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Search results 1 to 100 out of 335 for Bcar1

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0.041s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Domain
Type: Family
Description: Breast cancer anti-estrogen resistance protein 1 (BCAR1, also known as p130Cas) is a member of the Cas (Crk-associated substrate) family of adaptor proteins, which function as key signalling nodes with important regulatory roles in normal and pathological cells [, ]. BCAR1 plays a central coordinating role for tyrosine kinase-based signalling through focal adhesion kinase (FAK) []. It is readily phosphorylated by FAK and Src []. Overexpression of BCAR1 confers anti-estrogen resistance on breast cancer cells []. It regulates the tumour suppressor function of TGF-beta during breast cancer progression through regulation of Smad2/3 activity [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Publication
First Author: Wendt MK
Year: 2009
Journal: J Biol Chem
Title: p130Cas is required for mammary tumor growth and transforming growth factor-beta-mediated metastasis through regulation of Smad2/3 activity.
Volume: 284
Issue: 49
Pages: 34145-56
Publication
First Author: Cabodi S
Year: 2006
Journal: Cancer Res
Title: p130Cas as a new regulator of mammary epithelial cell proliferation, survival, and HER2-neu oncogene-dependent breast tumorigenesis.
Volume: 66
Issue: 9
Pages: 4672-80
Publication
First Author: Tikhmyanova N
Year: 2010
Journal: Cell Mol Life Sci
Title: CAS proteins in normal and pathological cell growth control.
Volume: 67
Issue: 7
Pages: 1025-48
Publication
First Author: Barrett A
Year: 2013
Journal: Cell Signal
Title: p130Cas: a key signalling node in health and disease.
Volume: 25
Issue: 4
Pages: 766-77
Protein
Organism: Mus musculus/domesticus
Length: 874  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 874  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 874  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 874  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 874  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 874  
Fragment?: false
GXD Expression    
Probe: MGI:6168414
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6189851
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Bcar1
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6168414
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6189851
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Bcar1
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6168414
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189851
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Bcar1
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6168414
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189851
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Bcar1
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6168414
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6189851
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Bcar1
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6168414
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6189851
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Bcar1
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6168414
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189851
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Bcar1
Detected: true
Specimen Num: 7
Publication
First Author: Shimizu T
Year: 2019
Journal: J Neurochem
Title: Mechanical regulation of oligodendrocyte morphology and maturation by the mechanosensor p130Cas.
Volume: 150
Issue: 2
Pages: 158-172
Publication
First Author: Brinkman A
Year: 2000
Journal: J Natl Cancer Inst
Title: BCAR1, a human homologue of the adapter protein p130Cas, and antiestrogen resistance in breast cancer cells.
Volume: 92
Issue: 2
Pages: 112-20
Publication
First Author: Mahmoud M
Year: 2022
Journal: Cardiovasc Res
Title: Bcar1/p130Cas is essential for ventricular development and neural crest cell remodelling of the cardiac outflow tract.
Volume: 118
Issue: 8
Pages: 1993-2005
Publication
First Author: Vahedi-Hunter TA
Year: 2018
Journal: Sci Rep
Title: Cas Adaptor Proteins Coordinate Sensory Axon Fasciculation.
Volume: 8
Issue: 1
Pages: 5996
Publication
First Author: Riccomagno MM
Year: 2014
Journal: Neuron
Title: Cas adaptor proteins organize the retinal ganglion cell layer downstream of integrin signaling.
Volume: 81
Issue: 4
Pages: 779-86
Publication
First Author: Wong W
Year: 2023
Journal: PLoS Biol
Title: An adhesion signaling axis involving Dystroglycan, β1-Integrin, and Cas adaptor proteins regulates the establishment of the cortical glial scaffold.
Volume: 21
Issue: 8
Pages: e3002212
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Wen Y
Year: 2022
Journal: Cell Rep
Title: Endothelial p130cas confers resistance to anti-angiogenesis therapy.
Volume: 38
Issue: 4
Pages: 110301
Publication
First Author: Akimoto T
Year: 2013
Journal: Am J Physiol Cell Physiol
Title: Skeletal muscle adaptation in response to mechanical stress in p130cas-/- mice.
Volume: 304
Issue: 6
Pages: C541-7
Publication  
First Author: Inoue A
Year: 2022
Journal: Bone
Title: Deletion of epithelial cell-specific p130Cas impairs the maturation stage of amelogenesis.
Volume: 154
Pages: 116210
Publication
First Author: Honda H
Year: 1998
Journal: Nat Genet
Title: Cardiovascular anomaly, impaired actin bundling and resistance to Src-induced transformation in mice lacking p130Cas.
