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Search results 1 to 100 out of 285 for Atxn2

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Hits by Category

Hits by Strain

Type Details Score
Gene
6311 | ATXN2
Type: gene
Organism: human
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Gene
100490147 | atxn2
Type: gene
Organism: frog, western clawed
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Gene
288663 | Atxn2
Type: gene
Organism: rat
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Gene
452247 | ATXN2
Type: gene
Organism: chimpanzee
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Gene
486270 | ATXN2
Type: gene
Organism: dog, domestic
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Gene
532649 | ATXN2
Type: gene
Organism: cattle
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Gene
416877 | ATXN2
Type: gene
Organism: chicken
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Gene
569210 | atxn2
Type: gene
Organism: zebrafish
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Gene
710742 | ATXN2
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:1277223 | Atxn2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR033093 | ATXN2
Type: Family
Description: Ataxin-2 has many functions, such as endocytic receptor cycling [], translational regulation, embryonic development [], energy metabolism and weight regulation []. Mutations of the Ataxin-2 gene cause spinocerebellar ataxia 2 (SCA2), a neurodegenerative disorder leading to predominant loss of Purkinje cells in the cerebellum and impairment of motor coordination []. In SCA2, expansion of a CAG repeat in exon 1 of the Ataxin-2 (ATXN2) gene causes expansion of a polyQ domain in the ATXN2 protein []. ATXN2 has been shown to interact with many proteins. It interacts with multiple RNA-binding proteins (RBPs), staufen, IP3R, RGS8 mRNA, endophilins and CIN85 [].
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Publication
25902068 | J:224692
First Author: Dansithong W
Year: 2015
Journal: PLoS Genet
Title: Ataxin-2 regulates RGS8 translation in a new BAC-SCA2 transgenic mouse model.
Volume: 11
Issue: 4
Pages: e1005182
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Gene
102723619 | ATXN2-AS
Type: gene
Organism: human
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Publication
8896555 | J:20378
First Author: Pulst SM
Year: 1996
Journal: Nat Genet
Title: Moderate expansion of a normally biallelic trinucleotide repeat in spinocerebellar ataxia type 2.
Volume: 14
Issue: 3
Pages: 269-76
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Publication
16293225 | J:103805
First Author: Kiehl TR
Year: 2006
Journal: Biochem Biophys Res Commun
Title: Generation and characterization of Sca2 (ataxin-2) knockout mice.
Volume: 339
Issue: 1
Pages: 17-24
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Publication
26868665 | J:277334
First Author: Halbach MV
Year: 2017
Journal: Cerebellum
Title: Atxn2 Knockout and CAG42-Knock-in Cerebellum Shows Similarly Dysregulated Expression in Calcium Homeostasis Pathway.
Volume: 16
Issue: 1
Pages: 68-81
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Publication
32024018 | J:297882
 
First Author: Hansen M
Year: 2020
Journal: Int J Mol Sci
Title: The RNA-Binding Protein ATXN2 is Expressed during Megakaryopoiesis and May Control Timing of Gene Expression.
Volume: 21
Issue: 3
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Publication
25790475 | J:242443
First Author: Halbach MV
Year: 2015
Journal: PLoS One
Title: Both ubiquitin ligases FBXW8 and PARK2 are sequestrated into insolubility by ATXN2 PolyQ expansions, but only FBXW8 expression is dysregulated.
Volume: 10
Issue: 3
Pages: e0121089
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Publication
18602463 | -
First Author: Nonis D
Year: 2008
Journal: Cell Signal
Title: Ataxin-2 associates with the endocytosis complex and affects EGF receptor trafficking.
Volume: 20
Issue: 10
Pages: 1725-39
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Publication
15342467 | -
First Author: Ciosk R
Year: 2004
Journal: Development
Title: ATX-2, the C. elegans ortholog of ataxin 2, functions in translational regulation in the germline.
Volume: 131
Issue: 19
Pages: 4831-41
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Publication
29427103 | -
 
First Author: Scoles DR
Year: 2018
Journal: Adv Exp Med Biol
Title: Spinocerebellar Ataxia Type 2.
Volume: 1049
Pages: 175-195
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Protein
F6U209
Organism: Mus musculus/domesticus
Length: 65  
Fragment?: true
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Protein
A0A0G2JF15
Organism: Mus musculus/domesticus
Length: 64  
Fragment?: true
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Protein
F6U2Q5
Organism: Mus musculus/domesticus
Length: 96  
Fragment?: true
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Protein
F6UTV7
Organism: Mus musculus/domesticus
Length: 234  
Fragment?: true
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Protein
F6U2C2
Organism: Mus musculus/domesticus
Length: 929  
Fragment?: true
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Protein
F7B6X4
Organism: Mus musculus/domesticus
Length: 330  
Fragment?: true
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Protein
Q3UX07
Organism: Mus musculus/domesticus
Length: 947  
Fragment?: true
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Protein
F6V8M6
Organism: Mus musculus/domesticus
Length: 662  
Fragment?: true
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Protein
Q3UX51
Organism: Mus musculus/domesticus
Length: 664  
Fragment?: true
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Protein
O70305
Organism: Mus musculus/domesticus
Length: 1285  
Fragment?: false
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Protein
E9QM77
Organism: Mus musculus/domesticus
Length: 1286  
Fragment?: false
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Protein
A0A286YDU2
Organism: Mus musculus/domesticus
Length: 402  
Fragment?: true
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Publication
30194296 | J:267958
First Author: Paul S
Year: 2018
Journal: Nat Commun
Title: Staufen1 links RNA stress granules and autophagy in a model of neurodegeneration.
Volume: 9
Issue: 1
Pages: 3648
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Publication
32932600 | J:360889
 
