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Search results 1 to 100 out of 454 for Bnip3

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Type Details Score
Protein Domain
Type: Family
Description: This family consists of several mammalian specific BCL2/adenovirus E1B 19kDa protein-interacting protein 3 or BNIP3 sequences. BNIP3 belongs to the Bcl-2 homology 3 (BH3)-only family, a Bcl-2-related family possessing an atypical Bcl-2 homology 3 (BH3) domain, which regulates PCD from mitochondrial sites by selective Bcl-2/Bcl-XL interactions. BNIP3 family members contain a C-terminal transmembrane domain that is required for their mitochondrial localisation, homodimerisation, as well as regulation of their pro-apoptotic activities. BNIP3-mediated apoptosis has been reported to be independent of caspase activation and cytochrome c release and is characterised by early plasma membrane and mitochondrial damage, prior to the appearance of chromatin condensation or DNA fragmentation [].
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 187  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 218  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 218  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 75  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 173  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 204  
Fragment?: false
Publication
First Author: Lamy L
Year: 2003
Journal: J Biol Chem
Title: CD47 and the 19 kDa interacting protein-3 (BNIP3) in T cell apoptosis.
Volume: 278
Issue: 26
Pages: 23915-21
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Publication
First Author: Ghavami S
Year: 2009
Journal: Biochim Biophys Acta
Title: Role of BNIP3 in TNF-induced cell death--TNF upregulates BNIP3 expression.
Volume: 1793
Issue: 3
Pages: 546-60
Publication
First Author: Hamacher-Brady A
Year: 2007
Journal: Cell Death Differ
Title: Response to myocardial ischemia/reperfusion injury involves Bnip3 and autophagy.
Volume: 14
Issue: 1
Pages: 146-57
Publication
First Author: Ney PA
Year: 2015
Journal: Biochim Biophys Acta
Title: Mitochondrial autophagy: Origins, significance, and role of BNIP3 and NIX.
Volume: 1853
Issue: 10 Pt B
Pages: 2775-83
Publication
First Author: Li C
Year: 2013
Journal: J Neurochem
Title: BNIP3 mediates pre-myelinating oligodendrocyte cell death in hypoxia and ischemia.
Volume: 127
Issue: 3
Pages: 426-33
Publication
First Author: Glick D
Year: 2012
Journal: Mol Cell Biol
Title: BNip3 regulates mitochondrial function and lipid metabolism in the liver.
Volume: 32
Issue: 13
Pages: 2570-84
Publication
First Author: Rikka S
Year: 2011
Journal: Cell Death Differ
Title: Bnip3 impairs mitochondrial bioenergetics and stimulates mitochondrial turnover.
Volume: 18
Issue: 4
Pages: 721-31
Publication
First Author: Singh A
Year: 2018
Journal: PLoS One
Title: The BH3 only Bcl-2 family member BNIP3 regulates cellular proliferation.
Volume: 13
Issue: 10
Pages: e0204792
Publication
First Author: Tracy K
Year: 2007
Journal: Mol Cell Biol
Title: BNIP3 is an RB/E2F target gene required for hypoxia-induced autophagy.
Volume: 27
Issue: 17
Pages: 6229-42
Publication
First Author: Chourasia AH
Year: 2015
Journal: EMBO Rep
Title: Mitophagy defects arising from BNip3 loss promote mammary tumor progression to metastasis.
Volume: 16
Issue: 9
Pages: 1145-63
Publication
First Author: Diwan A
Year: 2007
Journal: J Clin Invest
Title: Inhibition of ischemic cardiomyocyte apoptosis through targeted ablation of Bnip3 restrains postinfarction remodeling in mice.
Volume: 117
Issue: 10
Pages: 2825-33
Publication
First Author: Dhingra R
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Bnip3 mediates doxorubicin-induced cardiac myocyte necrosis and mortality through changes in mitochondrial signaling.
Volume: 111
Issue: 51
Pages: E5537-44
Publication
First Author: Vande Velde C
Year: 2000
Journal: Mol Cell Biol
Title: BNIP3 and genetic control of necrosis-like cell death through the mitochondrial permeability transition pore.
