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Search results 1 to 100 out of 2298 for Bax

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Type Details Score
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Domain
Type: Family
Description: B cell CLL/lymphoma-2 (Bcl-2) and related proteins comprise the Bcl-2 family. Bcl-2 proteins are central regulators of caspase activation, and play a key role in cell death by regulating the integrity of the mitochondrial and endoplasmic reticulum (ER) membranes []. Though originally characterised with respect to their roles in controlling outer mitochondrial membrane integrity and apoptosis, the members of the Bcl-2 family are involved in numerous cellular pathways [].Bcl-2 and its relatives are functionally classified as either antiapoptoticor proapoptotic. All members contain at least one of four conserved motifs, termed Bcl-2 Homology (BH) domains. Antiapoptotic BCL-2 proteins contain four Bcl-2 homology domains (BH1-4). The major antiapoptotic proteins are Bcl-2-related gene A1 (A1), Bcl-2, Bcl-2-related gene, long isoform (Bcl-xL), Bcl-w, and myeloid cell leukemia 1 (MCL-1). They preserve outer mitochondrial membrane (OMM) integrity by directly inhibiting the proapoptotic Bcl-2 proteins [].The proapoptotic Bcl-2 members are divided into the effector proteins and the BH3-only proteins. The effector proteins Bcl-2 antagonist killer 1 (BAK) and Bcl-2-associated x protein (BAX) were originally described to contain only BH1-3; however, structure-based alignments revealed a conserved BH4 motif []. Upon activation BAK and BAX homo-oligomerise into proteolipid pores within the OMM to promote MOMP (mitochondrial outer membrane permeabilisation). The BH3-only proteins function in distinct cellular stress scenarios and are subdivided based on their ability to interact with the antiapoptotic or both the antiapoptotic and the effector proteins [].Bcl-2-associated x protein (BAX) is a proapoptotic member of the Bcl-2 family. It accelerates programmed cell death by binding to, and antagonising the apoptosis repressor Bcl2 [, ].
HT Sample  
Organism Name: mouse, laboratory
Sex: Male
Age: postnatal day 56
Stage: 28
Structure . Name: testis
Curation Status: Curated
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Oltvai ZN
Year: 1993
Journal: Cell
Title: Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death.
Volume: 74
Issue: 4
Pages: 609-19
Publication
First Author: Ku B
Year: 2011
Journal: Cell Res
Title: Evidence that inhibition of BAX activation by BCL-2 involves its tight and preferential interaction with the BH3 domain of BAX.
Volume: 21
Issue: 4
Pages: 627-41
Protein
Organism: Mus musculus/domesticus
Length: 192  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 114  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 74  
Fragment?: true
GXD Expression  
Probe: MGI:5500011
Assay Type: Immunohistochemistry
Annotation Date: 2013-08-08
Strength: Present
Sex: Female
Emaps: EMAPS:1796521
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:5500062
Age: embryonic day 13.5
Image: 5C BAX Female
Specimen Label: 5C BAX Female
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:5500011
Assay Type: Immunohistochemistry
Annotation Date: 2013-08-08
Strength: Present
Sex: Male
Emaps: EMAPS:1797521
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:5500062
Age: embryonic day 13.5
Image: 5C BAX Male
Specimen Label: 5C BAX Male
Detected: true
Specimen Num: 1
Protein
Organism: Mus musculus/domesticus
Length: 171  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 172  
Fragment?: true
GXD Expression      
Probe: MGI:1329383
Assay Type: RT-PCR
Annotation Date: 1999-02-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360464
Stage: TS04
Assay Id: MGI:1329452
Age: embryonic day 4.0
Specimen Label: Bax
Detected: true
Specimen Num: 1
Publication
First Author: Kvansakul M
Year: 2008
Journal: Cell Death Differ
Title: Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligands.
Volume: 15
Issue: 10
Pages: 1564-71
Publication
First Author: Chipuk JE
Year: 2010
Journal: Mol Cell
Title: The BCL-2 family reunion.
Volume: 37
Issue: 3
Pages: 299-310
Protein
Organism: Mus musculus/domesticus
Length: 139  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 173  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 192  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 192  
Fragment?: false
Publication
First Author: Germain M
Year: 2003
Journal: Sci STKE
Title: Cellular distribution of Bcl-2 family proteins.
Volume: 2003
Issue: 173
Pages: pe10
GXD Expression  
Probe: MGI:5500009
Assay Type: Immunohistochemistry
Annotation Date: 2013-08-08
Strength: Present
Sex: Female
Emaps: EMAPS:1796521
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:5500039
Age: embryonic day 13.5
Image: 5C BAX Female
Specimen Label: 5C BAX Female
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:5500009
Assay Type: Immunohistochemistry
Annotation Date: 2013-08-08
Strength: Present
Sex: Male
Emaps: EMAPS:1797521
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:5500039
Age: embryonic day 13.5
Image: 5C BAX Male
Specimen Label: 5C BAX Male
Detected: true
Specimen Num: 4
Protein
Organism: Mus musculus/domesticus
Length: 235  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 193  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 204  
Fragment?: true
Publication
First Author: Bax R
Year: 2006
Journal: RNA
Title: Slx9p facilitates efficient ITS1 processing of pre-rRNA in Saccharomyces cerevisiae.
Volume: 12
Issue: 11
Pages: 2005-13
GXD Expression      
Probe: MGI:5295249
Assay Type: Immunohistochemistry
Annotation Date: 2011-11-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1616417
Stage: TS17
Assay Id: MGI:5295631
Age: embryonic day 10.5
Specimen Label: 6I Bax wt
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5295249
Assay Type: Immunohistochemistry
Annotation Date: 2011-11-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1616417
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:5295631
Age: embryonic day 10.5
Specimen Label: 6I Bax L24 Bst/+
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:5295249
Assay Type: Immunohistochemistry
Annotation Date: 2011-11-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1616417
Stage: TS17
Assay Id: MGI:5295631
Age: embryonic day 10.5
Specimen Label: 6I Bax wt
Detected: false
Specimen Num: 3
GXD Expression    
Probe: MGI:5295249
Assay Type: Immunohistochemistry
Annotation Date: 2011-11-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1616417
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:5295631
Age: embryonic day 10.5
Specimen Label: 6I Bax L24 Bst/+
Detected: true
Specimen Num: 4
Publication
First Author: D'Orsi B
Year: 2015
Journal: J Neurosci
Title: Bax regulates neuronal Ca2+ homeostasis.
Volume: 35
Issue: 4
Pages: 1706-22
Protein
Organism: Mus musculus/domesticus
Length: 237  
Fragment?: false
Publication
First Author: Bax NA
Year: 2010
Journal: Dev Dyn
Title: Cardiac malformations in Pdgfralpha mutant embryos are associated with increased expression of WT1 and Nkx2.5 in the second heart field.
Volume: 239
Issue: 8
Pages: 2307-17
Publication
First Author: Bax B
Year: 1997
Journal: Structure
Title: Structure of mouse 7S NGF: a complex of nerve growth factor with four binding proteins.
Volume: 5
Issue: 10
Pages: 1275-85
Publication
First Author: Greenfeld CR
Year: 2007
Journal: Reproduction
Title: BAX regulates follicular endowment in mice.
Volume: 133
Issue: 5
Pages: 865-76
Publication
First Author: Chae HJ
Year: 2004
Journal: Mol Cell
Title: BI-1 regulates an apoptosis pathway linked to endoplasmic reticulum stress.
Volume: 15
Issue: 3
Pages: 355-66
Publication
First Author: Xiang H
Year: 1998
Journal: J Neurosci
Title: Bax involvement in p53-mediated neuronal cell death.
Volume: 18
Issue: 4
Pages: 1363-73
Publication
First Author: Knudson CM
Year: 2001
Journal: Cancer Res
Title: Bax accelerates tumorigenesis in p53-deficient mice.
Volume: 61
Issue: 2
Pages: 659-65
Publication
First Author: Castillo K
Year: 2011
Journal: EMBO J
Title: BAX inhibitor-1 regulates autophagy by controlling the IRE1α branch of the unfolded protein response.
Volume: 30
Issue: 21
Pages: 4465-78
Publication  
First Author: Krahe TE
Year: 2015
Journal: Brain Res
Title: Hyperactivity and depression-like traits in Bax KO mice.
Volume: 1625
Pages: 246-54
Publication
First Author: Liang M
Year: 2008
Journal: J Bone Miner Res
Title: Bim, Bak, and Bax regulate osteoblast survival.
Volume: 23
Issue: 5
Pages: 610-20
Publication
First Author: Whelan RS
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Bax regulates primary necrosis through mitochondrial dynamics.
Volume: 109
Issue: 17
Pages: 6566-71
Publication
First Author: Knudson CM
Year: 1997
Journal: Nat Genet
Title: Bcl-2 and Bax function independently to regulate cell death.
Volume: 16
Issue: 4
Pages: 358-63
Publication
First Author: Dargusch R
Year: 2001
Journal: J Neurochem
Title: The role of Bax in glutamate-induced nerve cell death.
