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Search results 1 to 100 out of 204 for Atxn2

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Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Domain
Type: Family
Description: Ataxin-2 has many functions such as endocytic receptor cycling [], translational regulation, embryonic development [], energy metabolism and weight regulation []. Mutations of the Ataxin-2 gene cause spinocerebellar ataxia 2 (SCA2), a neurodegenerative disorder leading to predominant loss of Purkinje cells in the cerebellum and impairment of motor coordination []. In SCA2, expansion of a CAG repeat in exon 1 of the Ataxin-2 (ATXN2) gene causes expansion of a polyQ domain in the ATXN2 protein [].
Publication
First Author: Dansithong W
Year: 2015
Journal: PLoS Genet
Title: Ataxin-2 regulates RGS8 translation in a new BAC-SCA2 transgenic mouse model.
Volume: 11
Issue: 4
Pages: e1005182
Gene
Type: gene
Organism: Homo sapiens
Publication
First Author: Pulst SM
Year: 1996
Journal: Nat Genet
Title: Moderate expansion of a normally biallelic trinucleotide repeat in spinocerebellar ataxia type 2.
Volume: 14
Issue: 3
Pages: 269-76
Publication
First Author: Kiehl TR
Year: 2006
Journal: Biochem Biophys Res Commun
Title: Generation and characterization of Sca2 (ataxin-2) knockout mice.
Volume: 339
Issue: 1
Pages: 17-24
Publication
First Author: Halbach MV
Year: 2017
Journal: Cerebellum
Title: Atxn2 Knockout and CAG42-Knock-in Cerebellum Shows Similarly Dysregulated Expression in Calcium Homeostasis Pathway.
Volume: 16
Issue: 1
Pages: 68-81
Publication
First Author: Halbach MV
Year: 2015
Journal: PLoS One
Title: Both ubiquitin ligases FBXW8 and PARK2 are sequestrated into insolubility by ATXN2 PolyQ expansions, but only FBXW8 expression is dysregulated.
Volume: 10
Issue: 3
Pages: e0121089
Publication
First Author: Nonis D
Year: 2008
Journal: Cell Signal
Title: Ataxin-2 associates with the endocytosis complex and affects EGF receptor trafficking.
Volume: 20
Issue: 10
Pages: 1725-39
Protein
Organism: Mus musculus
Length: 64  
Fragment?: true
Protein
Organism: Mus musculus
Length: 65  
Fragment?: true
Protein
Organism: Mus musculus
Length: 234  
Fragment?: true
Protein
Organism: Mus musculus
Length: 96  
Fragment?: true
Publication
First Author: Ciosk R
Year: 2004
Journal: Development
Title: ATX-2, the C. elegans ortholog of ataxin 2, functions in translational regulation in the germline.
Volume: 131
Issue: 19
Pages: 4831-41
Protein
Organism: Mus musculus
Length: 664  
Fragment?: true
Protein
Organism: Mus musculus
Length: 947  
Fragment?: true
Protein
Organism: Mus musculus
Length: 662  
Fragment?: true
Protein
Organism: Mus musculus
Length: 929  
Fragment?: true
Protein
Organism: Mus musculus
Length: 330  
Fragment?: true
Protein
Organism: Mus musculus
Length: 1285  
Fragment?: false
Protein
Organism: Mus musculus
Length: 1286  
Fragment?: false
Protein
Organism: Mus musculus
Length: 402  
Fragment?: true
Publication
First Author: Paul S
Year: 2018
Journal: Nat Commun
Title: Staufen1 links RNA stress granules and autophagy in a model of neurodegeneration.
Volume: 9
Issue: 1
Pages: 3648
Publication
First Author: Hansen ST
Year: 2013
Journal: Hum Mol Genet
Title: Changes in Purkinje cell firing and gene expression precede behavioral pathology in a mouse model of SCA2.
Volume: 22
Issue: 2
Pages: 271-83
Publication
First Author: Pflieger LT
Year: 2017
Journal: Hum Mol Genet
Title: Gene co-expression network analysis for identifying modules and functionally enriched pathways in SCA2.
Volume: 26
Issue: 16
Pages: 3069-3080
Publication
First Author: Fittschen M
Year: 2015
Journal: Neurogenetics
Title: Genetic ablation of ataxin-2 increases several global translation factors in their transcript abundance but decreases translation rate.
Volume: 16
Issue: 3
Pages: 181-92
Publication  
First Author: Sen NE
Year: 2016
Journal: Neurobiol Dis
Title: Search for SCA2 blood RNA biomarkers highlights Ataxin-2 as strong modifier of the mitochondrial factor PINK1 levels.
Volume: 96
Pages: 115-126
Publication
First Author: Damrath E
Year: 2012
Journal: PLoS Genet
Title: ATXN2-CAG42 sequesters PABPC1 into insolubility and induces FBXW8 in cerebellum of old ataxic knock-in mice.
Volume: 8
Issue: 8
Pages: e1002920
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Nechiporuk T
Year: 1998
Journal: Hum Mol Genet
Title: The mouse SCA2 gene: cDNA sequence, alternative splicing and protein expression.
Volume: 7
Issue: 8
Pages: 1301-9
Publication
First Author: Becker LA
Year: 2017
Journal: Nature
Title: Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice.
Volume: 544
Issue: 7650
Pages: 367-371
Publication
First Author: Huynh DP
Year: 2009
Journal: PLoS One
Title: Dissociated fear and spatial learning in mice with deficiency of ataxin-2.
