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Search results 1 to 100 out of 525 for Bace1

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Hits by Strain

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Type Details Score
Gene
23621 | BACE1
Type: gene
Organism: human
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Gene
614333 | BACE1
Type: gene
Organism: cattle
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Gene
419768 | BACE1
Type: gene
Organism: chicken
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Gene
403005 | bace1
Type: gene
Organism: zebrafish
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Gene
697694 | BACE1
Type: gene
Organism: macaque, rhesus
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Gene
779940 | bace1
Type: gene
Organism: frog, western clawed
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Protein Domain
IPR009120 | BACE1
Type: Family
Description: The beta-site APP cleaving enzyme-1 (BACE1), also known as Aspartyl protease 2 and memapsin-2, mediates one of the two proteolytic cleavages of beta-amyloid precursor protein (APP) to yield the amyloid β-peptide (Abeta), a key pathogenic agent in Alzheimer's disease (AD) []. Axonal and Schwann cell BACE1 is also required for remyelination of injured nerves []. BACE1 inhibitor drugs have been evaluated for AD treatment []. BACE1 is () and MEROPS identifier A01.004.
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Gene
29392 | Bace1
Type: gene
Organism: rat
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Gene
489390 | BACE1
Type: gene
Organism: dog, domestic
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Gene
451573 | BACE1
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:1346542 | Bace1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
25621019 | -
First Author: Vassar R
Year: 2014
Journal: Alzheimers Res Ther
Title: BACE1 inhibitor drugs in clinical trials for Alzheimer's disease.
Volume: 6
Issue: 9
Pages: 89
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Publication
25740511 | -
First Author: Hu X
Year: 2015
Journal: J Neurosci
Title: Axonal and Schwann cell BACE1 is equally required for remyelination of peripheral nerves.
Volume: 35
Issue: 9
Pages: 3806-14
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Gene
100379571 | BACE1-AS
Type: gene
Organism: human
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Publication
20354142 | -
First Author: Okada H
Year: 2010
Journal: FASEB J
Title: Proteomic identification of sorting nexin 6 as a negative regulator of BACE1-mediated APP processing.
Volume: 24
Issue: 8
Pages: 2783-94
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Protein
F6TV37
Organism: Mus musculus/domesticus
Length: 360  
Fragment?: true
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Protein
Q69ZQ6
Organism: Mus musculus/domesticus
Length: 373  
Fragment?: true
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Protein
Q9CUU5
Organism: Mus musculus/domesticus
Length: 267  
Fragment?: false
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Protein
F6UH57
Organism: Mus musculus/domesticus
Length: 65  
Fragment?: true
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Protein
P56818
Organism: Mus musculus/domesticus
Length: 501  
Fragment?: false
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Protein
Q8C7R1
Organism: Mus musculus/domesticus
Length: 501  
Fragment?: false
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Protein
Q8BQY4
Organism: Mus musculus/domesticus
Length: 501  
Fragment?: false
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Protein
Q8C4F4
Organism: Mus musculus/domesticus
Length: 467  
Fragment?: false
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Publication
36370042 | J:341140
First Author: Benoit MR
Year: 2023
Journal: Hum Mol Genet
Title: Postnatal neuronal Bace1 deletion impairs neuroblast and oligodendrocyte maturation.
Volume: 32
Issue: 7
Pages: 1193-1207
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Publication
23831026 | J:200998
First Author: Hu X
Year: 2013
Journal: Cell Rep
Title: BACE1 regulates hippocampal astrogenesis via the Jagged1-Notch pathway.
Volume: 4
Issue: 1
Pages: 40-9
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Publication
22042227 | J:328041
First Author: Treiber H
Year: 2012
Journal: Mol Psychiatry
Title: BACE1 in central nervous system myelination revisited.
Volume: 17
Issue: 3
Pages: 237-9
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Publication
20592204 | J:161845
First Author: Hu X
Year: 2010
Journal: J Neurosci
Title: BACE1 deficiency causes altered neuronal activity and neurodegeneration.
Volume: 30
Issue: 26
Pages: 8819-29
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Publication
28669600 | J:311971
First Author: Hou H
Year: 2017
Journal: Stem Cell Reports
Title: BACE1 Deficiency Causes Abnormal Neuronal Clustering in the Dentate Gyrus.
Volume: 9
Issue: 1
Pages: 217-230
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Publication
17099708 | J:116162
First Author: Hu X
Year: 2006
Journal: Nat Neurosci
Title: Bace1 modulates myelination in the central and peripheral nervous system.
Volume: 9
Issue: 12
Pages: 1520-5
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Publication
17644063 | J:123487
First Author: Miyazaki H
Year: 2007
Journal: Biochem Biophys Res Commun
Title: BACE1 modulates filopodia-like protrusions induced by sodium channel beta4 subunit.
Volume: 361
Issue: 1
Pages: 43-8
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Publication
17576410 | J:129458
First Author: Kim DY
Year: 2007
Journal: Nat Cell Biol
Title: BACE1 regulates voltage-gated sodium channels and neuronal activity.
Volume: 9
Issue: 7
Pages: 755-64
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Publication
26283960 | J:288950
 
