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Search results 1 to 100 out of 137 for Birc6

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0.057s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Domain
Type: Family
Description: Baculoviral IAP repeat-containing protein 6 (BIRC6, also known as BRUCE) is an anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase []. It has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase []. It is crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification [].
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Pohl C
Year: 2008
Journal: Cell
Title: Final stages of cytokinesis and midbody ring formation are controlled by BRUCE.
Volume: 132
Issue: 5
Pages: 832-45
Publication
First Author: Bartke T
Year: 2004
Journal: Mol Cell
Title: Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase.
Volume: 14
Issue: 6
Pages: 801-11
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Homo sapiens
Protein
Organism: Mus musculus
Length: 4882  
Fragment?: false
Publication
First Author: Ren J
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: The Birc6 (Bruce) gene regulates p53 and the mitochondrial pathway of apoptosis and is essential for mouse embryonic development.
Volume: 102
Issue: 3
Pages: 565-70
Protein
Organism: Mus musculus
Length: 4853  
Fragment?: false
Protein
Organism: Mus musculus
Length: 4869  
Fragment?: false
Protein
Organism: Mus musculus
Length: 4882  
Fragment?: false
Protein
Organism: Mus musculus
Length: 4939  
Fragment?: false
Publication
First Author: Qiu XB
Year: 2004
Journal: EMBO J
Title: Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis.
Volume: 23
Issue: 4
Pages: 800-10
Gene
Type: gene
Organism: Danio rerio
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Hauser HP
Year: 1998
Journal: J Cell Biol
Title: A giant ubiquitin-conjugating enzyme related to IAP apoptosis inhibitors.
Volume: 141
Issue: 6
Pages: 1415-22
Publication
First Author: Lotz K
Year: 2004
Journal: Mol Cell Biol
Title: BRUCE, a giant E2/E3 ubiquitin ligase and inhibitor of apoptosis protein of the trans-Golgi network, is required for normal placenta development and mouse survival.
Volume: 24
Issue: 21
Pages: 9339-50
Publication
First Author: Hao Y
Year: 2004
Journal: Nat Cell Biol
Title: Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function.
Volume: 6
Issue: 9
Pages: 849-60
Publication
First Author: Chen Z
Year: 1999
Journal: Biochem Biophys Res Commun
Title: A human IAP-family gene, apollon, expressed in human brain cancer cells.
Volume: 264
Issue: 3
Pages: 847-54
GXD Expression    
Probe: MGI:2667710
Assay Type: Northern blot
Annotation Date: 2003-07-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:2667717
Age: postnatal adult
Image: 2
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:2667709
Assay Type: Northern blot
Annotation Date: 2003-07-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:2667715
Age: postnatal adult
Image: 2
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:2667710
Assay Type: Northern blot
Annotation Date: 2003-07-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:2667717
Age: postnatal adult
Image: 2
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:2667709
Assay Type: Northern blot
Annotation Date: 2003-07-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:2667715
Age: postnatal adult
Image: 2
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3802745
Assay Type: Western blot
Annotation Date: 2008-08-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603922
Stage: TS22
Assay Id: MGI:3802748
Age: embryonic day 14.5
Image: 5
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:3802745
Assay Type: Western blot
Annotation Date: 2008-08-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603922
Stage: TS22
Assay Id: MGI:3802748
Age: embryonic day 14.5
Image: 5
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:3802745
Assay Type: Western blot
Annotation Date: 2008-08-19
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603922
Stage: TS22
Assay Id: MGI:3802748
Age: embryonic day 14.5
Image: 5
Detected: false
Specimen Num: 3
GXD Expression    
Probe: MGI:3802745
Assay Type: Western blot
Annotation Date: 2008-08-19
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603922
Stage: TS22
Assay Id: MGI:3802748
Age: embryonic day 14.5
Image: 5
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:3802745
Assay Type: Western blot
Annotation Date: 2008-08-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603922
Stage: TS22
Assay Id: MGI:3802748
Age: embryonic day 14.5
Image: 5
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:2667710
Assay Type: Northern blot
Annotation Date: 2003-07-30
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1603925
Stage: TS25
Assay Id: MGI:2667721
Age: embryonic day 17.0
Image: 2
Specimen Num: 4
GXD Expression      
Probe: MGI:2667710
Assay Type: Northern blot
Annotation Date: 2003-07-30
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:2667721
Age: embryonic day 15.0
Image: 2
Specimen Num: 3
GXD Expression      
Probe: MGI:2667710
Assay Type: Northern blot
Annotation Date: 2003-07-30
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1603918
Stage: TS18
Assay Id: MGI:2667721
Age: embryonic day 11.0
Image: 2
Specimen Num: 2
GXD Expression      
Probe: MGI:2667710
Assay Type: Northern blot
Annotation Date: 2003-07-30
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1603910
Stage: TS10
Assay Id: MGI:2667721
Age: embryonic day 7.0
Image: 2
Specimen Num: 1
GXD Expression      
Probe: MGI:2667709
Assay Type: Northern blot
Annotation Date: 2003-07-30
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1603925
Stage: TS25
Assay Id: MGI:2667718
Age: embryonic day 17.0
Image: 2
Specimen Num: 4
GXD Expression      
Probe: MGI:2667709
Assay Type: Northern blot
Annotation Date: 2003-07-30
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:2667718
Age: embryonic day 15.0
Image: 2
Specimen Num: 3
GXD Expression      
Probe: MGI:2667709
Assay Type: Northern blot
Annotation Date: 2003-07-30
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1603918
Stage: TS18
Assay Id: MGI:2667718
Age: embryonic day 11.0
Image: 2
Specimen Num: 2
GXD Expression      
Probe: MGI:2667709
Assay Type: Northern blot
Annotation Date: 2003-07-30
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1603910
Stage: TS10
Assay Id: MGI:2667718
Age: embryonic day 7.0
Image: 2
Specimen Num: 1
GXD Expression      
Probe: MGI:2667712
Assay Type: Western blot
Annotation Date: 2003-07-30
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2667722
Age: postnatal adult
Image: 3
Specimen Num: 1
GXD Expression    
Probe: MGI:2667710
Assay Type: Northern blot
Annotation Date: 2003-07-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2667717
Age: postnatal adult
Image: 2
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:2667709
Assay Type: Northern blot
Annotation Date: 2003-07-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2667715
Age: postnatal adult
Image: 2
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:2667710
Assay Type: Northern blot
Annotation Date: 2003-07-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:2667717
Age: postnatal adult
Image: 2
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:2667709
Assay Type: Northern blot
Annotation Date: 2003-07-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:2667715
Age: postnatal adult
Image: 2
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:2667710
Assay Type: Northern blot
Annotation Date: 2003-07-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:2667717
Age: postnatal adult
Image: 2
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:2667709
Assay Type: Northern blot
Annotation Date: 2003-07-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:2667715
Age: postnatal adult
Image: 2
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:2667710
Assay Type: Northern blot
Annotation Date: 2003-07-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:2667717
Age: postnatal adult
Image: 2
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:2667709
Assay Type: Northern blot
Annotation Date: 2003-07-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:2667715
Age: postnatal adult
Image: 2
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:2667710
Assay Type: Northern blot
Annotation Date: 2003-07-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:2667717
Age: postnatal adult
Image: 2
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:2667709
Assay Type: Northern blot
Annotation Date: 2003-07-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:2667715
Age: postnatal adult
Image: 2
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:2667710
Assay Type: Northern blot
Annotation Date: 2003-07-30
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:2667717
Age: postnatal adult
Image: 2
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:2667709
Assay Type: Northern blot
Annotation Date: 2003-07-30
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:2667715
Age: postnatal adult
Image: 2
Detected: true
Specimen Num: 8
GXD Expression  
Probe: MGI:3507283
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1647017
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:3509603
Age: embryonic day 10.5
Image: 1
Note: Authors stated that in some instances they could not determine expression levels with certainty.
Specimen Num: 1
GXD Expression  
Probe: MGI:3507283
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2852723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5540203
Age: embryonic day 15.5
Image: GUDMAP:6279
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3507283
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2850023
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5540203
Age: embryonic day 15.5
Image: GUDMAP:6279
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3507283
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2762123
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5540203
Age: embryonic day 15.5
Image: GUDMAP:6279
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3507283
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:1796223
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5540203
Age: embryonic day 15.5
Image: GUDMAP:6279
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3507283
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Ambiguous
Sex: Female
Emaps: EMAPS:3152723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5540203
Age: embryonic day 15.5
Image: GUDMAP:12302
Specimen Num: 2
GXD Expression  
Probe: MGI:3507283
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2845723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5540203
Age: embryonic day 15.5
Image: GUDMAP:6279
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3507283
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:1832123
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5540203
Age: embryonic day 15.5
Image: GUDMAP:6279
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3507283
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2854023
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5540203
Age: embryonic day 15.5
Image: GUDMAP:6279
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3507283
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2760523
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5540203
Age: embryonic day 15.5
Image: GUDMAP:6279
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3507283
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Ambiguous
Sex: Female
Emaps: EMAPS:2866123
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5540203
Age: embryonic day 15.5
Image: GUDMAP:12302
Specimen Num: 2
GXD Expression  
Probe: MGI:3507283
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2769723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5540203
Age: embryonic day 15.5
Image: GUDMAP:6279
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3507283
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2874723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5540203
Age: embryonic day 15.5
Image: GUDMAP:12302
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3507283
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2874723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5540203
Age: embryonic day 15.5
Image: GUDMAP:6279
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3507283
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2851823
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5540203
Age: embryonic day 15.5
Image: GUDMAP:6279
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3507283
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2875323
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5540203
Age: embryonic day 15.5
Image: GUDMAP:12302
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3507283
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:1795023
Stage: TS23
Assay Id: MGI:5540203
Age: embryonic day 15.5
Image: GUDMAP:6279
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:3507283
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2876523
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5540203
Age: embryonic day 15.5
Image: GUDMAP:12302
Detected: true
Specimen Num: 2
Publication
First Author: Wu X
Year: 2004
Journal: Mol Cell Biol
Title: Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8.
Volume: 24
Issue: 17
Pages: 7748-57
Publication
First Author: Jansen KM
Year: 2008
Journal: Cell Death Differ
Title: Prostaglandin F2alpha promotes muscle cell survival and growth through upregulation of the inhibitor of apoptosis protein BRUCE.
Volume: 15
Issue: 10
Pages: 1619-28
Publication
First Author: Ge C
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: BRUCE regulates DNA double-strand break response by promoting USP8 deubiquitination of BRIT1.
Volume: 112
Issue: 11
Pages: E1210-9
Publication
First Author: Deveraux QL
Year: 1999
Journal: Genes Dev
Title: IAP family proteins--suppressors of apoptosis.
Volume: 13
Issue: 3
Pages: 239-52
Publication
First Author: Hitz C
Year: 2005
Journal: Genesis
Title: Progressive loss of the spongiotrophoblast layer of Birc6/Bruce mutants results in embryonic lethality.
Volume: 42
Issue: 2
Pages: 91-103
Publication
First Author: LaCasse EC
Year: 1998
Journal: Oncogene
Title: The inhibitors of apoptosis (IAPs) and their emerging role in cancer.
Volume: 17
Issue: 25
Pages: 3247-59
Publication
First Author: Mitchell KJ
Year: 2001
Journal: Nat Genet
Title: Functional analysis of secreted and transmembrane proteins critical to mouse development.
Volume: 28
Issue: 3
Pages: 241-9
Publication
First Author: Reed JC
Year: 2003
Journal: Genome Res
Title: Comparative analysis of apoptosis and inflammation genes of mice and humans.
Volume: 13
Issue: 6B
Pages: 1376-88
Publication      
First Author: The Australian Phenomics Facility at The Australian National University
Year: 2006
Journal: MGI Direct Data Submission
Title: Heritable mouse mutants from the ENU mutagenesis program at the Australian Phenomics Facility at The Australian National University
Publication
First Author: Cobellis G
Year: 2005
Journal: Nucleic Acids Res
Title: Tagging genes with cassette-exchange sites.
Volume: 33
Issue: 4
Pages: e44
Publication      
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics