Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity []:Serine/threonine-protein kinasesTyrosine-protein kinasesDual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)Protein kinase function is evolutionarily conserved from Escherichia coli to human []. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation []. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [].Bone morphogenetic proteins (BMPs) regulate a wide range of cellular functions that contribute to embryonic development from mesoderm formation to organogenesis []. BMP type II receptor (BMPR2) transduces BMP signals from all BMPs by forming heteromeric complexes with and phosphorylating BMP type I receptors. Heterozygous germline mutations of BMPR-II gene in mice []complement the finding of BMPR-II mutations in patients with familial and sporadic primary pulmonary hypertension, indicating that BMPR-II may contribute to the maintenance of normal pulmonary vascular structure and function [, ].Mice with a smooth muscle-specific transgenic mouse expressing a dominant-negative BMPR-II under control of the tetracycline develop pulmonary hypertension []. Knockout studies have demonstrated that BMPR-II is essential for epiblast differentiation and mesoderm induction during early mouse development []. In contrast, knockout mice that express a BMPR-II lacking half of the ligand-binding domain die at midgestation with cardiovascular and skeletal defects []. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
West J |
Year: |
2004 |
Journal: |
Circ Res |
Title: |
Pulmonary hypertension in transgenic mice expressing a dominant-negative BMPRII gene in smooth muscle. |
Volume: |
94 |
Issue: |
8 |
Pages: |
1109-14 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3654042 |
Assay Type: |
RT-PCR |
Annotation Date: |
2006-09-13 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603925 |
|
Stage: |
TS25 |
Assay Id: |
MGI:3654493 |
Age: |
embryonic day 17.5 |
Image: |
2 |
|
Specimen Label: |
BMPR2 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3654042 |
Assay Type: |
RT-PCR |
Annotation Date: |
2006-09-13 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1737319 |
|
Stage: |
TS19 |
Assay Id: |
MGI:3654543 |
Age: |
embryonic day 11.5 |
Image: |
2 |
|
Specimen Label: |
BMPR2 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Beppu H |
Year: |
2005 |
Journal: |
Genesis |
Title: |
Generation of a floxed allele of the mouse BMP type II receptor gene. |
Volume: |
41 |
Issue: |
3 |
Pages: |
133-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Beppu H |
Year: |
2004 |
Journal: |
Am J Physiol Lung Cell Mol Physiol |
Title: |
BMPR-II heterozygous mice have mild pulmonary hypertension and an impaired pulmonary vascular remodeling response to prolonged hypoxia. |
Volume: |
287 |
Issue: |
6 |
Pages: |
L1241-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Délot EC |
Year: |
2003 |
Journal: |
Development |
Title: |
BMP signaling is required for septation of the outflow tract of the mammalian heart. |
Volume: |
130 |
Issue: |
1 |
Pages: |
209-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Beppu H |
Year: |
2000 |
Journal: |
Dev Biol |
Title: |
BMP type II receptor is required for gastrulation and early development of mouse embryos. |
Volume: |
221 |
Issue: |
1 |
Pages: |
249-58 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zheng J |
Year: |
2023 |
Journal: |
Int J Mol Sci |
Title: |
BMPR2 Variants Underlie Nonsyndromic Oligodontia. |
Volume: |
24 |
Issue: |
2 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Majka S |
Year: |
2011 |
Journal: |
Respir Res |
Title: |
Physiologic and molecular consequences of endothelial Bmpr2 mutation. |
Volume: |
12 |
|
Pages: |
84 |
|
•
•
•
•
•
|
Publication |
First Author: |
Roberts KE |
Year: |
2004 |
Journal: |
Eur Respir J |
Title: |
BMPR2 mutations in pulmonary arterial hypertension with congenital heart disease. |
Volume: |
24 |
Issue: |
3 |
Pages: |
371-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nagashima T |
Year: |
2013 |
Journal: |
J Clin Invest |
Title: |
BMPR2 is required for postimplantation uterine function and pregnancy maintenance. |
Volume: |
123 |
Issue: |
6 |
Pages: |
