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Search results 1 to 100 out of 379 for Bbc3

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0.042s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Domain
Type: Family
Description: PUMA (p53 upregulated modulator of apoptosis), also known as Bbc3 (Bcl-2-binding component 3), is a critical mediator of p53-dependent and -independent apoptosis []. PUMA transduces death signals primarily to the mitochondria. It is induced in cells after p53 activation. It binds to Bcl-2, localises to the mitochondria to induce cytochrome c release, and activates the rapid induction of apoptosis []. PUMA is capable of inhibiting all the five major anti-apoptotic Bcl-2-like proteins (Mcl-1, Bcl-2, Bcl-XL, Bcl-W and A1) []. The binding of PUMA to the inhibitory members of the Bcl-2 family via its BH3 domain results in the displacement of the proteins Bax and/or Bak, and seems to be a critical regulatory step in the induction of apoptosis [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication  
First Author: Harder JM
Year: 2011
Journal: Mol Neurodegener
Title: BBC3 (PUMA) regulates developmental apoptosis but not axonal injury induced death in the retina.
Volume: 6
Pages: 50
Publication
First Author: Harder JM
Year: 2013
Journal: Cell Death Differ
Title: Deficiency in Bim, Bid and Bbc3 (Puma) do not prevent axonal injury induced death.
Volume: 20
Issue: 1
Pages: 182
Protein
Organism: Mus musculus/domesticus
Length: 193  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 128  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 91  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 193  
Fragment?: false
Publication
First Author: Nakano K
Year: 2001
Journal: Mol Cell
Title: PUMA, a novel proapoptotic gene, is induced by p53.
Volume: 7
Issue: 3
Pages: 683-94
Publication  
First Author: Yu J
Year: 2008
Journal: Oncogene
Title: PUMA, a potent killer with or without p53.
Volume: 27 Suppl 1
Pages: S71-83
Publication
First Author: Hikisz P
Year: 2012
Journal: Cell Mol Biol Lett
Title: PUMA, a critical mediator of cell death--one decade on from its discovery.
Volume: 17
Issue: 4
Pages: 646-69
Publication
First Author: Zhang Y
Year: 2016
Journal: Autophagy
Title: Mir143-BBC3 cascade reduces microglial survival via interplay between apoptosis and autophagy: Implications for methamphetamine-mediated neurotoxicity.
Volume: 12
Issue: 9
Pages: 1538-59
Publication
First Author: Omori K
Year: 2016
Journal: Am J Physiol Endocrinol Metab
Title: Involvement of a proapoptotic gene (BBC3) in islet injury mediated by cold preservation and rewarming.
Volume: 310
Issue: 11
Pages: E1016-26
Publication
First Author: Han J
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals.
Volume: 98
Issue: 20
Pages: 11318-23
Publication  
First Author: Ulmke PA
Year: 2021
Journal: Development
Title: Post-transcriptional regulation by the exosome complex is required for cell survival and forebrain development via repression of P53 signaling.
Volume: 148
Issue: 3
Publication
First Author: Myers M
Year: 2014
Journal: Reproduction
Title: PUMA regulates germ cell loss and primordial follicle endowment in mice.
Volume: 148
Issue: 2
Pages: 211-9
Publication
First Author: Hamard PJ
Year: 2013
Journal: Genes Dev
Title: The C terminus of p53 regulates gene expression by multiple mechanisms in a target- and tissue-specific manner in vivo.
Volume: 27
Issue: 17
Pages: 1868-85
Publication
First Author: Klimovich B
Year: 2020
Journal: Cell Cycle
Title: Inactivation of Mdm2 restores apoptosis proficiency of cooperativity mutant p53 in vivo.
Volume: 19
Issue: 1
Pages: 109-123
Publication
First Author: Mérino D
Year: 2012
Journal: Blood
Title: Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells.
Volume: 119
Issue: 24
Pages: 5807-16
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Wang P
Year: 2009
Journal: Cell Death Differ
Title: PUMA is directly activated by NF-kappaB and contributes to TNF-alpha-induced apoptosis.
Volume: 16
Issue: 9
Pages: 1192-202
Publication
First Author: Garrison SP
Year: 2010
Journal: PLoS Pathog
Title: The p53-target gene puma drives neutrophil-mediated protection against lethal bacterial sepsis.
Volume: 6
Issue: 12
Pages: e1001240
Publication
First Author: Toth A
Year: 2006
Journal: Am J Physiol Heart Circ Physiol
Title: Targeted deletion of Puma attenuates cardiomyocyte death and improves cardiac function during ischemia-reperfusion.
Volume: 291
Issue: 1
Pages: H52-60
Publication
First Author: Garrison SP
Year: 2008
Journal: Mol Cell Biol
Title: Selection against PUMA gene expression in Myc-driven B-cell lymphomagenesis.
