| Type |
Details |
Score |
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chimpanzee |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chicken |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cory S |
| Year: |
2002 |
| Journal: |
Nat Rev Cancer |
| Title: |
The Bcl2 family: regulators of the cellular life-or-death switch. |
| Volume: |
2 |
| Issue: |
9 |
| Pages: |
647-56 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Strasser A |
| Year: |
1991 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease. |
| Volume: |
88 |
| Issue: |
19 |
| Pages: |
8661-5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Deng X |
| Year: |
2003 |
| Journal: |
Blood |
| Title: |
Bcl2 retards G1/S cell cycle transition by regulating intracellular ROS. |
| Volume: |
102 |
| Issue: |
9 |
| Pages: |
3179-85 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang YY |
| Year: |
2008 |
| Journal: |
Exp Hematol |
| Title: |
Bcl2 enhances induced hematopoietic differentiation of murine embryonic stem cells. |
| Volume: |
36 |
| Issue: |
2 |
| Pages: |
128-39 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Qing Y |
| Year: |
2014 |
| Journal: |
Blood |
| Title: |
Bcl2 overexpression rescues the hematopoietic stem cell defects in Ku70-deficient mice by restoration of quiescence. |
| Volume: |
123 |
| Issue: |
7 |
| Pages: |
1002-11 |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Slape CI |
| Year: |
2012 |
| Journal: |
Blood |
| Title: |
Inhibition of apoptosis by BCL2 prevents leukemic transformation of a murine myelodysplastic syndrome. |
| Volume: |
120 |
| Issue: |
12 |
| Pages: |
2475-83 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Larsen CJ |
| Year: |
1994 |
| Journal: |
Ann Genet |
| Title: |
[The BCL2 gene, prototype of a gene family that controls programmed cell death (apoptosis)]. |
| Volume: |
37 |
| Issue: |
3 |
| Pages: |
121-34 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
González-Herrero I |
| Year: |
2010 |
| Journal: |
Carcinogenesis |
| Title: |
Bcl2 is not required for the development and maintenance of leukemia stem cells in mice. |
| Volume: |
31 |
| Issue: |
7 |
| Pages: |
1292-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ha Y |
| Year: |
2014 |
| Journal: |
Cell Tissue Res |
| Title: |
Sigma receptor 1 modulates ER stress and Bcl2 in murine retina. |
| Volume: |
356 |
| Issue: |
1 |
| Pages: |
15-27 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
DÃaz-Muñoz MD |
| Year: |
2015 |
| Journal: |
PLoS One |
| Title: |
Deletion of AU-rich elements within the Bcl2 3'UTR reduces protein expression and B cell survival in vivo. |
| Volume: |
10 |
| Issue: |
2 |
| Pages: |
e0116899 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Brunner C |
| Year: |
2003 |
| Journal: |
J Exp Med |
| Title: |
B cell-specific transgenic expression of Bcl2 rescues early B lymphopoiesis but not B cell responses in BOB.1/OBF.1-deficient mice. |
| Volume: |
197 |
| Issue: |
9 |
| Pages: |
1205-11 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6168431 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689419 |
| Pattern: |
Not Specified |
| Stage: |
TS19 |
| Assay Id: |
MGI:6189856 |
| Age: |
embryonic day 11.5 |
|
|
| Specimen Label: |
Table S2 - E11.5 - Bcl2 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6168431 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689421 |
| Pattern: |
Not Specified |
| Stage: |
TS21 |
| Assay Id: |
MGI:6189856 |
| Age: |
embryonic day 13.5 |
|
|
| Specimen Label: |
Table S2 - E13.5 - Bcl2 |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6168431 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1689424 |
| Pattern: |
Not Specified |
| Stage: |
TS24 |
| Assay Id: |
MGI:6189856 |
| Age: |
embryonic day 15.5 |
|
|
| Specimen Label: |
Table S2 - E15.5 - Bcl2 |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6168431 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1689426 |
| Pattern: |
Not Specified |
| Stage: |