First Author: Dong WG
Year: 2015
Journal: Front Aging Neurosci
Title: Electroacupuncture Reduces Aβ Production and BACE1 Expression in SAMP8 Mice.
Volume: 7
Pages: 148
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Publication
26296617 | J:227022
First Author: Lundgren JL
Year: 2015
Journal: J Neurochem
Title: ADAM10 and BACE1 are localized to synaptic vesicles.
Volume: 135
Issue: 3
Pages: 606-15
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Publication
25957769 | J:221641
First Author: Kizuka Y
Year: 2015
Journal: FEBS Lett
Title: Clec4g (LSECtin) interacts with BACE1 and suppresses Aβ generation.
Volume: 589
Issue: 13
Pages: 1418-22
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Publication
27179792 | J:237310
First Author: Miyagawa T
Year: 2016
Journal: Hum Mol Genet
Title: BIN1 regulates BACE1 intracellular trafficking and amyloid-β production.
Volume: 25
Issue: 14
Pages: 2948-2958
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Publication
31882662 | J:287115
First Author: Lombardo S
Year: 2019
Journal: Sci Rep
Title: BACE1 partial deletion induces synaptic plasticity deficit in adult mice.
Volume: 9
Issue: 1
Pages: 19877
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Publication
22728825 | J:186413
First Author: Kuhn PH
Year: 2012
Journal: EMBO J
Title: Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons.
Volume: 31
Issue: 14
Pages: 3157-68
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Publication
28191691 | J:241878
First Author: Hu X
Year: 2017
Journal: Glia
Title: BACE1 regulates the proliferation and cellular functions of Schwann cells.
Volume: 65
Issue: 5
Pages: 712-726
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Publication
31527119 | J:283677
First Author: Dierich M
Year: 2019
Journal: J Neurosci
Title: β-Secretase BACE1 Is Required for Normal Cochlear Function.
Volume: 39
Issue: 45
Pages: 9013-9027
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Publication
26710318 | J:231480
First Author: Kim J
Year: 2016
Journal: J Neurochem
Title: miR-186 is decreased in aged brain and suppresses BACE1 expression.
Volume: 137
Issue: 3
Pages: 436-45
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Publication
25599931 | J:284014
First Author: Filser S
Year: 2015
Journal: Biol Psychiatry
Title: Pharmacological inhibition of BACE1 impairs synaptic plasticity and cognitive functions.
Volume: 77
Issue: 8
Pages: 729-39
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Publication
28028177 | J:240707
First Author: Feng T
Year: 2017
Journal: J Biol Chem
Title: Autophagy-mediated Regulation of BACE1 Protein Trafficking and Degradation.
Volume: 292
Issue: 5
Pages: 1679-1690
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Publication
23202730 | J:194181
First Author: Ly PT
Year: 2013
Journal: J Clin Invest
Title: Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes.
Volume: 123
Issue: 1
Pages: 224-35
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Publication
26467158 | J:237673
First Author: Kizuka Y
Year: 2016
Journal: Biochem J
Title: Bisecting GlcNAc modification stabilizes BACE1 protein under oxidative stress conditions.
Volume: 473
Issue: 1
Pages: 21-30
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Publication
29444819 | J:259749
First Author: Hu X
Year: 2018
Journal: J Exp Med
Title: BACE1 deletion in the adult mouse reverses preformed amyloid deposition and improves cognitive functions.
Volume: 215
Issue: 3
Pages: 927-940
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Publication
28281673 | J:271903
 