Volume: 19
Issue: 4
Pages: 361-5
Publication
First Author: Iida M
Year: 2019
Journal: Nat Commun
Title: Src inhibition attenuates polyglutamine-mediated neuromuscular degeneration in spinal and bulbar muscular atrophy.
Volume: 10
Issue: 1
Pages: 4262
Publication
First Author: Casamassima A
Year: 1997
Journal: J Biol Chem
Title: Tyrosine phosphorylation of p130(cas) by bombesin, lysophosphatidic acid, phorbol esters, and platelet-derived growth factor. Signaling pathways and formation of a p130(cas)-Crk complex.
Volume: 272
Issue: 14
Pages: 9363-70
Publication
First Author: Dadke S
Year: 2002
Journal: Biochem J
Title: Interaction of protein tyrosine phosphatase (PTP) 1B with its substrates is influenced by two distinct binding domains.
Volume: 364
Issue: Pt 2
Pages: 377-83
Publication
First Author: Kabuyama Y
Year: 2006
Journal: Mol Cell Proteomics
Title: Functional proteomics identifies protein-tyrosine phosphatase 1B as a target of RhoA signaling.
Volume: 5
Issue: 8
Pages: 1359-67
Publication
First Author: Jücker M
Year: 1997
Journal: J Biol Chem
Title: The Fes protein-tyrosine kinase phosphorylates a subset of macrophage proteins that are involved in cell adhesion and cell-cell signaling.
Volume: 272
Issue: 4
Pages: 2104-9
Publication
First Author: Nakamura I
Year: 1998
Journal: J Biol Chem
Title: Tyrosine phosphorylation of p130Cas is involved in actin organization in osteoclasts.
Volume: 273
Issue: 18
Pages: 11144-9
Publication
First Author: Xing L
Year: 2004
Journal: Mol Cell Biol
Title: The adapter molecule Sin regulates T-cell-receptor-mediated signal transduction by modulating signaling substrate availability.
Volume: 24
Issue: 10
Pages: 4581-92
Publication
First Author: Liu G
Year: 2007
Journal: J Neurosci
Title: p130CAS is required for netrin signaling and commissural axon guidance.
Volume: 27
Issue: 4
Pages: 957-68
Publication
First Author: Ambrogio C
Year: 2005
Journal: Blood
Title: p130Cas mediates the transforming properties of the anaplastic lymphoma kinase.
Volume: 106
Issue: 12
Pages: 3907-16
Publication
First Author: Janoštiak R
Year: 2011
Journal: Mol Biol Cell
Title: Tyrosine phosphorylation within the SH3 domain regulates CAS subcellular localization, cell migration, and invasiveness.
Volume: 22
Issue: 22
Pages: 4256-67
Publication
First Author: Zhang C
Year: 2017
Journal: J Biol Chem
Title: Structural and functional insights into the interaction between the Cas family scaffolding protein p130Cas and the focal adhesion-associated protein paxillin.
Volume: 292
Issue: 44
Pages: 18281-18289
GXD Expression    
Probe: MGI:1205252
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:1205254
Age: postnatal week 6-8
Image: st96_442
Specimen Label: None
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:1205252
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:1205254
Age: postnatal week 6-8
Image: st96_442
Specimen Label: None
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:1205252
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:3284528
Stage: TS28
Assay Id: MGI:1205254
Age: postnatal week 6-8
Image: st96_442
Specimen Label: None
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:1205252
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1697428
Stage: TS28
Assay Id: MGI:1205254
Age: postnatal week 6-8
Image: st96_442
Specimen Label: None
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:1205252
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1754928
Stage: TS28
Assay Id: MGI:1205254
Age: postnatal week 6-8
Image: st96_442
Specimen Label: None
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:1205252
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:3280928
Stage: TS28
Assay Id: MGI:1205254
Age: postnatal week 6-8
Image: st96_442
Specimen Label: None
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:1205252
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:1205254
Age: postnatal week 6-8
Image: st96_442
Specimen Label: None
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:1205252
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1757728
Stage: TS28
Assay Id: MGI:1205254
Age: postnatal week 6-8
Image: st96_442
Specimen Label: None
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:1205252
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:3599828
Stage: TS28
Assay Id: MGI:1205254
Age: postnatal week 6-8
Image: st96_442
Specimen Label: None
Detected: true
Specimen Num: 9
GXD Expression    
Probe: MGI:1205252
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:1205254
Age: postnatal week 6-8
Image: st96_442
Specimen Label: None
Detected: true
Specimen Num: 10
GXD Expression    
Probe: MGI:1205252
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:1205254
Age: postnatal week 6-8
Image: st96_442
Specimen Label: None
Detected: true
Specimen Num: 11
GXD Expression    
Probe: MGI:1205252
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:1205254
Age: postnatal week 6-8
Image: st96_442
Specimen Label: None
Detected: true
Specimen Num: 12
GXD Expression    
Probe: MGI:1205252
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:1205254
Age: postnatal week 6-8
Image: st96_442
Specimen Label: None
Detected: true
Specimen Num: 13
GXD Expression    
Probe: MGI:1205252
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:1205254
Age: postnatal week 6-8
Image: st96_442
Specimen Label: None
Detected: true
Specimen Num: 14
GXD Expression    
Probe: MGI:1205252
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:1205254
Age: postnatal week 6-8
Image: st96_442
Specimen Label: None
Detected: true
Specimen Num: 15
GXD Expression    
Probe: MGI:1205252
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1720228
Stage: TS28
Assay Id: MGI:1205254
Age: postnatal week 6-8
Image: st96_442
Specimen Label: None
Detected: true
Specimen Num: 16
GXD Expression    
Probe: MGI:1205252
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Absent
Sex: Pooled
Emaps: EMAPS:1750328
Stage: TS28
Assay Id: MGI:1205254
Age: postnatal week 6-8
Image: st96_442
Specimen Label: None
Detected: false
Specimen Num: 17
GXD Expression    
Probe: MGI:1205252
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:1205254
Age: postnatal week 6-8
Image: st96_442
Specimen Label: None
Detected: true
Specimen Num: 18
GXD Expression    
Probe: MGI:1205252
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1832128
Stage: TS28
Assay Id: MGI:1205254
Age: postnatal week 6-8
Image: st96_442
Specimen Label: None
Detected: true
Specimen Num: 19
GXD Expression    
Probe: MGI:1205252
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1842628
Stage: TS28
Assay Id: MGI:1205254
Age: postnatal week 6-8
Image: st96_442
Specimen Label: None
Detected: true
Specimen Num: 20
GXD Expression    
Probe: MGI:1205252
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1752528
Stage: TS28
Assay Id: MGI:1205254
Age: postnatal week 6-8
Image: st96_442
Specimen Label: None
Detected: true
Specimen Num: 21
GXD Expression    
Probe: MGI:1205252
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:3511228
Stage: TS28
Assay Id: MGI:1205254
Age: postnatal week 6-8
Image: st96_442
Specimen Label: None
Detected: true
Specimen Num: 22
GXD Expression    
Probe: MGI:1205252
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Absent
Sex: Pooled
Emaps: EMAPS:1914328
Stage: TS28
Assay Id: MGI:1205254
Age: postnatal week 6-8
Image: st96_442
Specimen Label: None
Detected: false
Specimen Num: 23
GXD Expression    
Probe: MGI:1205252
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1742828
Stage: TS28
Assay Id: MGI:1205254
Age: postnatal week 6-8
Image: st96_442
Specimen Label: None
Detected: true
Specimen Num: 24
GXD Expression    
Probe: MGI:1205252
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:3288928
Stage: TS28
Assay Id: MGI:1205254
Age: postnatal week 6-8
Image: st96_442
Specimen Label: None
Detected: true
Specimen Num: 25
GXD Expression    
Probe: MGI:1205252
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1718528
Stage: TS28
Assay Id: MGI:1205254
Age: postnatal week 6-8
Image: st96_442
Specimen Label: None
Detected: true
Specimen Num: 26
GXD Expression    
Probe: MGI:1205252
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1775128
Stage: TS28
Assay Id: MGI:1205254
Age: postnatal week 6-8
Image: st96_442
Specimen Label: None
Detected: true
Specimen Num: 27
GXD Expression    
Probe: MGI:1205252
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1683328
Stage: TS28
Assay Id: MGI:1205254
Age: postnatal week 6-8
Image: st96_442
Specimen Label: None
Detected: true
Specimen Num: 28
GXD Expression    
Probe: MGI:1205252
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1788628
Stage: TS28
Assay Id: MGI:1205254
Age: postnatal week 6-8
Image: st96_442
Specimen Label: None
Detected: true
Specimen Num: 29
GXD Expression    
Probe: MGI:1205252
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1789128
Stage: TS28
Assay Id: MGI:1205254
Age: postnatal week 6-8
Image: st96_442
Specimen Label: None
Detected: true
Specimen Num: 30