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Search results 1 to 100 out of 2356 for Bax

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
394793 | bax
Type: gene
Organism: frog, western clawed
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Gene
581 | BAX
Type: gene
Organism: human
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Gene
24887 | Bax
Type: gene
Organism: rat
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Gene
403523 | BAX
Type: gene
Organism: dog, domestic
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Gene
747093 | BAX
Type: gene
Organism: chimpanzee
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Gene
280730 | BAX
Type: gene
Organism: cattle
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Gene
718948 | BAX
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR026304 | BAX
Type: Family
Description: B cell CLL/lymphoma-2 (Bcl-2) and related proteins comprise the Bcl-2 family. Bcl-2 proteins are central regulators of caspase activation, and play a key role in cell death by regulating the integrity of the mitochondrial and endoplasmic reticulum (ER) membranes []. Though originally characterised with respect to their roles in controlling outer mitochondrial membrane integrity and apoptosis, the members of the Bcl-2 family are involved in numerous cellular pathways [].Bcl-2 and its relatives are functionally classified as either antiapoptoticor proapoptotic. All members contain at least one of four conserved motifs, termed Bcl-2 Homology (BH) domains. Antiapoptotic BCL-2 proteins contain four Bcl-2 homology domains (BH1-4). The major antiapoptotic proteins are Bcl-2-related gene A1 (A1), Bcl-2, Bcl-2-related gene, long isoform (Bcl-xL), Bcl-w, and myeloid cell leukemia 1 (MCL-1). They preserve outer mitochondrial membrane (OMM) integrity by directly inhibiting the proapoptotic Bcl-2 proteins [].The proapoptotic Bcl-2 members are divided into the effector proteins and the BH3-only proteins. The effector proteins Bcl-2 antagonist killer 1 (BAK) and Bcl-2-associated x protein (BAX) were originally described to contain only BH1-3; however, structure-based alignments revealed a conserved BH4 motif []. Upon activation BAK and BAX homo-oligomerise into proteolipid pores within the OMM to promote MOMP (mitochondrial outer membrane permeabilisation). The BH3-only proteins function in distinct cellular stress scenarios and are subdivided based on their ability to interact with the antiapoptotic or both the antiapoptotic and the effector proteins [].Bcl-2-associated x protein (BAX) is a proapoptotic member of the Bcl-2 family. It accelerates programmed cell death by binding to, and antagonising the apoptosis repressor Bcl2 [, ].
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HT Sample
Bax
 
Organism Name: mouse, laboratory
Sex: Male
Age: postnatal day 56
Stage: 28
Structure . Name: testis
Curation Status: Curated
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Protein Coding Gene
MGI:99702 | Bax
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
8358790 | J:19076
First Author: Oltvai ZN
Year: 1993
Journal: Cell
Title: Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death.
Volume: 74
Issue: 4
Pages: 609-19
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Publication
21060336 | -
First Author: Ku B
Year: 2011
Journal: Cell Res
Title: Evidence that inhibition of BAX activation by BCL-2 involves its tight and preferential interaction with the BH3 domain of BAX.
Volume: 21
Issue: 4
Pages: 627-41
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Protein
Q07813
Organism: Mus musculus/domesticus
Length: 192  
Fragment?: false
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Protein
A0A1B0GS13
Organism: Mus musculus/domesticus
Length: 114  
Fragment?: true
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Protein
A0A1B0GT35
Organism: Mus musculus/domesticus
Length: 74  
Fragment?: true
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GXD Expression
GXD Expression
 
Probe: MGI:5500011
Assay Type: Immunohistochemistry
Annotation Date: 2013-08-08
Strength: Present
Sex: Female
Emaps: EMAPS:1796521
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:5500062
Age: embryonic day 13.5
Image: 5C BAX Female
Specimen Label: 5C BAX Female
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:5500011
Assay Type: Immunohistochemistry
Annotation Date: 2013-08-08
Strength: Present
Sex: Male
Emaps: EMAPS:1797521
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:5500062
Age: embryonic day 13.5
Image: 5C BAX Male
Specimen Label: 5C BAX Male
Detected: true
Specimen Num: 1
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Protein
A0A1B0GT81
Organism: Mus musculus/domesticus
Length: 171  
Fragment?: false
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Protein
A0A1B0GTA4
Organism: Mus musculus/domesticus
Length: 172  
Fragment?: true
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GXD Expression
GXD Expression
     
Probe: MGI:1329383
Assay Type: RT-PCR
Annotation Date: 1999-02-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360464
Stage: TS04
Assay Id: MGI:1329452
Age: embryonic day 4.0
Specimen Label: Bax
Detected: true
Specimen Num: 1
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Publication
18551131 | -
First Author: Kvansakul M
Year: 2008
Journal: Cell Death Differ
Title: Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligands.
Volume: 15
Issue: 10
Pages: 1564-71
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Publication
20159550 | -
First Author: Chipuk JE
Year: 2010
Journal: Mol Cell
Title: The BCL-2 family reunion.
Volume: 37
Issue: 3
Pages: 299-310
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Protein
A0A165ELP6
Organism: Mus musculus/domesticus
Length: 139  
Fragment?: true
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Protein
Q8K3J2
Organism: Mus musculus/domesticus
Length: 173  
Fragment?: false
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Protein
Q3TXJ7
Organism: Mus musculus/domesticus
Length: 192  
Fragment?: false
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Protein
Q544Z6
Organism: Mus musculus/domesticus
Length: 192  
Fragment?: false
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Publication
12631689 | -
First Author: Germain M
Year: 2003
Journal: Sci STKE
Title: Cellular distribution of Bcl-2 family proteins.
Volume: 2003
Issue: 173
Pages: pe10
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GXD Expression
GXD Expression
 
Probe: MGI:5500009
Assay Type: Immunohistochemistry
Annotation Date: 2013-08-08
Strength: Present
Sex: Female
Emaps: EMAPS:1796521
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:5500039
Age: embryonic day 13.5
Image: 5C BAX Female
Specimen Label: 5C BAX Female
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:5500009
Assay Type: Immunohistochemistry
Annotation Date: 2013-08-08
Strength: Present
Sex: Male
Emaps: EMAPS:1797521
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:5500039
Age: embryonic day 13.5
Image: 5C BAX Male
Specimen Label: 5C BAX Male
Detected: true
Specimen Num: 4
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Protein
E0CX98
Organism: Mus musculus/domesticus
Length: 235  
Fragment?: true
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Protein
A0A2R8W6Y1
Organism: Mus musculus/domesticus
Length: 193  
Fragment?: true
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Protein
E0CXR0
Organism: Mus musculus/domesticus
Length: 204  
Fragment?: true
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Publication
17018574 | -
First Author: Bax R
Year: 2006
Journal: RNA
Title: Slx9p facilitates efficient ITS1 processing of pre-rRNA in Saccharomyces cerevisiae.
Volume: 12
Issue: 11
Pages: 2005-13
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GXD Expression
GXD Expression
     
Probe: MGI:5295249
Assay Type: Immunohistochemistry
Annotation Date: 2011-11-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1616417
Stage: TS17
Assay Id: MGI:5295631
Age: embryonic day 10.5
Specimen Label: 6I Bax wt
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:5295249
Assay Type: Immunohistochemistry
Annotation Date: 2011-11-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1616417
Stage: TS17
Assay Id: MGI:5295631
Age: embryonic day 10.5
Specimen Label: 6I Bax wt
Detected: false
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:5295249
Assay Type: Immunohistochemistry
Annotation Date: 2011-11-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1616417
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:5295631
Age: embryonic day 10.5
Specimen Label: 6I Bax L24 Bst/+
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:5295249
Assay Type: Immunohistochemistry
Annotation Date: 2011-11-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1616417
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:5295631
Age: embryonic day 10.5
Specimen Label: 6I Bax L24 Bst/+
Detected: true
Specimen Num: 4
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Protein
Q9D2C7
Organism: Mus musculus/domesticus
Length: 237  
Fragment?: false
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Publication
25632145 | J:218973
First Author: D'Orsi B
Year: 2015
Journal: J Neurosci
Title: Bax regulates neuronal Ca2+ homeostasis.
Volume: 35
Issue: 4
Pages: 1706-22
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Publication
20658695 | J:162870
First Author: Bax NA
Year: 2010
Journal: Dev Dyn
Title: Cardiac malformations in Pdgfralpha mutant embryos are associated with increased expression of WT1 and Nkx2.5 in the second heart field.
Volume: 239
Issue: 8
Pages: 2307-17
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Publication
9351801 | -
First Author: Bax B
Year: 1997
Journal: Structure
Title: Structure of mouse 7S NGF: a complex of nerve growth factor with four binding proteins.
Volume: 5
Issue: 10
Pages: 1275-85
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Publication
17616717 | J:122810
First Author: Greenfeld CR
Year: 2007
Journal: Reproduction
Title: BAX regulates follicular endowment in mice.
Volume: 133
Issue: 5
Pages: 865-76
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Publication
15304216 | J:91831
First Author: Chae HJ
Year: 2004
Journal: Mol Cell
Title: BI-1 regulates an apoptosis pathway linked to endoplasmic reticulum stress.
Volume: 15
Issue: 3
Pages: 355-66
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Publication
11212265 | J:67325
First Author: Knudson CM
Year: 2001
Journal: Cancer Res
Title: Bax accelerates tumorigenesis in p53-deficient mice.
Volume: 61
Issue: 2
Pages: 659-65
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Publication
9454845 | J:45765
First Author: Xiang H
Year: 1998
Journal: J Neurosci
Title: Bax involvement in p53-mediated neuronal cell death.
Volume: 18
Issue: 4
Pages: 1363-73
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Publication
21926971 | J:180014
First Author: Castillo K
Year: 2011
Journal: EMBO J
Title: BAX inhibitor-1 regulates autophagy by controlling the IRE1α branch of the unfolded protein response.
Volume: 30
Issue: 21
Pages: 4465-78
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Publication
26363094 | J:229099
 
First Author: Krahe TE
Year: 2015
Journal: Brain Res
Title: Hyperactivity and depression-like traits in Bax KO mice.
Volume: 1625
Pages: 246-54
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Publication
18251703 | J:150167
First Author: Liang M
Year: 2008
Journal: J Bone Miner Res
Title: Bim, Bak, and Bax regulate osteoblast survival.
Volume: 23
Issue: 5
Pages: 610-20
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Publication
22493254 | J:183839
First Author: Whelan RS
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Bax regulates primary necrosis through mitochondrial dynamics.
Volume: 109
Issue: 17
Pages: 6566-71
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Publication
9241272 | J:42051
First Author: Knudson CM
Year: 1997
Journal: Nat Genet
Title: Bcl-2 and Bax function independently to regulate cell death.
Volume: 16
Issue: 4
Pages: 358-63
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Publication
17273174 | J:139275
First Author: Upton JP
Year: 2007
Journal: Cell Death Differ
Title: The N-terminal conformation of Bax regulates cell commitment to apoptosis.
Volume: 14
Issue: 5
Pages: 932-42
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Publication
11146002 | J:68970
First Author: Dargusch R
Year: 2001
Journal: J Neurochem
Title: The role of Bax in glutamate-induced nerve cell death.
Volume: 76
Issue: 1
Pages: 295-301
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Publication
16854590 | J:147030
First Author: Coulpier M
Year: 2006
Journal: Neurobiol Dis
Title: Bax deletion does not protect neurons from BSE-induced death.
Volume: 23
Issue: 3
Pages: 603-11
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Publication
39307450 | J:358457
 
First Author: Sheibani N
Year: 2024
Journal: Exp Eye Res
Title: Bax expression impacts postnatal retinal vascular development and hyperoxia sensitivity.
Volume: 248
Pages: 110107
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Publication
9024662 | J:38331
First Author: Yin C
Year: 1997
Journal: Nature
Title: Bax suppresses tumorigenesis and stimulates apoptosis in vivo.
Volume: 385
Issue: 6617
Pages: 637-40
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Publication
30478310 | J:267574
First Author: Chin HS
Year: 2018
Journal: Nat Commun
Title: VDAC2 enables BAX to mediate apoptosis and limit tumor development.
Volume: 9
Issue: 1
Pages: 4976
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Publication
12433363 | J:93139
First Author: Khaled AR
Year: 2002
Journal: Immunity
Title: Bax deficiency partially corrects interleukin-7 receptor alpha deficiency.
Volume: 17
Issue: 5
Pages: 561-73
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Publication
15776018 | J:97306
First Author: Ruiz-Vela A
Year: 2005
Journal: EMBO Rep
Title: Proapoptotic BAX and BAK control multiple initiator caspases.
Volume: 6
Issue: 4
Pages: 379-85
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Publication
17035996 | J:113296
First Author: Karbowski M
Year: 2006
Journal: Nature
Title: Role of Bax and Bak in mitochondrial morphogenesis.
Volume: 443
Issue: 7112
Pages: 658-62
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Publication
23142367 | J:197074
 
First Author: Luedke AC
Year: 2013
Journal: Behav Brain Res
Title: Altered anxiety and defensive behaviors in Bax knockout mice.
Volume: 239
Pages: 115-20
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Publication
28381544 | J:242296
First Author: Li R
Year: 2017
Journal: Cancer Res
Title: Modulation of Bax and mTOR for Cancer Therapeutics.
Volume: 77
Issue: 11
Pages: 3001-3012
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Publication
12925707 | J:86030
First Author: Valentijn AJ
Year: 2003
Journal: J Cell Biol
Title: Spatial and temporal changes in Bax subcellular localization during anoikis.
Volume: 162
Issue: 4
Pages: 599-612
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Publication
23459946 | J:203748
First Author: Wang Z
Year: 2013
Journal: Mol Cell Biol
Title: Nucleophosmin, a critical Bax cofactor in ischemia-induced cell death.
Volume: 33
Issue: 10
Pages: 1916-24
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Gene
7009 | TMBIM6
Type: gene
Organism: human
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Gene
64114 | TMBIM1
Type: gene
Organism: human
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Gene
51643 | TMBIM4
Type: gene
Organism: human
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Gene
105375396 | TMBIM7P
Type: gene
Organism: human
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Gene
119369034 | LOC119369034
Type: gene
Organism: human
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Publication
22015607 | J:203074
First Author: Dewson G
Year: 2012
Journal: Cell Death Differ
Title: Bax dimerizes via a symmetric BH3:groove interface during apoptosis.
Volume: 19
Issue: 4
Pages: 661-70
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Publication
20621101 | J:201305
First Author: Teijido O
Year: 2010
Journal: FEBS Lett
Title: Upregulation of Bcl2 inhibits apoptosis-driven BAX insertion but favors BAX relocalization in mitochondria.
Volume: 584
Issue: 15
Pages: 3305-10
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Publication
12742833 | J:83909
First Author: Hochhauser E
Year: 2003
Journal: Am J Physiol Heart Circ Physiol
Title: Bax ablation protects against myocardial ischemia-reperfusion injury in transgenic mice.
Volume: 284
Issue: 6
Pages: H2351-9
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Publication
15342910 | J:92614
First Author: Forger NG
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Deletion of Bax eliminates sex differences in the mouse forebrain.
Volume: 101
Issue: 37
Pages: 13666-71
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Publication
11836241 | J:76058
First Author: Degenhardt K
Year: 2002
Journal: J Biol Chem
Title: Bax and Bak independently promote cytochrome C release from mitochondria.
Volume: 277
Issue: 16
Pages: 14127-34
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Publication
17443816 | J:241692
First Author: Heitz S
Year: 2007
Journal: Dev Neurobiol
Title: BAX contributes to Doppel-induced apoptosis of prion-protein-deficient Purkinje cells.
Volume: 67
Issue: 5
Pages: 670-86
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Publication
11738041 | -
First Author: Bax B
Year: 2001
Journal: Structure
Title: The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation.
Volume: 9
Issue: 12
Pages: 1143-52
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Publication
15861188 | J:111864
First Author: Lindenboim L
Year: 2005
Journal: Cell Death Differ
Title: Bak but not Bax is essential for Bcl-xS-induced apoptosis.
Volume: 12
Issue: 7
Pages: 713-23
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Publication
24825107 | J:230024
First Author: Comitato A
Year: 2014
Journal: Invest Ophthalmol Vis Sci
Title: Activation of Bax in three models of retinitis pigmentosa.
Volume: 55
Issue: 6
Pages: 3555-62
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Protein
A0A0G2JFN2
Organism: Mus musculus/domesticus
Length: 125  
Fragment?: true
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Protein
F7AB47
Organism: Mus musculus/domesticus
Length: 206  
Fragment?: true
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Protein
Q9D561
Organism: Mus musculus/domesticus
Length: 224  
Fragment?: false
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Protein
Q9D592
Organism: Mus musculus/domesticus
Length: 302  
Fragment?: false
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Publication
12816867 | J:85839
First Author: Cao X
Year: 2003
Journal: Blood
Title: Cleavage of Bax to p18 Bax accelerates stress-induced apoptosis, and a cathepsin-like protease may rapidly degrade p18 Bax.
Volume: 102
Issue: 7
Pages: 2605-14
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Publication
21738214 | J:203086
First Author: Cabon L
Year: 2012
Journal: Cell Death Differ
Title: BID regulates AIF-mediated caspase-independent necroptosis by promoting BAX activation.
Volume: 19
Issue: 2
Pages: 245-56
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Publication
10570968 | J:58225
First Author: Igata E
Year: 1999
Journal: Gene
Title: Molecular cloning and functional analysis of the murine bax gene promoter.
Volume: 238
Issue: 2
Pages: 407-15
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Publication
26299946 | J:247394
First Author: Sung TC
Year: 2015
Journal: Structure
Title: Solution Structure of Apoptotic BAX Oligomer: Oligomerization Likely Precedes Membrane Insertion.
Volume: 23
Issue: 10
Pages: 1878-88
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Publication
8816704 | J:35372
First Author: Deckwerth TL
Year: 1996
Journal: Neuron
Title: BAX is required for neuronal death after trophic factor deprivation and during development.
Volume: 17
Issue: 3
Pages: 401-11
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Publication
18468793 | J:136970
First Author: Teles AV
Year: 2008
Journal: Neurosci Lett
Title: Increase in bax expression and apoptosis are associated in Huntington's disease progression.
Volume: 438
Issue: 1
Pages: 59-63
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Publication
22910913 | J:192965
First Author: Haferkamp B
Year: 2012
Journal: J Biol Chem
Title: BaxΔ2 is a novel bax isoform unique to microsatellite unstable tumors.
Volume: 287
Issue: 41
Pages: 34722-9
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Publication
10828882 | J:62297
First Author: Bruckheimer EM
Year: 2000
Journal: Oncogene
Title: The impact of bcl-2 expression and bax deficiency on prostate homeostasis in vivo.
Volume: 19
Issue: 20
Pages: 2404-12
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Publication
9560217 | J:47609
First Author: Jürgensmeier JM
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: Bax directly induces release of cytochrome c from isolated mitochondria.
Volume: 95
Issue: 9
Pages: 4997-5002
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Publication
14752510 | J:233583
First Author: Gotoh T
Year: 2004
Journal: Cell Death Differ
Title: hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria.
Volume: 11
Issue: 4
Pages: 390-402
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Publication
16676001 | J:126409
First Author: Lindsten T
Year: 2006
Journal: Cell Death Differ
Title: Cell death in the absence of Bax and Bak.
Volume: 13
Issue: 8
Pages: 1272-6
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Publication
14561915 | J:89724
First Author: Robinson AM
Year: 2003
Journal: Neuroreport
Title: Olfactory neurons in bax knockout mice are protected from bulbectomy-induced apoptosis.
Volume: 14
Issue: 15
Pages: 1891-4
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Publication
29487339 | J:278546
First Author: Tam BT
Year: 2018
Journal: Sci Rep
Title: Ablation of Bax and Bak protects skeletal muscle against pressure-induced injury.
Volume: 8
Issue: 1
Pages: 3689
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Publication
12244308 | J:79218
First Author: Rathmell JC
Year: 2002
Journal: Nat Immunol
Title: Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis.
Volume: 3
Issue: 10
Pages: 932-9
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Publication
22279230 | J:180579
First Author: Clayton KB
Year: 2012
Journal: J Neurosci
Title: NP1 regulates neuronal activity-dependent accumulation of BAX in mitochondria and mitochondrial dynamics.
Volume: 32
Issue: 4
Pages: 1453-66
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Publication
31976859 | J:305519
   
First Author: Chi X
Year: 2020
Journal: Elife
Title: The carboxyl-terminal sequence of bim enables bax activation and killing of unprimed cells.
Volume: 9
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Publication
29148970 | J:254971
   
First Author: Karch J
Year: 2017
Journal: Elife
Title: Autophagic cell death is dependent on lysosomal membrane permeability through Bax and Bak.
Volume: 6
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Publication
32533918 | J:297175
First Author: Hauseman ZJ
Year: 2020
Journal: Mol Cell
Title: Homogeneous Oligomers of Pro-apoptotic BAX Reveal Structural Determinants of Mitochondrial Membrane Permeabilization.
Volume: 79
Issue: 1
Pages: 68-83.e7
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Publication
22442678 | J:187038
First Author: Zaman F
Year: 2012
Journal: PLoS One
Title: Ablation of the pro-apoptotic protein Bax protects mice from glucocorticoid-induced bone growth impairment.
Volume: 7
Issue: 3
Pages: e33168
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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