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Search results 1 to 100 out of 118 for Aurkc

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0.041s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: rat
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Domain
Type: Family
Description: Aurora kinase C (AURKC) is a serine/threonine-protein kinase found in some mammals. It is a component of the chromosomal passenger protein that forms complexes with Aurora-B and inner centromere protein (INCENP), and it has redundant cellular functions with AURKB []. It is required for spermatogenesis and oocyte development [, ]. The overexpression of AURKC has been linked to various cancers []. Overexpression of Aurora-C displaces the centromeric localisation of chromosomal passenger complex (CPC) proteins, including Aurora-B []. CPC plays a crucial role in controlling accurate chromosome segregation and cytokinesis during cell division.The Aurora kinases are highly conserved serine/threonine kinases that regulate chromosomal alignment and segregation during mitosis and meiosis. Three mammalian Aurora kinases, Aurora A, B and C, have been identified. They all contain a protein kinase domain and a destruction box (D-box) recognised by the multi-subunit E3-ubiquitin ligase anaphase promoting complex/cyclosome (APC/C), which mediates their proteasomal degradation. However, their N-terminal domain share little sequence identity and confer unique protein-protein interaction abilities among the Aurora kinases []. They are differentially expressed at high levels in rapidly dividing tissues such as hematopoietic cells (A and B) and germ cells (C only). Their expression is low or absent in most adult tissues due to their lower rates of proliferation [].
Publication
First Author: Kimmins S
Year: 2007
Journal: Mol Endocrinol
Title: Differential functions of the Aurora-B and Aurora-C kinases in mammalian spermatogenesis.
Volume: 21
Issue: 3
Pages: 726-39
Publication
First Author: Fellmeth JE
Year: 2016
Journal: Hum Mol Genet
Title: Characterization of macrozoospermia-associated AURKC mutations in a mammalian meiotic system.
Volume: 25
Issue: 13
Pages: 2698-2711
Publication
First Author: Nguyen AL
Year: 2018
Journal: Curr Biol
Title: Genetic Interactions between the Aurora Kinases Reveal New Requirements for AURKB and AURKC during Oocyte Meiosis.
Volume: 28
Issue: 21
Pages: 3458-3468.e5
Publication
First Author: Li X
Year: 2004
Journal: J Biol Chem
Title: Direct association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C.
Volume: 279
Issue: 45
Pages: 47201-11
Publication
First Author: Zekri A
Year: 2012
Journal: Oncol Res
Title: Gene amplification and overexpression of Aurora-C in breast and prostate cancer cell lines.
Volume: 20
Issue: 5-6
Pages: 241-50
Publication  
First Author: Lin BW
Year: 2014
Journal: Cell Death Dis
Title: Overexpression of Aurora-C interferes with the spindle checkpoint by promoting the degradation of Aurora-B.
Volume: 5
Pages: e1106
Protein
Organism: Mus musculus/domesticus
Length: 105  
Fragment?: false
Publication
First Author: Carmena M
Year: 2003
Journal: Nat Rev Mol Cell Biol
Title: The cellular geography of aurora kinases.
Volume: 4
Issue: 11
Pages: 842-54
Publication
First Author: Goldenson B
Year: 2015
Journal: Oncogene
Title: The aurora kinases in cell cycle and leukemia.
Volume: 34
Issue: 5
Pages: 537-45
Protein
Organism: Mus musculus/domesticus
Length: 146  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 276  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 315  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 308  
Fragment?: true
Publication
First Author: Balboula AZ
Year: 2017
Journal: Biol Reprod
Title: Maternal RNA regulates Aurora C kinase during mouse oocyte maturation in a translation-independent fashion.
Volume: 96
Issue: 6
Pages: 1197-1209
Publication
First Author: Balboula AZ
Year: 2016
Journal: J Cell Sci
Title: Haspin kinase regulates microtubule-organizing center clustering and stability through Aurora kinase C in mouse oocytes.
Volume: 129
Issue: 19
Pages: 3648-3660
Publication
First Author: Balboula AZ
Year: 2014
Journal: PLoS Genet
Title: Selective disruption of aurora C kinase reveals distinct functions from aurora B kinase during meiosis in mouse oocytes.
Volume: 10
Issue: 2
Pages: e1004194
Publication  
First Author: Wellard SR
Year: 2020
Journal: J Cell Sci
Title: Aurora B and C kinases regulate chromosome desynapsis and segregation during mouse and human spermatogenesis.
Volume: 133
Issue: 23
Publication
First Author: Schindler K
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Maternally recruited Aurora C kinase is more stable than Aurora B to support mouse oocyte maturation and early development.
Volume: 109
Issue: 33
Pages: E2215-22
Publication  
First Author: Aboelenain M
Year: 2021
Journal: Development
Title: Aurora kinase B inhibits aurora kinase A to control maternal mRNA translation in mouse oocytes.
Volume: 148
Issue: 21
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Tseng TC
Year: 1998
Journal: DNA Cell Biol
Title: Protein kinase profile of sperm and eggs: cloning and characterization of two novel testis-specific protein kinases (AIE1, AIE2) related to yeast and fly chromosome segregation regulators.
