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Search results 1 to 100 out of 224 for Best1

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
7439 | BEST1
Type: gene
Organism: human
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Gene
100302038 | best1
Type: gene
Organism: frog, western clawed
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Gene
293735 | Best1
Type: gene
Organism: rat
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Gene
483791 | BEST1
Type: gene
Organism: dog, domestic
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Gene
466630 | BEST1
Type: gene
Organism: chimpanzee
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Gene
508924 | BEST1
Type: gene
Organism: cattle
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Gene
423124 | BEST1
Type: gene
Organism: chicken
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Gene
560608 | best1
Type: gene
Organism: zebrafish
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Gene
718993 | BEST1
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:1346332 | Best1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR033041 | Best1
Type: Family
Description: Bestrophin-1 (Best1) forms calcium-sensitive chloride channels that are involved in distinct basic cellular processes such as Ca2+ homeostasis, neurotransmitter release, and cell volume regulation [, , ]. It has been linked to various retinopathies. Mutations in the Best1 gene cause vitelliform macular dystrophy (VMD2), an autosomal dominant form of macular degeneration that usually begins in childhood or adolescence [].
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Publication
25941382 | J:221655
First Author: Milenkovic A
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Bestrophin 1 is indispensable for volume regulation in human retinal pigment epithelium cells.
Volume: 112
Issue: 20
Pages: E2630-9
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Publication
29121962 | J:319401
First Author: Oh SJ
Year: 2017
Journal: Mol Brain
Title: Direct interaction with 14-3-3γ promotes surface expression of Best1 channel in astrocyte.
Volume: 10
Issue: 1
Pages: 51
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Publication
23021213 | J:188266
First Author: Woo DH
Year: 2012
Journal: Cell
Title: TREK-1 and Best1 channels mediate fast and slow glutamate release in astrocytes upon GPCR activation.
Volume: 151
Issue: 1
Pages: 25-40
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Publication
19675239 | J:151935
First Author: Boudes M
Year: 2009
Journal: J Neurosci
Title: Best1 is a gene regulated by nerve injury and required for Ca2+-activated Cl- current expression in axotomized sensory neurons.
Volume: 29
Issue: 32
Pages: 10063-71
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Publication
9700209 | J:49670
First Author: Marquardt A
Year: 1998
Journal: Hum Mol Genet
Title: Mutations in a novel gene, VMD2, encoding a protein of unknown properties cause juvenile-onset vitelliform macular dystrophy (Best's disease).
Volume: 7
Issue: 9
Pages: 1517-25
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Publication
24664688 | -
 
First Author: Strauß O
Year: 2014
Journal: Adv Exp Med Biol
Title: The role of bestrophin-1 in intracellular Ca(2+) signaling.
Volume: 801
Pages: 113-9
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Publication
23062602 | -
 
First Author: Oh SJ
Year: 2012
Journal: Mol Brain
Title: Protease activated receptor 1-induced glutamate release in cultured astrocytes is mediated by Bestrophin-1 channel but not by vesicular exocytosis.
Volume: 5
Pages: 38
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Protein
O88870
Organism: Mus musculus/domesticus
Length: 551  
Fragment?: false
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Protein
A0A494B8Z9
Organism: Mus musculus/domesticus
Length: 420  
Fragment?: true
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Publication
20929730 | J:165844
First Author: Lee S
Year: 2010
Journal: Science
Title: Channel-mediated tonic GABA release from glia.
Volume: 330
Issue: 6005
Pages: 790-6
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Publication
17003041 | J:127210
First Author: Barro Soria R
Year: 2009
Journal: J Biol Chem
Title: Bestrophin-1 enables Ca2+-activated Cl- conductance in epithelia.
Volume: 284
Issue: 43
Pages: 29405-12
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Publication
33264655 | J:305495
 
First Author: Chen M
Year: 2021
Journal: Exp Eye Res
Title: An efficient inducible RPE-Selective cre transgenic mouse line.
Volume: 202
Pages: 108370
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Publication
20053664 | J:157645
First Author: Zhang Y
Year: 2010
Journal: Hum Mol Genet
Title: Suppression of Ca2+ signaling in a mouse model of Best disease.
Volume: 19
Issue: 6
Pages: 1108-18
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Publication
31201163 | J:280642
 
