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Search results 1 to 100 out of 289 for Atxn3

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Zeng L
Year: 2018
Journal: PLoS One
Title: Loss of the Spinocerebellar Ataxia type 3 disease protein ATXN3 alters transcription of multiple signal transduction pathways.
Volume: 13
Issue: 9
Pages: e0204438
Publication
First Author: Schmitt I
Year: 2007
Journal: Biochem Biophys Res Commun
Title: Inactivation of the mouse Atxn3 (ataxin-3) gene increases protein ubiquitination.
Volume: 362
Issue: 3
Pages: 734-9
Publication      
First Author: Paulson HL
Year: 2013
Journal: MGI Direct Data Submission
Title: Knock-in of an expanded CAG repeat into the Atxn3 gene
Publication
First Author: Pastori V
Year: 2010
Journal: Biochim Biophys Acta
Title: CK2 and GSK3 phosphorylation on S29 controls wild-type ATXN3 nuclear uptake.
Volume: 1802
Issue: 7-8
Pages: 583-92
Publication  
First Author: Hsu JY
Year: 2017
Journal: Front Mol Neurosci
Title: The Truncated C-terminal Fragment of Mutant ATXN3 Disrupts Mitochondria Dynamics in Spinocerebellar Ataxia Type 3 Models.
Volume: 10
Pages: 196
Publication
First Author: Toulis V
Year: 2020
Journal: Cell Rep
Title: The Deubiquitinating Enzyme Ataxin-3 Regulates Ciliogenesis and Phagocytosis in the Retina.
Volume: 33
Issue: 6
Pages: 108360
Publication
First Author: Reina CP
Year: 2012
Journal: Cell Stress Chaperones
Title: Basal and stress-induced Hsp70 are modulated by ataxin-3.
Volume: 17
Issue: 6
Pages: 729-42
Publication  
First Author: Schuster KH
Year: 2022
Journal: Cells
Title: Pathogenetic Mechanisms Underlying Spinocerebellar Ataxia Type 3 Are Altered in Primary Oligodendrocyte Culture.
Volume: 11
Issue: 16
Publication  
First Author: Luo H
Year: 2023
Journal: Front Mol Neurosci
Title: Regional and age-dependent changes in ubiquitination in cellular and mouse models of spinocerebellar ataxia type 3.
Volume: 16
Pages: 1154203
Publication
First Author: Ramani B
Year: 2017
Journal: Hum Mol Genet
Title: Comparison of spinocerebellar ataxia type 3 mouse models identifies early gain-of-function, cell-autonomous transcriptional changes in oligodendrocytes.
Volume: 26
Issue: 17
Pages: 3362-3374
Publication
First Author: Schmidt J
Year: 2019
Journal: Hum Mol Genet
Title: Vulnerability of frontal brain neurons for the toxicity of expanded ataxin-3.
Volume: 28
Issue: 9
Pages: 1463-1473
Publication
First Author: Ramani B
Year: 2015
Journal: Hum Mol Genet
Title: A knockin mouse model of spinocerebellar ataxia type 3 exhibits prominent aggregate pathology and aberrant splicing of the disease gene transcript.
Volume: 24
Issue: 5
Pages: 1211-24
Publication  
First Author: Schuster KH
Year: 2023
Journal: Front Neurosci
Title: Disease-associated oligodendrocyte signatures are spatiotemporally dysregulated in spinocerebellar ataxia type 3.
Volume: 17
Pages: 1118429
Publication  
First Author: Switonski PM
Year: 2015
Journal: Neurobiol Dis
Title: A new humanized ataxin-3 knock-in mouse model combines the genetic features, pathogenesis of neurons and glia and late disease onset of SCA3/MJD.
Volume: 73
Pages: 174-88
Publication
First Author: Rodrigues AJ
Year: 2010
Journal: Biochim Biophys Acta
Title: Absence of ataxin-3 leads to cytoskeletal disorganization and increased cell death.
Volume: 1803
Issue: 10
Pages: 1154-63
Publication
First Author: Neves-Carvalho A
Year: 2015
Journal: Hum Mol Genet
Title: Dominant negative effect of polyglutamine expansion perturbs normal function of ataxin-3 in neuronal cells.
Volume: 24
Issue: 1
Pages: 100-17
Publication
First Author: Esteves S
Year: 2015
Journal: PLoS One
Title: Limited Effect of Chronic Valproic Acid Treatment in a Mouse Model of Machado-Joseph Disease.
