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Search results 1 to 100 out of 644 for Bmpr2

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: chimpanzee
Protein Domain
Type: Family
Description: Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity []:Serine/threonine-protein kinasesTyrosine-protein kinasesDual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)Protein kinase function is evolutionarily conserved from Escherichia coli to human []. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation []. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [].Bone morphogenetic proteins (BMPs) regulate a wide range of cellular functions that contribute to embryonic development from mesoderm formation to organogenesis []. BMP type II receptor (BMPR2) transduces BMP signals from all BMPs by forming heteromeric complexes with and phosphorylating BMP type I receptors. Heterozygous germline mutations of BMPR-II gene in mice []complement the finding of BMPR-II mutations in patients with familial and sporadic primary pulmonary hypertension, indicating that BMPR-II may contribute to the maintenance of normal pulmonary vascular structure and function [, ].Mice with a smooth muscle-specific transgenic mouse expressing a dominant-negative BMPR-II under control of the tetracycline develop pulmonary hypertension []. Knockout studies have demonstrated that BMPR-II is essential for epiblast differentiation and mesoderm induction during early mouse development []. In contrast, knockout mice that express a BMPR-II lacking half of the ligand-binding domain die at midgestation with cardiovascular and skeletal defects [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: West J
Year: 2004
Journal: Circ Res
Title: Pulmonary hypertension in transgenic mice expressing a dominant-negative BMPRII gene in smooth muscle.
Volume: 94
Issue: 8
Pages: 1109-14
GXD Expression    
Probe: MGI:3654042
Assay Type: RT-PCR
Annotation Date: 2006-09-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737319
Stage: TS19
Assay Id: MGI:3654543
Age: embryonic day 11.5
Image: 2
Specimen Label: BMPR2
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3654042
Assay Type: RT-PCR
Annotation Date: 2006-09-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603925
Stage: TS25
Assay Id: MGI:3654493
Age: embryonic day 17.5
Image: 2
Specimen Label: BMPR2
Detected: true
Specimen Num: 2
Publication
First Author: Beppu H
Year: 2005
Journal: Genesis
Title: Generation of a floxed allele of the mouse BMP type II receptor gene.
Volume: 41
Issue: 3
Pages: 133-7
Publication
First Author: Beppu H
Year: 2004
Journal: Am J Physiol Lung Cell Mol Physiol
Title: BMPR-II heterozygous mice have mild pulmonary hypertension and an impaired pulmonary vascular remodeling response to prolonged hypoxia.
Volume: 287
Issue: 6
Pages: L1241-7
Publication
First Author: Délot EC
Year: 2003
Journal: Development
Title: BMP signaling is required for septation of the outflow tract of the mammalian heart.
Volume: 130
Issue: 1
Pages: 209-20
Publication
First Author: Beppu H
Year: 2000
Journal: Dev Biol
Title: BMP type II receptor is required for gastrulation and early development of mouse embryos.
Volume: 221
Issue: 1
Pages: 249-58
Publication  
First Author: Zheng J
Year: 2023
Journal: Int J Mol Sci
Title: BMPR2 Variants Underlie Nonsyndromic Oligodontia.
Volume: 24
Issue: 2
Publication  
First Author: Majka S
Year: 2011
Journal: Respir Res
Title: Physiologic and molecular consequences of endothelial Bmpr2 mutation.
Volume: 12
Pages: 84
Publication
First Author: Roberts KE
Year: 2004
Journal: Eur Respir J
Title: BMPR2 mutations in pulmonary arterial hypertension with congenital heart disease.
Volume: 24
Issue: 3
Pages: 371-4
Publication
First Author: Nagashima T
Year: 2013
Journal: J Clin Invest
Title: BMPR2 is required for postimplantation uterine function and pregnancy maintenance.
Volume: 123
Issue: 6
Pages: 2539-50
Publication
First Author: Tada Y
Year: 2007
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Molecular effects of loss of BMPR2 signaling in smooth muscle in a transgenic mouse model of PAH.
Volume: 292
Issue: 6
Pages: L1556-63
Publication
First Author: Pickup MW
Year: 2015
Journal: Mol Oncol
Title: BMPR2 loss in fibroblasts promotes mammary carcinoma metastasis via increased inflammation.
