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Search results 1 to 100 out of 490 for Becn1

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
8678 | BECN1
Type: gene
Organism: human
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Gene
619357 | becn1
Type: gene
Organism: frog, western clawed
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Gene
114558 | Becn1
Type: gene
Organism: rat
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Gene
454700 | BECN1
Type: gene
Organism: chimpanzee
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Gene
480513 | BECN1
Type: gene
Organism: dog, domestic
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Gene
527278 | BECN1
Type: gene
Organism: cattle
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Gene
420018 | BECN1
Type: gene
Organism: chicken
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Gene
393846 | becn1
Type: gene
Organism: zebrafish
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Gene
711649 | BECN1
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:1891828 | Becn1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR032913 | BECN1
Type: Family
Description: Beclin-1 (BECN1) coordinates the assembly of multiple VPS34 complexes whose distinct phosphatidylinositol 3-kinase III (PI3K-III) lipid kinase activities regulate autophagy at different steps [, ]. It regulates degradative endocytic trafficking and is required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 [, ]. It is also involved in endocytosis and is required for neuron viability in vivo []. It is implicated in many disorders, including cancer and neurodegeneration [, ].
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Publication
19270693 | J:219088
First Author: Zhong Y
Year: 2009
Journal: Nat Cell Biol
Title: Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex.
Volume: 11
Issue: 4
Pages: 468-76
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Publication
25275521 | J:232323
First Author: McKnight NC
Year: 2014
Journal: PLoS Genet
Title: Beclin 1 is required for neuron viability and regulates endosome pathways via the UVRAG-VPS34 complex.
Volume: 10
Issue: 10
Pages: e1004626
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Publication
31373534 | J:319591
First Author: Liu K
Year: 2020
Journal: Autophagy
Title: A fine-tuning mechanism underlying self-control for autophagy: deSUMOylation of BECN1 by SENP3.
Volume: 16
Issue: 6
Pages: 975-990
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Publication
25483966 | J:310371
First Author: Cicchini M
Year: 2014
Journal: Autophagy
Title: Autophagy regulator BECN1 suppresses mammary tumorigenesis driven by WNT1 activation and following parity.
Volume: 10
Issue: 11
Pages: 2036-52
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Publication
26636486 | J:329795
First Author: Zhang D
Year: 2015
Journal: Autophagy
Title: GADD45A inhibits autophagy by regulating the interaction between BECN1 and PIK3C3.
Volume: 11
Issue: 12
Pages: 2247-58
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Publication
34038729 | J:310052
First Author: Kuramoto K
Year: 2021
Journal: Cell Rep
Title: The autophagy protein Becn1 improves insulin sensitivity by promoting adiponectin secretion via exocyst binding.
Volume: 35
Issue: 8
Pages: 109184
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Publication
28409693 | J:310229
First Author: Bae SY
Year: 2017
Journal: Autophagy
Title: TPT1 (tumor protein, translationally-controlled 1) negatively regulates autophagy through the BECN1 interactome and an MTORC1-mediated pathway.
Volume: 13
Issue: 5
Pages: 820-833
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Publication
28806762 | J:244104
First Author: Rocchi A
Year: 2017
Journal: PLoS Genet
Title: A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease.
Volume: 13
Issue: 8
Pages: e1006962
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Publication
31508820 | J:299781
First Author: Wang HY
Year: 2020
Journal: J Cell Physiol
Title: Autophagy inhibition via Becn1 downregulation improves the mesenchymal stem cells antifibrotic potential in experimental liver fibrosis.
Volume: 235
Issue: 3
Pages: 2722-2737
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Publication
28542134 | J:328435
First Author: Nah J
Year: 2017
Journal: Cell Death Dis
Title: Phosphorylated CAV1 activates autophagy through an interaction with BECN1 under oxidative stress.
Volume: 8
Issue: 5
Pages: e2822
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Publication
10604474 | -
First Author: Liang XH
Year: 1999
Journal: Nature
Title: Induction of autophagy and inhibition of tumorigenesis by beclin 1.
Volume: 402
Issue: 6762
Pages: 672-6
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Protein
O88597
Organism: Mus musculus/domesticus
Length: 448  
Fragment?: false
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Protein
E9PX06
Organism: Mus musculus/domesticus
Length: 46  
Fragment?: false
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Protein
F7DB15
Organism: Mus musculus/domesticus
Length: 110  
Fragment?: true
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Protein
F7C090
Organism: Mus musculus/domesticus
Length: 168  
Fragment?: true
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Protein
F7CVL9
Organism: Mus musculus/domesticus
Length: 125  
Fragment?: true
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Protein
E9PYD6
Organism: Mus musculus/domesticus
Length: 277  
Fragment?: false
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Protein
E9QAM0
Organism: Mus musculus/domesticus
Length: 105  
Fragment?: false
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Publication
21311563 | -
First Author: Kang R
Year: 2011
Journal: Cell Death Differ
Title: The Beclin 1 network regulates autophagy and apoptosis.
Volume: 18
Issue: 4
Pages: 571-80
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Publication
20643123 | -
First Author: Thoresen SB
Year: 2010
Journal: Exp Cell Res
Title: A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic.
Volume: 316
Issue: 20
Pages: 3368-78
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Publication
20208530 | J:160640
First Author: Sagona AP
Year: 2010
Journal: Nat Cell Biol
Title: PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody.
Volume: 12
Issue: 4
Pages: 362-71
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Publication
24385262 | -
First Author: O'Brien CE
Year: 2014
Journal: J Neuroimmune Pharmacol
Title: Sorting through the roles of beclin 1 in microglia and neurodegeneration.
Volume: 9
Issue: 3
Pages: 285-92
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Publication
33046512 | J:302302
First Author: Jin Y
Year: 2021
Journal: Diabetes
Title: Depletion of Adipocyte Becn1 Leads to Lipodystrophy and Metabolic Dysregulation.
Volume: 70
Issue: 1
Pages: 182-195
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Publication
35499056 | J:351294
 
First Author: Liu Y
Year: 2022
Journal: J Adv Res
Title: Leucine-rich repeat kinase-2 deficiency protected against cardiac remodelling in mice via regulating autophagy formation and degradation.
Volume: 37
Pages: 107-117
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Publication
38814784 | J:350951
First Author: Tam TH
Year: 2024
Journal: Cell Rep
Title: Pain hypersensitivity is dependent on autophagy protein Beclin 1 in males but not females.
Volume: 43
Issue: 6
Pages: 114293
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Publication
25586377 | J:220595
First Author: Niso-Santano M
Year: 2015
Journal: EMBO J
Title: Unsaturated fatty acids induce non-canonical autophagy.
Volume: 34
Issue: 8
Pages: 1025-41
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Publication
21464117 | J:180916
First Author: Gawriluk TR
Year: 2011
Journal: Reproduction
Title: Autophagy is a cell survival program for female germ cells in the murine ovary.
Volume: 141
Issue: 6
Pages: 759-65
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Publication
29610308 | J:261482
First Author: Vega-Rubín-de-Celis S
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Increased autophagy blocks HER2-mediated breast tumorigenesis.
Volume: 115
Issue: 16
Pages: 4176-4181
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Publication
32984329 | J:301727
 
First Author: Xia R
Year: 2020
Journal: Front Cell Dev Biol
Title: Differential Requirement of Beclin 1 for Regulating the Balance of Naïve and Activated CD4+ T Cells.
Volume: 8
Pages: 834
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Publication
35409185 | J:323407
 
First Author: Bork T
Year: 2022
Journal: Int J Mol Sci
Title: BECLIN1 Is Essential for Podocyte Secretory Pathways Mediating VEGF Secretion and Podocyte-Endothelial Crosstalk.
Volume: 23
Issue: 7
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Publication
31923184 | J:283381
First Author: Delaney JR
Year: 2020
Journal: PLoS Genet
Title: Autophagy gene haploinsufficiency drives chromosome instability, increases migration, and promotes early ovarian tumors.
Volume: 16
Issue: 1
Pages: e1008558
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Publication
30617086 | J:278302
 
First Author: Houtman J
Year: 2019
Journal: EMBO J
Title: Beclin1-driven autophagy modulates the inflammatory response of microglia via NLRP3.
Volume: 38
Issue: 4
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Publication
29327342 | J:336827
First Author: Zhang L
Year: 2018
Journal: J Pathol
Title: Reduced lysosomal clearance of autophagosomes promotes survival and colonization of Helicobacter pylori.
Volume: 244
Issue: 4
Pages: 432-444
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Publication
38473806 | J:346609
 
First Author: Bork T
Year: 2024
Journal: Int J Mol Sci
Title: Cisplatin Nephrotoxicity Is Critically Mediated by the Availability of BECLIN1.
Volume: 25
Issue: 5
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Publication
32498399 | J:302505
 
First Author: Karuppan MKM
Year: 2020
Journal: Viruses
Title: Reduced-Beclin1-Expressing Mice Infected with Zika-R103451 and Viral-Associated Pathology during Pregnancy.
Volume: 12
Issue: 6
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Publication
24905722 | J:329746
First Author: Nassif M
Year: 2014
Journal: Autophagy
Title: Pathogenic role of BECN1/Beclin 1 in the development of amyotrophic lateral sclerosis.
Volume: 10
Issue: 7
Pages: 1256-71
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Publication
35106510 | J:351480
First Author: Zhang Y
Year: 2022
Journal: Cell Rep Med
Title: Pegylated arginine deiminase drives arginine turnover and systemic autophagy to dictate energy metabolism.
Volume: 3
Issue: 1
Pages: 100498
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Publication
25246579 | J:216461
First Author: Gawriluk TR
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Beclin-1 deficiency in the murine ovary results in the reduction of progesterone production to promote preterm labor.
Volume: 111
Issue: 40
Pages: E4194-203
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Publication
33355624 | J:306129
 
First Author: Wang A
Year: 2021
Journal: J Exp Med
Title: ZFP91 is required for the maintenance of regulatory T cell homeostasis and function.
Volume: 218
Issue: 2
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Publication
37169793 | J:335750
First Author: Wu R
Year: 2023
Journal: Nat Commun
Title: Genetically prolonged beige fat in male mice confers long-lasting metabolic health.
Volume: 14
Issue: 1
Pages: 2731
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Publication
36528652 | J:332255
First Author: Li J
Year: 2022
Journal: Nat Commun
Title: USP5-Beclin 1 axis overrides p53-dependent senescence and drives Kras-induced tumorigenicity.
Volume: 13
Issue: 1
Pages: 7799
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Publication
37739117 | J:341686
 
First Author: Mehanna S
Year: 2023
Journal: Dev Biol
Title: Beclin1 is essential for the pancreas development.
Volume: 504
Pages: 113-119
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Publication
29849149 | J:263555
First Author: Fernández ÁF
Year: 2018
Journal: Nature
Title: Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice.
Volume: 558
Issue: 7708
Pages: 136-140
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Publication
29157081 | J:287713
First Author: Liu GS
Year: 2018
Journal: Autophagy
Title: Regulation of BECN1-mediated autophagy by HSPB6: Insights from a human HSPB6S10F mutant.
Volume: 14
Issue: 1
Pages: 80-97
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Publication
37023120 | J:334630
First Author: Hsu WL
Year: 2023
Journal: PLoS One
Title: Identification of Ndfip1 as a novel negative regulator for spatial memory formation associated with increased ubiquitination of Beclin 1 and PTEN.
Volume: 18
Issue: 4
Pages: e0283908
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Publication
38744820 | J:348291
First Author: Song Y
Year: 2024
Journal: Nat Commun
Title: Dysfunctional adipocytes promote tumor progression through YAP/TAZ-dependent cancer-associated adipocyte transformation.
Volume: 15
Issue: 1
Pages: 4052
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Publication
31503548 | J:283322
First Author: Tan P
Year: 2019
Journal: J Clin Invest
Title: Myeloid loss of Beclin 1 promotes PD-L1hi precursor B cell lymphoma development.
Volume: 129
Issue: 12
Pages: 5261-5277
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Publication
36652438 | J:352198
First Author: Hegdekar N
Year: 2023
Journal: Autophagy
Title: Inhibition of autophagy in microglia and macrophages exacerbates innate immune responses and worsens brain injury outcomes.
Volume: 19
Issue: 7
Pages: 2026-2044
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Publication
18497889 | J:137727
First Author: Pickford F
Year: 2008
Journal: J Clin Invest
Title: The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice.
Volume: 118
Issue: 6
Pages: 2190-9
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Protein Coding Gene
MGP_CAROLIEiJ_G0017210 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0019193 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0019161 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0019130 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0019135 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0018944 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1891828 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0019584 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0018498 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0018913 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0019025 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0019015 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0019094 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0019046 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0019622 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0018261 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0018547 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0018340 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0018053 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
14657337 | J:86982
First Author: Yue Z
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor.
Volume: 100
Issue: 25
Pages: 15077-82
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Publication
21479246 | J:171443
First Author: Goldman SJ
Year: 2011
Journal: PLoS One
Title: Use of the ODD-luciferase transgene for the non-invasive imaging of spontaneous tumors in mice.
Volume: 6
Issue: 3
Pages: e18269
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Publication
26810478 | J:357823
 
First Author: Tokuda E
Year: 2016
Journal: Acta Neuropathol Commun
Title: Low autophagy capacity implicated in motor system vulnerability to mutant superoxide dismutase.
Volume: 4
Pages: 6
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Publication
21660048 | J:203090
First Author: Kovacs JR
Year: 2012
Journal: Cell Death Differ
Title: Autophagy promotes T-cell survival through degradation of proteins of the cell death machinery.
Volume: 19
Issue: 1
Pages: 144-52
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Publication
14638851 | J:86953
First Author: Qu X
Year: 2003
Journal: J Clin Invest
Title: Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene.
Volume: 112
Issue: 12
Pages: 1809-20
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Publication
32344065 | J:292182
 
First Author: Son Y
Year: 2020
Journal: Mol Metab
Title: Adipocyte-specific Beclin1 deletion impairs lipolysis and mitochondrial integrity in adipose tissue.
Volume: 39
Pages: 101005
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Publication
23894198 | J:205820
First Author: Reed M
Year: 2013
Journal: J Immunol
Title: Autophagy-inducing protein beclin-1 in dendritic cells regulates CD4 T cell responses and disease severity during respiratory syncytial virus infection.
Volume: 191
Issue: 5
Pages: 2526-37
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Publication
24012002 | J:201742
First Author: Lucin KM
Year: 2013
Journal: Neuron
Title: Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer's disease.
Volume: 79
Issue: 5
Pages: 873-86
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Publication
23308102 | J:195814
First Author: Hariharan N
Year: 2013
Journal: PLoS One
Title: Autophagy plays an essential role in mediating regression of hypertrophy during unloading of the heart.
Volume: 8
Issue: 1
Pages: e51632
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Publication
32598088 | J:324327
First Author: Wang J
Year: 2020
Journal: FASEB J
Title: Autophagy plays a positive role in induction of epidermal proliferation.
Volume: 34
Issue: 8
Pages: 10657-10667
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Publication
17607355 | J:124190
First Author: Zhu H
Year: 2007
Journal: J Clin Invest
Title: Cardiac autophagy is a maladaptive response to hemodynamic stress.
Volume: 117
Issue: 7
Pages: 1782-93
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Publication
30232271 | J:285266
 
First Author: Pabón MA
Year: 2018
Journal: JCI Insight
Title: Beclin-1 regulates cigarette smoke-induced kidney injury in a murine model of chronic obstructive pulmonary disease.
Volume: 3
Issue: 18
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Publication
23197835 | J:193111
First Author: Niu H
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Autophagosomes induced by a bacterial Beclin 1 binding protein facilitate obligatory intracellular infection.
Volume: 109
Issue: 51
Pages: 20800-7
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Publication
23825228 | J:201170
First Author: Lira VA
Year: 2013
Journal: FASEB J
Title: Autophagy is required for exercise training-induced skeletal muscle adaptation and improvement of physical performance.
Volume: 27
Issue: 10
Pages: 4184-93
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Publication
28592537 | J:336820
 
First Author: Mazzuca P
Year: 2017
Journal: J Virol
Title: Role of Autophagy in HIV-1 Matrix Protein p17-Driven Lymphangiogenesis.
Volume: 91
Issue: 16
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Publication
29853517 | J:287811
First Author: Sun Y
Year: 2018
Journal: Circulation
Title: Beclin-1-Dependent Autophagy Protects the Heart During Sepsis.
Volume: 138
Issue: 20
Pages: 2247-2262
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Publication
34298888 | J:320572
 
First Author: Gunawan M
Year: 2021
Journal: Int J Mol Sci
Title: The Role of Autophagy in Chemical Proteasome Inhibition Model of Retinal Degeneration.
Volume: 22
Issue: 14
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Publication
20812860 | J:271821
First Author: Hariharan N
Year: 2011
Journal: Antioxid Redox Signal
Title: Oxidative stress stimulates autophagic flux during ischemia/reperfusion.
Volume: 14
Issue: 11
Pages: 2179-90
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Publication
29752681 | J:315613
First Author: Lapierre J
Year: 2018
Journal: J Neuroimmune Pharmacol
Title: Critical Role of Beclin1 in HIV Tat and Morphine-Induced Inflammation and Calcium Release in Glial Cells from Autophagy Deficient Mouse.
Volume: 13
Issue: 3
Pages: 355-370
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Publication
29724354 | J:310780
First Author: Sciarretta S
Year: 2018
Journal: J Am Coll Cardiol
Title: Trehalose-Induced Activation of Autophagy Improves Cardiac Remodeling After Myocardial Infarction.
Volume: 71
Issue: 18
Pages: 1999-2010
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Publication
26984939 | J:243954
First Author: Li DL
Year: 2016
Journal: Circulation
Title: Doxorubicin Blocks Cardiomyocyte Autophagic Flux by Inhibiting Lysosome Acidification.
Volume: 133
Issue: 17
Pages: 1668-87
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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