Volume: 10
Issue: 10
Pages: e0141610
Publication
First Author: Gerson JE
Year: 2020
Journal: Hum Mol Genet
Title: Ubiquilin-2 differentially regulates polyglutamine disease proteins.
Volume: 29
Issue: 15
Pages: 2596-2610
Publication
First Author: Switonski PM
Year: 2011
Journal: Neuromolecular Med
Title: Mouse ataxin-3 functional knock-out model.
Volume: 13
Issue: 1
Pages: 54-65
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Sowa AS
Year: 2021
Journal: Mol Brain
Title: Neurodegenerative phosphoprotein signaling landscape in models of SCA3.
Volume: 14
Issue: 1
Pages: 57
Publication
First Author: Bichelmeier U
Year: 2007
Journal: J Neurosci
Title: Nuclear localization of ataxin-3 is required for the manifestation of symptoms in SCA3: in vivo evidence.
Volume: 27
Issue: 28
Pages: 7418-28
Publication
First Author: Cemal CK
Year: 2002
Journal: Hum Mol Genet
Title: YAC transgenic mice carrying pathological alleles of the MJD1 locus exhibit a mild and slowly progressive cerebellar deficit.
Volume: 11
Issue: 9
Pages: 1075-94
Publication
First Author: Haas E
Year: 2022
Journal: Mol Neurobiol
Title: A Novel SCA3 Knock-in Mouse Model Mimics the Human SCA3 Disease Phenotype Including Neuropathological, Behavioral, and Transcriptional Abnormalities Especially in Oligodendrocytes.
Volume: 59
Issue: 1
Pages: 495-522
Publication
First Author: Harris GM
Year: 2010
Journal: PLoS One
Title: Splice isoforms of the polyglutamine disease protein ataxin-3 exhibit similar enzymatic yet different aggregation properties.
Volume: 5
Issue: 10
Pages: e13695
Publication  
First Author: Wiatr K
Year: 2021
Journal: Front Mol Neurosci
Title: Broad Influence of Mutant Ataxin-3 on the Proteome of the Adult Brain, Young Neurons, and Axons Reveals Central Molecular Processes and Biomarkers in SCA3/MJD Using Knock-In Mouse Model.
Volume: 14
Pages: 658339
Publication  
First Author: Harmuth T
Year: 2018
Journal: Front Mol Neurosci
Title: Mitochondrial Morphology, Function and Homeostasis Are Impaired by Expression of an N-terminal Calpain Cleavage Fragment of Ataxin-3.
Volume: 11
Pages: 368
Publication
First Author: Hübener J
Year: 2011
Journal: Brain
Title: N-terminal ataxin-3 causes neurological symptoms with inclusions, endoplasmic reticulum stress and ribosomal dislocation.
Volume: 134
Issue: Pt 7
Pages: 1925-42
Publication
First Author: Chou AH
Year: 2008
Journal: Neurobiol Dis
Title: Polyglutamine-expanded ataxin-3 causes cerebellar dysfunction of SCA3 transgenic mice by inducing transcriptional dysregulation.
Volume: 31
Issue: 1
Pages: 89-101
Publication
First Author: Nóbrega C
Year: 2013
Journal: PLoS One
Title: Silencing mutant ataxin-3 rescues motor deficits and neuropathology in Machado-Joseph disease transgenic mice.
Volume: 8
Issue: 1
Pages: e52396
Publication
First Author: Simões AT
Year: 2012
Journal: Brain
Title: Calpastatin-mediated inhibition of calpains in the mouse brain prevents mutant ataxin 3 proteolysis, nuclear localization and aggregation, relieving Machado-Joseph disease.
Volume: 135
Issue: Pt 8
Pages: 2428-39
Publication
First Author: Pozzi C
Year: 2008
Journal: Neurobiol Dis
Title: Study of subcellular localization and proteolysis of ataxin-3.
Volume: 30
Issue: 2
Pages: 190-200
Publication
First Author: Reina CP
Year: 2010
Journal: Hum Mol Genet
Title: Proteotoxic stress increases nuclear localization of ataxin-3.
Volume: 19
Issue: 2
Pages: 235-49
Publication
First Author: Ikeda H
Year: 1996
Journal: Nat Genet
Title: Expanded polyglutamine in the Machado-Joseph disease protein induces cell death in vitro and in vivo.
