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Search results 1 to 99 out of 99 for Bloc1s1

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Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
2647 | BLOC1S1
Type: gene
Organism: human
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Gene
615149 | BLOC1S1
Type: gene
Organism: cattle
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Gene
100857285 | BLOC1S1
Type: gene
Organism: chicken
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Gene
556597 | bloc1s1
Type: gene
Organism: zebrafish
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Gene
707395 | BLOC1S1
Type: gene
Organism: macaque, rhesus
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Gene
779698 | bloc1s1
Type: gene
Organism: frog, western clawed
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Gene
106557465 | BLOC1S1
Type: gene
Organism: dog, domestic
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Gene
288785 | Bloc1s1
Type: gene
Organism: rat
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Gene
451968 | BLOC1S1
Type: gene
Organism: chimpanzee
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Protein Domain
IPR009395 | BLOC1S1
Type: Family
Description: GCN5L1 (general control of amino acid synthesis 5-like 1), also known as BLOC1S1 (biogenesis of lysosome-related organelles complex 1 subunit 1). It is a component of the BLOC-1 complex, a complex required for normal biogenesis of lysosome-related organelles []. GCN5L1 has been identified as a critical component of the mitochondrial protein acetylation programme []. It acts as a nutrient-sensing regulator that controls mitochondrial content through coordinated regulation of mitochondrial biogenesis and autophagy [].
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Protein Coding Gene
MGI:1195276 | Bloc1s1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
22309213 | J:182526
First Author: Scott I
Year: 2012
Journal: Biochem J
Title: Identification of a molecular component of the mitochondrial acetyltransferase programme: a novel role for GCN5L1.
Volume: 443
Issue: 3
Pages: 655-61
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Publication
24356961 | J:213033
First Author: Scott I
Year: 2014
Journal: J Biol Chem
Title: GCN5-like protein 1 (GCN5L1) controls mitochondrial content through coordinated regulation of mitochondrial biogenesis and mitophagy.
Volume: 289
Issue: 5
Pages: 2864-72
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Publication
36535215 | J:344546
 
First Author: Wu K
Year: 2023
Journal: Biochem Biophys Res Commun
Title: The endo-lysosomal regulatory protein BLOC1S1 modulates hepatic lysosomal content and lysosomal lipolysis.
Volume: 642
Pages: 1-10
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Protein
O55102
Organism: Mus musculus/domesticus
Length: 125  
Fragment?: false
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Protein
D3Z4L7
Organism: Mus musculus/domesticus
Length: 94  
Fragment?: false
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Protein
D3YVM8
Organism: Mus musculus/domesticus
Length: 121  
Fragment?: false
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Publication
17182842 | J:124026
First Author: Setty SR
Year: 2007
Journal: Mol Biol Cell
Title: BLOC-1 is required for cargo-specific sorting from vacuolar early endosomes toward lysosome-related organelles.
Volume: 18
Issue: 3
Pages: 768-80
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Publication
33629936 | J:344691
First Author: Wu K
Year: 2021
Journal: Autophagy
Title: BLOC1S1/GCN5L1/BORCS1 is a critical mediator for the initiation of autolysosomal tubulation.
Volume: 17
Issue: 11
Pages: 3707-3724
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Protein Coding Gene
MGP_CAROLIEiJ_G0015962 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0017890 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0017865 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0017828 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0017829 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0017652 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1195276 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0018284 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0017213 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0017622 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0017728 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0017723 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0017802 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0017751 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0018324 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0016998 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0017272 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0031122 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0016787 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
35924321 | J:327609
First Author: Thapa D
Year: 2022
Journal: Physiol Rep
Title: GCN5L1 impairs diastolic function in mice exposed to a high fat diet by restricting cardiac pyruvate oxidation.
Volume: 10
Issue: 15
Pages: e15415
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Publication
30333138 | J:266974
 
First Author: Wu K
Year: 2018
Journal: J Cell Sci
Title: GCN5L1 interacts with αTAT1 and RanBP2 to regulate hepatic α-tubulin acetylation and lysosome trafficking.
Volume: 131
Issue: 22
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Publication
30323061 | J:272827
First Author: Thapa D
Year: 2018
Journal: J Biol Chem
Title: The protein acetylase GCN5L1 modulates hepatic fatty acid oxidation activity via acetylation of the mitochondrial β-oxidation enzyme HADHA.
Volume: 293
Issue: 46
Pages: 17676-17684
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GXD Expression
GXD Expression
   
Probe: MGI:7367602
Assay Type: Western blot
Annotation Date: 2022-10-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689417
Stage: TS17
Assay Id: MGI:7377780
Age: embryonic day 10.5
Image: 8
Specimen Label: WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7367602
Assay Type: Western blot
Annotation Date: 2022-10-31
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689417
Stage: TS17
Assay Id: MGI:7377780
Age: embryonic day 10.5
Image: 8
Specimen Label: Bloc1s1-/-
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:7383018
Assay Type: RT-PCR
Annotation Date: 2022-11-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3550728
Stage: TS28
Assay Id: MGI:7383038
Age: postnatal week 2
Specimen Label: PZ WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:7383018
Assay Type: RT-PCR
Annotation Date: 2022-11-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3550728
Stage: TS28
Assay Id: MGI:7383038
Age: postnatal week 2
Specimen Label: PZ Xbp1CartEx2
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:7383018
Assay Type: RT-PCR
Annotation Date: 2022-11-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3550628
Stage: TS28
Assay Id: MGI:7383042
Age: postnatal week 2
Specimen Label: HZ WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:7383018
Assay Type: RT-PCR
Annotation Date: 2022-11-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3550628
Stage: TS28
Assay Id: MGI:7383042
Age: postnatal week 2
Specimen Label: HZ Xbp1CartEx2
Detected: true
Specimen Num: 2
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Publication
33179593 | J:298681
   
First Author: Zhang C
Year: 2020
Journal: Elife
Title: BLOS1 mediates kinesin switch during endosomal recycling of LDL receptor.
Volume: 9
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Publication
28900165 | J:252610
First Author: Wang L
Year: 2017
Journal: Nat Commun
Title: GCN5L1 modulates cross-talk between mitochondria and cell signaling to regulate FoxO1 stability and gluconeogenesis.
Volume: 8
Issue: 1
Pages: 523
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Publication
30776374 | J:272490
 
First Author: Manning JR
Year: 2019
Journal: J Mol Cell Cardiol
Title: Cardiac-specific deletion of GCN5L1 restricts recovery from ischemia-reperfusion injury.
Volume: 129
Pages: 69-78
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Publication
32606301 | J:295924
First Author: Thapa D
Year: 2020
Journal: Sci Rep
Title: Cardiomyocyte-specific deletion of GCN5L1 in mice restricts mitochondrial protein hyperacetylation in response to a high fat diet.
Volume: 10
Issue: 1
Pages: 10665
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Publication
30787040 | J:273315
First Author: Bae D
Year: 2019
Journal: J Cell Biol
Title: Degradation of Blos1 mRNA by IRE1 repositions lysosomes and protects cells from stress.
Volume: 218
Issue: 4
Pages: 1118-1127
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Publication
33680286 | J:308099
 