Volume: 17
Issue: 10
Pages: 823-33
Publication
First Author: Hu HM
Year: 2000
Journal: DNA Cell Biol
Title: Genomic organization, expression, and chromosome localization of a third aurora-related kinase gene, Aie1.
Volume: 19
Issue: 11
Pages: 679-88
Publication
First Author: Khan J
Year: 2011
Journal: PLoS One
Title: Overexpression of active Aurora-C kinase results in cell transformation and tumour formation.
Volume: 6
Issue: 10
Pages: e26512
GXD Expression      
Probe: MGI:3831562
Assay Type: Northern blot
Annotation Date: 2009-02-12
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3831567
Age: postnatal adult
Image: 4
Specimen Label: Liver
Specimen Num: 1
GXD Expression      
Probe: MGI:3831562
Assay Type: Northern blot
Annotation Date: 2009-02-12
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3831567
Age: postnatal adult
Image: 4
Specimen Label: Heart
Specimen Num: 2
GXD Expression      
Probe: MGI:3831562
Assay Type: Northern blot
Annotation Date: 2009-02-12
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3831567
Age: postnatal adult
Image: 4
Specimen Label: Kidney
Specimen Num: 3
GXD Expression      
Probe: MGI:3831562
Assay Type: Northern blot
Annotation Date: 2009-02-12
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3831567
Age: postnatal adult
Image: 4
Specimen Label: Brain
Specimen Num: 4
GXD Expression    
Probe: MGI:3831562
Assay Type: Northern blot
Annotation Date: 2009-02-12
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:3831567
Age: postnatal adult
Image: 4
Specimen Label: Testis
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:3831562
Assay Type: Northern blot
Annotation Date: 2009-02-12
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:3831567
Age: postnatal adult
Image: 4
Specimen Label: Ovary
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:3831562
Assay Type: Northern blot
Annotation Date: 2009-02-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:3831568
Age: embryonic day 8.5
Image: 5
Specimen Label: 8.5 dpc
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3831562
Assay Type: Northern blot
Annotation Date: 2009-02-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603919
Stage: TS19
Assay Id: MGI:3831568
Age: embryonic day 11.5
Image: 5
Specimen Label: 11.5 dpc
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:3831562
Assay Type: Northern blot
Annotation Date: 2009-02-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:3831568
Age: embryonic day 12.5
Image: 5
Specimen Label: 12.5 dpc
Detected: false
Specimen Num: 3
GXD Expression    
Probe: MGI:3831562
Assay Type: Northern blot
Annotation Date: 2009-02-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603921
Stage: TS21
Assay Id: MGI:3831568
Age: embryonic day 13.5
Image: 5
Specimen Label: 13.5 dpc
Detected: false
Specimen Num: 4
GXD Expression    
Probe: MGI:3831562
Assay Type: Northern blot
Annotation Date: 2009-02-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603922
Stage: TS22
Assay Id: MGI:3831568
Age: embryonic day 14.5
Image: 5
Specimen Label: 14.5 dpc
Detected: false
Specimen Num: 5
GXD Expression    
Probe: MGI:3831562
Assay Type: Northern blot
Annotation Date: 2009-02-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:3831568
Age: embryonic day 15.5
Image: 5
Specimen Label: 15.5 dpc
Detected: false
Specimen Num: 6
GXD Expression    
Probe: MGI:3831562
Assay Type: Northern blot
Annotation Date: 2009-02-12
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:3831568
Age: postnatal adult
Image: 5
Specimen Label: Adult Testis
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:3831562
Assay Type: Northern blot
Annotation Date: 2009-02-12
Strength: Absent
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:3831569
Age: postnatal day 7
Image: 6
Specimen Label: 7 d
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3831562
Assay Type: Northern blot
Annotation Date: 2009-02-12
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:3831569
Age: postnatal day 17
Image: 6
Specimen Label: 17 d
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3831562
Assay Type: Northern blot
Annotation Date: 2009-02-12
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:3831569
Age: postnatal adult
Image: 6
Specimen Label: Adult
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:3831562
Assay Type: Northern blot
Annotation Date: 2009-02-12
Strength: Absent
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:3831569
Age: postnatal adult
Image: 6
Specimen Label: Sl<17H>
Detected: false
Specimen Num: 4
GXD Expression      
Probe: MGI:5305809
Assay Type: RT-PCR
Annotation Date: 2012-02-14
Strength: Present
Sex: Female
Emaps: EMAPS:3102528
Stage: TS28
Assay Id: MGI:5305822
Age: postnatal
Specimen Label: Hsf1-/-
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5305809
Assay Type: RT-PCR
Annotation Date: 2012-02-14
Strength: Present
Sex: Female
Emaps: EMAPS:3102528
Stage: TS28
Assay Id: MGI:5305822
Age: postnatal
Specimen Label: WT
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3831566
Assay Type: RNA in situ
Annotation Date: 2009-02-12
Strength: Absent
Sex: Male
Emaps: EMAPS:3148228
Stage: TS28
Assay Id: MGI:3831570
Age: postnatal adult
Image: 7F
Specimen Label: 7F
Detected: false
Specimen Num: 4
GXD Expression  
Probe: MGI:3831566
Assay Type: RNA in situ
Annotation Date: 2009-02-12
Strength: Present
Sex: Male
Emaps: EMAPS:3148428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3831570
Age: postnatal adult
Image: 7F
Specimen Label: 7F
Detected: true
Specimen Num: 4
GXD Expression
Probe: MGI:3831566
Assay Type: RNA in situ
Annotation Date: 2009-02-12
Strength: Present
Sex: Male
Emaps: EMAPS:3148628
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:3831570
Age: postnatal adult
Image: 7F
Note: Expression was detected in round spermatids but not in elongating spermatids.