Volume: 20
Issue: 15
Pages: 5454-68
Publication
First Author: Thompson JW
Year: 2015
Journal: PLoS One
Title: Bnip3 Binds and Activates p300: Possible Role in Cardiac Transcription and Myocyte Morphology.
Volume: 10
Issue: 8
Pages: e0136847
Publication
First Author: Liu J
Year: 2020
Journal: Aging (Albany NY)
Title: Bnip3 interacts with vimentin, an intermediate filament protein, and regulates autophagy of hepatic stellate cells.
Volume: 13
Issue: 1
Pages: 957-972
Publication
First Author: Shi RY
Year: 2014
Journal: CNS Neurosci Ther
Title: BNIP3 interacting with LC3 triggers excessive mitophagy in delayed neuronal death in stroke.
Volume: 20
Issue: 12
Pages: 1045-55
Publication
First Author: An HJ
Year: 2006
Journal: J Biol Chem
Title: Activation of Ras up-regulates pro-apoptotic BNIP3 in nitric oxide-induced cell death.
Volume: 281
Issue: 45
Pages: 33939-48
Publication
First Author: Gang H
Year: 2011
Journal: Circ Res
Title: A novel hypoxia-inducible spliced variant of mitochondrial death gene Bnip3 promotes survival of ventricular myocytes.
Volume: 108
Issue: 9
Pages: 1084-92
Publication    
First Author: Pedanou VE
Year: 2016
Journal: Elife
Title: The histone H3K9 demethylase KDM3A promotes anoikis by transcriptionally activating pro-apoptotic genes BNIP3 and BNIP3L.
Volume: 5
Publication  
First Author: Lee SI
Year: 2024
Journal: Biochem Biophys Res Commun
Title: HDAC6 preserves BNIP3 expression and mitochondrial integrity by deacetylating p53 at lysine 320.
Volume: 691
Pages: 149320
Publication
First Author: Ha SD
Year: 2007
Journal: J Biol Chem
Title: Mitochondrial proteins Bnip3 and Bnip3L are involved in anthrax lethal toxin-induced macrophage cell death.
Volume: 282
Issue: 36
Pages: 26275-83
Publication
First Author: Yook YH
Year: 2004
Journal: Biochem Biophys Res Commun
Title: Nitric oxide induces BNIP3 expression that causes cell death in macrophages.
Volume: 321
Issue: 2
Pages: 298-305
Publication
First Author: Metukuri MR
Year: 2009
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Expression and subcellular localization of BNIP3 in hypoxic hepatocytes and liver stress.
Volume: 296
Issue: 3
Pages: G499-509
Publication
First Author: Qi Y
Year: 2012
Journal: J Cell Biol
Title: Bnip3 and AIF cooperate to induce apoptosis and cavitation during epithelial morphogenesis.
Volume: 198
Issue: 1
Pages: 103-14
Publication
First Author: Lee Y
Year: 2011
Journal: Am J Physiol Heart Circ Physiol
Title: Mitochondrial autophagy by Bnip3 involves Drp1-mediated mitochondrial fission and recruitment of Parkin in cardiac myocytes.
Volume: 301
Issue: 5
Pages: H1924-31
Publication
First Author: Bellot G
Year: 2009
Journal: Mol Cell Biol
Title: Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains.
Volume: 29
Issue: 10
Pages: 2570-81
Publication
First Author: Moriyama M
Year: 2014
Journal: J Invest Dermatol
Title: BNIP3 plays crucial roles in the differentiation and maintenance of epidermal keratinocytes.
Volume: 134
Issue: 6
Pages: 1627-1635
Publication
First Author: Fuller KNZ
Year: 2020
Journal: J Appl Physiol (1985)
Title: Sex and BNIP3 genotype, rather than acute lipid injection, modulate hepatic mitochondrial function and steatosis risk in mice.
Volume: 128
Issue: 5
Pages: 1251-1261
Publication
First Author: Li E
Year: 2020
Journal: Protein Cell
Title: BMAL1 regulates mitochondrial fission and mitophagy through mitochondrial protein BNIP3 and is critical in the development of dilated cardiomyopathy.
