Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Bcl-2-modifying factor (BMF) is thought to play a role in inducing apoptosis. It is thought to bind to Bcl-2 proteins []. This family of proteins is found in eukaryotes. Proteins in this family are typically between 75 and 190 amino acids in length. There are two conserved sequence motifs: GNA and DQF. |
|
•
•
•
•
•
|
Publication |
First Author: |
Puthalakath H |
Year: |
2001 |
Journal: |
Science |
Title: |
Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis. |
Volume: |
293 |
Issue: |
5536 |
Pages: |
1829-32 |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Publication |
First Author: |
Contreras AU |
Year: |
2013 |
Journal: |
J Cell Biol |
Title: |
Deacetylation of p53 induces autophagy by suppressing Bmf expression. |
Volume: |
201 |
Issue: |
3 |
Pages: |
427-37 |
|
•
•
•
•
•
|
Publication |
First Author: |
Grespi F |
Year: |
2010 |
Journal: |
Cell Death Differ |
Title: |
BH3-only protein Bmf mediates apoptosis upon inhibition of CAP-dependent protein synthesis. |
Volume: |
17 |
Issue: |
11 |
Pages: |
1672-83 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hübner A |
Year: |
2010 |
Journal: |
Mol Cell Biol |
Title: |
Functional cooperation of the proapoptotic Bcl2 family proteins Bmf and Bim in vivo. |
Volume: |
30 |
Issue: |
1 |
Pages: |
98-105 |
|
•
•
•
•
•
|
Publication |
First Author: |
Frenzel A |
Year: |
2010 |
Journal: |
Blood |
Title: |
Suppression of B-cell lymphomagenesis by the BH3-only proteins Bmf and Bad. |
Volume: |
115 |
Issue: |
5 |
Pages: |
995-1005 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
185
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Labi V |
Year: |
2008 |
Journal: |
J Exp Med |
Title: |
Loss of the BH3-only protein Bmf impairs B cell homeostasis and accelerates gamma irradiation-induced thymic lymphoma development. |
Volume: |
205 |
Issue: |
3 |
Pages: |
641-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Woess C |
Year: |
2015 |
Journal: |
Cell Death Differ |
Title: |
Combined loss of the BH3-only proteins Bim and Bmf restores B-cell development and function in TACI-Ig transgenic mice. |
Volume: |
22 |
Issue: |
9 |
Pages: |
1477-88 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
62
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
271
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
190
 |
Fragment?: |
false |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7852275 |
Assay Type: |
RT-PCR |
Annotation Date: |
2025-01-14 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3518626 |
|
Stage: |
TS26 |
Assay Id: |
MGI:7852283 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
BMF |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7852276 |
Assay Type: |
RT-PCR |
Annotation Date: |
2025-01-14 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3518626 |
|
Stage: |
TS26 |
Assay Id: |
MGI:7852284 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
BMF |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7852279 |
Assay Type: |
RT-PCR |
Annotation Date: |
2025-01-14 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3518626 |
|
Stage: |
TS26 |
Assay Id: |
MGI:7852287 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
BMF |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7852272 |
Assay Type: |
RT-PCR |
Annotation Date: |
2025-01-14 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3518626 |
|
Stage: |
TS26 |
Assay Id: |
MGI:7852280 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
BMF |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7852273 |
Assay Type: |
RT-PCR |
Annotation Date: |
2025-01-14 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3518626 |
|
Stage: |
TS26 |
Assay Id: |
MGI:7852281 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
BMF |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7852278 |
Assay Type: |
RT-PCR |
Annotation Date: |
2025-01-14 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3518626 |
|
Stage: |
TS26 |
Assay Id: |
MGI:7852286 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
BMF |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7852274 |
Assay Type: |
RT-PCR |
Annotation Date: |
2025-01-14 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3518626 |
|
Stage: |
TS26 |
Assay Id: |
MGI:7852282 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
BMF |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7852277 |
Assay Type: |
RT-PCR |
Annotation Date: |
2025-01-14 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3518626 |
|
Stage: |
TS26 |
Assay Id: |
MGI:7852285 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
BMF |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liew SH |
Year: |
2014 |
Journal: |
Biol Reprod |
Title: |
Loss of the proapoptotic BH3-only protein BCL-2 modifying factor prolongs the fertile life span in female mice. |
Volume: |
90 |
Issue: |
4 |
Pages: |
77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Labi V |
Year: |
2014 |
Journal: |
Blood |
Title: |
Deregulated cell death and lymphocyte homeostasis cause premature lethality in mice lacking the BH3-only proteins Bim and Bmf. |
Volume: |
123 |
Issue: |
17 |
Pages: |
2652-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Baumgartner F |
Year: |
2013 |
Journal: |
Oncogene |
Title: |
Minor cell-death defects but reduced tumor latency in mice lacking the BH3-only proteins Bad and Bmf. |
