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Search results 1 to 100 out of 348 for Atxn1

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0.041s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Protein Domain
Type: Family
Description: Ataxin-1 (ATXN1) is the causative factor for spinocerebellar ataxia type 1 (SCA1), which manifests in poor co-ordination of hand and feet movement []. ATXN1 is a transcription repressor in the Notch signalling pathway []and colocalizes with the deubiquitinating enzyme USP7 in the nucleus [].
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Gene
Type: gene
Organism: Homo sapiens
Publication
First Author: Jorgensen ND
Year: 2009
Journal: J Neurochem
Title: Phosphorylation of ATXN1 at Ser776 in the cerebellum.
Volume: 110
Issue: 2
Pages: 675-86
Publication
First Author: Servadio A
Year: 1995
Journal: Nat Genet
Title: Expression analysis of the ataxin-1 protein in tissues from normal and spinocerebellar ataxia type 1 individuals.
Volume: 10
Issue: 1
Pages: 94-8
Publication
First Author: Tong X
Year: 2011
Journal: EMBO Rep
Title: Ataxin-1 and Brother of ataxin-1 are components of the Notch signalling pathway.
Volume: 12
Issue: 5
Pages: 428-35
Publication
First Author: Hong S
Year: 2002
Journal: Mol Cell Neurosci
Title: USP7, a ubiquitin-specific protease, interacts with ataxin-1, the SCA1 gene product.
Volume: 20
Issue: 2
Pages: 298-306
Publication
First Author: Lee Y
Year: 2011
Journal: Dev Cell
Title: ATXN1 protein family and CIC regulate extracellular matrix remodeling and lung alveolarization.
Volume: 21
Issue: 4
Pages: 746-57
Protein
Organism: Mus musculus
Length: 791  
Fragment?: false
Protein
Organism: Mus musculus
Length: 799  
Fragment?: false
Publication
First Author: Ingram M
Year: 2016
Journal: Neuron
Title: Cerebellar Transcriptome Profiles of ATXN1 Transgenic Mice Reveal SCA1 Disease Progression and Protection Pathways.
Volume: 89
Issue: 6
Pages: 1194-1207
Publication
First Author: Duvick L
Year: 2010
Journal: Neuron
Title: SCA1-like disease in mice expressing wild-type ataxin-1 with a serine to aspartic acid replacement at residue 776.
Volume: 67
Issue: 6
Pages: 929-35
Publication  
First Author: Cvetanovic M
Year: 2015
Journal: Neuroscience
Title: Early activation of microglia and astrocytes in mouse models of spinocerebellar ataxia type 1.
Volume: 289
Pages: 289-99
Publication  
First Author: Öz G
Year: 2015
Journal: Neurobiol Dis
Title: Assessing recovery from neurodegeneration in spinocerebellar ataxia 1: Comparison of in vivo magnetic resonance spectroscopy with motor testing, gene expression and histology.
Volume: 74
Pages: 158-66
Publication
First Author: Ebner BA
Year: 2013
Journal: J Neurosci
Title: Purkinje cell ataxin-1 modulates climbing fiber synaptic input in developing and adult mouse cerebellum.
Volume: 33
Issue: 13
Pages: 5806-20
Publication
First Author: Cvetanovic M
Year: 2011
Journal: Nat Med
Title: Vascular endothelial growth factor ameliorates the ataxic phenotype in a mouse model of spinocerebellar ataxia type 1.
Volume: 17
Issue: 11
Pages: 1445-7
Publication    
First Author: Lasagna-Reeves CA
Year: 2015
Journal: Elife
Title: Ataxin-1 oligomers induce local spread of pathology and decreasing them by passive immunization slows Spinocerebellar ataxia type 1 phenotypes.
Volume: 4
Publication
First Author: Sánchez I
Year: 2013
Journal: Hum Mol Genet
Title: A novel function of Ataxin-1 in the modulation of PP2A activity is dysregulated in the spinocerebellar ataxia type 1.
Volume: 22
Issue: 17
Pages: 3425-37
Publication
First Author: Barnes JA
Year: 2011
Journal: J Neurosci
Title: Abnormalities in the climbing fiber-Purkinje cell circuitry contribute to neuronal dysfunction in ATXN1[82Q] mice.