Volume: 9
Issue: 1
Pages: 179-91
Publication
First Author: Qian S
Year: 2020
Journal: Commun Biol
Title: BMPR2 promotes fatty acid oxidation and protects white adipocytes from cell death in mice.
Volume: 3
Issue: 1
Pages: 200
Publication
First Author: Lowery JW
Year: 2015
Journal: J Cell Sci
Title: Loss of BMPR2 leads to high bone mass due to increased osteoblast activity.
Volume: 128
Issue: 7
Pages: 1308-15
Publication
First Author: Mushaben EM
Year: 2012
Journal: PLoS One
Title: Chronic allergic inflammation causes vascular remodeling and pulmonary hypertension in BMPR2 hypomorph and wild-type mice.
Volume: 7
Issue: 3
Pages: e32468
Publication
First Author: Frump AL
Year: 2013
Journal: PLoS One
Title: Abnormal trafficking of endogenously expressed BMPR2 mutant allelic products in patients with heritable pulmonary arterial hypertension.
Volume: 8
Issue: 11
Pages: e80319
Publication
First Author: Hopper RK
Year: 2016
Journal: Circulation
Title: In Pulmonary Arterial Hypertension, Reduced BMPR2 Promotes Endothelial-to-Mesenchymal Transition via HMGA1 and Its Target Slug.
Volume: 133
Issue: 18
Pages: 1783-94
Publication
First Author: Diebold I
Year: 2015
Journal: Cell Metab
Title: BMPR2 preserves mitochondrial function and DNA during reoxygenation to promote endothelial cell survival and reverse pulmonary hypertension.
Volume: 21
Issue: 4
Pages: 596-608
Publication
First Author: Hong KH
Year: 2008
Journal: Circulation
Title: Genetic ablation of the BMPR2 gene in pulmonary endothelium is sufficient to predispose to pulmonary arterial hypertension.
Volume: 118
Issue: 7
Pages: 722-30
Publication
First Author: Frank DB
Year: 2008
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Increased susceptibility to hypoxic pulmonary hypertension in Bmpr2 mutant mice is associated with endothelial dysfunction in the pulmonary vasculature.
Volume: 294
Issue: 1
Pages: L98-109
GXD Expression    
Probe: MGI:6168546
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6189879
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Bmpr2
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6168546
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6189879
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Bmpr2
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6168546
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6189879
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Bmpr2
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6168546
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6189879
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Bmpr2
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6168546
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189879
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Bmpr2
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6168546
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189879
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Bmpr2
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6168546
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189879
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Bmpr2
Detected: true
Specimen Num: 7
Publication
First Author: Talati M
Year: 2010
Journal: Am J Physiol Lung Cell Mol Physiol
Title: BMPR2 mutation alters the lung macrophage endothelin-1 cascade in a mouse model and patients with heritable pulmonary artery hypertension.
Volume: 299
Issue: 3
Pages: L363-73
Protein
Organism: Mus musculus/domesticus
Length: 1038  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 768  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 580  
Fragment?: true
Publication
First Author: Hanks SK
Year: 1988
Journal: Science
Title: The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.
Volume: 241
Issue: 4861
Pages: 42-52
Publication
First Author: Manning G
Year: 2002
Journal: Trends Biochem Sci
Title: Evolution of protein kinase signaling from yeast to man.
Volume: 27
Issue: 10
Pages: 514-20
Publication
First Author: Manning G
Year: 2002
Journal: Science
Title: The protein kinase complement of the human genome.
Volume: 298
Issue: 5600
Pages: 1912-34
Publication
First Author: Stout TJ
Year: 2004
Journal: Curr Pharm Des
Title: High-throughput structural biology in drug discovery: protein kinases.
Volume: 10
Issue: 10
Pages: 1069-82
Publication
First Author: Li B
Year: 2004
Journal: Comb Chem High Throughput Screen
Title: Creating chemical diversity to target protein kinases.
Volume: 7
Issue: 5
Pages: 453-72
Publication
First Author: Zhicheng J
Year: 2004
Journal: Biochem Biophys Res Commun
Title: Bone morphogenetic protein receptor-II mutation Arg491Trp causes malignant phenotype of familial primary pulmonary hypertension.
Volume: 315
Issue: 4
Pages: 1033-8
Publication
First Author: Larabee SM
Year: 2015
Journal: Stem Cells Dev
Title: miRNA-17 members that target Bmpr2 influence signaling mechanisms important for embryonic stem cell differentiation in vitro and gastrulation in embryos.
Volume: 24
Issue: 3
Pages: 354-71
Publication
First Author: Theilmann AL
Year: 2020
Journal: Arterioscler Thromb Vasc Biol
Title: Endothelial BMPR2 Loss Drives a Proliferative Response to BMP (Bone Morphogenetic Protein) 9 via Prolonged Canonical Signaling.
Volume: 40
Issue: 11
Pages: 2605-2618
Publication  
First Author: Shimizu T
Year: 2021
Journal: Sci Signal
Title: PERK inhibition attenuates vascular remodeling in pulmonary arterial hypertension caused by BMPR2 mutation.
Volume: 14
Issue: 667
Publication
First Author: Hagen M
Year: 2007
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Interaction of interleukin-6 and the BMP pathway in pulmonary smooth muscle.
Volume: 292
Issue: 6
Pages: L1473-9
Publication
First Author: Owens P
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Disruption of bone morphogenetic protein receptor 2 (BMPR2) in mammary tumors promotes metastases through cell autonomous and paracrine mediators.
Volume: 109
Issue: 8
Pages: 2814-9
Publication
First Author: Aihara S
Year: 2021
Journal: Cell Rep
Title: BMPR-2 gates activity-dependent stabilization of primary dendrites during mitral cell remodeling.
Volume: 35
Issue: 12
Pages: 109276
Publication
First Author: Johnson JA
Year: 2012
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Cytoskeletal defects in Bmpr2-associated pulmonary arterial hypertension.
Volume: 302
Issue: 5
Pages: L474-84
Publication
First Author: Hemnes AR
Year: 2014
Journal: Am J Respir Crit Care Med
Title: Evidence for right ventricular lipotoxicity in heritable pulmonary arterial hypertension.
Volume: 189
Issue: 3
Pages: 325-34
Publication
First Author: Fessel JP
Year: 2013
Journal: Am J Respir Cell Mol Biol
Title: Hyperoxia synergizes with mutant bone morphogenic protein receptor 2 to cause metabolic stress, oxidant injury, and pulmonary hypertension.
Volume: 49
Issue: 5
Pages: 778-87
Publication
First Author: Spiekerkoetter E
Year: 2013
Journal: J Clin Invest
Title: FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension.
Volume: 123
Issue: 8
Pages: 3600-13
Publication
First Author: Song Y
Year: 2005
Journal: Circulation
Title: Increased susceptibility to pulmonary hypertension in heterozygous BMPR2-mutant mice.
Volume: 112
Issue: 4
Pages: 553-62
Publication
First Author: Chowdhury HM
Year: 2019
Journal: Hum Mol Genet
Title: BMPRII deficiency impairs apoptosis via the BMPRII-ALK1-BclX-mediated pathway in pulmonary arterial hypertension.
Volume: 28
Issue: 13
Pages: 2161-2173
Publication
First Author: Tojais NF
Year: 2017
Journal: Arterioscler Thromb Vasc Biol
Title: Codependence of Bone Morphogenetic Protein Receptor 2 and Transforming Growth Factor-β in Elastic Fiber Assembly and Its Perturbation in Pulmonary Arterial Hypertension.
Volume: 37
Issue: 8
Pages: 1559-1569
Publication
First Author: Wauchope OR
Year: 2018
Journal: Nucleic Acids Res
Title: Oxidative stress increases M1dG, a major peroxidation-derived DNA adduct, in mitochondrial DNA.
Volume: 46
Issue: 7
Pages: 3458-3467
Publication
First Author: Han R
Year: 2012
Journal: Genesis
Title: A pair of transmembrane receptors essential for the retention and pigmentation of hair.
Volume: 50
Issue: 11
Pages: 783-800
Publication
First Author: Lu X
Year: 2017
Journal: Genes Dev
Title: Opposing roles of TGFβ and BMP signaling in prostate cancer development.
Volume: 31
Issue: 23-24
Pages: 2337-2342
Publication
First Author: Ongaro L
Year: 2020
Journal: Biol Reprod
Title: Gonadotrope-specific deletion of the BMP type 2 receptor does not affect reproductive physiology in mice†‡.
Volume: 102
Issue: 3
Pages: 639-646
Publication
First Author: Mayeur C
Year: 2014
Journal: Blood
Title: BMP type II receptors have redundant roles in the regulation of hepatic hepcidin gene expression and iron metabolism.
Volume: 124
Issue: 13
Pages: 2116-23
Publication
First Author: Long L
Year: 2015
Journal: Nat Med
Title: Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension.
Volume: 21
Issue: 7
Pages: 777-85
Publication
First Author: Prewitt AR
Year: 2015
Journal: J Biol Chem
Title: Heterozygous null bone morphogenetic protein receptor type 2 mutations promote SRC kinase-dependent caveolar trafficking defects and endothelial dysfunction in pulmonary arterial hypertension.
Volume: 290
Issue: 2
Pages: 960-71
Publication
First Author: Yu PB
Year: 2005
Journal: J Biol Chem
Title: Bone morphogenetic protein (BMP) type II receptor deletion reveals BMP ligand-specific gain of signaling in pulmonary artery smooth muscle cells.
Volume: 280
Issue: 26
Pages: 24443-50
Publication
First Author: Nasim MT
Year: 2012
Journal: Hum Mol Genet
Title: BMPR-II deficiency elicits pro-proliferative and anti-apoptotic responses through the activation of TGFβ-TAK1-MAPK pathways in PAH.
Volume: 21
Issue: 11
Pages: 2548-58
Publication
First Author: Wright AF
Year: 2015
Journal: Cardiovasc Res
Title: Oestrogen receptor alpha in pulmonary hypertension.
Volume: 106
Issue: 2
Pages: 206-16
Publication
First Author: Wang SS
Year: 2013
Journal: FEBS J
Title: Gdf6 induces commitment of pluripotent mesenchymal C3H10T1/2 cells to the adipocyte lineage.
Volume: 280
Issue: 11
Pages: 2644-51
Publication
First Author: Miyagawa K
Year: 2019
Journal: Circ Res
Title: Smooth Muscle Contact Drives Endothelial Regeneration by BMPR2-Notch1-Mediated Metabolic and Epigenetic Changes.
Volume: 124
Issue: 2
Pages: 211-224
Publication
First Author: Song Y
Year: 2008
Journal: Am J Physiol Heart Circ Physiol
Title: Inflammation, endothelial injury, and persistent pulmonary hypertension in heterozygous BMPR2-mutant mice.
Volume: 295
Issue: 2
Pages: H677-90
Publication
First Author: Kashima R
Year: 2016
Journal: Sci Signal
Title: Augmented noncanonical BMP type II receptor signaling mediates the synaptic abnormality of fragile X syndrome.
Volume: 9
Issue: 431
Pages: ra58
Publication
First Author: Leyton PA
Year: 2013
Journal: PLoS One
Title: Deletion of the sequence encoding the tail domain of the bone morphogenetic protein type 2 receptor reveals a bone morphogenetic protein 7-specific gain of function.
Volume: 8
Issue: 10
Pages: e76947
Publication  
First Author: Dehghan Z
Year: 2021
Journal: Dev Biol
Title: MicroRNA-21 is involved in oocyte maturation, blastocyst formation, and pre-implantation embryo development.
Volume: 480
Pages: 69-77
Publication
First Author: Lai YC
Year: 2014
Journal: Circ Res
Title: Pulmonary arterial hypertension: the clinical syndrome.
Volume: 115
Issue: 1
Pages: 115-30
Publication
First Author: Lee HW
Year: 2017
Journal: Arterioscler Thromb Vasc Biol
Title: Alk2/ACVR1 and Alk3/BMPR1A Provide Essential Function for Bone Morphogenetic Protein-Induced Retinal Angiogenesis.
Volume: 37
Issue: 4
Pages: 657-663
Publication
First Author: Gomez-Arroyo J
Year: 2012
Journal: Am J Physiol Lung Cell Mol Physiol
Title: A brief overview of mouse models of pulmonary arterial hypertension: problems and prospects.
Volume: 302
Issue: 10
Pages: L977-91
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Brittain EL
Year: 2016
Journal: Circulation
Title: Fatty Acid Metabolic Defects and Right Ventricular Lipotoxicity in Human Pulmonary Arterial Hypertension.
Volume: 133
Issue: 20
Pages: 1936-44