Volume: 13
Issue: 2
Pages: 196-202
Publication
First Author: Colomer Gould VF
Year: 2007
Journal: Neurobiol Dis
Title: A mutant ataxin-3 fragment results from processing at a site N-terminal to amino acid 190 in brain of Machado-Joseph disease-like transgenic mice.
Volume: 27
Issue: 3
Pages: 362-9
Publication
First Author: Hübener J
Year: 2010
Journal: Neurobiol Dis
Title: Polyglutamine-induced neurodegeneration in SCA3 is not mitigated by non-expanded ataxin-3: conclusions from double-transgenic mouse models.
Volume: 38
Issue: 1
Pages: 116-24
GXD Expression      
Probe: MGI:5438308
Assay Type: Western blot
Annotation Date: 2012-10-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757728
Stage: TS28
Assay Id: MGI:5438309
Age: postnatal adult
Specimen Label: spinal cord
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5438308
Assay Type: Western blot
Annotation Date: 2012-10-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267828
Stage: TS28
Assay Id: MGI:5438309
Age: postnatal adult
Specimen Label: brainstem
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:5438308
Assay Type: Western blot
Annotation Date: 2012-10-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:5438309
Age: postnatal adult
Specimen Label: cerebellum
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:5438308
Assay Type: Western blot
Annotation Date: 2012-10-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:5438309
Age: postnatal adult
Specimen Label: cerebral cortex
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:5438308
Assay Type: Western blot
Annotation Date: 2012-10-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5438309
Age: postnatal adult
Specimen Label: heart
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:5438308
Assay Type: Western blot
Annotation Date: 2012-10-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:5438309
Age: postnatal adult
Specimen Label: skeletal muscle
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:5438308
Assay Type: Western blot
Annotation Date: 2012-10-12
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:5438309
Age: postnatal adult
Specimen Label: testis
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:5438308
Assay Type: Western blot
Annotation Date: 2012-10-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5438309
Age: postnatal adult
Specimen Label: kidney
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:5438308
Assay Type: Western blot
Annotation Date: 2012-10-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:5438309
Age: postnatal adult
Specimen Label: lung
Detected: true
Specimen Num: 9
GXD Expression      
Probe: MGI:5438308
Assay Type: Western blot
Annotation Date: 2012-10-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:5438309
Age: postnatal adult
Specimen Label: spleen
Detected: true
Specimen Num: 10
GXD Expression      
Probe: MGI:5438308
Assay Type: Western blot
Annotation Date: 2012-10-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750328
Stage: TS28
Assay Id: MGI:5438309
Age: postnatal adult
Specimen Label: pancreas
Detected: true
Specimen Num: 11
GXD Expression      
Probe: MGI:5438308
Assay Type: Western blot
Annotation Date: 2012-10-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:5438309
Age: postnatal adult
Specimen Label: liver
Detected: true
Specimen Num: 12
GXD Expression      
Probe: MGI:5438308
Assay Type: Western blot
Annotation Date: 2012-10-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1702128
Stage: TS28
Assay Id: MGI:5438309
Age: postnatal adult
Specimen Label: stomach
Detected: true
Specimen Num: 13
GXD Expression    
Probe: MGI:5438308
Assay Type: Immunohistochemistry
Annotation Date: 2012-10-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3526028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5438319
Age: postnatal adult
Specimen Label: 7G
Detected: true
Specimen Num: 16
GXD Expression    
Probe: MGI:5438308
Assay Type: Immunohistochemistry
Annotation Date: 2012-10-12
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1760624
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:5438319
Age: embryonic day 16.5
Specimen Label: 8F
Detected: true
Specimen Num: 25
GXD Expression    
Probe: MGI:5438308
Assay Type: Immunohistochemistry
Annotation Date: 2012-10-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3535528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5438319
Age: postnatal adult
Specimen Label: 7C
Detected: true
Specimen Num: 12
GXD Expression  
Probe: MGI:5438308
Assay Type: Immunohistochemistry
Annotation Date: 2012-10-12
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3535528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5438319
Age: postnatal adult
Note: Expression is present in the cells of the ependyma, including in their cilia.
Specimen Label: 7D
Detected: true
Specimen Num: 13
GXD Expression    
Probe: MGI:5438308
Assay Type: Immunohistochemistry
Annotation Date: 2012-10-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737324
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:5438319
Age: embryonic day 16.5
Specimen Label: 8F
Detected: true
Specimen Num: 25
GXD Expression  
Probe: MGI:5438308
Assay Type: Immunohistochemistry
Annotation Date: 2012-10-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5438319
Age: postnatal adult
Note: Expression is present in neurons.
