.
Volume: 20
Issue: 11
Pages: 2213-24
UniProt Feature
Begin: 1
Description: Transcriptional regulator ATRX
Type: chain
End: 2476
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory