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Search results 1 to 85 out of 85 for Atxn7l3

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Type Details Score
Gene
56970 | ATXN7L3
Type: gene
Organism: human
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Gene
454725 | ATXN7L3
Type: gene
Organism: chimpanzee
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Gene
612754 | ATXN7L3
Type: gene
Organism: dog, domestic
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Gene
525252 | ATXN7L3
Type: gene
Organism: cattle
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Gene
714437 | ATXN7L3
Type: gene
Organism: macaque, rhesus
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Gene
100379754 | atxn7l3
Type: gene
Organism: frog, western clawed
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Gene
287734 | Atxn7l3
Type: gene
Organism: rat
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Protein Coding Gene
MGI:3036270 | Atxn7l3
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene
392485 | ATXN7L3P1
Type: gene
Organism: human
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Gene
101926967 | ATXN7L3-AS1
Type: gene
Organism: human
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Publication
33731875 | J:310080
First Author: Wang F
Year: 2021
Journal: Cell Death Differ
Title: Histone H2Bub1 deubiquitylation is essential for mouse development, but does not regulate global RNA polymerase II transcription.
Volume: 28
Issue: 8
Pages: 2385-2403
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Protein Coding Gene
MGP_CAROLIEiJ_G0017247 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0019230 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0019198 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0019167 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0019172 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0018981 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_3036270 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0019621 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0018535 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0018950 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0019062 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0019052 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0019131 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0019083 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0019659 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0018298 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0018584 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0018377 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0018090 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
25228644 | J:213770
First Author: Bonnet J
Year: 2014
Journal: Genes Dev
Title: The SAGA coactivator complex acts on the whole transcribed genome and is required for RNA polymerase II transcription.
Volume: 28
Issue: 18
Pages: 1999-2012
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Publication
11564863 | J:320036
First Author: Martinez E
Year: 2001
Journal: Mol Cell Biol
Title: Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo.
Volume: 21
Issue: 20
Pages: 6782-95
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Publication
19114550 | J:320037
First Author: Nagy Z
Year: 2009
Journal: Mol Cell Biol
Title: The human SPT20-containing SAGA complex plays a direct role in the regulation of endoplasmic reticulum stress-induced genes.
Volume: 29
Issue: 6
Pages: 1649-60
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Publication
11406595 | J:320001
First Author: Brand M
Year: 2001
Journal: EMBO J
Title: UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation.
Volume: 20
Issue: 12
Pages: 3187-96
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Publication
10373431 | J:320038
First Author: Brand M
Year: 1999
Journal: J Biol Chem
Title: Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction.
Volume: 274
Issue: 26
Pages: 18285-9
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Publication
18206972 | J:320111
First Author: Zhao Y
Year: 2008
Journal: Mol Cell
Title: A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing.
Volume: 29
Issue: 1
Pages: 92-101
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Publication
34815492 | J:314906
First Author: Khang R
Year: 2021
Journal: Sci Rep
Title: Loss of zinc-finger protein 212 leads to Purkinje cell death and locomotive abnormalities with phospholipase D3 downregulation.
Volume: 11
Issue: 1
Pages: 22745
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Publication
- | J:342612
       
First Author: UniProt curators
Year: 2014
Title: Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features
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Publication
- | J:342607
       
First Author: Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom
Year: 2023
Title: Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
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Publication
15226823 | J:93300
First Author: Blackshaw S
Year: 2004
Journal: PLoS Biol
Title: Genomic analysis of mouse retinal development.
Volume: 2
Issue: 9
Pages: E247
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Publication
27626380 | J:236599
First Author: Dickinson ME
Year: 2016
Journal: Nature
Title: High-throughput discovery of novel developmental phenotypes.
Volume: 537
Issue: 7621
Pages: 508-514
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Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
27132940 | J:252865
First Author: Atanassov BS
Year: 2016
Journal: Mol Cell
Title: ATXN7L3 and ENY2 Coordinate Activity of Multiple H2B Deubiquitinases Important for Cellular Proliferation and Tumor Growth.
Volume: 62
Issue: 4
Pages: 558-71
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Protein
A2AWT3
Organism: Mus musculus/domesticus
Length: 347  
Fragment?: false
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Protein
Q8R4I1
Organism: Mus musculus/domesticus
Length: 867  
Fragment?: false
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Protein
Q8C8K6
Organism: Mus musculus/domesticus
Length: 696  
Fragment?: false
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Protein
B2RW07
Organism: Mus musculus/domesticus
Length: 739  
Fragment?: false
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Protein
F6X2K7
Organism: Mus musculus/domesticus
Length: 824  
Fragment?: false
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Protein
Q3U1F1
Organism: Mus musculus/domesticus
Length: 739  
Fragment?: false
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Protein
B7ZCC3
Organism: Mus musculus/domesticus
Length: 664  
Fragment?: false
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Protein
Z4YN62
Organism: Mus musculus/domesticus
Length: 350  
Fragment?: true
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Protein
F7C0E4
Organism: Mus musculus/domesticus
Length: 927  
Fragment?: false
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Protein
F6RCN9
Organism: Mus musculus/domesticus
Length: 258  
Fragment?: true
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Protein
Q6KAM3
Organism: Mus musculus/domesticus
Length: 410  
Fragment?: true
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Protein
Q5HZJ2
Organism: Mus musculus/domesticus
Length: 697  
Fragment?: true
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Protein
B2RQB7
Organism: Mus musculus/domesticus
Length: 870  
Fragment?: false
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Protein
A0A286YDW9
Organism: Mus musculus/domesticus
Length: 920  
Fragment?: false
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Protein
D3Z7I2
Organism: Mus musculus/domesticus
Length: 741  
Fragment?: false
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Protein
B7ZMR6
Organism: Mus musculus/domesticus
Length: 696  
Fragment?: false
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Protein
B7ZCC4
Organism: Mus musculus/domesticus
Length: 661  
Fragment?: false
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Publication
15932941 | -
First Author: McMahon SJ
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Polyglutamine-expanded spinocerebellar ataxia-7 protein disrupts normal SAGA and SLIK histone acetyltransferase activity.
Volume: 102
Issue: 24
Pages: 8478-82
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Publication
20634802 | -
First Author: Bonnet J
Year: 2010
Journal: EMBO Rep
Title: The structural plasticity of SCA7 domains defines their differential nucleosome-binding properties.
Volume: 11
Issue: 8
Pages: 612-8
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Protein Domain
IPR013243 | SCA7_dom
Type: Domain
Description: SAGA (Spt-Ada-Gcn5 acetyltransferase), a coactivator complex involved inchromatin remodelling, harbours both histone acetylation and deubiquitinationactivities. SAGA-associated factor 73 (Sgf734/ATXN7) and Ataxin-7-like protein 3 (ATXN7L3), two subunits of the SAGA deubiquitinationmodule, contain an ~50-residue SCA7 domain characterised by an atypical zinc-finger (Znf) with a Cys-X(9,10)-Cys-X(5)-Cys-X(2)-His motif and a long sequence insertion between the first two zinccoordinating residues.The SCA7 domain is found exclusively in members of theATXN7 gene family, which includes two distinct subunits of SAGA complexes:ATXN7 and ATXN7L3 orthologues. The analysis of multiple alignments highlightsthe consensus signature for the SCA7 domain, encompassing the putative zinc-coordinating residues, but also reveals the distinct features of the twoproteins. Marked differences are found mostly in the carboxy-terminal of thedomain, suggesting that divergent evolution of the SCA7 Znf domain occurred inorder to achieve specific functions in the SAGA complex. Both SCA7 domainscontain disordered regions, albeit not in the same region. Whereas the firstand last 10 residues of ATXN7-SCA7 are not folded, the N-terminal region of ATXN7L3-SCA7 is well structured and thelast 30 residues of this domain are not folded. In both ATXN7-SCA7 andATXN7L3-SCA7, the large sequence insertion between the first and second zinc-coordinating cysteines corresponds to a protruding extended hairpin structure.The core of the zinc-binding sites shows a conserved structure formed by twoshort adjacent loops located at the bottom of the hairpin. Although the SCA7domains of both ATXN7 and ATXN7L3 contain two α-helices, these are notlocated at similar positions in the sequences. In ATXN7-SCA7, the two alpha-helices are located downstream from the zinc-binding site and are separated bya loop containing a large number of positively charged residues. In ATXN7L3-SCA7, the two helices lie to either side of the zinc-binding site, leading toa different packing of the two helices. In ATXN7-SCA7, the two helices have analmost perpendicular orientation, the alpha2 helix being anchored to the zinc-binding site. In ATXN7L3-SCA7, the helices alpha1 and alpha2 adopt an anti-parallel orientation defined by hydrophobic interactions. The ATXN7-SCA7domain binds to the core or the C-terminal ends of the histone H2A and H2Bdimer, a region located on the lateral face of the nucleosome that containsthe ubiquitinated Lys 120 of H2B. This property is lost in the ATXN7-SCA7domain [, ].This entry represents the SCA7 domain.
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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