First Author: Lv T
Year: 2021
Journal: Oxid Med Cell Longev
Title: General Control of Amino Acid Synthesis 5-Like 1-Mediated Acetylation of Manganese Superoxide Dismutase Regulates Oxidative Stress in Diabetic Kidney Disease.
Volume: 2021
Pages: 6691226
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Publication
9426003 | J:44704
First Author: Driessen CA
Year: 1997
Journal: Gene
Title: Cloning and structural analysis of the murine GCN5L1 gene.
Volume: 203
Issue: 1
Pages: 27-31
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Publication
25183008 | J:238911
First Author: Zhang A
Year: 2014
Journal: J Biol Chem
Title: Biogenesis of lysosome-related organelles complex-1 subunit 1 (BLOS1) interacts with sorting nexin 2 and the endosomal sorting complex required for transport-I (ESCRT-I) component TSG101 to mediate the sorting of epidermal growth factor receptor into endosomal compartments.
Volume: 289
Issue: 42
Pages: 29180-94
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Publication
28319092 | J:246734
First Author: Donato V
Year: 2017
Journal: Nat Cell Biol
Title: The TDH-GCN5L1-Fbxo15-KBP axis limits mitochondrial biogenesis in mouse embryonic stem cells.
Volume: 19
Issue: 4
Pages: 341-351
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Publication
31138772 | J:278441
First Author: Manning JR
Year: 2019
Journal: Biochem J
Title: Loss of GCN5L1 in cardiac cells disrupts glucose metabolism and promotes cell death via reduced Akt/mTORC2 signaling.
Volume: 476
Issue: 12
Pages: 1713-1724
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Publication
22554196 | J:192646
First Author: Yang Q
Year: 2012
Journal: Traffic
Title: The BLOS1-interacting protein KXD1 is involved in the biogenesis of lysosome-related organelles.
Volume: 13
Issue: 8
Pages: 1160-9
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Publication
16837549 | J:114587
First Author: Di Pietro SM
Year: 2006
Journal: Mol Biol Cell
Title: BLOC-1 interacts with BLOC-2 and the AP-3 complex to facilitate protein trafficking on endosomes.
Volume: 17
Issue: 9
Pages: 4027-38
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Publication
15102850 | J:90887
First Author: Starcevic M
Year: 2004
Journal: J Biol Chem
Title: Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1).
Volume: 279
Issue: 27
Pages: 28393-401
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Publication
15265785 | J:94897
First Author: Gwynn B
Year: 2004
Journal: Blood
Title: Reduced pigmentation (rp), a mouse model of Hermansky-Pudlak syndrome, encodes a novel component of the BLOC-1 complex.
Volume: 104
Issue: 10
Pages: 3181-9
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Publication
25898167 | J:320078
First Author: Pu J
Year: 2015
Journal: Dev Cell
Title: BORC, a multisubunit complex that regulates lysosome positioning.
Volume: 33
Issue: 2
Pages: 176-88
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Publication
31314175 | J:319692
First Author: Yordanov TE
Year: 2019
Journal: Traffic
Title: Biogenesis of lysosome-related organelles complex-1 (BORC) regulates late endosomal/lysosomal size through PIKfyve-dependent phosphatidylinositol-3,5-bisphosphate.
Volume: 20
Issue: 9
Pages: 674-696
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Publication
16760431 | J:114481
First Author: Salazar G
Year: 2006
Journal: Mol Biol Cell
Title: BLOC-1 complex deficiency alters the targeting of adaptor protein complex-3 cargoes.
Volume: 17
Issue: 9
Pages: 4014-26
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Publication
19546860 | J:188897
First Author: Ghiani CA
Year: 2010
Journal: Mol Psychiatry
Title: The dysbindin-containing complex (BLOC-1) in brain: developmental regulation, interaction with SNARE proteins and role in neurite outgrowth.
Volume: 15
Issue: 2
Pages: 115, 204-15
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Publication
21998198 | J:187545
First Author: Larimore J
Year: 2011
Journal: Mol Biol Cell
Title: The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse.
Volume: 22
Issue: 24
Pages: 4854-67
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Publication
27719760 | J:238623
   
First Author: Zhou W
Year: 2016
Journal: Elife
Title: BLOS2 negatively regulates Notch signaling during neural and hematopoietic stem and progenitor cell development.
Volume: 5
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Publication
25600960 | J:231358
First Author: Cameron TL
Year: 2015
Journal: Osteoarthritis Cartilage
Title: Cartilage-specific ablation of XBP1 signaling in mouse results in a chondrodysplasia characterized by reduced chondrocyte proliferation and delayed cartilage maturation and mineralization.
Volume: 23
Issue: 4
Pages: 661-70
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Publication
- | J:165965
     
First Author: Mouse Genome Informatics and the Europhenome Mouse Phenotyping Resource
Year: 2010
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from Europhenome
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Publication
18614015 | J:151002
First Author: Pagliarini DJ
Year: 2008
Journal: Cell
Title: A mitochondrial protein compendium elucidates complex I disease biology.
Volume: 134
Issue: 1
Pages: 112-23
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Publication
- | J:342607
       
First Author: Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom
Year: 2023
Title: Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
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Publication
20059953 | J:156017
First Author: Yokoyama S
Year: 2009
Journal: Dev Cell
Title: A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Volume: 17
Issue: 6
Pages: 836-48
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Publication
- | J:81858
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
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Publication
- | J:346132
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
35587649 | J:325052
   
First Author: Wells KM
Year: 2022
Journal: Elife
Title: Brucella activates the host RIDD pathway to subvert BLOS1-directed immune defense.
Volume: 11
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