First Author: Weber M
Year: 2017
Journal: Sci Rep
Title: BACE1 across species: a comparison of the in vivo consequences of BACE1 deletion in mice and rats.
Volume: 7
Pages: 44249
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Publication
26923405 | J:234508
 
First Author: Jiang Y
Year: 2016
Journal: Neurobiol Aging
Title: Partial BACE1 reduction in a Down syndrome mouse model blocks Alzheimer-related endosomal anomalies and cholinergic neurodegeneration: role of APP-CTF.
Volume: 39
Pages: 90-8
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Publication
25716831 | J:219853
First Author: Hessler S
Year: 2015
Journal: J Neurosci
Title: β-Secretase BACE1 regulates hippocampal and reconstituted M-currents in a β-subunit-like fashion.
Volume: 35
Issue: 8
Pages: 3298-311
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Publication
18413858 | J:137970
First Author: Hu X
Year: 2008
Journal: FASEB J
Title: Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves.
Volume: 22
Issue: 8
Pages: 2970-80
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Publication
37536983 | J:340326
First Author: Yao AY
Year: 2023
Journal: J Neurosci
Title: Bace1 Deletion in the Adult Reverses Epileptiform Activity and Sleep-wake Disturbances in AD Mice.
Volume: 43
Issue: 35
Pages: 6197-6211
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Publication
33074142 | J:299802
 
First Author: Fissel JA
Year: 2020
Journal: J Neuroimmunol
Title: Macrophage-specific deletion of BACE1 does not enhance macrophage recruitment to the injured peripheral nerve.
Volume: 349
Pages: 577423
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Publication
17258906 | J:119002
First Author: Ohno M
Year: 2007
Journal: Neurobiol Dis
Title: BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic mice.
Volume: 26
Issue: 1
Pages: 134-45
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Publication
30647119 | J:273215
First Author: Lazic D
Year: 2019
Journal: J Exp Med
Title: 3K3A-activated protein C blocks amyloidogenic BACE1 pathway and improves functional outcome in mice.
Volume: 216
Issue: 2
Pages: 279-293
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Publication
14715132 | J:87453
First Author: Ohno M
Year: 2004
Journal: Neuron
Title: BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease.
Volume: 41
Issue: 1
Pages: 27-33
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Publication
14664815 | J:86936
First Author: Harrison SM
Year: 2003
Journal: Mol Cell Neurosci
Title: BACE1 (beta-secretase) transgenic and knockout mice: identification of neurochemical deficits and behavioral changes.
Volume: 24
Issue: 3
Pages: 646-55
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Publication
22728099 | J:192517
 
First Author: Marques SC
Year: 2012
Journal: Neuroscience
Title: Epigenetic regulation of BACE1 in Alzheimer's disease patients and in transgenic mice.
Volume: 220
Pages: 256-66
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Publication
22355745 | J:207280
 
First Author: Cao L
Year: 2012
Journal: Sci Rep
Title: The precision of axon targeting of mouse olfactory sensory neurons requires the BACE1 protease.
Volume: 2
Pages: 231
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Publication
31303501 | J:291128
 