First Author: Milenkovic A
Year: 2019
Journal: Biol Open
Title: The Y227N mutation affects bestrophin-1 protein stability and impairs sperm function in a mouse model of Best vitelliform macular dystrophy.
Volume: 8
Issue: 7
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Publication
31588000 | J:286115
First Author: Oh SJ
Year: 2019
Journal: Curr Biol
Title: Ultrasonic Neuromodulation via Astrocytic TRPA1.
Volume: 29
Issue: 20
Pages: 3386-3401.e8
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Publication
23825107 | J:202260
First Author: Johnson AA
Year: 2013
Journal: Hum Mol Genet
Title: Differential effects of Best disease causing missense mutations on bestrophin-1 trafficking.
Volume: 22
Issue: 23
Pages: 4688-97
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Publication
18652850 | J:140865
First Author: Barro-Soria R
Year: 2008
Journal: Biochim Biophys Acta
Title: Bestrophin 1 and 2 are components of the Ca(2+) activated Cl(-) conductance in mouse airways.
Volume: 1783
Issue: 10
Pages: 1993-2000
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Publication
29691318 | J:262071
First Author: Woo J
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Control of motor coordination by astrocytic tonic GABA release through modulation of excitation/inhibition balance in cerebellum.
Volume: 115
Issue: 19
Pages: 5004-5009
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Publication
23324492 | J:196901
 
First Author: Han KS
Year: 2013
Journal: Mol Brain
Title: Channel-mediated astrocytic glutamate release via Bestrophin-1 targets synaptic NMDARs.
Volume: 6
Pages: 4
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Publication
32706443 | J:347678
First Author: Woo J
Year: 2020
Journal: J Physiol
Title: The molecular mechanism of synaptic activity-induced astrocytic volume transient.
Volume: 598
Issue: 20
Pages: 4555-4572
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Protein Coding Gene
MGP_CAROLIEiJ_G0022677 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0024834 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0024802 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0024777 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0024802 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0024568 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1346332 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0025250 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0024041 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0024542 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0024669 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0024636 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0024756 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0024663 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0025298 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0023786 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0024103 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0014171 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0023591 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
9662395 | J:57560
First Author: Petrukhin K
Year: 1998
Journal: Nat Genet
Title: Identification of the gene responsible for Best macular dystrophy.
Volume: 19
Issue: 3
Pages: 241-7
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Publication
12058047 | J:78632
First Author: Marmorstein LY
Year: 2002
Journal: J Biol Chem
Title: Bestrophin interacts physically and functionally with protein phosphatase 2A.
Volume: 277
Issue: 34
Pages: 30591-7
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Publication
12907679 | J:84780
First Author: Tsunenari T
Year: 2003
Journal: J Biol Chem
Title: Structure-function analysis of the bestrophin family of anion channels.
Volume: 278
Issue: 42
Pages: 41114-25
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Publication
32905785 | J:301376
First Author: Kwak H
Year: 2020
Journal: Neuron
Title: Astrocytes Control Sensory Acuity via Tonic Inhibition in the Thalamus.
Volume: 108
Issue: 4
Pages: 691-706.e10
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Publication
19426717 | J:150591
First Author: O'Driscoll KE
Year: 2009
Journal: Biochem Biophys Res Commun
Title: Functional properties of murine bestrophin 1 channel.
Volume: 384
Issue: 4
Pages: 476-81
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Publication
19828819 | J:154057
First Author: Park H
Year: 2009
Journal: J Neurosci
Title: Bestrophin-1 encodes for the Ca2+-activated anion channel in hippocampal astrocytes.
Volume: 29
Issue: 41
Pages: 13063-73
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GXD Expression
GXD Expression
   
