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Search results 1 to 100 out of 100 for Bloc1s1

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Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
2647 | BLOC1S1
Type: gene
Organism: human
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Gene
779698 | bloc1s1
Type: gene
Organism: frog, western clawed
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Gene
106557465 | BLOC1S1
Type: gene
Organism: dog, domestic
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Gene
288785 | Bloc1s1
Type: gene
Organism: rat
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Gene
451968 | BLOC1S1
Type: gene
Organism: chimpanzee
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Gene
615149 | BLOC1S1
Type: gene
Organism: cattle
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Gene
100857285 | BLOC1S1
Type: gene
Organism: chicken
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Gene
556597 | bloc1s1
Type: gene
Organism: zebrafish
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Gene
707395 | BLOC1S1
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR009395 | BLOC1S1
Type: Family
Description: GCN5L1 (general control of amino acid synthesis 5-like 1), also known as BLOC1S1 (biogenesis of lysosome-related organelles complex 1 subunit 1). It is a component of the BLOC-1 complex, a complex required for normal biogenesis of lysosome-related organelles []. GCN5L1 has been identified as a critical component of the mitochondrial protein acetylation programme []. It acts as a nutrient-sensing regulator that controls mitochondrial content through coordinated regulation of mitochondrial biogenesis and autophagy [].
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Protein Coding Gene
MGI:1195276 | Bloc1s1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
22309213 | J:182526
First Author: Scott I
Year: 2012
Journal: Biochem J
Title: Identification of a molecular component of the mitochondrial acetyltransferase programme: a novel role for GCN5L1.
Volume: 443
Issue: 3
Pages: 655-61
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Publication
24356961 | J:213033
First Author: Scott I
Year: 2014
Journal: J Biol Chem
Title: GCN5-like protein 1 (GCN5L1) controls mitochondrial content through coordinated regulation of mitochondrial biogenesis and mitophagy.
Volume: 289
Issue: 5
Pages: 2864-72
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Publication
36535215 | J:344546
 
First Author: Wu K
Year: 2023
Journal: Biochem Biophys Res Commun
Title: The endo-lysosomal regulatory protein BLOC1S1 modulates hepatic lysosomal content and lysosomal lipolysis.
Volume: 642
Pages: 1-10
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Protein
O55102
Organism: Mus musculus/domesticus
Length: 125  
Fragment?: false
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Protein
D3Z4L7
Organism: Mus musculus/domesticus
Length: 94  
Fragment?: false
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Protein
D3YVM8
Organism: Mus musculus/domesticus
Length: 121  
Fragment?: false
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Publication
17182842 | J:124026
First Author: Setty SR
Year: 2007
Journal: Mol Biol Cell
Title: BLOC-1 is required for cargo-specific sorting from vacuolar early endosomes toward lysosome-related organelles.
Volume: 18
Issue: 3
Pages: 768-80
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Publication
33629936 | J:344691
First Author: Wu K
Year: 2021
Journal: Autophagy
Title: BLOC1S1/GCN5L1/BORCS1 is a critical mediator for the initiation of autolysosomal tubulation.
Volume: 17
Issue: 11
Pages: 3707-3724
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Protein Coding Gene
MGP_CAROLIEiJ_G0015962 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0017890 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0017865 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0017828 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0017829 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0017652 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1195276 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0018284 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0017213 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0017622 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0017728 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0017723 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0017802 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0017751 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0018324 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0016998 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0017272 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0031122 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0016787 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
30323061 | J:272827
First Author: Thapa D
Year: 2018
Journal: J Biol Chem
Title: The protein acetylase GCN5L1 modulates hepatic fatty acid oxidation activity via acetylation of the mitochondrial β-oxidation enzyme HADHA.
Volume: 293
Issue: 46
Pages: 17676-17684
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Publication
35924321 | J:327609
First Author: Thapa D
Year: 2022
Journal: Physiol Rep
Title: GCN5L1 impairs diastolic function in mice exposed to a high fat diet by restricting cardiac pyruvate oxidation.
Volume: 10
Issue: 15
Pages: e15415
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Publication
30333138 | J:266974
 
First Author: Wu K
Year: 2018
Journal: J Cell Sci
Title: GCN5L1 interacts with αTAT1 and RanBP2 to regulate hepatic α-tubulin acetylation and lysosome trafficking.
Volume: 131
Issue: 22
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GXD Expression
GXD Expression
   
Probe: MGI:7367602
Assay Type: Western blot
Annotation Date: 2022-10-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689417
Stage: TS17
Assay Id: MGI:7377780
Age: embryonic day 10.5
Image: 8
Specimen Label: WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7367602
Assay Type: Western blot
Annotation Date: 2022-10-31
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689417
Stage: TS17
Assay Id: MGI:7377780
Age: embryonic day 10.5
Image: 8
Specimen Label: Bloc1s1-/-
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:7383018
Assay Type: RT-PCR
Annotation Date: 2022-11-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3550728
Stage: TS28
Assay Id: MGI:7383038
Age: postnatal week 2
Specimen Label: PZ WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:7383018
Assay Type: RT-PCR
Annotation Date: 2022-11-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3550728
Stage: TS28
Assay Id: MGI:7383038
Age: postnatal week 2
Specimen Label: PZ Xbp1CartEx2
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:7383018
Assay Type: RT-PCR
Annotation Date: 2022-11-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3550628
Stage: TS28
Assay Id: MGI:7383042
Age: postnatal week 2
Specimen Label: HZ WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:7383018
Assay Type: RT-PCR
Annotation Date: 2022-11-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3550628
Stage: TS28
Assay Id: MGI:7383042
Age: postnatal week 2
Specimen Label: HZ Xbp1CartEx2
Detected: true
Specimen Num: 2
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Publication
33179593 | J:298681
   
First Author: Zhang C
Year: 2020
Journal: Elife
Title: BLOS1 mediates kinesin switch during endosomal recycling of LDL receptor.
Volume: 9
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Publication
32606301 | J:295924
First Author: Thapa D
Year: 2020
Journal: Sci Rep
Title: Cardiomyocyte-specific deletion of GCN5L1 in mice restricts mitochondrial protein hyperacetylation in response to a high fat diet.
Volume: 10
Issue: 1
Pages: 10665
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Publication
30776374 | J:272490
 
First Author: Manning JR
Year: 2019
Journal: J Mol Cell Cardiol
Title: Cardiac-specific deletion of GCN5L1 restricts recovery from ischemia-reperfusion injury.
Volume: 129
Pages: 69-78
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Publication
28900165 | J:252610
First Author: Wang L
Year: 2017
Journal: Nat Commun
Title: GCN5L1 modulates cross-talk between mitochondria and cell signaling to regulate FoxO1 stability and gluconeogenesis.
Volume: 8
Issue: 1
Pages: 523
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Publication
30787040 | J:273315
First Author: Bae D
Year: 2019
Journal: J Cell Biol
Title: Degradation of Blos1 mRNA by IRE1 repositions lysosomes and protects cells from stress.
Volume: 218
Issue: 4
Pages: 1118-1127
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Publication
33680286 | J:308099
 
