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Search results 1 to 100 out of 543 for Bad

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
572 | BAD
Type: gene
Organism: human
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Gene
100487418 | bad
Type: gene
Organism: frog, western clawed
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Gene
64639 | Bad
Type: gene
Organism: rat
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Gene
483763 | BAD
Type: gene
Organism: dog, domestic
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Gene
615013 | BAD
Type: gene
Organism: cattle
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Gene
100615623 | BAD
Type: gene
Organism: chimpanzee
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Gene
717740 | BAD
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR018868 | BAD
Type: Family
Description: BAD is a Bcl-2 homology domain 3 (BH3)-only pro-apoptotic member of the Bcl-2 protein family that is regulated by phosphorylation in response to survival factors []. Binding of BAD to mitochondria is thought to be exclusively mediated by its BH3 domain. Membrane localisation of BAD mediates membrane translocation of Bcl-XL. The C-terminal part of BAD is sufficient for membrane binding. There are two segments with differing lipid-binding preferences, LBD1 and LBD2, that are responsible for this binding: (i) LBD1 located in the proximity of the BH3 domain (amino acids 122-131) and (ii) LBD2, the putative C-terminal α-helix-5 []. Phosphorylation-regulated 14-3-3 protein binding may expose the cholesterol-preferring LBD1 and bury the LBD2, thereby mediating translocation of BAD to raft-like micro-domains [].
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Protein Coding Gene
MGI:1096330 | Bad
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
9372935 | J:44282
First Author: Kelekar A
Year: 1997
Journal: Mol Cell Biol
Title: Bad is a BH3 domain-containing protein that forms an inactivating dimer with Bcl-XL.
Volume: 17
Issue: 12
Pages: 7040-6
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Protein
Q61337
Organism: Mus musculus/domesticus
Length: 204  
Fragment?: false
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Publication
16226704 | -
First Author: She QB
Year: 2005
Journal: Cancer Cell
Title: The BAD protein integrates survival signaling by EGFR/MAPK and PI3K/Akt kinase pathways in PTEN-deficient tumor cells.
Volume: 8
Issue: 4
Pages: 287-97
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Publication
16603546 | -
First Author: Hekman M
Year: 2006
Journal: J Biol Chem
Title: Reversible membrane interaction of BAD requires two C-terminal lipid binding domains in conjunction with 14-3-3 protein binding.
Volume: 281
Issue: 25
Pages: 17321-36
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Publication
- | J:127794
     
First Author: Karst SY
Year: 2007
Journal: MGI Direct Data Submission
Title: Bad hair day: a semidominant X-linked mutation affecting skin and hair.
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GXD Expression
GXD Expression
 
Probe: MGI:6450779
Assay Type: Immunohistochemistry
Annotation Date: 2020-08-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2823926
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6450793
Age: embryonic day 18.5
Note: No significant differences between +/+ and -/- glomeruli.
Specimen Label: Bad Nphs1-/- not shown
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:6450779
Assay Type: Immunohistochemistry
Annotation Date: 2020-08-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2823926
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6450793
Age: embryonic day 18.5
Note: No significant differences between +/+ and -/- glomeruli.
Specimen Label: Bad Nphs1+/+ not shown
Detected: true
Specimen Num: 1
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Publication
25611386 | J:319118
 
First Author: Ottina E
Year: 2015
Journal: Cell Death Dis
Title: The BH3-only protein Bad is dispensable for TNF-mediated cell death.
Volume: 6
Pages: e1611
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Protein
F6S493
Organism: Mus musculus/domesticus
Length: 63  
Fragment?: true
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Protein
A0A494BBC4
Organism: Mus musculus/domesticus
Length: 131  
Fragment?: false
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Protein
Q3TFU7
Organism: Mus musculus/domesticus
Length: 173  
Fragment?: true
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Protein
D3YZR8
Organism: Mus musculus/domesticus
Length: 178  
Fragment?: false
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Protein
F7ABX5
Organism: Mus musculus/domesticus
Length: 161  
Fragment?: true
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Protein
Q3U9H3
Organism: Mus musculus/domesticus
Length: 162  
Fragment?: false
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Publication
18402774 | J:134669
First Author: Fueller J
Year: 2008
Journal: Biochem Biophys Res Commun
Title: C-RAF activation promotes BAD poly-ubiquitylation and turn-over by the proteasome.
Volume: 370
Issue: 4
Pages: 552-6
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Publication
29368690 | J:254911
   
First Author: Martínez-François JR
Year: 2018
Journal: Elife
Title: BAD and KATP channels regulate neuron excitability and epileptiform activity.
Volume: 7
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Publication
12431371 | J:88139
First Author: Datta SR
Year: 2002
Journal: Dev Cell
Title: Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis.
Volume: 3
Issue: 5
Pages: 631-43
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Publication
16166315 | J:101612
First Author: Zhang J
Year: 2005
Journal: Cancer Res
Title: BAD Ser128 is not phosphorylated by c-Jun NH2-terminal kinase for promoting apoptosis.
Volume: 65
Issue: 18
Pages: 8372-8
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Publication
33270017 | J:303557
   