TS26 |
| Assay Id: |
MGI:6189856 |
| Age: |
embryonic day 18.5 |
|
|
| Specimen Label: |
Table S2 - E18.5 - Bcl2 |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6168431 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1689428 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6189856 |
| Age: |
postnatal day 4 |
|
|
| Specimen Label: |
Table S2 - P4 - Bcl2 |
| Detected: |
true |
| Specimen Num: |
5 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6168431 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1689428 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6189856 |
| Age: |
postnatal day 14 |
|
|
| Specimen Label: |
Table S2 - P14 - Bcl2 |
| Detected: |
true |
| Specimen Num: |
6 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6168431 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1689428 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6189856 |
| Age: |
postnatal day 28 |
|
|
| Specimen Label: |
Table S2 - P28 - Bcl2 |
| Detected: |
true |
| Specimen Num: |
7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mak SS |
| Year: |
2006 |
| Journal: |
Dev Biol |
| Title: |
Indispensable role of Bcl2 in the development of the melanocyte stem cell. |
| Volume: |
291 |
| Issue: |
1 |
| Pages: |
144-53 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sochalska M |
| Year: |
2015 |
| Journal: |
FEBS J |
| Title: |
Lessons from gain- and loss-of-function models of pro-survival Bcl2 family proteins: implications for targeted therapy. |
| Volume: |
282 |
| Issue: |
5 |
| Pages: |
834-849 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Silva S |
| Year: |
2003 |
| Journal: |
Cancer Res |
| Title: |
BCL2 accelerates inflammation-induced BALB/c plasmacytomas and promotes novel tumors with coexisting T(12;15) and T(6;15) translocations. |
| Volume: |
63 |
| Issue: |
24 |
| Pages: |
8656-63 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Viant C |
| Year: |
2017 |
| Journal: |
J Exp Med |
| Title: |
Cell cycle progression dictates the requirement for BCL2 in natural killer cell survival. |
| Volume: |
214 |
| Issue: |
2 |
| Pages: |
491-510 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Moriishi T |
| Year: |
2014 |
| Journal: |
PLoS One |
| Title: |
Bcl2 deficiency activates FoxO through Akt inactivation and accelerates osteoblast differentiation. |
| Volume: |
9 |
| Issue: |
1 |
| Pages: |
e86629 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
McGill GG |
| Year: |
2002 |
| Journal: |
Cell |
| Title: |
Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability. |
| Volume: |
109 |
| Issue: |
6 |
| Pages: |
707-18 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Teijido O |
| Year: |
2010 |
| Journal: |
FEBS Lett |
| Title: |
Upregulation of Bcl2 inhibits apoptosis-driven BAX insertion but favors BAX relocalization in mitochondria. |
| Volume: |
584 |
| Issue: |
15 |
| Pages: |
3305-10 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Deckwerth TL |
| Year: |
1998 |
| Journal: |
Exp Neurol |
| Title: |
Placement of the BCL2 family member BAX in the death pathway of sympathetic neurons activated by trophic factor deprivation. |
| Volume: |
152 |
| Issue: |
1 |
| Pages: |
150-62 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yamashita J |
| Year: |
2008 |
| Journal: |
J Bone Miner Res |
| Title: |
Role of Bcl2 in osteoclastogenesis and PTH anabolic actions in bone. |
| Volume: |
23 |
| Issue: |
5 |
| Pages: |
621-32 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Xiang H |
| Year: |
2011 |
| Journal: |
Leukemia |
| Title: |
The immunoglobulin heavy chain gene 3' enhancers induce Bcl2 deregulation and lymphomagenesis in murine B cells. |
| Volume: |
25 |
| Issue: |
9 |
| Pages: |
1484-93 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Murthy SR |
| Year: |
2013 |
| Journal: |
Endocrinology |
| Title: |
Carboxypeptidase E protects hippocampal neurons during stress in male mice by up-regulating prosurvival BCL2 protein expression. |
| Volume: |
154 |
| Issue: |
9 |
| Pages: |
3284-93 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
An F |
| Year: |
2012 |
| Journal: |
Apoptosis |
| Title: |
miR-15b and miR-16 regulate TNF mediated hepatocyte apoptosis via BCL2 in acute liver failure. |
| Volume: |
17 |
| Issue: |
7 |
| Pages: |
702-16 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Okamoto T |
| Year: |
2014 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Enhanced stability of Mcl1, a prosurvival Bcl2 relative, blunts stress-induced apoptosis, causes male sterility, and promotes tumorigenesis. |
| Volume: |
111 |
| Issue: |
1 |
| Pages: |
261-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Aït-Ikhlef A |
| Year: |
1995 |
| Journal: |
Neurosci Lett |
| Title: |
The motoneuron degeneration in the wobbler mouse is independent of the overexpression of a Bcl2 transgene in neurons. |
| Volume: |
199 |
| Issue: |
3 |
| Pages: |
163-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Min S |
| Year: |
2013 |
| Journal: |
J Immunol |
| Title: |
Multiple tumor-associated microRNAs modulate the survival and longevity of dendritic cells by targeting YWHAZ and Bcl2 signaling pathways. |
| Volume: |
190 |
| Issue: |
5 |
| Pages: |
2437-46 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Masle-Farquhar E |
| Year: |
2021 |
| Journal: |
PLoS One |
| Title: |
Loss-of-function of Fbxo10, encoding a post-translational regulator of BCL2 in lymphomas, has no discernible effect on BCL2 or B lymphocyte accumulation in mice. |
| Volume: |
16 |
| Issue: |
4 |
| Pages: |
e0237830 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wen R |
| Year: |
2003 |
| Journal: |
J Biol Chem |
| Title: |
Phospholipase Cgamma2 provides survival signals via Bcl2 and A1 in different subpopulations of B cells. |
| Volume: |
278 |
| Issue: |
44 |
| Pages: |
43654-62 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jorgensen TN |
| Year: |
2007 |
| Journal: |
J Immunol |
| Title: |
Bim and Bcl-2 mutually affect the expression of the other in T cells. |
| Volume: |
179 |
| Issue: |
6 |
| Pages: |
3417-24 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Farlie PG |
| Year: |
1995 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
bcl-2 transgene expression can protect neurons against developmental and induced cell death. |
| Volume: |
92 |
| Issue: |
10 |
| Pages: |
4397-401 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bernard R |
| Year: |
1997 |
| Journal: |
Dev Neurosci |
| Title: |
NSE-bcl-2 transgenic mice, a model system for studying neuronal death and survival. |
| Volume: |
19 |
| Issue: |
1 |
| Pages: |
79-85 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Coleman GJ |
| Year: |
1999 |
| Journal: |
Brain Res |
| Title: |
Bcl-2 transgenic mice with increased number of neurons have a greater learning capacity. |
| Volume: |
832 |
| Issue: |
1-2 |
| Pages: |
188-94 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wojciechowski S |
| Year: |
2007 |
| Journal: |
J Exp Med |
| Title: |
Bim/Bcl-2 balance is critical for maintaining naive and memory T cell homeostasis. |
| Volume: |
204 |
| Issue: |
7 |
| Pages: |
1665-75 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nagase Y |
| Year: |
2009 |
| Journal: |
J Biol Chem |
| Title: |
Anti-apoptotic molecule Bcl-2 regulates the differentiation, activation, and survival of both osteoblasts and osteoclasts. |
| Volume: |
284 |
| Issue: |
52 |
| Pages: |
36659-69 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bouillet P |
| Year: |
2005 |
| Journal: |
Cell Death Differ |
| Title: |
Polycystic kidney disease prevented by transgenic RNA interference. |
| Volume: |
12 |
| Issue: |
7 |
| Pages: |
831-3 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Baker NL |
| Year: |
1999 |
| Journal: |
Brain Res Dev Brain Res |
| Title: |
Interactions between bcl-2 and the IGF system control apoptosis in the developing mouse brain. |
| Volume: |
118 |
| Issue: |
1-2 |
| Pages: |
109-18 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kim KH |
| Year: |
2009 |
| Journal: |
Neurosci Lett |
| Title: |
Genetic modulation of apoptotic pathways fails to alter disease course in tripeptidyl-peptidase 1 deficient mice. |
| Volume: |
453 |
| Issue: |
1 |
| Pages: |
27-30 |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bouillet P |
| Year: |
2001 |
| Journal: |
Dev Cell |
| Title: |
Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim. |
| Volume: |
1 |
| Issue: |
5 |
| Pages: |
645-53 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mérino D |
| Year: |
2012 |
| Journal: |
Oncogene |
| Title: |
Bim must be able to engage all pro-survival Bcl-2 family members for efficient tumor suppression. |
| Volume: |
31 |
| Issue: |
28 |
| Pages: |
3392-6 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
113
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
GarcÃa-RamÃrez I |
| Year: |
2017 |
| Journal: |
Blood |
| Title: |
Crebbp loss cooperates with Bcl2 overexpression to promote lymphoma in mice. |
| Volume: |
129 |
| Issue: |
19 |
| Pages: |
2645-2656 |
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| Publication |
| First Author: |
Craxton A |
| Year: |
2007 |
| Journal: |
Eur J Immunol |
| Title: |
Bim regulates BCR-induced entry of B cells into the cell cycle. |
| Volume: |
37 |
| Issue: |
10 |
| Pages: |
2715-22 |
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| Publication |
| First Author: |
Mérino D |
| Year: |
2009 |
| Journal: |
J Cell Biol |
| Title: |
The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins. |
| Volume: |
186 |
| Issue: |
3 |
| Pages: |
355-62 |
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| Publication |
| First Author: |
Marsden VS |
| Year: |
2002 |
| Journal: |
Nature |
| Title: |
Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome. |
| Volume: |
419 |
| Issue: |
6907 |
| Pages: |
634-7 |
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| Publication |
| First Author: |
Hale JS |
| Year: |
2011 |
| Journal: |
J Immunol |
| Title: |
Bcl-2-interacting mediator of cell death influences autoantigen-driven deletion and TCR revision. |
| Volume: |
186 |
| Issue: |
2 |
| Pages: |
799-806 |
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| Publication |
| First Author: |
Hughes P |
| Year: |
2006 |
| Journal: |
Cell Death Differ |
| Title: |
Loss of PKD1 and loss of Bcl-2 elicit polycystic kidney disease through distinct mechanisms. |
| Volume: |
13 |
| Issue: |
7 |
| Pages: |
1123-7 |
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| Publication |
| First Author: |
Schuler F |
| Year: |
2016 |
| Journal: |
Cell Death Differ |
| Title: |
The BH3-only protein BIM contributes to late-stage involution in the mouse mammary gland. |
| Volume: |
23 |
| Issue: |
1 |
| Pages: |
41-51 |
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| Gene |
| Type: |
gene |
| Organism: |
human |
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| Gene |
| Type: |
gene |
| Organism: |
human |
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| Gene |
| Type: |
gene |
| Organism: |
human |
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| Gene |
| Type: |
gene |
| Organism: |
human |
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| Gene |
| Type: |
gene |
| Organism: |
human |
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| Gene |
| Type: |
gene |
| Organism: |
human |
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| Gene |
| Type: |
gene |
| Organism: |
human |
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| Gene |
| Type: |
gene |
| Organism: |
human |
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| Gene |
| Type: |
gene |
| Organism: |
human |
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| Gene |
| Type: |
gene |
| Organism: |
human |
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| Gene |
| Type: |
gene |
| Organism: |
human |
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