Volume: 28
Issue: 17
Pages: 5391-402
Publication
First Author: Clybouw C
Year: 2011
Journal: Blood
Title: Regulation of memory B-cell survival by the BH3-only protein Puma.
Volume: 118
Issue: 15
Pages: 4120-8
Publication
First Author: Engel T
Year: 2010
Journal: Neuroscience
Title: Deletion of Puma protects hippocampal neurons in a model of severe status epilepticus.
Volume: 168
Issue: 2
Pages: 443-50
Publication
First Author: Kuroki K
Year: 2009
Journal: Neurosci Lett
Title: Effects of transient focal cerebral ischemia in mice deficient in puma.
Volume: 451
Issue: 3
Pages: 237-40
Publication
First Author: Kieran D
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Deletion of the BH3-only protein puma protects motoneurons from ER stress-induced apoptosis and delays motoneuron loss in ALS mice.
Volume: 104
Issue: 51
Pages: 20606-11
Publication
First Author: Michalak EM
Year: 2010
Journal: Genes Dev
Title: Apoptosis-promoted tumorigenesis: gamma-irradiation-induced thymic lymphomagenesis requires Puma-driven leukocyte death.
Volume: 24
Issue: 15
Pages: 1608-13
Publication  
First Author: Chen H
Year: 2015
Journal: Neuroscience
Title: PUMA is invovled in ischemia/reperfusion-induced apoptosis of mouse cerebral astrocytes.
Volume: 284
Pages: 824-32
Publication
First Author: Chen D
Year: 2019
Journal: Hepatology
Title: p53 Up-regulated Modulator of Apoptosis Induction Mediates Acetaminophen-Induced Necrosis and Liver Injury in Mice.
Volume: 69
Issue: 5
Pages: 2164-2179
Publication  
First Author: Yuan Q
Year: 2022
Journal: Front Pharmacol
Title: Disulfiram Protects Against Radiation-Induced Intestinal Injury in Mice.
Volume: 13
Pages: 852669
GXD Expression      
Probe: MGI:5660516
Assay Type: RT-PCR
Annotation Date: 2015-09-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:5660533
Age: embryonic day 8.5
Specimen Label: wild-type
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5660516
Assay Type: RT-PCR
Annotation Date: 2015-09-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:5660533
Age: embryonic day 8.5
Specimen Label: JMJD5-/-
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:5817979
Assay Type: RT-PCR
Annotation Date: 2017-01-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598827
Stage: TS27
Assay Id: MGI:5818011
Age: postnatal day 1
Image: 7
Specimen Label: Kbtbd5+/+
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5817979
Assay Type: RT-PCR
Annotation Date: 2017-01-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598827
Stage: TS27
Assay Id: MGI:5818011
Age: postnatal day 1
Image: 7
Specimen Label: Kbtbd5-/-
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:5817979
Assay Type: RT-PCR
Annotation Date: 2017-01-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598827
Stage: TS27
Assay Id: MGI:5818020
Age: postnatal day 1
Image: 8
Specimen Label: Kbtbd5+/+;E2F1-/-
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5817979
Assay Type: RT-PCR
Annotation Date: 2017-01-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598827
Stage: TS27
Assay Id: MGI:5818020
Age: postnatal day 1
Image: 8
Specimen Label: Kbtbd5-/-;E2F1-/-
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6214866
Assay Type: Western blot
Annotation Date: 2018-10-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603919
Stage: TS19
Assay Id: MGI:6214871
Age: embryonic day 11.5
Image: 5E
Specimen Label: 5E WT
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6214866
Assay Type: Western blot
Annotation Date: 2018-10-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603919
Stage: TS19
Assay Id: MGI:6214871
Age: embryonic day 11.5
Image: 5E
Specimen Label: 5E mut
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6379245
Assay Type: RT-PCR
Annotation Date: 2019-12-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:6379282
Age: embryonic day 9.5
Image: S2
Specimen Label: WT
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6379245
Assay Type: RT-PCR
Annotation Date: 2019-12-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:6379282
Age: embryonic day 9.5
Image: S2
Specimen Label: HET
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6383852
Assay Type: RT-PCR
Annotation Date: 2020-01-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3276028
Stage: TS28
Assay Id: MGI:6383872
Age: postnatal day 10
Image: S4
Specimen Label: 1
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6383852
Assay Type: RT-PCR
Annotation Date: 2020-01-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3276028
Stage: TS28
Assay Id: MGI:6383872
Age: postnatal day 10
Image: S4
Specimen Label: 2
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6383852
Assay Type: RT-PCR
Annotation Date: 2020-01-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3276028
Stage: TS28
Assay Id: MGI:6383872
Age: postnatal day 10
Image: S4
Specimen Label: 3
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6383852
Assay Type: RT-PCR
Annotation Date: 2020-01-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3276028
Stage: TS28
Assay Id: MGI:6383872
Age: postnatal day 10
Image: S4
Specimen Label: 4
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6383852
Assay Type: RT-PCR
Annotation Date: 2020-01-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:6383877
Age: postnatal day 10
Image: 6
Specimen Label: 1
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6383852
Assay Type: RT-PCR
Annotation Date: 2020-01-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:6383877
Age: postnatal day 10
Image: 6
Specimen Label: 2
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6383852
Assay Type: RT-PCR
Annotation Date: 2020-01-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:6383877
Age: postnatal day 10
Image: 6
Specimen Label: 3