First Author: Li J
Year: 2020
Journal: Elife
Title: BAD inactivation exacerbates rheumatoid arthritis pathology by promoting survival of sublining macrophages.
Volume: 9
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Publication
21609830 | J:174982
First Author: Jiao S
Year: 2011
Journal: Neuron
Title: Nonapoptotic function of BAD and BAX in long-term depression of synaptic transmission.
Volume: 70
Issue: 4
Pages: 758-72
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Publication
18223655 | J:133563
First Author: Danial NN
Year: 2008
Journal: Nat Med
Title: Dual role of proapoptotic BAD in insulin secretion and beta cell survival.
Volume: 14
Issue: 2
Pages: 144-53
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Publication
15901741 | J:100838
First Author: Hashimoto A
Year: 2005
Journal: J Biol Chem
Title: BAD detects coincidence of G2/M phase and growth factor deprivation to regulate apoptosis.
Volume: 280
Issue: 28
Pages: 26225-32
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Publication
23332762 | J:193499
First Author: Yan J
Year: 2013
Journal: Cell
Title: Inactivation of BAD by IKK inhibits TNFα-induced apoptosis independently of NF-κB activation.
Volume: 152
Issue: 1-2
Pages: 304-15
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Publication
29234155 | J:303476
First Author: Wan H
Year: 2018
Journal: Cell Death Differ
Title: Analysis of neuronal phosphoproteome reveals PINK1 regulation of BAD function and cell death.
Volume: 25
Issue: 5
Pages: 904-917
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Publication
34011960 | J:306333
First Author: Githaka JM
Year: 2021
Journal: Nat Commun
Title: BAD regulates mammary gland morphogenesis by 4E-BP1-mediated control of localized translation in mouse and human models.
Volume: 12
Issue: 1
Pages: 2939
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Publication
12931191 | J:85083
First Author: Danial NN
Year: 2003
Journal: Nature
Title: BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis.
Volume: 424
Issue: 6951
Pages: 952-6
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Publication
22430207 | J:193370
First Author: Baumgartner F
Year: 2013
Journal: Oncogene
Title: Minor cell-death defects but reduced tumor latency in mice lacking the BH3-only proteins Bad and Bmf.
Volume: 32
Issue: 5
Pages: 621-30
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Publication
11717309 | J:74669
First Author: Dramsi S
Year: 2002
Journal: J Biol Chem
Title: Identification of a novel phosphorylation site, Ser-170, as a regulator of bad pro-apoptotic activity.
Volume: 277
Issue: 8
Pages: 6399-405
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Publication
12954615 | J:86593
First Author: Yan B
Year: 2003
Journal: J Biol Chem
Title: The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death.
Volume: 278
Issue: 46
Pages: 45358-67
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Publication
16780816 | J:111236
First Author: Ness JM
Year: 2006
Journal: Brain Res
Title: Selective involvement of BH3-only Bcl-2 family members Bim and Bad in neonatal hypoxia-ischemia.
Volume: 1099
Issue: 1
Pages: 150-9
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Publication
21716255 | J:194718
First Author: Küper C
Year: 2011
Journal: Kidney Int
Title: Cyclooxygenase-2-dependent phosphorylation of the pro-apoptotic protein Bad inhibits tonicity-induced apoptosis in renal medullary cells.
Volume: 80
Issue: 9
Pages: 938-45
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Publication
22805310 | J:191339
First Author: Zimmerman MA
Year: 2012
Journal: Cancer Res
Title: Unphosphorylated STAT1 promotes sarcoma development through repressing expression of Fas and bad and conferring apoptotic resistance.
Volume: 72
Issue: 18
Pages: 4724-32
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Publication
15231831 | J:93470
First Author: Seo SY
Year: 2004
Journal: J Biol Chem
Title: BAD is a pro-survival factor prior to activation of its pro-apoptotic function.
Volume: 279
Issue: 40
Pages: 42240-9
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Publication
19915011 | J:160042
First Author: Quoyer J
Year: 2010
Journal: J Biol Chem
Title: GLP-1 mediates antiapoptotic effect by phosphorylating Bad through a beta-arrestin 1-mediated ERK1/2 activation in pancreatic beta-cells.
Volume: 285
Issue: 3
Pages: 1989-2002
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Publication
29171006 | J:273755
First Author: Foley J
Year: 2018
Journal: Epilepsia
Title: BAD knockout provides metabolic seizure resistance in a genetic model of epilepsy with sudden unexplained death in epilepsy.
Volume: 59
Issue: 1
Pages: e1-e4
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Publication
8929531 | J:230407
First Author: Zha J
Year: 1996
Journal: Cell
Title: Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)
Volume: 87
Issue: 4
Pages: 619-28
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Publication
29795446 | J:288217
First Author: Yan J
Year: 2018
Journal: Cell Res
Title: The BH3-only protein BAD mediates TNFα cytotoxicity despite concurrent activation of IKK and NF-κB in septic shock.
Volume: 28
Issue: 7
Pages: 701-718
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Heritable Phenotypic Marker
MGI:3764933 | Bhrd
Type: heritable_phenotypic_marker
Organism: mouse, laboratory
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Publication
16645638 | J:132234
First Author: Hinds MG
Year: 2007
Journal: Cell Death Differ
Title: Bim, Bad and Bmf: intrinsically unstructured BH3-only proteins that undergo a localized conformational change upon binding to prosurvival Bcl-2 targets.
Volume: 14
Issue: 1
Pages: 128-36
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Publication
20431598 | J:186358
First Author: Kelly PN
Year: 2010
Journal: Cell Death Differ
Title: Individual and overlapping roles of BH3-only proteins Bim and Bad in apoptosis of lymphocytes and platelets and in suppression of thymic lymphoma development.
Volume: 17
Issue: 10
Pages: 1655-64
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Publication
12876200 | J:84987
First Author: Ranger AM
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Bad-deficient mice develop diffuse large B cell lymphoma.
Volume: 100
Issue: 16
Pages: 9324-9
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Publication
34430820 | J:338669
First Author: Zhang L
Year: 2021
Journal: iScience
Title: BAD-mediated neuronal apoptosis and neuroinflammation contribute to Alzheimer's disease pathology.
Volume: 24
Issue: 9
Pages: 102942
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Publication
23348742 | J:194485
First Author: Hassan S
Year: 2013
Journal: J Clin Invest
Title: Behavioral stress accelerates prostate cancer development in mice.
Volume: 123
Issue: 2
Pages: 874-86
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Publication
12727206 | J:83681
First Author: Hsieh YC
Year: 2003
Journal: Biochem Biophys Res Commun
Title: Cloning of zebrafish BAD, a BH3-only proapoptotic protein, whose overexpression leads to apoptosis in COS-1 cells and zebrafish embryos.
Volume: 304
Issue: 4
Pages: 667-75
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Publication
11723239 | J:200329
First Author: Masters SC
Year: 2001
Journal: Mol Pharmacol
Title: 14-3-3 inhibits Bad-induced cell death through interaction with serine-136.
Volume: 60
Issue: 6
Pages: 1325-31
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Publication
7834748 | J:42326
First Author: Yang E
Year: 1995
Journal: Cell
Title: Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death.
Volume: 80
Issue: 2
Pages: 285-91
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Publication
24506868 | J:210651
First Author: Giménez-Cassina A
Year: 2014
Journal: Cell Metab
Title: Regulation of hepatic energy metabolism and gluconeogenesis by BAD.
Volume: 19
Issue: 2
Pages: 272-84
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Publication
22632729 | J:188361
First Author: Giménez-Cassina A
Year: 2012
Journal: Neuron
Title: BAD-dependent regulation of fuel metabolism and K(ATP) channel activity confers resistance to epileptic seizures.
Volume: 74
Issue: 4
Pages: 719-30
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Publication
14967141 | J:88294
First Author: Yu C
Year: 2004
Journal: Mol Cell
Title: JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD.
Volume: 13
Issue: 3
Pages: 329-40
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Publication
15634756 | J:95303
First Author: Fleischer A
Year: 2004
Journal: Mol Cancer Res
Title: Bad-dependent rafts alteration is a consequence of an early intracellular signal triggered by interleukin-4 deprivation.
Volume: 2
Issue: 12
Pages: 674-84
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Publication
24865460 | J:219251
First Author: de Joussineau C
Year: 2014
Journal: Hum Mol Genet
Title: mTOR pathway is activated by PKA in adrenocortical cells and participates in vivo to apoptosis resistance in primary pigmented nodular adrenocortical disease (PPNAD).
Volume: 23
Issue: 20
Pages: 5418-28
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Publication
15131699 | J:114796
First Author: Jeong SY
Year: 2004
Journal: EMBO J
Title: Bcl-x(L) sequesters its C-terminal membrane anchor in soluble, cytosolic homodimers.
Volume: 23
Issue: 10
Pages: 2146-55
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Publication
15694340 | J:114705
First Author: Chen L
Year: 2005
Journal: Mol Cell
Title: Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function.
Volume: 17
Issue: 3
Pages: 393-403
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Publication
12115603 | J:78230
First Author: Ayllón V
Year: 2002
Journal: Eur J Immunol
Title: The anti-apoptotic molecules Bcl-xL and Bcl-w target protein phosphatase 1alpha to Bad.
Volume: 32
Issue: 7
Pages: 1847-55
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Publication
23826368 | J:204337
First Author: Peltzer N
Year: 2013
Journal: PLoS One
Title: Role of mTOR, Bad, and Survivin in RasGAP Fragment N-Mediated Cell Protection.
Volume: 8
Issue: 6
Pages: e68123
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Publication
18287039 | J:132819
First Author: Fischer SF
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: BH3-only protein Puma contributes to death of antigen-specific T cells during shutdown of an immune response to acute viral infection.
Volume: 105
Issue: 8
Pages: 3035-40
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Publication
17535812 | J:124616
First Author: Kebache S
Year: 2007
Journal: J Biol Chem