First Author: Arsović A
Year: 2020
Journal: Int J Mol Sci
Title: Mouse Ataxin-2 Expansion Downregulates CamKII and Other Calcium Signaling Factors, Impairing Granule-Purkinje Neuron Synaptic Strength.
Volume: 21
Issue: 18
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Publication
34350994 | J:322072
First Author: Sundberg CA
Year: 2022
Journal: J Comp Neurol
Title: The RNA-binding protein and stress granule component ATAXIN-2 is expressed in mouse and human tissues associated with glaucoma pathogenesis.
Volume: 530
Issue: 2
Pages: 537-552
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Publication
28525545 | J:243495
First Author: Pflieger LT
Year: 2017
Journal: Hum Mol Genet
Title: Gene co-expression network analysis for identifying modules and functionally enriched pathways in SCA2.
Volume: 26
Issue: 16
Pages: 3069-3080
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Publication
23087021 | J:191127
First Author: Hansen ST
Year: 2013
Journal: Hum Mol Genet
Title: Changes in Purkinje cell firing and gene expression precede behavioral pathology in a mouse model of SCA2.
Volume: 22
Issue: 2
Pages: 271-83
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Publication
36894829 | J:360894
First Author: Bux J
Year: 2023
Journal: Mol Neurobiol
Title: TR-FRET-Based Immunoassay to Measure Ataxin-2 as a Target Engagement Marker in Spinocerebellar Ataxia Type 2.
Volume: 60
Issue: 6
Pages: 3553-3567
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Publication
25721894 | J:261271
First Author: Fittschen M
Year: 2015
Journal: Neurogenetics
Title: Genetic ablation of ataxin-2 increases several global translation factors in their transcript abundance but decreases translation rate.
Volume: 16
Issue: 3
Pages: 181-92
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Publication
33577922 | J:307703
 
First Author: Canet-Pons J
Year: 2021
Journal: Neurobiol Dis
Title: Atxn2-CAG100-KnockIn mouse spinal cord shows progressive TDP43 pathology associated with cholesterol biosynthesis suppression.
Volume: 152
Pages: 105289
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Publication
31766565 | J:283870
 
First Author: Sen NE
Year: 2019
Journal: Int J Mol Sci
Title: In Human and Mouse Spino-Cerebellar Tissue, Ataxin-2 Expansion Affects Ceramide-Sphingomyelin Metabolism.
Volume: 20
Issue: 23
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Publication
31376479 | J:283871
 
First Author: Sen NE
Year: 2019
Journal: Neurobiol Dis
Title: Generation of an Atxn2-CAG100 knock-in mouse reveals N-acetylaspartate production deficit due to early Nat8l dysregulation.
Volume: 132
Pages: 104559
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Publication
27597528 | J:260529
 
First Author: Sen NE
Year: 2016
Journal: Neurobiol Dis
Title: Search for SCA2 blood RNA biomarkers highlights Ataxin-2 as strong modifier of the mitochondrial factor PINK1 levels.
Volume: 96
Pages: 115-126
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Publication
22956915 | J:188118
First Author: Damrath E
Year: 2012
Journal: PLoS Genet
Title: ATXN2-CAG42 sequesters PABPC1 into insolubility and induces FBXW8 in cerebellum of old ataxic knock-in mice.
Volume: 8
Issue: 8
Pages: e1002920
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Protein Coding Gene
MGP_CAROLIEiJ_G0027692 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0030037 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0030002 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0029938 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0030013 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0029730 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1277223 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0030466 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0029139 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0029700 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0029850 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0029806 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0029939 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0029837 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0030507 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0028853 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0029214 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0024272 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0028690 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
9668173 | J:48962
First Author: Nechiporuk T
Year: 1998
Journal: Hum Mol Genet
Title: The mouse SCA2 gene: cDNA sequence, alternative splicing and protein expression.
Volume: 7
Issue: 8
Pages: 1301-9
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Publication
28405022 | J:251852
First Author: Becker LA
Year: 2017
Journal: Nature
Title: Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice.
Volume: 544
Issue: 7650
Pages: 367-371
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Publication
19617910 | J:151561
First Author: Huynh DP
Year: 2009
Journal: PLoS One
Title: Dissociated fear and spatial learning in mice with deficiency of ataxin-2.
Volume: 4
Issue: 7
Pages: e6235
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Publication
39419034 | J:358129
     
First Author: Wijegunawardana D
Year: 2024
Journal: Dev Cell
Title: Ataxin-2 polyglutamine expansions aberrantly sequester TDP-43 ribonucleoprotein condensates disrupting mRNA transport and local translation in neurons.
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GXD Expression
GXD Expression
     
Probe: MGI:1277374
Assay Type: Northern blot
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3287428
Stage: TS28
Assay Id: MGI:3814397
Age: postnatal adult
Specimen Label: None
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:1277374
Assay Type: Northern blot
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:3814397
Age: postnatal adult
Specimen Label: None
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:1277374
Assay Type: Northern blot
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3557728
Stage: TS28
Assay Id: MGI:3814397
Age: postnatal adult
Specimen Label: None
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:1277374
Assay Type: Northern blot
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3814397
Age: postnatal adult
Specimen Label: None
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:1277374
Assay Type: Northern blot
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3814397
Age: postnatal adult
Specimen Label: None
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:1277374
Assay Type: Northern blot
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:3814397
Age: postnatal adult
Specimen Label: None
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:1277374
Assay Type: Northern blot
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3814397
Age: postnatal adult
Specimen Label: None
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
     
Probe: MGI:1277374
Assay Type: Northern blot
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3814397
Age: postnatal adult
Specimen Label: None
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
     
Probe: MGI:1277374
Assay Type: Northern blot
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603912
Stage: TS12
Assay Id: MGI:3814398
Age: embryonic day 8.0
Specimen Label: E8
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:1277374
Assay Type: Northern blot
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603914
Stage: TS14
Assay Id: MGI:3814398
Age: embryonic day 9.0
Specimen Label: E9
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:1277374
Assay Type: Northern blot
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603916
Stage: TS16
Assay Id: MGI:3814398
Age: embryonic day 10.0
Specimen Label: E10
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:1277374
Assay Type: Northern blot
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603918
Stage: TS18
Assay Id: MGI:3814398
Age: embryonic day 11.0
Specimen Label: E11
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:1277374
Assay Type: Northern blot
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:3814398
Age: embryonic day 12.0
Specimen Label: E12
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:1277374
Assay Type: Northern blot
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603921
Stage: TS21
Assay Id: MGI:3814398
Age: embryonic day 13.0
Specimen Label: E13
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:1277374
Assay Type: Northern blot
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603922
Stage: TS22
Assay Id: MGI:3814398
Age: embryonic day 14.0
Specimen Label: E14
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
     
Probe: MGI:1277374
Assay Type: Northern blot
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:3814398
Age: embryonic day 15.0
Specimen Label: E15
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
     
Probe: MGI:1277374
Assay Type: Northern blot
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603924
Stage: TS24
Assay Id: MGI:3814398
Age: embryonic day 16.0
Specimen Label: E16
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
     
Probe: MGI:1277377
Assay Type: RT-PCR
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603924
Stage: TS24
Assay Id: MGI:3814402
Age: embryonic day 16.0
Specimen Label: E16
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:1277377
Assay Type: RT-PCR
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:3814402
Age: embryonic day 15.0
Specimen Label: E15
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:1277377
Assay Type: RT-PCR
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603922
Stage: TS22
Assay Id: MGI:3814402
Age: embryonic day 14.0
Specimen Label: E14
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:1277377
Assay Type: RT-PCR
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603921
Stage: TS21
Assay Id: MGI:3814402
Age: embryonic day 13.0
Specimen Label: E13
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:1277377
Assay Type: RT-PCR
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:3814402
Age: embryonic day 12.0
Specimen Label: E12
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:1277377
Assay Type: RT-PCR
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603918
Stage: TS18
Assay Id: MGI:3814402
Age: embryonic day 11.0
Specimen Label: E11
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
     
Probe: MGI:1277377
Assay Type: RT-PCR
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603916
Stage: TS16
Assay Id: MGI:3814402
Age: embryonic day 10.0
Specimen Label: E10
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
     
Probe: MGI:1277377
Assay Type: RT-PCR
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603914
Stage: TS14
Assay Id: MGI:3814402
Age: embryonic day 9.0
Specimen Label: E9
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
     
Probe: MGI:1277377
Assay Type: RT-PCR
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603912
Stage: TS12
Assay Id: MGI:3814402
Age: embryonic day 8.0
Specimen Label: E8
Detected: true
Specimen Num: 10
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:1277377
Assay Type: RT-PCR
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3814411
Age: postnatal adult
Specimen Label: Brain
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:1277377
Assay Type: RT-PCR
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3814411
Age: postnatal adult
Specimen Label: Heart
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:1277377
Assay Type: RT-PCR
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3814411
Age: postnatal adult
Specimen Label: Kidney
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:1277377
Assay Type: RT-PCR
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3557728
Stage: TS28
Assay Id: MGI:3814411
Age: postnatal adult
Specimen Label: Muscle
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:1277377
Assay Type: RT-PCR
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:3814411
Age: postnatal adult
Specimen Label: Lung
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:1277377
Assay Type: RT-PCR
Annotation Date: 2008-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:3814411
Age: postnatal adult
Specimen Label: Spleen
Detected: true
Specimen Num: 7
•
•
•
•
•




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