Specimen Label: 7H
Detected: true
Specimen Num: 17
GXD Expression    
Probe: MGI:5438308
Assay Type: Immunohistochemistry
Annotation Date: 2012-10-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5438319
Age: postnatal adult
Specimen Label: 7A
Detected: true
Specimen Num: 11
GXD Expression  
Probe: MGI:4833700
Assay Type: Immunohistochemistry
Annotation Date: 2010-10-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1852122
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4833706
Age: embryonic day 14.5
Image: 1C.1, C.3
Specimen Label: 1C.1, C.3
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:5438308
Assay Type: Immunohistochemistry
Annotation Date: 2012-10-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3148228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5438319
Age: postnatal adult
Specimen Label: 6H
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:5438308
Assay Type: Immunohistochemistry
Annotation Date: 2012-10-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3525728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5438319
Age: postnatal adult
Specimen Label: 7G
Detected: true
Specimen Num: 16
GXD Expression    
Probe: MGI:5438308
Assay Type: Immunohistochemistry
Annotation Date: 2012-10-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3532828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5438319
Age: postnatal adult
Specimen Label: 6E
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:5438308
Assay Type: Immunohistochemistry
Annotation Date: 2012-10-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3148428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5438319
Age: postnatal adult
Specimen Label: 6H
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:5438308
Assay Type: Immunohistochemistry
Annotation Date: 2012-10-12
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3268828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5438319
Age: postnatal adult
Specimen Label: 6C
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:5438308
Assay Type: Immunohistochemistry
Annotation Date: 2012-10-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3268824
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:5438319
Age: embryonic day 16.5
Specimen Label: 8F
Detected: true
Specimen Num: 25
GXD Expression  
Probe: MGI:5438308
Assay Type: Immunohistochemistry
Annotation Date: 2012-10-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2694224
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:5438319
Age: embryonic day 16.5
Note: Expression is present in the nonkeratinizing stratified squamous epithelium.
Specimen Label: 8F
Detected: true
Specimen Num: 25
GXD Expression    
Probe: MGI:5438308
Assay Type: Immunohistochemistry
Annotation Date: 2012-10-12
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3524724
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:5438319
Age: embryonic day 16.5
Specimen Label: 8F
Detected: true
Specimen Num: 25
GXD Expression    
Probe: MGI:5438308
Assay Type: Immunohistochemistry
Annotation Date: 2012-10-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1868728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5438319
Age: postnatal adult
Specimen Label: 6H
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:5438308
Assay Type: Immunohistochemistry
Annotation Date: 2012-10-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3525828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5438319
Age: postnatal adult
Specimen Label: 7G
Detected: true
Specimen Num: 16
GXD Expression  
Probe: MGI:5438308
Assay Type: Immunohistochemistry
Annotation Date: 2012-10-12
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3510028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5438319
Age: postnatal adult
Note: Expression is present in the cells of the ependyma, including in their cilia.
Specimen Label: Not shown
Detected: true
Specimen Num: 19
GXD Expression      
Probe: MGI:5438308
Assay Type: Immunohistochemistry
Annotation Date: 2012-10-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2910628
Stage: TS28
Assay Id: MGI:5438319
Age: postnatal adult
Specimen Label: 6H
Detected: false
Specimen Num: 7
GXD Expression    
Probe: MGI:5438308
Assay Type: Immunohistochemistry
Annotation Date: 2012-10-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5438319
Age: postnatal adult
Specimen Label: 7A
Detected: true
Specimen Num: 11
GXD Expression  
Probe: MGI:5438308
Assay Type: Immunohistochemistry
Annotation Date: 2012-10-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Pattern: Widespread
Stage: TS28
Assay Id: MGI:5438319
Age: postnatal adult
Note: Expression is present in all layers of the cerebral cortex. Myelinated fibers also stained, although that was less pronounced.
Specimen Label: 7G
Detected: true
Specimen Num: 16
GXD Expression    
Probe: MGI:5438308
Assay Type: Immunohistochemistry
Annotation Date: 2012-10-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3522128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5438319
Age: postnatal adult
Specimen Label: 7E
Detected: true
Specimen Num: 14