Specimen Label: 7F
Detected: true
Specimen Num: 4
GXD Expression
Probe: MGI:3831566
Assay Type: RNA in situ
Annotation Date: 2009-02-12
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:3831570
Age: postnatal adult
Image: 7A
Note: Expression was detected in germ cells but not testicular somatic cells.
Specimen Label: 7A
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3831566
Assay Type: RNA in situ
Annotation Date: 2009-02-12
Strength: Present
Sex: Male
Emaps: EMAPS:1797528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3831570
Age: postnatal adult
Image: 7A
Specimen Label: 7A
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3831566
Assay Type: RNA in situ
Annotation Date: 2009-02-12
Strength: Present
Sex: Female
Emaps: EMAPS:3102528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3831570
Age: postnatal adult
Image: 7C
Specimen Label: 7C
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3831566
Assay Type: RNA in situ
Annotation Date: 2009-02-12
Strength: Present
Sex: Female
Emaps: EMAPS:3102528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3831570
Age: postnatal adult
Image: 7E
Specimen Label: 7E
Detected: true
Specimen Num: 3
GXD Expression
Probe: MGI:3831566
Assay Type: RNA in situ
Annotation Date: 2009-02-12
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:3831570
Age: postnatal adult
Image: 7C
Note: Expression was detected in the oocytes but not in the surrounding somatic cells.
Specimen Label: 7C
Detected: true
Specimen Num: 2
Publication
First Author: Tang CJ
Year: 2001
Journal: J Biol Chem
Title: The zinc finger domain of Tzfp binds to the tbs motif located at the upstream flanking region of the Aie1 (aurora-C) kinase gene.
Volume: 276
Issue: 22
Pages: 19631-9
Publication
First Author: Sharif B
Year: 2010
Journal: J Cell Sci
Title: The chromosome passenger complex is required for fidelity of chromosome transmission and cytokinesis in meiosis of mouse oocytes.
Volume: 123
Issue: Pt 24
Pages: 4292-300
Publication
First Author: Hached K
Year: 2011
Journal: Development
Title: Mps1 at kinetochores is essential for female mouse meiosis I.
Volume: 138
Issue: 11
Pages: 2261-71
Publication
First Author: Kim J
Year: 2001
Journal: Genomics
Title: Imprinting and evolution of two Kruppel-type zinc-finger genes, ZIM3 and ZNF264, located in the PEG3/USP29 imprinted domain.
Volume: 77
Issue: 1-2
Pages: 91-8
Publication
First Author: Furuta T
Year: 2002
Journal: Genesis
Title: Caenorhabditis elegans Aurora A kinase AIR-1 is required for postembryonic cell divisions and germline development.
Volume: 34
Issue: 4
Pages: 244-50
Publication
First Author: Monk D
Year: 2003
Journal: Mamm Genome
Title: Imprinted methylation profiles for proximal mouse chromosomes 11 and 7 as revealed by methylation-sensitive representational difference analysis.
Volume: 14
Issue: 12
Pages: 805-16
Publication
First Author: Parra MT
Year: 2003
Journal: J Cell Sci
Title: Dynamic relocalization of the chromosomal passenger complex proteins inner centromere protein (INCENP) and aurora-B kinase during male mouse meiosis.
Volume: 116
Issue: Pt 6
Pages: 961-74
Publication
First Author: Gopalan G
Year: 1999
Journal: Mol Reprod Dev
Title: Novel mammalian kinase related to yeast and fly chromosome segregation regulators is exclusively expressed in the germline.
Volume: 52
Issue: 1
Pages: 18-28
Publication
First Author: Fernández-Miranda G
Year: 2011
Journal: Development
Title: Genetic disruption of aurora B uncovers an essential role for aurora C during early mammalian development.
Volume: 138
Issue: 13
Pages: 2661-72
Publication
First Author: Le Masson F
Year: 2011
Journal: Mol Cell Biol
Title: Identification of heat shock factor 1 molecular and cellular targets during embryonic and adult female meiosis.
Volume: 31
Issue: 16
Pages: 3410-23
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication        
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Mouse Synonym Curation
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference