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Search results 1 to 100 out of 184 for Best1

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0.066s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Danio rerio
Gene
Type: gene
Organism: Drosophila melanogaster
Gene
Type: gene
Organism: Rattus norvegicus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Domain
Type: Family
Description: Bestrophin-1 (Best1) forms calcium-sensitive chloride channels that are involved in distinct basic cellular processes such as Ca2+ homeostasis, neurotransmitter release, and cell volume regulation [, , ]. It has been linked to various retinopathies. Mutations in the Best1 gene cause vitelliform macular dystrophy (VMD2), an autosomal dominant form of macular degeneration that usually begins in childhood or adolescence [].
Publication
First Author: Milenkovic A
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Bestrophin 1 is indispensable for volume regulation in human retinal pigment epithelium cells.
Volume: 112
Issue: 20
Pages: E2630-9
Publication  
First Author: Chen M
Year: 2021
Journal: Exp Eye Res
Title: An efficient inducible RPE-Selective cre transgenic mouse line.
Volume: 202
Pages: 108370
Publication
First Author: Woo DH
Year: 2012
Journal: Cell
Title: TREK-1 and Best1 channels mediate fast and slow glutamate release in astrocytes upon GPCR activation.
Volume: 151
Issue: 1
Pages: 25-40
Publication
First Author: Boudes M
Year: 2009
Journal: J Neurosci
Title: Best1 is a gene regulated by nerve injury and required for Ca2+-activated Cl- current expression in axotomized sensory neurons.
Volume: 29
Issue: 32
Pages: 10063-71
Publication
First Author: Marquardt A
Year: 1998
Journal: Hum Mol Genet
Title: Mutations in a novel gene, VMD2, encoding a protein of unknown properties cause juvenile-onset vitelliform macular dystrophy (Best's disease).
Volume: 7
Issue: 9
Pages: 1517-25
Publication  
First Author: Strauß O
Year: 2014
Journal: Adv Exp Med Biol
Title: The role of bestrophin-1 in intracellular Ca(2+) signaling.
Volume: 801
Pages: 113-9
Publication  
First Author: Oh SJ
Year: 2012
Journal: Mol Brain
Title: Protease activated receptor 1-induced glutamate release in cultured astrocytes is mediated by Bestrophin-1 channel but not by vesicular exocytosis.
Volume: 5
Pages: 38
Protein
Organism: Mus musculus
Length: 551  
Fragment?: false
Protein
Organism: Mus musculus
Length: 420  
Fragment?: true
Publication
First Author: Barro Soria R
Year: 2009
Journal: J Biol Chem
Title: Bestrophin-1 enables Ca2+-activated Cl- conductance in epithelia.
Volume: 284
Issue: 43
Pages: 29405-12
Publication
First Author: Lee S
Year: 2010
Journal: Science
Title: Channel-mediated tonic GABA release from glia.
Volume: 330
Issue: 6005
Pages: 790-6
Allele
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Douglas Vollrath
Allele Type: Targeted
Attribute String: Inducible, Recombinase
Publication categories: ProxyCollection
Publication
First Author: Zhang Y
Year: 2010
Journal: Hum Mol Genet
Title: Suppression of Ca2+ signaling in a mouse model of Best disease.
Volume: 19
Issue: 6
Pages: 1108-18
Publication  
First Author: Milenkovic A
Year: 2019
Journal: Biol Open
Title: The Y227N mutation affects bestrophin-1 protein stability and impairs sperm function in a mouse model of Best vitelliform macular dystrophy.
Volume: 8
Issue: 7
Publication
First Author: Oh SJ
Year: 2019
Journal: Curr Biol
Title: Ultrasonic Neuromodulation via Astrocytic TRPA1.
Volume: 29
Issue: 20
Pages: 3386-3401.e8
Publication
First Author: Johnson AA
Year: 2013
Journal: Hum Mol Genet
Title: Differential effects of Best disease causing missense mutations on bestrophin-1 trafficking.
Volume: 22
Issue: 23
Pages: 4688-97
Publication
First Author: Storm T
Year: 2019
Journal: Invest Ophthalmol Vis Sci
Title: Selective Ablation of Megalin in the Retinal Pigment Epithelium Results in Megaophthalmos, Macromelanosome Formation and Severe Retina Degeneration.
Volume: 60
Issue: 1
Pages: 322-330
Strain
Attribute String: mutant stock, targeted mutation
Publication
First Author: Barro-Soria R
Year: 2008
Journal: Biochim Biophys Acta
Title: Bestrophin 1 and 2 are components of the Ca(2+) activated Cl(-) conductance in mouse airways.
Volume: 1783
Issue: 10
Pages: 1993-2000
Publication
First Author: Woo J
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Control of motor coordination by astrocytic tonic GABA release through modulation of excitation/inhibition balance in cerebellum.
Volume: 115
Issue: 19
Pages: 5004-5009
Publication  
First Author: Han KS
Year: 2013
Journal: Mol Brain
Title: Channel-mediated astrocytic glutamate release via Bestrophin-1 targets synaptic NMDARs.
Volume: 6
Pages: 4
Publication
First Author: Iacovelli J
Year: 2011
Journal: Invest Ophthalmol Vis Sci
Title: Generation of Cre transgenic mice with postnatal RPE-specific ocular expression.
Volume: 52
Issue: 3
Pages: 1378-83
Allele
Name: transgene insertion 1, Joshua L Dunaief
Allele Type: Transgenic
Attribute String: Recombinase
Publication categories: ProxyCollection
Allele
Name: transgene insertion 1, Yun-Zheng Le
Allele Type: Transgenic
Attribute String: Inducible, Recombinase, Transactivator
Publication categories: ProxyCollection
Publication
First Author: Ma JH
Year: 2016
Journal: Invest Ophthalmol Vis Sci
Title: The Role of IRE-XBP1 Pathway in Regulation of Retinal Pigment Epithelium Tight Junctions.
Volume: 57
Issue: 13
Pages: 5244-5252
Publication
First Author: Yang J
Year: 2019
Journal: Diabetologia
Title: Loss of X-box binding protein 1 in Müller cells augments retinal inflammation in a mouse model of diabetes.
Volume: 62
Issue: 3
Pages: 531-543
Publication
First Author: Zhong Y
Year: 2012
Journal: PLoS One
Title: X-box binding protein 1 is essential for the anti-oxidant defense and cell survival in the retinal pigment epithelium.
Volume: 7
Issue: 6
Pages: e38616
Strain
Attribute String: coisogenic, mutant strain, transgenic
Strain
Attribute String: coisogenic, mutant strain, transgenic
Publication
First Author: He L
Year: 2014
Journal: Am J Pathol
Title: Age- and gene-dosage-dependent cre-induced abnormalities in the retinal pigment epithelium.
Volume: 184
Issue: 6
Pages: 1660-7
Strain
Attribute String: transgenic, mutant stock
Publication
First Author: Schultz R
Year: 2018
Journal: Sci Rep
Title: Frataxin overexpression in Müller cells protects retinal ganglion cells in a mouse model of ischemia/reperfusion injury in vivo.
Volume: 8
Issue: 1
Pages: 4846
Genotype
Symbol: Tg(BEST1-cre)1Jdun/?
Background: C57BL/6-Tg(BEST1-cre)1Jdun
Zygosity: ot
Has Mutant Allele: true
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Petrukhin K
Year: 1998
Journal: Nat Genet
Title: Identification of the gene responsible for Best macular dystrophy.
Volume: 19
Issue: 3
Pages: 241-7
Publication
First Author: Marmorstein LY
Year: 2002
Journal: J Biol Chem
Title: Bestrophin interacts physically and functionally with protein phosphatase 2A.
Volume: 277
Issue: 34
Pages: 30591-7
Publication
First Author: Tsunenari T
Year: 2003
Journal: J Biol Chem
Title: Structure-function analysis of the bestrophin family of anion channels.
Volume: 278
Issue: 42
Pages: 41114-25
Publication
First Author: Kwak H
Year: 2020
Journal: Neuron
Title: Astrocytes Control Sensory Acuity via Tonic Inhibition in the Thalamus.
Volume: 108
Issue: 4
Pages: 691-706.e10
Publication
First Author: O'Driscoll KE
Year: 2009
Journal: Biochem Biophys Res Commun
Title: Functional properties of murine bestrophin 1 channel.
Volume: 384
Issue: 4
Pages: 476-81
Publication
First Author: Park H
Year: 2009
Journal: J Neurosci
Title: Bestrophin-1 encodes for the Ca2+-activated anion channel in hippocampal astrocytes.
Volume: 29
Issue: 41
Pages: 13063-73
GXD Expression    
Probe: MGI:6360290
Assay Type: RT-PCR
Annotation Date: 2019-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:6360538
Age: postnatal day 7
Image: 8
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6360290
Assay Type: RT-PCR
Annotation Date: 2019-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:6360538
Age: postnatal day 7
Image: 8
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6360290
Assay Type: RT-PCR
Annotation Date: 2019-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:6360538
Age: postnatal day 7
Image: 8
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6360290
Assay Type: RT-PCR
Annotation Date: 2019-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:6360542
Age: postnatal day 22
Image: 8
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6360290
Assay Type: RT-PCR
Annotation Date: 2019-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:6360542
Age: postnatal day 22
Image: 8
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6360290
Assay Type: RT-PCR
Annotation Date: 2019-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:6360542
Age: postnatal day 22
Image: 8
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:5614435
Assay Type: Immunohistochemistry
Annotation Date: 2015-02-05
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3284222
Pattern: Uniform
Stage: TS22
Assay Id: MGI:5614495
Age: embryonic day 14.5
Image: 5A
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:5614435
Assay Type: Immunohistochemistry
Annotation Date: 2015-02-05
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3274122
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:5614495
Age: embryonic day 14.5
Image: 5B
Note: Expression was in choroid plexus epithelium.
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:5614435
Assay Type: Immunohistochemistry
Annotation Date: 2015-02-05
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1777422
Pattern: Uniform
Stage: TS22
Assay Id: MGI:5614495
Age: embryonic day 14.5
Image: 5A
Detected: true
Specimen Num: 1
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6NCrl
Zygosity: ht
Has Mutant Allele: true
Publication
First Author: Huang J
Year: 2019
Journal: Theranostics
Title: Abnormal mTORC1 signaling leads to retinal pigment epithelium degeneration.
Volume: 9
Issue: 4
Pages: 1170-1180
Publication
First Author: Bullock J
Year: 2021
Journal: Invest Ophthalmol Vis Sci
Title: Degradation of Photoreceptor Outer Segments by the Retinal Pigment Epithelium Requires Pigment Epithelium-Derived Factor Receptor (PEDF-R).
Volume: 62
Issue: 2
Pages: 30
Publication
First Author: Patil H
Year: 2014
Journal: J Biol Chem
Title: Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation.
Volume: 289
Issue: 43
Pages: 29767-89
Publication
First Author: Masuda T
Year: 2014
Journal: J Biol Chem
Title: Transcription factor SOX9 plays a key role in the regulation of visual cycle gene expression in the retinal pigment epithelium.
Volume: 289
Issue: 18
Pages: 12908-21
Publication    
First Author: Storti F
Year: 2019
Journal: Elife
Title: Impaired ABCA1/ABCG1-mediated lipid efflux in the mouse retinal pigment epithelium (RPE) leads to retinal degeneration.
Volume: 8
Publication
First Author: Yao J
Year: 2015
Journal: Autophagy
Title: Deletion of autophagy inducer RB1CC1 results in degeneration of the retinal pigment epithelium.
Volume: 11
Issue: 6
Pages: 939-53
Publication
First Author: Valapala M
Year: 2014
Journal: Aging Cell
Title: Increased Lipocalin-2 in the retinal pigment epithelium of Cryba1 cKO mice is associated with a chronic inflammatory response.
Volume: 13
Issue: 6
Pages: 1091-4
Publication
First Author: Zhao C
Year: 2011
Journal: J Clin Invest
Title: mTOR-mediated dedifferentiation of the retinal pigment epithelium initiates photoreceptor degeneration in mice.
Volume: 121
Issue: 1
Pages: 369-83
Publication
First Author: Ghosh S
Year: 2018
Journal: Invest Ophthalmol Vis Sci
Title: A Role for βA3/A1-Crystallin in Type 2 EMT of RPE Cells Occurring in Dry Age-Related Macular Degeneration.
Volume: 59
Issue: 4
Pages: AMD104-AMD113
Publication
First Author: Shang P
Year: 2017
Journal: Aging Cell
Title: The amino acid transporter SLC36A4 regulates the amino acid pool in retinal pigmented epithelial cells and mediates the mechanistic target of rapamycin, complex 1 signaling.
Volume: 16
Issue: 2
Pages: 349-359
Publication  
First Author: Ghosh S
Year: 2019
Journal: Commun Biol
Title: Neutrophils homing into the retina trigger pathology in early age-related macular degeneration.
Volume: 2
Pages: 348
Publication
First Author: Ghosh S
Year: 2017
Journal: J Pathol
Title: Activating the AKT2-nuclear factor-κB-lipocalin-2 axis elicits an inflammatory response in age-related macular degeneration.
Volume: 241
Issue: 5
Pages: 583-588
Publication  
First Author: Valapala M
Year: 2015
Journal: Sci Rep
Title: βA3/A1-crystallin is a critical mediator of STAT3 signaling in optic nerve astrocytes.
Volume: 5
Pages: 8755
Publication
First Author: Valapala M
Year: 2014
Journal: Autophagy
Title: Lysosomal-mediated waste clearance in retinal pigment epithelial cells is regulated by CRYBA1/βA3/A1-crystallin via V-ATPase-MTORC1 signaling.
Volume: 10
Issue: 3
Pages: 480-96
Publication
First Author: Swarup A
Year: 2019
Journal: Am J Physiol Cell Physiol
Title: Modulating GLUT1 expression in retinal pigment epithelium decreases glucose levels in the retina: impact on photoreceptors and Müller glial cells.
Volume: 316
Issue: 1
Pages: C121-C133
Publication
First Author: Lin M
Year: 2011
Journal: Diabetologia
Title: Ischaemia-induced retinal neovascularisation and diabetic retinopathy in mice with conditional knockout of hypoxia-inducible factor-1 in retinal Müller cells.
Volume: 54
Issue: 6
Pages: 1554-66
Publication
First Author: Wang J
Year: 2010
Journal: Diabetes
Title: Müller cell-derived VEGF is essential for diabetes-induced retinal inflammation and vascular leakage.
Volume: 59
Issue: 9
Pages: 2297-305
Publication  
First Author: Biswal MR
Year: 2016
Journal: Adv Exp Med Biol
Title: Conditional Induction of Oxidative Stress in RPE: A Mouse Model of Progressive Retinal Degeneration.
Volume: 854
Pages: 31-7
Publication
First Author: Zhou KK
Year: 2014
Journal: PLoS One
Title: Interruption of Wnt signaling in Müller cells ameliorates ischemia-induced retinal neovascularization.
Volume: 9
Issue: 10
Pages: e108454
Publication
First Author: Biswal MR
Year: 2018
Journal: PLoS One
Title: Daily zeaxanthin supplementation prevents atrophy of the retinal pigment epithelium (RPE) in a mouse model of mitochondrial oxidative stress.
Volume: 13
Issue: 9
Pages: e0203816
Publication
First Author: Oliveira SDS
Year: 2017
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Inflammation-induced caveolin-1 and BMPRII depletion promotes endothelial dysfunction and TGF-β-driven pulmonary vascular remodeling.
Volume: 312
Issue: 5
Pages: L760-L771
Publication
First Author: Bai Y
Year: 2009
Journal: J Pathol
Title: Müller cell-derived VEGF is a significant contributor to retinal neovascularization.
Volume: 219
Issue: 4
Pages: 446-54
Publication  
First Author: Biswal MR
Year: 2015
Journal: Exp Eye Res
Title: Systemic treatment with a 5HT1a agonist induces anti-oxidant protection and preserves the retina from mitochondrial oxidative stress.
Volume: 140
Pages: 94-105
Publication  
First Author: Brown EE
Year: 2019
Journal: Redox Biol
Title: Mitochondrial oxidative stress in the retinal pigment epithelium (RPE) led to metabolic dysfunction in both the RPE and retinal photoreceptors.
Volume: 24
Pages: 101201
Publication
First Author: Biswal MR
Year: 2017
Journal: Invest Ophthalmol Vis Sci
Title: Timing of Antioxidant Gene Therapy: Implications for Treating Dry AMD.
Volume: 58
Issue: 2
Pages: 1237-1245
Publication
First Author: Fu S
Year: 2015
Journal: Diabetes
Title: Müller Glia Are a Major Cellular Source of Survival Signals for Retinal Neurons in Diabetes.
Volume: 64
Issue: 10
Pages: 3554-63