Probe: MGI:6360290
Assay Type: RT-PCR
Annotation Date: 2019-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:6360538
Age: postnatal day 7
Image: 8
Specimen Label: Myrf+/fl
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6360290
Assay Type: RT-PCR
Annotation Date: 2019-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:6360538
Age: postnatal day 7
Image: 8
Specimen Label: Rxcre;Myrf+/fl
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6360290
Assay Type: RT-PCR
Annotation Date: 2019-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:6360538
Age: postnatal day 7
Image: 8
Specimen Label: Rxcre;Myrf fl/fl
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6360290
Assay Type: RT-PCR
Annotation Date: 2019-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:6360542
Age: postnatal day 22
Image: 8
Specimen Label: Myrf+/fl
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6360290
Assay Type: RT-PCR
Annotation Date: 2019-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:6360542
Age: postnatal day 22
Image: 8
Specimen Label: Rxcre;Myrf+/fl
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6360290
Assay Type: RT-PCR
Annotation Date: 2019-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:6360542
Age: postnatal day 22
Image: 8
Specimen Label: Rxcre;Myrf fl/fl
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:5614435
Assay Type: Immunohistochemistry
Annotation Date: 2015-02-05
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3284222
Pattern: Uniform
Stage: TS22
Assay Id: MGI:5614495
Age: embryonic day 14.5
Image: 5A
Specimen Label: 5A
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:5614435
Assay Type: Immunohistochemistry
Annotation Date: 2015-02-05
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3274122
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:5614495
Age: embryonic day 14.5
Image: 5B
Note: Expression was in choroid plexus epithelium.
Specimen Label: 5B
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:5614435
Assay Type: Immunohistochemistry
Annotation Date: 2015-02-05
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1777422
Pattern: Uniform
Stage: TS22
Assay Id: MGI:5614495
Age: embryonic day 14.5
Image: 5A
Specimen Label: 5A
Detected: true
Specimen Num: 1
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Publication
16707793 | J:108704
First Author: Qu Z
Year: 2006
Journal: J Neurosci
Title: The anion-selective pore of the bestrophins, a family of chloride channels associated with retinal degeneration.
Volume: 26
Issue: 20
Pages: 5411-9
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Publication
15218265 | J:107882
First Author: Krämer F
Year: 2004
Journal: Cytogenet Genome Res
Title: Cloning and characterization of the murine Vmd2 RFP-TM gene family.
Volume: 105
Issue: 1
Pages: 107-14
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Publication
12032738 | J:98703
First Author: Stöhr H
Year: 2002
Journal: Eur J Hum Genet
Title: Three novel human VMD2-like genes are members of the evolutionary highly conserved RFP-TM family.
Volume: 10
Issue: 4
Pages: 281-4
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Publication
25239459 | J:227592
First Author: Yoon BE
Year: 2014
Journal: J Physiol
Title: Glial GABA, synthesized by monoamine oxidase B, mediates tonic inhibition.
Volume: 592
Issue: 22
Pages: 4951-68
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Publication
16636205 | J:136113
First Author: Marmorstein LY
Year: 2006
Journal: J Gen Physiol
Title: The light peak of the electroretinogram is dependent on voltage-gated calcium channels and antagonized by bestrophin (best-1).
Volume: 127
Issue: 5
Pages: 577-89
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Publication
25645137 | J:345001
 
First Author: Park H
Year: 2015
Journal: Mol Brain
Title: Channel-mediated astrocytic glutamate modulates hippocampal synaptic plasticity by activating postsynaptic NMDA receptors.
Volume: 8
Pages: 7
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Publication
23437266 | J:196070
First Author: Tochitani S
Year: 2013
Journal: PLoS One
Title: Immunoreactivity for GABA, GAD65, GAD67 and Bestrophin-1 in the meninges and the choroid plexus: implications for non-neuronal sources for GABA in the developing mouse brain.
Volume: 8
Issue: 2
Pages: e56901
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Publication
30590377 | J:281944
First Author: Michael HT
Year: 2018
Journal: Invest Ophthalmol Vis Sci
Title: Partial Rescue of Ocular Pigment Cells and Structure by Inducible Ectopic Expression of Mitf-M in MITF-Deficient Mice.
Volume: 59
Issue: 15
Pages: 6067-6073
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Publication
31048900 | J:275842
First Author: Garnai SJ
Year: 2019
Journal: PLoS Genet
Title: Variants in myelin regulatory factor (MYRF) cause autosomal dominant and syndromic nanophthalmos in humans and retinal degeneration in mice.
Volume: 15
Issue: 5
Pages: e1008130
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
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Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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