First Author: Lv T
Year: 2021
Journal: Oxid Med Cell Longev
Title: General Control of Amino Acid Synthesis 5-Like 1-Mediated Acetylation of Manganese Superoxide Dismutase Regulates Oxidative Stress in Diabetic Kidney Disease.
Volume: 2021
Pages: 6691226
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Publication
9426003 | J:44704
First Author: Driessen CA
Year: 1997
Journal: Gene
Title: Cloning and structural analysis of the murine GCN5L1 gene.
Volume: 203
Issue: 1
Pages: 27-31
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Publication
28319092 | J:246734
First Author: Donato V
Year: 2017
Journal: Nat Cell Biol
Title: The TDH-GCN5L1-Fbxo15-KBP axis limits mitochondrial biogenesis in mouse embryonic stem cells.
Volume: 19
Issue: 4
Pages: 341-351
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Publication
25183008 | J:238911
First Author: Zhang A
Year: 2014
Journal: J Biol Chem
Title: Biogenesis of lysosome-related organelles complex-1 subunit 1 (BLOS1) interacts with sorting nexin 2 and the endosomal sorting complex required for transport-I (ESCRT-I) component TSG101 to mediate the sorting of epidermal growth factor receptor into endosomal compartments.
Volume: 289
Issue: 42
Pages: 29180-94
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Publication
31138772 | J:278441
First Author: Manning JR
Year: 2019
Journal: Biochem J
Title: Loss of GCN5L1 in cardiac cells disrupts glucose metabolism and promotes cell death via reduced Akt/mTORC2 signaling.
Volume: 476
Issue: 12
Pages: 1713-1724
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Publication
22554196 | J:192646
First Author: Yang Q
Year: 2012
Journal: Traffic
Title: The BLOS1-interacting protein KXD1 is involved in the biogenesis of lysosome-related organelles.
Volume: 13
Issue: 8
Pages: 1160-9
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Publication
16837549 | J:114587
First Author: Di Pietro SM
Year: 2006
Journal: Mol Biol Cell
Title: BLOC-1 interacts with BLOC-2 and the AP-3 complex to facilitate protein trafficking on endosomes.
Volume: 17
Issue: 9
Pages: 4027-38
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Publication
15102850 | J:90887
First Author: Starcevic M
Year: 2004
Journal: J Biol Chem
Title: Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1).
Volume: 279
Issue: 27
Pages: 28393-401
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Publication
15265785 | J:94897
First Author: Gwynn B
Year: 2004
Journal: Blood
Title: Reduced pigmentation (rp), a mouse model of Hermansky-Pudlak syndrome, encodes a novel component of the BLOC-1 complex.
Volume: 104
Issue: 10
Pages: 3181-9
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Publication
25898167 | J:320078
First Author: Pu J
Year: 2015
Journal: Dev Cell
Title: BORC, a multisubunit complex that regulates lysosome positioning.
Volume: 33
Issue: 2
Pages: 176-88
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Publication
31314175 | J:319692
First Author: Yordanov TE
Year: 2019
Journal: Traffic
Title: Biogenesis of lysosome-related organelles complex-1 (BORC) regulates late endosomal/lysosomal size through PIKfyve-dependent phosphatidylinositol-3,5-bisphosphate.
Volume: 20
Issue: 9
Pages: 674-696
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Publication
16760431 | J:114481
First Author: Salazar G
Year: 2006
Journal: Mol Biol Cell
Title: BLOC-1 complex deficiency alters the targeting of adaptor protein complex-3 cargoes.
Volume: 17
Issue: 9
Pages: 4014-26
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Publication
19546860 | J:188897
First Author: Ghiani CA
Year: 2010
Journal: Mol Psychiatry
Title: The dysbindin-containing complex (BLOC-1) in brain: developmental regulation, interaction with SNARE proteins and role in neurite outgrowth.
Volume: 15
Issue: 2
Pages: 115, 204-15
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Publication
21998198 | J:187545
First Author: Larimore J
Year: 2011
Journal: Mol Biol Cell
Title: The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse.
Volume: 22
Issue: 24
Pages: 4854-67
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Publication
27719760 | J:238623
   
First Author: Zhou W
Year: 2016
Journal: Elife
Title: BLOS2 negatively regulates Notch signaling during neural and hematopoietic stem and progenitor cell development.
Volume: 5
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Publication
25600960 | J:231358
First Author: Cameron TL
Year: 2015
Journal: Osteoarthritis Cartilage
Title: Cartilage-specific ablation of XBP1 signaling in mouse results in a chondrodysplasia characterized by reduced chondrocyte proliferation and delayed cartilage maturation and mineralization.
Volume: 23
Issue: 4
Pages: 661-70
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Publication
- | J:165965
     
First Author: Mouse Genome Informatics and the Europhenome Mouse Phenotyping Resource
Year: 2010
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from Europhenome
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Publication
18614015 | J:151002
First Author: Pagliarini DJ
Year: 2008
Journal: Cell
Title: A mitochondrial protein compendium elucidates complex I disease biology.
Volume: 134
Issue: 1
Pages: 112-23
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Publication
- | J:342607
       
First Author: Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom
Year: 2023
Title: Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
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Publication
20059953 | J:156017
First Author: Yokoyama S
Year: 2009
Journal: Dev Cell
Title: A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Volume: 17
Issue: 6
Pages: 836-48
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Publication
- | J:81858
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
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Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
35587649 | J:325052
   
First Author: Wells KM
Year: 2022
Journal: Elife
Title: Brucella activates the host RIDD pathway to subvert BLOS1-directed immune defense.
Volume: 11
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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