First Author: Fan YG
Year: 2019
Journal: EBioMedicine
Title: Paricalcitol accelerates BACE1 lysosomal degradation and inhibits calpain-1 dependent neuronal loss in APP/PS1 transgenic mice.
Volume: 45
Pages: 393-407
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Publication
30232227 | J:266958
 
First Author: Ou-Yang MH
Year: 2018
Journal: Sci Transl Med
Title: Axonal organization defects in the hippocampus of adult conditional BACE1 knockout mice.
Volume: 10
Issue: 459
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Publication
36750595 | J:334802
First Author: Ulku I
Year: 2023
Journal: Sci Rep
Title: Mechanisms of amyloid-β34 generation indicate a pivotal role for BACE1 in amyloid homeostasis.
Volume: 13
Issue: 1
Pages: 2216
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Publication
21880018 | J:179224
First Author: Meakin PJ
Year: 2012
Journal: Biochem J
Title: Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice.
Volume: 441
Issue: 1
Pages: 285-96
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Publication
36810097 | J:335690
First Author: Müller SA
Year: 2023
Journal: Mol Neurodegener
Title: The Alzheimer's disease-linked protease BACE1 modulates neuronal IL-6 signaling through shedding of the receptor gp130.
Volume: 18
Issue: 1
Pages: 13
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Publication
33548223 | J:305239
   
First Author: Kim W
Year: 2021
Journal: J Biol Chem
Title: Spatiotemporal processing of neural cell adhesion molecules 1 and 2 by BACE1 in vivo.
Pages: 100372
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Publication
30079376 | J:266883
 
First Author: Chatila ZK
Year: 2018
Journal: eNeuro
Title: BACE1 Regulates Proliferation and Neuronal Differentiation of Newborn Cells in the Adult Hippocampus in Mice.
Volume: 5
Issue: 4
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Publication
24637500 | J:215109
First Author: Wang H
Year: 2014
Journal: PLoS One
Title: Postsynaptic target specific synaptic dysfunctions in the CA3 area of BACE1 knockout mice.
Volume: 9
Issue: 3
Pages: e92279
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Publication
25457554 | J:219502
First Author: Katsouri L
Year: 2015
Journal: Neurobiol Aging
Title: Systemic administration of fibroblast growth factor-2 (FGF2) reduces BACE1 expression and amyloid pathology in APP23 mice.
Volume: 36
Issue: 2
Pages: 821-31
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Publication
26240147 | J:225794
First Author: Wang R
Year: 2015
Journal: J Biol Chem
Title: All-trans-retinoic acid reduces BACE1 expression under inflammatory conditions via modulation of nuclear factor κB (NFκB) signaling.
Volume: 290
Issue: 37
Pages: 22532-42
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Publication
29716987 | J:325843
First Author: Herber J
Year: 2018
Journal: Mol Cell Proteomics
Title: Click Chemistry-mediated Biotinylation Reveals a Function for the Protease BACE1 in Modulating the Neuronal Surface Glycoproteome.
Volume: 17
Issue: 8
Pages: 1487-1501
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Publication
23792428 | J:199150
First Author: Cheret C
Year: 2013
Journal: EMBO J
Title: Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles.
Volume: 32
Issue: 14
Pages: 2015-28
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Publication
29632166 | J:261965
First Author: Stern AL
Year: 2018
Journal: J Neurosci
Title: BACE1 Mediates HIV-Associated and Excitotoxic Neuronal Damage Through an APP-Dependent Mechanism.
Volume: 38
Issue: 18
Pages: 4288-4300
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Publication
31442405 | J:290398
First Author: Suh J
Year: 2019
Journal: Cell
Title: Loss of Ataxin-1 Potentiates Alzheimer's Pathogenesis by Elevating Cerebral BACE1 Transcription.
Volume: 178
Issue: 5
Pages: 1159-1175.e17
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Publication
25961820 | J:235334
First Author: Heindl M
Year: 2015
Journal: PLoS One
Title: Loss of Bace1 in mice does not alter the severity of caerulein induced pancreatitis.
Volume: 10
Issue: 5
Pages: e0125556
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Publication
29325091 | J:276403
First Author: Wang X
Year: 2018
Journal: J Mol Cell Biol
Title: α-secretase ADAM10 physically interacts with β-secretase BACE1 in neurons and regulates CHL1 proteolysis.
Volume: 10
Issue: 5
Pages: 411-422
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Publication
18680556 | J:140135
First Author: Chen L
Year: 2008
Journal: J Neurochem
Title: Lipid peroxidation up-regulates BACE1 expression in vivo: a possible early event of amyloidogenesis in Alzheimer's disease.
Volume: 107
Issue: 1
Pages: 197-207
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Publication
29507146 | J:261021
First Author: Hartmann S
Year: 2018
Journal: J Neurosci
Title: β-Secretase BACE1 Promotes Surface Expression and Function of Kv3.4 at Hippocampal Mossy Fiber Synapses.
Volume: 38
Issue: 14
Pages: 3480-3494
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Publication
31164420 | J:279242
First Author: Bahn G
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: NRF2/ARE pathway negatively regulates BACE1 expression and ameliorates cognitive deficits in mouse Alzheimer's models.
Volume: 116
Issue: 25
Pages: 12516-12523
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Publication
26299962 | J:265989
First Author: Barão S
Year: 2015
Journal: Cell Rep
Title: Antagonistic Effects of BACE1 and APH1B-γ-Secretase Control Axonal Guidance by Regulating Growth Cone Collapse.
Volume: 12
Issue: 9
Pages: 1367-76
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Publication
29610518 | J:261936
First Author: Meakin PJ
Year: 2018
Journal: Nat Commun
Title: The beta secretase BACE1 regulates the expression of insulin receptor in the liver.
Volume: 9
Issue: 1
Pages: 1306
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Publication
19074428 | J:232987
First Author: Vetrivel KS
Year: 2009
Journal: J Biol Chem
Title: Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts.
Volume: 284
Issue: 6
Pages: 3793-803
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Publication
21812781 | J:176601
First Author: Rabe S
Year: 2011
Journal: J Neurochem
Title: The Swedish APP mutation alters the effect of genetically reduced BACE1 expression on the APP processing.
Volume: 119
Issue: 1
Pages: 231-9
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Publication
27080468 | J:240850
 