Volume: 31
Issue: 36
Pages: 12778-89
Publication  
First Author: Takechi Y
Year: 2013
Journal: Neurosci Lett
Title: Impairment of spinal motor neurons in spinocerebellar ataxia type 1-knock-in mice.
Volume: 535
Pages: 67-72
Publication  
First Author: Orengo JP
Year: 2018
Journal: Dis Model Mech
Title: Motor neuron degeneration correlates with respiratory dysfunction in SCA1.
Volume: 11
Issue: 2
Publication
First Author: Edamakanti CR
Year: 2018
Journal: J Clin Invest
Title: Mutant ataxin1 disrupts cerebellar development in spinocerebellar ataxia type 1.
Volume: 128
Issue: 6
Pages: 2252-2265
Publication
First Author: Cvetanovic M
Year: 2012
Journal: Neurobiol Dis
Title: LANP mediates neuritic pathology in Spinocerebellar ataxia type 1.
Volume: 48
Issue: 3
Pages: 526-32
Publication
First Author: Bowman AB
Year: 2007
Journal: Nat Genet
Title: Duplication of Atxn1l suppresses SCA1 neuropathology by decreasing incorporation of polyglutamine-expanded ataxin-1 into native complexes.
Volume: 39
Issue: 3
Pages: 373-9
Publication
First Author: Ju H
Year: 2013
Journal: J Neurosci
Title: Polyglutamine disease toxicity is regulated by Nemo-like kinase in spinocerebellar ataxia type 1.
Volume: 33
Issue: 22
Pages: 9328-36
Publication    
First Author: Lasagna-Reeves CA
Year: 2015
Journal: Elife
Title: A native interactor scaffolds and stabilizes toxic ATAXIN-1 oligomers in SCA1.
Volume: 4
Publication
First Author: Fryer JD
Year: 2011
Journal: Science
Title: Exercise and genetic rescue of SCA1 via the transcriptional repressor Capicua.
Volume: 334
Issue: 6056
Pages: 690-3
Publication
First Author: Fujita K
Year: 2017
Journal: Nat Commun
Title: Developmental YAPdeltaC determines adult pathology in a model of spinocerebellar ataxia type 1.
Volume: 8
Issue: 1
Pages: 1864
Publication  
First Author: Asher M
Year: 2016
Journal: Neuroscience
Title: Ataxin-1 regulates proliferation of hippocampal neural precursors.
Volume: 322
Pages: 54-65
Publication
First Author: Serra HG
Year: 2006
Journal: Cell
Title: RORalpha-mediated Purkinje cell development determines disease severity in adult SCA1 mice.
Volume: 127
Issue: 4
Pages: 697-708
Publication
First Author: Park J
Year: 2013
Journal: Nature
Title: RAS-MAPK-MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1.
Volume: 498
Issue: 7454
Pages: 325-331
Publication
First Author: Lim J
Year: 2008
Journal: Nature
Title: Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1.
Volume: 452
Issue: 7188
Pages: 713-8
Publication
First Author: Jorgensen ND
Year: 2007
Journal: J Neurochem
Title: Hsp70/Hsc70 regulates the effect phosphorylation has on stabilizing ataxin-1.
Volume: 102
Issue: 6
Pages: 2040-8
Publication
First Author: Venkatraman A
Year: 2014
Journal: Hum Mol Genet
Title: The histone deacetylase HDAC3 is essential for Purkinje cell function, potentially complicating the use of HDAC inhibitors in SCA1.
Volume: 23
Issue: 14
Pages: 3733-45
Publication
First Author: Jafar-Nejad P
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Regional rescue of spinocerebellar ataxia type 1 phenotypes by 14-3-3epsilon haploinsufficiency in mice underscores complex pathogenicity in neurodegeneration.
Volume: 108
Issue: 5
Pages: 2142-7
Publication
First Author: Gehrking KM
Year: 2011
Journal: Hum Mol Genet
Title: Partial loss of Tip60 slows mid-stage neurodegeneration in a spinocerebellar ataxia type 1 (SCA1) mouse model.
Volume: 20
Issue: 11
Pages: 2204-12
Publication
First Author: Ito H
Year: 2015
Journal: EMBO Mol Med
Title: HMGB1 facilitates repair of mitochondrial DNA damage and extends the lifespan of mutant ataxin-1 knock-in mice.
Volume: 7
Issue: 1
Pages: 78-101
Publication
First Author: Goold R
Year: 2007
Journal: Hum Mol Genet
Title: Down-regulation of the dopamine receptor D2 in mice lacking ataxin 1.