Volume: |
32 |
Issue: |
5 |
Pages: |
621-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hinds MG |
Year: |
2007 |
Journal: |
Cell Death Differ |
Title: |
Bim, Bad and Bmf: intrinsically unstructured BH3-only proteins that undergo a localized conformational change upon binding to prosurvival Bcl-2 targets. |
Volume: |
14 |
Issue: |
1 |
Pages: |
128-36 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lau GJ |
Year: |
2012 |
Journal: |
Diabetes |
Title: |
Bcl-2-modifying factor induces renal proximal tubular cell apoptosis in diabetic mice. |
Volume: |
61 |
Issue: |
2 |
Pages: |
474-84 |
|
•
•
•
•
•
|
Publication |
First Author: |
Day CL |
Year: |
2004 |
Journal: |
Biochem J |
Title: |
Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands. |
Volume: |
377 |
Issue: |
Pt 3 |
Pages: |
597-605 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fahl SP |
Year: |
2018 |
Journal: |
J Immunol |
Title: |
c-Myb Coordinates Survival and the Expression of Genes That Are Critical for the Pre-BCR Checkpoint. |
Volume: |
200 |
Issue: |
10 |
Pages: |
3450-3463 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sakamoto K |
Year: |
2016 |
Journal: |
Mol Cell Biol |
Title: |
Janus Kinase 1 Is Essential for Inflammatory Cytokine Signaling and Mammary Gland Remodeling. |
Volume: |
36 |
Issue: |
11 |
Pages: |
1673-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vaithiyanathan K |
Year: |
2016 |
Journal: |
Reproduction |
Title: |
BCL2-modifying factor promotes germ cell loss during murine oogenesis. |
Volume: |
151 |
Issue: |
5 |
Pages: |
553-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Du H |
Year: |
2011 |
Journal: |
J Biol Chem |
Title: |
BH3 domains other than Bim and Bid can directly activate Bax/Bak. |
Volume: |
286 |
Issue: |
1 |
Pages: |
491-501 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schuler F |
Year: |
2016 |
Journal: |
Cell Death Differ |
Title: |
The BH3-only protein BIM contributes to late-stage involution in the mouse mammary gland. |
Volume: |
23 |
Issue: |
1 |
Pages: |
41-51 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Liew SH |
Year: |
2017 |
Journal: |
Cell Death Dis |
Title: |
The ovarian reserve is depleted during puberty in a hormonally driven process dependent on the pro-apoptotic protein BMF. |
Volume: |
8 |
Issue: |
8 |
Pages: |
e2971 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hubner A |
Year: |
2011 |
Journal: |
MGI Direct Data Submission |
Title: |
Generation of a control for Bmftm2.1 and Bmf3.1 |
|
|
|
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7384627 |
Assay Type: |
RT-PCR |
Annotation Date: |
2022-11-17 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689428 |
|
Stage: |
TS28 |
Assay Id: |
MGI:7384782 |
Age: |
postnatal month 2 |
|
|
Specimen Label: |
+/+ |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7384627 |
Assay Type: |
RT-PCR |
Annotation Date: |
2022-11-17 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689428 |
|
Stage: |
TS28 |
Assay Id: |
MGI:7384782 |
Age: |
postnatal month 2 |
|
|
Specimen Label: |
Fancd2<-/-> |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7384627 |
Assay Type: |
RT-PCR |
Annotation Date: |
2022-11-17 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689428 |
|
Stage: |
TS28 |
Assay Id: |
MGI:7384782 |
Age: |
postnatal month 2 |
|
|
Specimen Label: |
Foxo3a<-/-> |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7384627 |
Assay Type: |
RT-PCR |
Annotation Date: |
2022-11-17 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689428 |
|
Stage: |
TS28 |
Assay Id: |
MGI:7384782 |
Age: |
postnatal month 2 |
|
|
Specimen Label: |
DKO |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4423162 |
Assay Type: |
RNA in situ |
Annotation Date: |
2024-04-22 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1672822 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:7621948 |
Age: |
embryonic day 14.5 |
Image: |
S3Cb |
|
Specimen Label: |
S3Cb |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4423162 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:3599823 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4823481 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_008005_10 |
|
Specimen Label: |
euxassay_008005_10 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4423162 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:3599823 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4823481 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_008005_11 |
|
Specimen Label: |
euxassay_008005_11 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4423162 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:3599823 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4823481 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_008005_12 |
|
Specimen Label: |
euxassay_008005_12 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4423162 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:3599823 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4823481 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_008005_13 |
|
Specimen Label: |
euxassay_008005_13 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4423162 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:3599823 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4823481 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_008005_14 |
