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Search results 1 to 99 out of 99 for Bin2

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Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
51411 | BIN2
Type: gene
Organism: human
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Gene
366988 | Bin2
Type: gene
Organism: rat
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Gene
451903 | BIN2
Type: gene
Organism: chimpanzee
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Gene
486539 | BIN2
Type: gene
Organism: dog, domestic
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Gene
515025 | BIN2
Type: gene
Organism: cattle
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Gene
777552 | BIN2
Type: gene
Organism: chicken
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Gene
695389 | BIN2
Type: gene
Organism: macaque, rhesus
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Gene
100486620 | bin2
Type: gene
Organism: frog, western clawed
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Protein Coding Gene
MGI:3611448 | Bin2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR028827 | BIN2
Type: Family
Description: Bridging integrator 2 (BIN2) promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton []. It contains a BAR domain that mediates dimerisation and interaction with membranes enriched in phosphatidylinositides [].
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Publication
32750041 | J:302510
First Author: Volz J
Year: 2020
Journal: J Clin Invest
Title: BIN2 orchestrates platelet calcium signaling in thrombosis and thrombo-inflammation.
Volume: 130
Issue: 11
Pages: 6064-6079
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Publication
23285027 | -
First Author: Sánchez-Barrena MJ
Year: 2012
Journal: PLoS One
Title: Bin2 is a membrane sculpting N-BAR protein that influences leucocyte podosomes, motility and phagocytosis.
Volume: 7
Issue: 12
Pages: e52401
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Protein
D3Z6Q9
Organism: Mus musculus/domesticus
Length: 489  
Fragment?: false
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Protein
S4R171
Organism: Mus musculus/domesticus
Length: 210  
Fragment?: true
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Protein
S4R1B8
Organism: Mus musculus/domesticus
Length: 478  
Fragment?: false
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Protein
A0A5F8MQ05
Organism: Mus musculus/domesticus
Length: 518  
Fragment?: false
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Protein
S4R2J8
Organism: Mus musculus/domesticus
Length: 473  
Fragment?: false
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Protein
S4R1Q1
Organism: Mus musculus/domesticus
Length: 160  
Fragment?: true
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Protein
S4R270
Organism: Mus musculus/domesticus
Length: 505  
Fragment?: false
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Publication
37118338 | J:344336
First Author: Zhu FY
Year: 2021
Journal: Nat Aging
Title: Inhibiting bridge integrator 2 phosphorylation leads to improved oocyte quality, ovarian health and fertility in aging and after chemotherapy in mice.
Volume: 1
Issue: 11
Pages: 1010-1023
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Protein Coding Gene
MGP_CAROLIEiJ_G0020297 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0022358 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0022320 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0022296 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0022324 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0022094 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_3611448 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0022772 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0021619 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0022063 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0022190 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0022169 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0022261 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0022190 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0022786 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0021358 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0021669 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0020298 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0021190 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
 
Probe: MGI:4426558
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1752323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823476
Age: embryonic day 14.5
Image: euxassay_014160_10
Specimen Label: euxassay_014160_10
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
 
Probe: MGI:4426558
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1752323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823476
Age: embryonic day 14.5
Image: euxassay_014160_11
Specimen Label: euxassay_014160_11
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
 
Probe: MGI:4426558
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1752323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823476
Age: embryonic day 14.5
Image: euxassay_014160_12
Specimen Label: euxassay_014160_12
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
 
Probe: MGI:4426558
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1752323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823476
Age: embryonic day 14.5
Image: euxassay_014160_13
Specimen Label: euxassay_014160_13
Detected: true
Specimen Num: 13
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GXD Expression
GXD Expression
 
Probe: MGI:4426558
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1752323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823476
Age: embryonic day 14.5
Image: euxassay_014160_14
Specimen Label: euxassay_014160_14
Detected: true
Specimen Num: 14
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GXD Expression
GXD Expression
 
Probe: MGI:4426558
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1752323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823476
Age: embryonic day 14.5
Image: euxassay_014160_15
Specimen Label: euxassay_014160_15
Detected: true
Specimen Num: 15
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GXD Expression
GXD Expression
 