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6383852
Assay Type: RT-PCR
Annotation Date: 2020-01-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:6383877
Age: postnatal day 10
Image: 6
Specimen Label: 4
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6383852
Assay Type: RT-PCR
Annotation Date: 2020-01-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6383883
Age: postnatal day 10
Image: 8
Specimen Label: 1
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6383852
Assay Type: RT-PCR
Annotation Date: 2020-01-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6383883
Age: postnatal day 10
Image: 8
Specimen Label: 2
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6383852
Assay Type: RT-PCR
Annotation Date: 2020-01-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6383883
Age: postnatal day 10
Image: 8
Specimen Label: 3
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6383852
Assay Type: RT-PCR
Annotation Date: 2020-01-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6383883
Age: postnatal day 10
Image: 8
Specimen Label: 4
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6383852
Assay Type: RT-PCR
Annotation Date: 2020-01-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:6383893
Age: postnatal day 10
Image: 9
Specimen Label: 1
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6383852
Assay Type: RT-PCR
Annotation Date: 2020-01-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:6383893
Age: postnatal day 10
Image: 9
Specimen Label: 2
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6383852
Assay Type: RT-PCR
Annotation Date: 2020-01-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:6383893
Age: postnatal day 10
Image: 9
Specimen Label: 3
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6383852
Assay Type: RT-PCR
Annotation Date: 2020-01-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:6383893
Age: postnatal day 10
Image: 9
Specimen Label: 4
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6383852
Assay Type: RT-PCR
Annotation Date: 2020-01-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684622
Stage: TS22
Assay Id: MGI:6383898
Age: embryonic day 14.5
Image: S5
Specimen Label: 1
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6383852
Assay Type: RT-PCR
Annotation Date: 2020-01-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684622
Stage: TS22
Assay Id: MGI:6383898
Age: embryonic day 14.5
Image: S5
Specimen Label: 2
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6383852
Assay Type: RT-PCR
Annotation Date: 2020-01-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684622
Stage: TS22
Assay Id: MGI:6383898
Age: embryonic day 14.5
Image: S5
Specimen Label: 3
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6383852
Assay Type: RT-PCR
Annotation Date: 2020-01-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:6383904
Age: postnatal day 10
Image: S6
Specimen Label: 1
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6383852
Assay Type: RT-PCR
Annotation Date: 2020-01-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:6383904
Age: postnatal day 10
Image: S6
Specimen Label: 2
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6383852
Assay Type: RT-PCR
Annotation Date: 2020-01-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:6383904
Age: postnatal day 10
Image: S6
Specimen Label: 3
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6383852
Assay Type: RT-PCR
Annotation Date: 2020-01-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:6383904
Age: postnatal day 10
Image: S6
Specimen Label: 4
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6383852
Assay Type: RT-PCR
Annotation Date: 2020-01-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267828
Stage: TS28
Assay Id: MGI:6383904
Age: postnatal day 10
Image: S6
Specimen Label: 1
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6383852
Assay Type: RT-PCR
Annotation Date: 2020-01-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267828
Stage: TS28
Assay Id: MGI:6383904
Age: postnatal day 10
Image: S6
Specimen Label: 2
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6383852
Assay Type: RT-PCR
Annotation Date: 2020-01-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267828
Stage: TS28
Assay Id: MGI:6383904
Age: postnatal day 10
Image: S6
Specimen Label: 3
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:6383852
Assay Type: RT-PCR
Annotation Date: 2020-01-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267828
Stage: TS28
Assay Id: MGI:6383904
Age: postnatal day 10
Image: S6
Specimen Label: 4
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:6383860
Assay Type: Western blot
Annotation Date: 2020-01-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:6383915
Age: postnatal day 10
Image: 6
Specimen Label: +/+
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6383860
Assay Type: Western blot
Annotation Date: 2020-01-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:6383915
Age: postnatal day 10
Image: 6
Specimen Label: delta/+
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6383860
Assay Type: Western blot
Annotation Date: 2020-01-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:6383915
Age: postnatal day 10
Image: 6
Specimen Label: delta/delta
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6383860
Assay Type: Western blot
Annotation Date: 2020-01-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:6383915
Age: postnatal day 10
Image: 6
Specimen Label: -/-
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6383860
Assay Type: Western blot
Annotation Date: 2020-01-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:6383920
Age: postnatal day 10
Image: 9
Specimen Label: +/+
Detected: true
Specimen Num: 1