Volume: 16
Issue: 17
Pages: 2122-34
Publication
First Author: Crespo-Barreto J
Year: 2010
Journal: PLoS Genet
Title: Partial loss of ataxin-1 function contributes to transcriptional dysregulation in spinocerebellar ataxia type 1 pathogenesis.
Volume: 6
Issue: 7
Pages: e1001021
Publication
First Author: Sánchez I
Year: 2016
Journal: Hum Mol Genet
Title: Ataxin-1 regulates the cerebellar bioenergetics proteome through the GSK3β-mTOR pathway which is altered in Spinocerebellar ataxia type 1 (SCA1).
Volume: 25
Issue: 18
Pages: 4021-4040
Publication
First Author: Rousseaux MWC
Year: 2018
Journal: Neuron
Title: ATXN1-CIC Complex Is the Primary Driver of Cerebellar Pathology in Spinocerebellar Ataxia Type 1 through a Gain-of-Function Mechanism.
Volume: 97
Issue: 6
Pages: 1235-1243.e5
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Klement IA
Year: 1998
Journal: Cell
Title: Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice.
Volume: 95
Issue: 1
Pages: 41-53
Publication
First Author: Watase K
Year: 2002
Journal: Neuron
Title: A long CAG repeat in the mouse Sca1 locus replicates SCA1 features and reveals the impact of protein solubility on selective neurodegeneration.
Volume: 34
Issue: 6
Pages: 905-19
Publication
First Author: Chen KA
Year: 2011
Journal: Mol Cell Neurosci
Title: Cellular fusion for gene delivery to SCA1 affected Purkinje neurons.
Volume: 47
Issue: 1
Pages: 61-70
Publication
First Author: Skinner PJ
Year: 1997
Journal: Nature
Title: Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures.
Volume: 389
Issue: 6654
Pages: 971-4
Publication
First Author: Matilla A
Year: 1998
Journal: J Neurosci
Title: Mice lacking ataxin-1 display learning deficits and decreased hippocampal paired-pulse facilitation.
Volume: 18
Issue: 14
Pages: 5508-16
Publication
First Author: Lorenzetti D
Year: 2000
Journal: Hum Mol Genet
Title: Repeat instability and motor incoordination in mice with a targeted expanded CAG repeat in the Sca1 locus.
Volume: 9
Issue: 5
Pages: 779-85
Publication
First Author: Perroud B
Year: 2013
Journal: PLoS One
Title: Pharmacometabolomic signature of ataxia SCA1 mouse model and lithium effects.
Volume: 8
Issue: 8
Pages: e70610
Publication  
First Author: Hatanaka Y
Year: 2015
Journal: Sci Rep
Title: Abnormalities in synaptic dynamics during development in a mouse model of spinocerebellar ataxia type 1.
Volume: 5
Pages: 16102
Publication    
First Author: Driessen TM
Year: 2018
Journal: Elife
Title: Molecular pathway analysis towards understanding tissue vulnerability in spinocerebellar ataxia type 1.
Volume: 7
Publication
First Author: Burright EN
Year: 1995
Journal: Cell
Title: SCA1 transgenic mice: a model for neurodegeneration caused by an expanded CAG trinucleotide repeat.
Volume: 82
Issue: 6
Pages: 937-48
Publication
First Author: Clark HB
Year: 1997
Journal: J Neurosci
Title: Purkinje cell expression of a mutant allele of SCA1 in transgenic mice leads to disparate effects on motor behaviors, followed by a progressive cerebellar dysfunction and histological alterations.
Volume: 17
Issue: 19
Pages: 7385-95
Publication
First Author: Shahbazian MD
Year: 2001
Journal: Neurobiol Dis
Title: Reduction of Purkinje cell pathology in SCA1 transgenic mice by p53 deletion.
Volume: 8
Issue: 6
Pages: 974-81
Publication
First Author: Clark HB
Year: 2000
Journal: J Neuropathol Exp Neurol
Title: Spinocerebellar ataxia type 1--modeling the pathogenesis of a polyglutamine neurodegenerative disorder in transgenic mice.
Volume: 59
Issue: 4
Pages: 265-70
Publication
First Author: Limprasert P
Year: 1997
Journal: Am J Med Genet
Title: Comparative studies of the CAG repeats in the spinocerebellar ataxia type 1 (SCA1) gene.