Volume: 76
Issue: 1
Pages: 295-301
Publication
First Author: Coulpier M
Year: 2006
Journal: Neurobiol Dis
Title: Bax deletion does not protect neurons from BSE-induced death.
Volume: 23
Issue: 3
Pages: 603-11
Publication
First Author: Upton JP
Year: 2007
Journal: Cell Death Differ
Title: The N-terminal conformation of Bax regulates cell commitment to apoptosis.
Volume: 14
Issue: 5
Pages: 932-42
Publication
First Author: Yin C
Year: 1997
Journal: Nature
Title: Bax suppresses tumorigenesis and stimulates apoptosis in vivo.
Volume: 385
Issue: 6617
Pages: 637-40
Publication
First Author: Valentijn AJ
Year: 2003
Journal: J Cell Biol
Title: Spatial and temporal changes in Bax subcellular localization during anoikis.
Volume: 162
Issue: 4
Pages: 599-612
Publication
First Author: Chin HS
Year: 2018
Journal: Nat Commun
Title: VDAC2 enables BAX to mediate apoptosis and limit tumor development.
Volume: 9
Issue: 1
Pages: 4976
Publication
First Author: Karbowski M
Year: 2006
Journal: Nature
Title: Role of Bax and Bak in mitochondrial morphogenesis.
Volume: 443
Issue: 7112
Pages: 658-62
Publication
First Author: Khaled AR
Year: 2002
Journal: Immunity
Title: Bax deficiency partially corrects interleukin-7 receptor alpha deficiency.
Volume: 17
Issue: 5
Pages: 561-73
Publication
First Author: Ruiz-Vela A
Year: 2005
Journal: EMBO Rep
Title: Proapoptotic BAX and BAK control multiple initiator caspases.
Volume: 6
Issue: 4
Pages: 379-85
Publication  
First Author: Luedke AC
Year: 2013
Journal: Behav Brain Res
Title: Altered anxiety and defensive behaviors in Bax knockout mice.
Volume: 239
Pages: 115-20
Publication
First Author: Li R
Year: 2017
Journal: Cancer Res
Title: Modulation of Bax and mTOR for Cancer Therapeutics.
Volume: 77
Issue: 11
Pages: 3001-3012
Publication
First Author: Wang Z
Year: 2013
Journal: Mol Cell Biol
Title: Nucleophosmin, a critical Bax cofactor in ischemia-induced cell death.
Volume: 33
Issue: 10
Pages: 1916-24
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Publication
First Author: Dewson G
Year: 2012
Journal: Cell Death Differ
Title: Bax dimerizes via a symmetric BH3:groove interface during apoptosis.
Volume: 19
Issue: 4
Pages: 661-70
Publication
First Author: Teijido O
Year: 2010
Journal: FEBS Lett
Title: Upregulation of Bcl2 inhibits apoptosis-driven BAX insertion but favors BAX relocalization in mitochondria.
Volume: 584
Issue: 15
Pages: 3305-10
Publication
First Author: Forger NG
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Deletion of Bax eliminates sex differences in the mouse forebrain.
Volume: 101
Issue: 37
Pages: 13666-71
Publication
First Author: Hochhauser E
Year: 2003
Journal: Am J Physiol Heart Circ Physiol
Title: Bax ablation protects against myocardial ischemia-reperfusion injury in transgenic mice.
Volume: 284
Issue: 6
Pages: H2351-9
Publication
First Author: Heitz S
Year: 2007
Journal: Dev Neurobiol
Title: BAX contributes to Doppel-induced apoptosis of prion-protein-deficient Purkinje cells.
Volume: 67
Issue: 5
Pages: 670-86
Publication
First Author: Degenhardt K
Year: 2002
Journal: J Biol Chem
Title: Bax and Bak independently promote cytochrome C release from mitochondria.
Volume: 277
Issue: 16
Pages: 14127-34
Publication
First Author: Comitato A
Year: 2014
Journal: Invest Ophthalmol Vis Sci
Title: Activation of Bax in three models of retinitis pigmentosa.
Volume: 55
Issue: 6
Pages: 3555-62
Publication
First Author: Bax B
Year: 2001
Journal: Structure
Title: The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation.
Volume: 9
Issue: 12
Pages: 1143-52
Publication
First Author: Lindenboim L
Year: 2005
Journal: Cell Death Differ
Title: Bak but not Bax is essential for Bcl-xS-induced apoptosis.