|
Specimen Label: |
euxassay_008005_14 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cory S |
Year: |
2003 |
Journal: |
Oncogene |
Title: |
The Bcl-2 family: roles in cell survival and oncogenesis. |
Volume: |
22 |
Issue: |
53 |
Pages: |
8590-607 |
|
•
•
•
•
•
|
Publication |
First Author: |
Smits C |
Year: |
2008 |
Journal: |
Structure |
Title: |
Structural plasticity underpins promiscuous binding of the prosurvival protein A1. |
Volume: |
16 |
Issue: |
5 |
Pages: |
818-29 |
|
•
•
•
•
•
|
Publication |
First Author: |
Girnius N |
Year: |
2017 |
Journal: |
Cell Rep |
Title: |
JNK Promotes Epithelial Cell Anoikis by Transcriptional and Post-translational Regulation of BH3-Only Proteins. |
Volume: |
21 |
Issue: |
7 |
Pages: |
1910-1921 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen L |
Year: |
2005 |
Journal: |
Mol Cell |
Title: |
Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. |
Volume: |
17 |
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213 |
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Mol Cell |
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Proc Natl Acad Sci U S A |
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Blood |
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The BH3-only protein Puma plays an essential role in cytokine deprivation induced apoptosis of mast cells. |
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Cancer Cell |
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9 |
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Gray DH |
Year: |
2012 |
Journal: |
Immunity |
Title: |
The BH3-only proteins Bim and Puma cooperate to impose deletional tolerance of organ-specific antigens. |
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37 |
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3 |
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451-62 |
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Year: |
2010 |
Journal: |
Blood |
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AICAR induces apoptosis independently of AMPK and p53 through up-regulation of the BH3-only proteins BIM and NOXA in chronic lymphocytic leukemia cells. |
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116 |
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2019 |
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Cell Rep |
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Loss of p53 Causes Stochastic Aberrant X-Chromosome Inactivation and Female-Specific Neural Tube Defects. |
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27 |
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Year: |
2015 |
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J Biol Chem |
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The transcription factor Mesp1 interacts with cAMP-responsive element binding protein 1 (Creb1) and coactivates Ets variant 2 (Etv2) gene expression. |
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290 |
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2012 |
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Development |
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Antioxid Redox Signal |
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21 |
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12 |
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29 |
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2024 |
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Stem Cells |
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O-Linked N-Acetylglucosamine Transferase Ensures Survival of Mouse Fetal Liver Hematopoietic Progenitors Partly by Regulating Bcl-xL and Oxidative Phosphorylation. |
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Front Genet |
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A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b Signaling on Epithelial Tip Progenitor Cells During Early Mouse Lung Branching Morphogenesis. |
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Shanghai Model Organisms Center |
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2017 |
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MGI Direct Data Submission |
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Mouse Genome Informatics Scientific Curators |
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2002 |
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Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data |
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Wellcome Trust Sanger Institute |
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MGI Direct Data Submission |
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Genome Res |
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The Gene Ontology Consortium |
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2014 |
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Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
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Mouse Genome Informatics Scientific Curators |
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2002 |
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Proc Natl Acad Sci U S A |
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Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
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