Volume: 74
Issue: 5
Pages: 488-93
Publication
First Author: Emamian ES
Year: 2003
Journal: Neuron
Title: Serine 776 of ataxin-1 is critical for polyglutamine-induced disease in SCA1 transgenic mice.
Volume: 38
Issue: 3
Pages: 375-87
GXD Expression      
Probe: MGI:3815622
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360422
Stage: TS02
Assay Id: MGI:3816426
Age: embryonic day 1.5
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3815622
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:360443
Stage: TS03
Assay Id: MGI:3816426
Age: embryonic day 2.5
Detected: false
Specimen Num: 4
GXD Expression      
Probe: MGI:3815622
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360453
Stage: TS03
Assay Id: MGI:3816426
Age: embryonic day 3.0
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3815622
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:160415
Stage: TS05
Assay Id: MGI:3816426
Age: embryonic day 4.5
Detected: false
Specimen Num: 8
GXD Expression      
Probe: MGI:3815622
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360433
Stage: TS03
Assay Id: MGI:3816426
Age: embryonic day 2.0
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3815622
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360465
Stage: TS05
Assay Id: MGI:3816426
Age: embryonic day 4.5
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:3815622
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360464
Stage: TS04
Assay Id: MGI:3816426
Age: embryonic day 3.5
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:3815622
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Female
Emaps: EMAPS:3102528
Stage: TS28
Assay Id: MGI:3816426
Age: postnatal
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3507137
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1753621
Stage: TS21
Assay Id: MGI:3508575
Age: embryonic day 13.5
Image: 1
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3507114
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1753621
Stage: TS21
Assay Id: MGI:3508565
Age: embryonic day 13.5
Image: 1
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5438517
Assay Type: RNA in situ
Annotation Date: 2012-10-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3540528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5438522
Age: postnatal adult
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5438517
Assay Type: RNA in situ
Annotation Date: 2012-10-16
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3540928
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5438522
Age: postnatal adult
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:3507137
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1647018
Pattern: Not Specified
Stage: TS18
Assay Id: MGI:3509924
Age: embryonic day 10.5
Image: 2 - right embryo
Note: Authors stated that in some instances they could not determine expression levels with certainty.
Specimen Num: 2
GXD Expression  
Probe: MGI:3507114
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1647018
Pattern: Not Specified
Stage: TS18
Assay Id: MGI:3509896
Age: embryonic day 10.5
Image: 2 - right embryo
Note: Authors stated that in some instances they could not determine expression levels with certainty.
Specimen Num: 2
GXD Expression  
Probe: MGI:3507137
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1647017
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:3509924
Age: embryonic day 10.5
Image: 1 - left embryo
Note: Authors stated that in some instances they could not determine expression levels with certainty.
Specimen Num: 1
GXD Expression  
Probe: MGI:3507114
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1647017
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:3509896
Age: embryonic day 10.5
Image: 1 - left embryo
Note: Authors stated that in some instances they could not determine expression levels with certainty.
Specimen Num: 1
GXD Expression    
Probe: MGI:3507137
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1647021
Stage: TS21
Assay Id: MGI:3508575
Age: embryonic day 13.5
Image: 1
Detected: false
Specimen Num: 1
GXD Expression
Probe: MGI:3507114
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1647021
Pattern: Single cells
Stage: TS21
Assay Id: MGI:3508565
Age: embryonic day 13.5
Image: 1
Note: Expression was detected in some cells.
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5438517
Assay Type: RNA in situ
Annotation Date: 2012-10-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684622
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:5438522
Age: embryonic day 14.5
Detected: true
Specimen Num: 12
GXD Expression  
Probe: MGI:5002041
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2852723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5542595
Age: embryonic day 15.5
Image: GUDMAP:13235
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:5002041
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2852723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5542595
Age: embryonic day 15.5
Image: GUDMAP:13234
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3507114
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2852723
Stage: TS23
Assay Id: MGI:5540064
Age: embryonic day 15.5
Image: GUDMAP:12778
Detected: false
Specimen Num: 3
GXD Expression    
Probe: MGI:3507114
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2852723
Stage: TS23
Assay Id: MGI:5540064
Age: embryonic day 15.5
Image: GUDMAP:12777
Detected: false
Specimen Num: 2