Probe: MGI:4426558
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1684623
Pattern: Spotted
Stage: TS23
Assay Id: MGI:4823476
Age: embryonic day 14.5
Image: euxassay_014160_01
Specimen Label: euxassay_014160_01
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:4426558
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1684623
Pattern: Spotted
Stage: TS23
Assay Id: MGI:4823476
Age: embryonic day 14.5
Image: euxassay_014160_02
Specimen Label: euxassay_014160_02
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:4426558
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1684623
Pattern: Spotted
Stage: TS23
Assay Id: MGI:4823476
Age: embryonic day 14.5
Image: euxassay_014160_03
Specimen Label: euxassay_014160_03
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:4426558
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1684623
Pattern: Spotted
Stage: TS23
Assay Id: MGI:4823476
Age: embryonic day 14.5
Image: euxassay_014160_04
Specimen Label: euxassay_014160_04
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:4426558
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1684623
Pattern: Spotted
Stage: TS23
Assay Id: MGI:4823476
Age: embryonic day 14.5
Image: euxassay_014160_05
Specimen Label: euxassay_014160_05
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:4426558
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1684623
Pattern: Spotted
Stage: TS23
Assay Id: MGI:4823476
Age: embryonic day 14.5
Image: euxassay_014160_06
Specimen Label: euxassay_014160_06
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:4426558
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1684623
Pattern: Spotted
Stage: TS23
Assay Id: MGI:4823476
Age: embryonic day 14.5
Image: euxassay_014160_07
Specimen Label: euxassay_014160_07
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Probe: MGI:4426558
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1684623
Pattern: Spotted
Stage: TS23
Assay Id: MGI:4823476
Age: embryonic day 14.5
Image: euxassay_014160_08
Specimen Label: euxassay_014160_08
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
 
Probe: MGI:4426558
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1684623
Pattern: Spotted
Stage: TS23
Assay Id: MGI:4823476
Age: embryonic day 14.5
Image: euxassay_014160_09
Specimen Label: euxassay_014160_09
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
 
Probe: MGI:4426558
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1684623
Pattern: Spotted
Stage: TS23
Assay Id: MGI:4823476
Age: embryonic day 14.5
Image: euxassay_014160_10
Specimen Label: euxassay_014160_10
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
 
Probe: MGI:4426558
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1684623
Pattern: Spotted
Stage: TS23
Assay Id: MGI:4823476
Age: embryonic day 14.5
Image: euxassay_014160_11
Specimen Label: euxassay_014160_11
Detected: true
Specimen Num: 11
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•
GXD Expression
GXD Expression
 
Probe: MGI:4426558
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1684623
Pattern: Spotted
Stage: TS23
Assay Id: MGI:4823476
Age: embryonic day 14.5
Image: euxassay_014160_12
Specimen Label: euxassay_014160_12
Detected: true
Specimen Num: 12
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•
GXD Expression
GXD Expression
 
Probe: MGI:4426558
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1684623
Pattern: Spotted
Stage: TS23
Assay Id: MGI:4823476
Age: embryonic day 14.5
Image: euxassay_014160_13
Specimen Label: euxassay_014160_13
Detected: true
Specimen Num: 13
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•
GXD Expression
GXD Expression
 
Probe: MGI:4426558
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1684623
Pattern: Spotted
Stage: TS23
Assay Id: MGI:4823476
Age: embryonic day 14.5
Image: euxassay_014160_14
Specimen Label: euxassay_014160_14
Detected: true
Specimen Num: 14
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GXD Expression
GXD Expression
 
Probe: MGI:4426558
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1684623
Pattern: Spotted
Stage: TS23
Assay Id: MGI:4823476
Age: embryonic day 14.5
Image: euxassay_014160_15
Specimen Label: euxassay_014160_15
Detected: true
Specimen Num: 15
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•
GXD Expression
GXD Expression
 
Probe: MGI:4426558
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1684623
Pattern: Spotted
Stage: TS23
Assay Id: MGI:4823476
Age: embryonic day 14.5
Image: euxassay_014160_16
Specimen Label: euxassay_014160_16
Detected: true
Specimen Num: 16
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•
GXD Expression
GXD Expression
 
Probe: MGI:4426558
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1684623
Pattern: Spotted
Stage: TS23
Assay Id: MGI:4823476
Age: embryonic day 14.5
Image: euxassay_014160_17
Specimen Label: euxassay_014160_17
Detected: true
Specimen Num: 17
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•
GXD Expression
GXD Expression
 
Probe: MGI:4426558
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1684623
Pattern: Spotted
Stage: TS23
Assay Id: MGI:4823476
Age: embryonic day 14.5
Image: euxassay_014160_18
Specimen Label: euxassay_014160_18
Detected: true
Specimen Num: 18
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•
GXD Expression
GXD Expression
 
Probe: MGI:4426558
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1684623
Pattern: Spotted
Stage: TS23
Assay Id: MGI:4823476
Age: embryonic day 14.5
Image: euxassay_014160_19
Specimen Label: euxassay_014160_19
Detected: true
Specimen Num: 19
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•
GXD Expression
GXD Expression
 
Probe: MGI:4426558
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1684623
Pattern: Spotted
Stage: TS23
Assay Id: MGI:4823476
Age: embryonic day 14.5
Image: euxassay_014160_20
Specimen Label: euxassay_014160_20
Detected: true
Specimen Num: 20
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•
GXD Expression
GXD Expression
 
Probe: MGI:4426558
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1684623
Pattern: Spotted
Stage: TS23
Assay Id: MGI:4823476
Age: embryonic day 14.5
Image: euxassay_014160_21
Specimen Label: euxassay_014160_21
Detected: true
Specimen Num: 21
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•
GXD Expression
GXD Expression
 