Volume: 4
Issue: 7
Pages: e6235
GXD Expression      
Probe: MGI:1277377
Assay Type: RT-PCR
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:3814411
Age: postnatal adult
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:1277374
Assay Type: Northern blot
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:3814397
Age: postnatal adult
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:1277377
Assay Type: RT-PCR
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3814411
Age: postnatal adult
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:1277374
Assay Type: Northern blot
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3814397
Age: postnatal adult
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:1277377
Assay Type: RT-PCR
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603912
Stage: TS12
Assay Id: MGI:3814402
Age: embryonic day 8.0
Detected: true
Specimen Num: 10
GXD Expression      
Probe: MGI:1277377
Assay Type: RT-PCR
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603914
Stage: TS14
Assay Id: MGI:3814402
Age: embryonic day 9.0
Detected: true
Specimen Num: 9
GXD Expression      
Probe: MGI:1277377
Assay Type: RT-PCR
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603916
Stage: TS16
Assay Id: MGI:3814402
Age: embryonic day 10.0
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:1277377
Assay Type: RT-PCR
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603918
Stage: TS18
Assay Id: MGI:3814402
Age: embryonic day 11.0
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:1277377
Assay Type: RT-PCR
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:3814402
Age: embryonic day 12.0
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:1277377
Assay Type: RT-PCR
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603921
Stage: TS21
Assay Id: MGI:3814402
Age: embryonic day 13.0
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:1277377
Assay Type: RT-PCR
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603922
Stage: TS22
Assay Id: MGI:3814402
Age: embryonic day 14.0
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:1277377
Assay Type: RT-PCR
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:3814402
Age: embryonic day 15.0
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:1277377
Assay Type: RT-PCR
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603924
Stage: TS24
Assay Id: MGI:3814402
Age: embryonic day 16.0
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:1277374
Assay Type: Northern blot
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603924
Stage: TS24
Assay Id: MGI:3814398
Age: embryonic day 16.0
Detected: true
Specimen Num: 9
GXD Expression      
Probe: MGI:1277374
Assay Type: Northern blot
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:3814398
Age: embryonic day 15.0
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:1277374
Assay Type: Northern blot
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603922
Stage: TS22
Assay Id: MGI:3814398
Age: embryonic day 14.0
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:1277374
Assay Type: Northern blot
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603921
Stage: TS21
Assay Id: MGI:3814398
Age: embryonic day 13.0
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:1277374
Assay Type: Northern blot
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:3814398
Age: embryonic day 12.0
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:1277374
Assay Type: Northern blot
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603918
Stage: TS18
Assay Id: MGI:3814398
Age: embryonic day 11.0
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:1277374
Assay Type: Northern blot
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603916
Stage: TS16
Assay Id: MGI:3814398
Age: embryonic day 10.0
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:1277374
Assay Type: Northern blot
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603914
Stage: TS14
Assay Id: MGI:3814398
Age: embryonic day 9.0
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:1277374
Assay Type: Northern blot
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603912
Stage: TS12
Assay Id: MGI:3814398
Age: embryonic day 8.0
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:1277374
Assay Type: Northern blot
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3287428
Stage: TS28
Assay Id: MGI:3814397
Age: postnatal adult
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:1277377
Assay Type: RT-PCR
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3557728
Stage: TS28
Assay Id: MGI:3814411
Age: postnatal adult
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:1277374
Assay Type: Northern blot
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3557728
Stage: TS28
Assay Id: MGI:3814397
Age: postnatal adult
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3814359
Assay Type: Western blot
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3814425
Age: postnatal adult
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3814357
Assay Type: Western blot
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3814424
Age: postnatal adult
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3814354
Assay Type: Western blot
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3814423
Age: postnatal adult
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3814352
Assay Type: Western blot
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3814421
Age: postnatal adult
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:1277377
Assay Type: RT-PCR
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3814411
Age: postnatal adult
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:1277374
Assay Type: Northern blot
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3814397
Age: postnatal adult
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:1277377
Assay Type: RT-PCR
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:3814411
Age: postnatal adult
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:1277374
Assay Type: Northern blot
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:3814397
Age: postnatal adult
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:1277377
Assay Type: RT-PCR
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3814411
Age: postnatal adult
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:1277374
Assay Type: Northern blot
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3814397
Age: postnatal adult
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:1277374
Assay Type: Northern blot
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3814397
Age: postnatal adult
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:3814354
Assay Type: Immunohistochemistry
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1753628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3814430
Age: postnatal adult
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4426115
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1859023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823349
Age: embryonic day 14.5
Image: euxassay_013424_20
Detected: true
Specimen Num: 19
GXD Expression  
Probe: MGI:4426115
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1859023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823349
Age: embryonic day 14.5
Image: euxassay_013424_03
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4426115
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1859023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823349
Age: embryonic day 14.5
Image: euxassay_013424_02
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4426115
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1859023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823349
Age: embryonic day 14.5
Image: euxassay_013424_01
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3814354
Assay Type: Immunohistochemistry
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3814430
Age: postnatal adult
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4426115
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823349
Age: embryonic day 14.5
Image: euxassay_013424_12
Detected: true
Specimen Num: 12
GXD Expression  
Probe: MGI:4426115
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823349
Age: embryonic day 14.5
Image: euxassay_013424_11
Detected: true
Specimen Num: 11
GXD Expression  
Probe: MGI:4426115
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823349
Age: embryonic day 14.5
Image: euxassay_013424_10
Detected: true
Specimen Num: 10
GXD Expression  
Probe: MGI:4426115
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823349
Age: embryonic day 14.5
Image: euxassay_013424_07
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:4426115
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823349
Age: embryonic day 14.5
Image: euxassay_013424_06
Detected: true
Specimen Num: 6