2539-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
West JD |
Year: |
2019 |
Journal: |
Pulm Circ |
Title: |
Adverse effects of BMPR2 suppression in macrophages in animal models of pulmonary hypertension. |
|
|
Pages: |
2045894019856483 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tada Y |
Year: |
2007 |
Journal: |
Am J Physiol Lung Cell Mol Physiol |
Title: |
Molecular effects of loss of BMPR2 signaling in smooth muscle in a transgenic mouse model of PAH. |
Volume: |
292 |
Issue: |
6 |
Pages: |
L1556-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pickup MW |
Year: |
2015 |
Journal: |
Mol Oncol |
Title: |
BMPR2 loss in fibroblasts promotes mammary carcinoma metastasis via increased inflammation. |
Volume: |
9 |
Issue: |
1 |
Pages: |
179-91 |
|
•
•
•
•
•
|
Publication |
First Author: |
Qian S |
Year: |
2020 |
Journal: |
Commun Biol |
Title: |
BMPR2 promotes fatty acid oxidation and protects white adipocytes from cell death in mice. |
Volume: |
3 |
Issue: |
1 |
Pages: |
200 |
|
•
•
•
•
•
|
Publication |
First Author: |
Frump AL |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
Abnormal trafficking of endogenously expressed BMPR2 mutant allelic products in patients with heritable pulmonary arterial hypertension. |
Volume: |
8 |
Issue: |
11 |
Pages: |
e80319 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mushaben EM |
Year: |
2012 |
Journal: |
PLoS One |
Title: |
Chronic allergic inflammation causes vascular remodeling and pulmonary hypertension in BMPR2 hypomorph and wild-type mice. |
Volume: |
7 |
Issue: |
3 |
Pages: |
e32468 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lowery JW |
Year: |
2015 |
Journal: |
J Cell Sci |
Title: |
Loss of BMPR2 leads to high bone mass due to increased osteoblast activity. |
Volume: |
128 |
Issue: |
7 |
Pages: |
1308-15 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hopper RK |
Year: |
2016 |
Journal: |
Circulation |
Title: |
In Pulmonary Arterial Hypertension, Reduced BMPR2 Promotes Endothelial-to-Mesenchymal Transition via HMGA1 and Its Target Slug. |
Volume: |
133 |
Issue: |
18 |
Pages: |
1783-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Diebold I |
Year: |
2015 |
Journal: |
Cell Metab |
Title: |
BMPR2 preserves mitochondrial function and DNA during reoxygenation to promote endothelial cell survival and reverse pulmonary hypertension. |
Volume: |
21 |
Issue: |
4 |
Pages: |
596-608 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hong KH |
Year: |
2008 |
Journal: |
Circulation |
Title: |
Genetic ablation of the BMPR2 gene in pulmonary endothelium is sufficient to predispose to pulmonary arterial hypertension. |
Volume: |
118 |
Issue: |
7 |
Pages: |
722-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Frank DB |
Year: |
2008 |
Journal: |
Am J Physiol Lung Cell Mol Physiol |
Title: |
Increased susceptibility to hypoxic pulmonary hypertension in Bmpr2 mutant mice is associated with endothelial dysfunction in the pulmonary vasculature. |
Volume: |
294 |
Issue: |
1 |
Pages: |
L98-109 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6168546 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689419 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:6189879 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
Table S2 - E11.5 - Bmpr2 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6168546 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689421 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:6189879 |
Age: |
embryonic day 13.5 |
|
|
Specimen Label: |
Table S2 - E13.5 - Bmpr2 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6168546 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689424 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:6189879 |
Age: |
embryonic day 15.5 |
|
|
Specimen Label: |
Table S2 - E15.5 - Bmpr2 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6168546 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689426 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:6189879 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
Table S2 - E18.5 - Bmpr2 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6168546 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6189879 |
Age: |
postnatal day 4 |
|
|
Specimen Label: |
Table S2 - P4 - Bmpr2 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6168546 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6189879 |
Age: |
postnatal day 14 |
|
|
Specimen Label: |
Table S2 - P14 - Bmpr2 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6168546 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6189879 |
Age: |
postnatal day 28 |
|
|
Specimen Label: |
Table S2 - P28 - Bmpr2 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Talati M |
Year: |
2010 |
Journal: |
Am J Physiol Lung Cell Mol Physiol |
Title: |
BMPR2 mutation alters the lung macrophage endothelin-1 cascade in a mouse model and patients with heritable pulmonary artery hypertension. |
Volume: |
299 |
Issue: |
3 |
Pages: |
L363-73 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1038
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
768
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
580
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Hanks SK |
Year: |
1988 |
Journal: |
Science |
Title: |
The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. |
Volume: |
241 |
Issue: |
4861 |
Pages: |
42-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Manning G |
Year: |
2002 |
Journal: |
Trends Biochem Sci |
Title: |
Evolution of protein kinase signaling from yeast to man. |
Volume: |
27 |
Issue: |
10 |
Pages: |
514-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Manning G |
Year: |
2002 |
Journal: |
Science |
Title: |
The protein kinase complement of the human genome. |
Volume: |
298 |
Issue: |
5600 |
Pages: |
1912-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stout TJ |
Year: |
2004 |
Journal: |
Curr Pharm Des |
Title: |
High-throughput structural biology in drug discovery: protein kinases. |
Volume: |
10 |
Issue: |
10 |
Pages: |
1069-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li B |
Year: |
2004 |
Journal: |
Comb Chem High Throughput Screen |
Title: |
Creating chemical diversity to target protein kinases. |
Volume: |
7 |
Issue: |
5 |
Pages: |
453-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhicheng J |
Year: |
2004 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Bone morphogenetic protein receptor-II mutation Arg491Trp causes malignant phenotype of familial primary pulmonary hypertension. |
Volume: |
315 |
Issue: |
4 |
Pages: |
1033-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Larabee SM |
Year: |
2015 |
Journal: |
Stem Cells Dev |
Title: |
miRNA-17 members that target Bmpr2 influence signaling mechanisms important for embryonic stem cell differentiation in vitro and gastrulation in embryos. |
Volume: |
24 |
Issue: |
3 |
Pages: |
354-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Theilmann AL |
Year: |
2020 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Endothelial BMPR2 Loss Drives a Proliferative Response to BMP (Bone Morphogenetic Protein) 9 via Prolonged Canonical Signaling. |
Volume: |
40 |
Issue: |
11 |
Pages: |
2605-2618 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shimizu T |
Year: |
2021 |
Journal: |
Sci Signal |
Title: |
PERK inhibition attenuates vascular remodeling in pulmonary arterial hypertension caused by BMPR2 mutation. |
Volume: |
14 |
Issue: |
667 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hagen M |
Year: |
2007 |
Journal: |
Am J Physiol Lung Cell Mol Physiol |
Title: |
Interaction of interleukin-6 and the BMP pathway in pulmonary smooth muscle. |
Volume: |
292 |
Issue: |
6 |
Pages: |
L1473-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Owens P |
Year: |
2012 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Disruption of bone morphogenetic protein receptor 2 (BMPR2) in mammary tumors promotes metastases through cell autonomous and paracrine mediators. |
Volume: |
109 |
Issue: |
8 |
Pages: |
2814-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Aihara S |
Year: |
2021 |
Journal: |
Cell Rep |
Title: |
BMPR-2 gates activity-dependent stabilization of primary dendrites during mitral cell remodeling. |
Volume: |
35 |
Issue: |
12 |
Pages: |
109276 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hemnes AR |
Year: |
2014 |
Journal: |
Am J Respir Crit Care Med |
Title: |
Evidence for right ventricular lipotoxicity in heritable pulmonary arterial hypertension. |
Volume: |
189 |
Issue: |
3 |
Pages: |
325-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Johnson JA |
Year: |
2012 |
Journal: |
Am J Physiol Lung Cell Mol Physiol |
Title: |
Cytoskeletal defects in Bmpr2-associated pulmonary arterial hypertension. |
Volume: |
302 |
Issue: |
5 |
Pages: |
L474-84 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fessel JP |
Year: |
2013 |
Journal: |
Am J Respir Cell Mol Biol |
Title: |
Hyperoxia synergizes with mutant bone morphogenic protein receptor 2 to cause metabolic stress, oxidant injury, and pulmonary hypertension. |
Volume: |
49 |
Issue: |
5 |
Pages: |
778-87 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chowdhury HM |
Year: |
2019 |
Journal: |
Hum Mol Genet |
Title: |
BMPRII deficiency impairs apoptosis via the BMPRII-ALK1-BclX-mediated pathway in pulmonary arterial hypertension. |
Volume: |
28 |
Issue: |
13 |
Pages: |
2161-2173 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tojais NF |
Year: |
2017 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Codependence of Bone Morphogenetic Protein Receptor 2 and Transforming Growth Factor-β in Elastic Fiber Assembly and Its Perturbation in Pulmonary Arterial Hypertension. |
Volume: |
37 |
Issue: |
8 |
Pages: |
1559-1569 |
|
•
•
•
•
•
|
Publication |
First Author: |
Spiekerkoetter E |
Year: |
2013 |
Journal: |
J Clin Invest |
Title: |
FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension. |
Volume: |
123 |
Issue: |
8 |
Pages: |
3600-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Song Y |
Year: |
2005 |
Journal: |
Circulation |
Title: |
Increased susceptibility to pulmonary hypertension in heterozygous BMPR2-mutant mice. |
Volume: |
112 |
Issue: |
4 |
Pages: |
553-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wauchope OR |
Year: |
2018 |
Journal: |
Nucleic Acids Res |
Title: |
Oxidative stress increases M1dG, a major peroxidation-derived DNA adduct, in mitochondrial DNA. |
Volume: |
46 |
Issue: |
7 |
Pages: |
3458-3467 |
|
•
•
•
•
•
|
Publication |
First Author: |
Han R |
Year: |
2012 |
Journal: |
Genesis |
Title: |
A pair of transmembrane receptors essential for the retention and pigmentation of hair. |
Volume: |
50 |
Issue: |
11 |
Pages: |
783-800 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lu X |
Year: |
2017 |
Journal: |
Genes Dev |
Title: |
Opposing roles of TGFβ and BMP signaling in prostate cancer development. |
Volume: |
31 |
Issue: |
23-24 |
Pages: |
2337-2342 |
|
•
•
•
•
•
|
Publication |
First Author: |
Isobe S |
Year: |
2023 |
Journal: |
Nat Commun |
Title: |
Reduced FOXF1 links unrepaired DNA damage to pulmonary arterial hypertension. |
Volume: |
14 |
Issue: |
1 |
Pages: |
7578 |
|
•
•
•
•
•
|
Publication |
First Author: |
Long L |
Year: |
2015 |
Journal: |
Nat Med |
Title: |
Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension. |
Volume: |
21 |
Issue: |
7 |
Pages: |
777-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mayeur C |
Year: |
2014 |
Journal: |
Blood |
Title: |
BMP type II receptors have redundant roles in the regulation of hepatic hepcidin gene expression and iron metabolism. |
Volume: |
124 |
Issue: |
13 |
Pages: |
2116-23 |
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Publication |
First Author: |
Yu PB |
Year: |
2005 |
Journal: |
J Biol Chem |
Title: |
Bone morphogenetic protein (BMP) type II receptor deletion reveals BMP ligand-specific gain of signaling in pulmonary artery smooth muscle cells. |
Volume: |
280 |
Issue: |
26 |
Pages: |
24443-50 |
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Publication |
First Author: |
Ongaro L |
Year: |
2020 |
Journal: |
Biol Reprod |
Title: |
Gonadotrope-specific deletion of the BMP type 2 receptor does not affect reproductive physiology in mice†‡. |
Volume: |
102 |
Issue: |
3 |
Pages: |
639-646 |
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Publication |
First Author: |
Prewitt AR |
Year: |
2015 |
Journal: |
J Biol Chem |
Title: |
Heterozygous null bone morphogenetic protein receptor type 2 mutations promote SRC kinase-dependent caveolar trafficking defects and endothelial dysfunction in pulmonary arterial hypertension. |
Volume: |
290 |
Issue: |
2 |
Pages: |
960-71 |
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Publication |
First Author: |
Nasim MT |
Year: |
2012 |
Journal: |
Hum Mol Genet |
Title: |
BMPR-II deficiency elicits pro-proliferative and anti-apoptotic responses through the activation of TGFβ-TAK1-MAPK pathways in PAH. |
Volume: |
21 |
Issue: |
11 |
Pages: |
2548-58 |
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Publication |
First Author: |
Wright AF |
Year: |
2015 |
Journal: |
Cardiovasc Res |
Title: |
Oestrogen receptor alpha in pulmonary hypertension. |
Volume: |
106 |
Issue: |
2 |
Pages: |
206-16 |
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Publication |
First Author: |
Wang SS |
Year: |
2013 |
Journal: |
FEBS J |
Title: |
Gdf6 induces commitment of pluripotent mesenchymal C3H10T1/2 cells to the adipocyte lineage. |
Volume: |
280 |
Issue: |
11 |
Pages: |
2644-51 |
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Publication |
First Author: |
Song Y |
Year: |
2008 |
Journal: |
Am J Physiol Heart Circ Physiol |
Title: |
Inflammation, endothelial injury, and persistent pulmonary hypertension in heterozygous BMPR2-mutant mice. |
Volume: |
295 |
Issue: |
2 |
Pages: |
H677-90 |
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Publication |
First Author: |
Miyagawa K |
Year: |
2019 |
Journal: |
Circ Res |
Title: |
Smooth Muscle Contact Drives Endothelial Regeneration by BMPR2-Notch1-Mediated Metabolic and Epigenetic Changes. |
Volume: |
124 |
Issue: |
2 |
Pages: |
211-224 |
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Publication |
First Author: |
Kashima R |
Year: |
2016 |
Journal: |
Sci Signal |
Title: |
Augmented noncanonical BMP type II receptor signaling mediates the synaptic abnormality of fragile X syndrome. |
Volume: |
9 |
Issue: |
431 |
Pages: |
ra58 |
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Publication |
First Author: |
Leyton PA |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
Deletion of the sequence encoding the tail domain of the bone morphogenetic protein type 2 receptor reveals a bone morphogenetic protein 7-specific gain of function. |
Volume: |
8 |
Issue: |
10 |
Pages: |
e76947 |
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Publication |
First Author: |
Dehghan Z |
Year: |
2021 |
Journal: |
Dev Biol |
Title: |
MicroRNA-21 is involved in oocyte maturation, blastocyst formation, and pre-implantation embryo development. |
Volume: |
480 |
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Pages: |
69-77 |
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Publication |
First Author: |
Lai YC |
Year: |
2014 |
Journal: |
Circ Res |
Title: |
Pulmonary arterial hypertension: the clinical syndrome. |
Volume: |
115 |
Issue: |
1 |
Pages: |
115-30 |
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Publication |
First Author: |
Lee HW |
Year: |
2017 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Alk2/ACVR1 and Alk3/BMPR1A Provide Essential Function for Bone Morphogenetic Protein-Induced Retinal Angiogenesis. |
Volume: |
37 |
Issue: |
4 |
Pages: |
657-663 |
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Publication |
First Author: |
Gomez-Arroyo J |
Year: |
2012 |
Journal: |
Am J Physiol Lung Cell Mol Physiol |
Title: |
A brief overview of mouse models of pulmonary arterial hypertension: problems and prospects. |
Volume: |
302 |
Issue: |
10 |
Pages: |
L977-91 |
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
•
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
•
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
•
•
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
•
•
•
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
•
•
•
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
•
•
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
•
•
•
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
•
•
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
•
•
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
•
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
•
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
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