Probe: MGI:4426558
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1684623
Pattern: Spotted
Stage: TS23
Assay Id: MGI:4823476
Age: embryonic day 14.5
Image: euxassay_014160_22
Specimen Label: euxassay_014160_22
Detected: true
Specimen Num: 22
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•
GXD Expression
GXD Expression
 
Probe: MGI:4426558
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1684623
Pattern: Spotted
Stage: TS23
Assay Id: MGI:4823476
Age: embryonic day 14.5
Image: euxassay_014160_23
Specimen Label: euxassay_014160_23
Detected: true
Specimen Num: 23
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•
GXD Expression
GXD Expression
 
Probe: MGI:4426558
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1684623
Pattern: Spotted
Stage: TS23
Assay Id: MGI:4823476
Age: embryonic day 14.5
Image: euxassay_014160_24
Specimen Label: euxassay_014160_24
Detected: true
Specimen Num: 24
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Publication
- | J:193309
       
First Author: Mouse Genome Informatics Scientfic Curators
Year: 2013
Title: Curated associations of genes in MGI and UniProt sequence records
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Publication
- | J:237616
     
First Author: MGI and IMPC
Year: 2017
Journal: MGI Direct Data Submission
Title: MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:81858
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
26387715 | -
First Author: Anne P
Year: 2015
Journal: Curr Biol
Title: OCTOPUS Negatively Regulates BIN2 to Control Phloem Differentiation in Arabidopsis thaliana.
Volume: 25
Issue: 19
Pages: 2584-90
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Publication
28575660 | -
First Author: Zhu JY
Year: 2017
Journal: Mol Cell
Title: The F-box Protein KIB1 Mediates Brassinosteroid-Induced Inactivation and Degradation of GSK3-like Kinases in Arabidopsis.
Volume: 66
Issue: 5
Pages: 648-657.e4
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Publication
30938771 | -
First Author: Lama S
Year: 2019
Journal: Mol Biol Evol
Title: Neofunctionalization of Mitochondrial Proteins and Incorporation into Signaling Networks in Plants.
Volume: 36
Issue: 5
Pages: 974-989
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Publication
22395740 | -
First Author: Truernit E
Year: 2012
Journal: Development
Title: OCTOPUS, a polarly localised membrane-associated protein, regulates phloem differentiation entry in Arabidopsis thaliana.
Volume: 139
Issue: 7
Pages: 1306-15
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Publication
28652362 | -
First Author: Breda AS
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Phosphosite charge rather than shootward localization determines OCTOPUS activity in root protophloem.
Volume: 114
Issue: 28
Pages: E5721-E5730
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Protein Domain
IPR005174 | DUF295
Type: Domain
Description: This domain is found in plant proteins, many of which also contain an F-box domain []. This domain can be found in KIB3 from Arabidopsis. KIB3 is a F-box E3 ubiquitin ligase that promotes the degradation of GSK3-like kinase BIN2 while blocking its substrate access [].
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Protein Domain
IPR008004 | OCTOPUS-like
Type: Family
Description: This family consists of several plant proteins, including protein OCTOPUS (OPS, At3g09070) and OPSL1 (At5g01170) from Arabidopsis []. OPS is a membrane-associated protein that regulates phloem differentiation entry []. It is a positive regulator of the brassinosteroid (BR) signaling pathway and sequesters BIN2 to the plasma membrane to promote phloem differentiation [].
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Publication
24654956 | -
First Author: Lee E
Year: 2014
Journal: Plant J
Title: Arabidopsis guard cell integrity involves the epigenetic stabilization of the FLP and FAMA transcription factor genes.
Volume: 78
Issue: 4
Pages: 566-77
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Publication
22466366 | -
First Author: Gudesblat GE
Year: 2012
Journal: Nat Cell Biol
Title: SPEECHLESS integrates brassinosteroid and stomata signalling pathways.
Volume: 14
Issue: 5
Pages: 548-54
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Publication
17183265 | -
First Author: MacAlister CA
Year: 2007
Journal: Nature
Title: Transcription factor control of asymmetric cell divisions that establish the stomatal lineage.
Volume: 445
Issue: 7127
Pages: 537-40
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Protein Domain
IPR044283 | FAMA/SPEECHLESS/MUTE
Type: Family
Description: This entry represents a group of plant bHLH transcription factors, including FAMA, SPEECHLESS and MUTE from Arabidopsis. These proteins have been shown to play important parts in stomatal lineage development. SPEECHLESS (SPCH) generates stem cells and promotes their asymmetric division while MUTE regulates the meristemoid to Guard Mother Cell (GMC) transition. FAMA confers guard cell (GC) fate and is expressed at the equal division producing the two young GCs, but not in mature stomata [, ].SPCH can be regulated through phosphorylation by MAPK-mediated and BIN2 (BR INSENSITIVE2). It has been suggested that SPCH integrates brassinosteroid and stomata signalling pathways [].
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