First Author: Liu L
Year: 2016
Journal: Neurobiol Dis
Title: Increased TNFR1 expression and signaling in injured peripheral nerves of mice with reduced BACE1 activity.
Volume: 93
Pages: 21-7
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Publication
28869759 | J:257178
First Author: Saadipour K
Year: 2018
Journal: J Neurochem
Title: p75 neurotrophin receptor interacts with and promotes BACE1 localization in endosomes aggravating amyloidogenesis.
Volume: 144
Issue: 3
Pages: 302-317
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Publication
31741224 | J:319510
First Author: Kim N
Year: 2020
Journal: Neurotherapeutics
Title: Picrorhiza kurroa Prevents Memory Deficits by Inhibiting NLRP3 Inflammasome Activation and BACE1 Expression in 5xFAD Mice.
Volume: 17
Issue: 1
Pages: 189-199
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Publication
11224536 | J:79847
First Author: Cai H
Year: 2001
Journal: Nat Neurosci
Title: BACE1 is the major beta-secretase for generation of Abeta peptides by neurons.
Volume: 4
Issue: 3
Pages: 233-4
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Publication
37216506 | J:345103
First Author: Zhou GF
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: ARL6IP1 mediates small-molecule-induced alleviation of Alzheimer pathology through FXR1-dependent BACE1 translation initiation.
Volume: 120
Issue: 22
Pages: e2220148120
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Publication
22692213 | J:188841
First Author: Zhou L
Year: 2012
Journal: J Biol Chem
Title: The neural cell adhesion molecules L1 and CHL1 are cleaved by BACE1 protease in vivo.
Volume: 287
Issue: 31
Pages: 25927-40
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Publication
27716410 | J:329588
First Author: Pigoni M
Year: 2016
Journal: Mol Neurodegener
Title: Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons.
Volume: 11
Issue: 1
Pages: 67
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Publication
28159908 | J:239680
First Author: Ye X
Year: 2017
Journal: J Neurosci
Title: Regulation of Synaptic Amyloid-β Generation through BACE1 Retrograde Transport in a Mouse Model of Alzheimer's Disease.
Volume: 37
Issue: 10
Pages: 2639-2655
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Publication
23820808 | J:263411
First Author: Kandalepas PC
Year: 2013
Journal: Acta Neuropathol
Title: The Alzheimer's β-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques.
Volume: 126
Issue: 3
Pages: 329-52
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Publication
21490216 | J:170970
First Author: Farah MH
Year: 2011
Journal: J Neurosci
Title: Reduced BACE1 activity enhances clearance of myelin debris and regeneration of axons in the injured peripheral nervous system.
Volume: 31
Issue: 15
Pages: 5744-54
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Publication
18753368 | J:138795
First Author: Wang H
Year: 2008
Journal: J Neurosci
Title: BACE1 knock-outs display deficits in activity-dependent potentiation of synaptic transmission at mossy fiber to CA3 synapses in the hippocampus.
Volume: 28
Issue: 35
Pages: 8677-81
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Publication
17616527 | J:124653
First Author: McConlogue L
Year: 2007
Journal: J Biol Chem
Title: Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP Transgenic Mice.
Volume: 282
Issue: 36
Pages: 26326-34
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Publication
26987953 | J:235878
 