Title: Grb10 and active Raf-1 kinase promote Bad-dependent cell survival.
Volume: 282
Issue: 30
Pages: 21873-83
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Publication
12944463 | J:85463
First Author: Chiang CW
Year: 2003
Journal: Mol Cell Biol
Title: Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis.
Volume: 23
Issue: 18
Pages: 6350-62
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Publication
21095239 | J:173139
First Author: Deng H
Year: 2011
Journal: Int J Biochem Cell Biol
Title: Phosphorylation of Bcl-associated death protein (Bad) by erythropoietin-activated c-Jun N-terminal protein kinase 1 contributes to survival of erythropoietin-dependent cells.
Volume: 43
Issue: 3
Pages: 409-15
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Publication
16116448 | J:101397
First Author: Götz R
Year: 2005
Journal: Nat Neurosci
Title: Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells.
Volume: 8
Issue: 9
Pages: 1169-78
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Publication
19965635 | J:156718
First Author: Frenzel A
Year: 2010
Journal: Blood
Title: Suppression of B-cell lymphomagenesis by the BH3-only proteins Bmf and Bad.
Volume: 115
Issue: 5
Pages: 995-1005
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Publication
12142566 | J:167678
First Author: Shibata M
Year: 2002
Journal: J Cereb Blood Flow Metab
Title: Temporal profiles of the subcellular localization of Bim, a BH3-only protein, during middle cerebral artery occlusion in mice.
Volume: 22
Issue: 7
Pages: 810-20
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Publication
12915712 | J:85726
First Author: Fernández EL
Year: 2003
Journal: Toxicol Sci
Title: Cadmium-induced changes in apoptotic gene expression levels and DNA damage in mouse embryos are blocked by zinc.
Volume: 76
Issue: 1
Pages: 162-70
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Publication
16705087 | J:138066
First Author: Ekert PG
Year: 2006
Journal: Blood
Title: Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma.
Volume: 108
Issue: 5
Pages: 1461-8
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Publication
16513830 | J:129658
First Author: Lu X
Year: 2006
Journal: Endocrinology
Title: DHCR24-knockout embryonic fibroblasts are susceptible to serum withdrawal-induced apoptosis because of dysfunction of caveolae and insulin-Akt-Bad signaling.
Volume: 147
Issue: 6
Pages: 3123-32
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Publication
26045049 | J:258604
First Author: Schuler F
Year: 2016
Journal: Cell Death Differ
Title: The BH3-only protein BIM contributes to late-stage involution in the mouse mammary gland.
Volume: 23
Issue: 1
Pages: 41-51
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Publication
21084607 | J:182379
First Author: Zhong Z
Year: 2010
Journal: J Neurosci
Title: Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like region.
Volume: 30
Issue: 46
Pages: 15521-34
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Protein Coding Gene
MGP_CAROLIEiJ_G0022620 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0024774 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0024740 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0024713 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0024740 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0024508 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1096330 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0025186 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0023980 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0024480 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0024607 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0024573 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0024693 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0024602 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0025234 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0023726 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0024042 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0014114 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0023531 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
24223137 | J:209329
First Author: Hassan S
Year: 2013
Journal: PLoS One
Title: Surgical stress delays prostate involution in mice.
Volume: 8
Issue: 11
Pages: e78175
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Publication
11697890 | J:200331
First Author: Subramanian RR
Year: 2001
Journal: Exp Cell Res
Title: Functional conservation of 14-3-3 isoforms in inhibiting bad-induced apoptosis.
Volume: 271
Issue: 1
Pages: 142-51
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GXD Expression
GXD Expression
   
Probe: MGI:1205887
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:1205889
Age: postnatal week 6-8
Image: st97_716
Specimen Label: None
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:1205887
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:1205889
Age: postnatal week 6-8
Image: st97_716
Specimen Label: None
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:1205887
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:3284528
Stage: TS28
Assay Id: MGI:1205889
Age: postnatal week 6-8
Image: st97_716
Specimen Label: None
Detected: true
Specimen Num: 3
•
•
•
•
•




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