Volume: 12
Issue: 7
Pages: 713-23
Publication
First Author: Cao X
Year: 2003
Journal: Blood
Title: Cleavage of Bax to p18 Bax accelerates stress-induced apoptosis, and a cathepsin-like protease may rapidly degrade p18 Bax.
Volume: 102
Issue: 7
Pages: 2605-14
Publication
First Author: Cabon L
Year: 2012
Journal: Cell Death Differ
Title: BID regulates AIF-mediated caspase-independent necroptosis by promoting BAX activation.
Volume: 19
Issue: 2
Pages: 245-56
Publication
First Author: Deckwerth TL
Year: 1996
Journal: Neuron
Title: BAX is required for neuronal death after trophic factor deprivation and during development.
Volume: 17
Issue: 3
Pages: 401-11
Publication
First Author: Igata E
Year: 1999
Journal: Gene
Title: Molecular cloning and functional analysis of the murine bax gene promoter.
Volume: 238
Issue: 2
Pages: 407-15
Publication
First Author: Teles AV
Year: 2008
Journal: Neurosci Lett
Title: Increase in bax expression and apoptosis are associated in Huntington's disease progression.
Volume: 438
Issue: 1
Pages: 59-63
Publication
First Author: Sung TC
Year: 2015
Journal: Structure
Title: Solution Structure of Apoptotic BAX Oligomer: Oligomerization Likely Precedes Membrane Insertion.
Volume: 23
Issue: 10
Pages: 1878-88
Publication
First Author: Haferkamp B
Year: 2012
Journal: J Biol Chem
Title: BaxΔ2 is a novel bax isoform unique to microsatellite unstable tumors.
Volume: 287
Issue: 41
Pages: 34722-9
Protein
Organism: Mus musculus/domesticus
Length: 125  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 206  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 224  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 302  
Fragment?: false
Publication
First Author: Bruckheimer EM
Year: 2000
Journal: Oncogene
Title: The impact of bcl-2 expression and bax deficiency on prostate homeostasis in vivo.
Volume: 19
Issue: 20
Pages: 2404-12
Publication
First Author: Jürgensmeier JM
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: Bax directly induces release of cytochrome c from isolated mitochondria.
Volume: 95
Issue: 9
Pages: 4997-5002
Publication    
First Author: Chi X
Year: 2020
Journal: Elife
Title: The carboxyl-terminal sequence of bim enables bax activation and killing of unprimed cells.
Volume: 9
Publication
First Author: Clayton KB
Year: 2012
Journal: J Neurosci
Title: NP1 regulates neuronal activity-dependent accumulation of BAX in mitochondria and mitochondrial dynamics.
Volume: 32
Issue: 4
Pages: 1453-66
Publication
First Author: Gotoh T
Year: 2004
Journal: Cell Death Differ
Title: hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria.
Volume: 11
Issue: 4
Pages: 390-402
Publication
First Author: Lindsten T
Year: 2006
Journal: Cell Death Differ
Title: Cell death in the absence of Bax and Bak.
Volume: 13
Issue: 8
Pages: 1272-6
Publication
First Author: Tam BT
Year: 2018
Journal: Sci Rep
Title: Ablation of Bax and Bak protects skeletal muscle against pressure-induced injury.
Volume: 8
Issue: 1
Pages: 3689
Publication
First Author: Robinson AM
Year: 2003
Journal: Neuroreport
Title: Olfactory neurons in bax knockout mice are protected from bulbectomy-induced apoptosis.
Volume: 14
Issue: 15
Pages: 1891-4
Publication    
First Author: Karch J
Year: 2017
Journal: Elife
Title: Autophagic cell death is dependent on lysosomal membrane permeability through Bax and Bak.
Volume: 6
Publication
First Author: Hauseman ZJ
Year: 2020
Journal: Mol Cell
Title: Homogeneous Oligomers of Pro-apoptotic BAX Reveal Structural Determinants of Mitochondrial Membrane Permeabilization.
Volume: 79
Issue: 1
Pages: 68-83.e7
Publication
First Author: Rathmell JC
Year: 2002
Journal: Nat Immunol
Title: Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis.
Volume: 3
Issue: 10
Pages: 932-9
Publication
First Author: Zaman F
Year: 2012
Journal: PLoS One
Title: Ablation of the pro-apoptotic protein Bax protects mice from glucocorticoid-induced bone growth impairment.
Volume: 7
Issue: 3
Pages: e33168
Publication
First Author: Jiao S
Year: 2011
Journal: Neuron
Title: Nonapoptotic function of BAD and BAX in long-term depression of synaptic transmission.
Volume: 70
Issue: 4
Pages: 758-72