First Author: Zhang JS
Year: 2016
Journal: Neuroscience
Title: Gastrodin suppresses BACE1 expression under oxidative stress condition via inhibition of the PKR/eIF2α pathway in Alzheimer's disease.
Volume: 325
Pages: 1-9
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Publication
13678669 | J:109503
First Author: Luo Y
Year: 2003
Journal: Neurobiol Dis
Title: BACE1 (beta-secretase) knockout mice do not acquire compensatory gene expression changes or develop neural lesions over time.
Volume: 14
Issue: 1
Pages: 81-8
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Publication
23750206 | J:203144
First Author: Lincoln S
Year: 2013
Journal: PLoS One
Title: LRRTM3 interacts with APP and BACE1 and has variants associating with late-onset Alzheimer's disease (LOAD).
Volume: 8
Issue: 6
Pages: e64164
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Publication
28855330 | J:248926
First Author: Choi GE
Year: 2017
Journal: J Neurosci
Title: Membrane-Associated Effects of Glucocorticoid on BACE1 Upregulation and Aβ Generation: Involvement of Lipid Raft-Mediated CREB Activation.
Volume: 37
Issue: 35
Pages: 8459-8476
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Publication
20943921 | J:238454
First Author: Wang H
Year: 2010
Journal: J Neurosci
Title: Mossy fiber long-term potentiation deficits in BACE1 knock-outs can be rescued by activation of alpha7 nicotinic acetylcholine receptors.
Volume: 30
Issue: 41
Pages: 13808-13
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Publication
25156639 | J:218551
First Author: Georgievska B
Year: 2015
Journal: J Neurochem
Title: Revisiting the peripheral sink hypothesis: inhibiting BACE1 activity in the periphery does not alter β-amyloid levels in the CNS.
Volume: 132
Issue: 4
Pages: 477-86
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Publication
26993139 | J:313426
First Author: Sadleir KR
Year: 2016
Journal: Acta Neuropathol
Title: Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aβ generation in Alzheimer's disease.
Volume: 132
Issue: 2
Pages: 235-256
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Publication
25592972 | J:229208
First Author: Kizuka Y
Year: 2015
Journal: EMBO Mol Med
Title: An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease.
Volume: 7
Issue: 2
Pages: 175-89
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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