Volume: 11
Issue: 9
Pages: 661-679
Publication
First Author: Berardi DE
Year: 2022
Journal: Sci Adv
Title: Lipid droplet turnover at the lysosome inhibits growth of hepatocellular carcinoma in a BNIP3-dependent manner.
Volume: 8
Issue: 41
Pages: eabo2510
Publication
First Author: Tang C
Year: 2019
Journal: Cell Death Dis
Title: Activation of BNIP3-mediated mitophagy protects against renal ischemia-reperfusion injury.
Volume: 10
Issue: 9
Pages: 677
Publication
First Author: Li J
Year: 2023
Journal: Cell Death Dis
Title: HIF1α-BNIP3-mediated mitophagy protects against renal fibrosis by decreasing ROS and inhibiting activation of the NLRP3 inflammasome.
Volume: 14
Issue: 3
Pages: 200
Publication
First Author: Zhang H
Year: 2008
Journal: J Biol Chem
Title: Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia.
Volume: 283
Issue: 16
Pages: 10892-903
Publication
First Author: Springer MZ
Year: 2021
Journal: Autophagy
Title: BNIP3-dependent mitophagy promotes cytosolic localization of LC3B and metabolic homeostasis in the liver.
Volume: 17
Issue: 11
Pages: 3530-3546
Publication
First Author: Oshima Y
Year: 2008
Journal: J Biol Chem
Title: Pivotal role of Bcl-2 family proteins in the regulation of chondrocyte apoptosis.
Volume: 283
Issue: 39
Pages: 26499-508
Publication
First Author: Lu P
Year: 2014
Journal: J Neurosci
Title: Poly(ADP-ribose) polymerase-1 causes mitochondrial damage and neuron death mediated by Bnip3.
Volume: 34
Issue: 48
Pages: 15975-87
Publication
First Author: Tol MJ
Year: 2016
Journal: Diabetes
Title: A PPARγ-Bnip3 Axis Couples Adipose Mitochondrial Fusion-Fission Balance to Systemic Insulin Sensitivity.
Volume: 65
Issue: 9
Pages: 2591-605
Publication
First Author: Moulis MF
Year: 2017
Journal: J Neurochem
Title: OPA1 haploinsufficiency induces a BNIP3-dependent decrease in mitophagy in neurons: relevance to Dominant Optic Atrophy.
Volume: 140
Issue: 3
Pages: 485-494
Publication  
First Author: Jin Q
Year: 2018
Journal: Redox Biol
Title: DUSP1 alleviates cardiac ischemia/reperfusion injury by suppressing the Mff-required mitochondrial fission and Bnip3-related mitophagy via the JNK pathways.
Volume: 14
Pages: 576-587
Publication
First Author: Kunimi H
Year: 2021
Journal: FASEB J
Title: Inhibition of the HIF-1α/BNIP3 pathway has a retinal neuroprotective effect.
Volume: 35
Issue: 8
Pages: e21829
Publication
First Author: Wu SY
Year: 2011
Journal: Neoplasia
Title: Ras-related tumorigenesis is suppressed by BNIP3-mediated autophagy through inhibition of cell proliferation.
Volume: 13
Issue: 12
Pages: 1171-82
Publication
First Author: Hoshino A
Year: 2012
Journal: J Mol Cell Cardiol
Title: p53-TIGAR axis attenuates mitophagy to exacerbate cardiac damage after ischemia.
Volume: 52
Issue: 1
Pages: 175-84
Publication
First Author: Cao DJ
Year: 2013
Journal: J Am Heart Assoc
Title: Mechanical unloading activates FoxO3 to trigger Bnip3-dependent cardiomyocyte atrophy.
Volume: 2
Issue: 2
Pages: e000016
Publication
First Author: McCoin CS
Year: 2019
Journal: Am J Physiol Endocrinol Metab
Title: Sex modulates hepatic mitochondrial adaptations to high-fat diet and physical activity.
Volume: 317
Issue: 2
Pages: E298-E311
Publication
First Author: Von Schulze A
Year: 2018
Journal: J Physiol
Title: Hepatic mitochondrial adaptations to physical activity: impact of sexual dimorphism, PGC1α and BNIP3-mediated mitophagy.
Volume: 596
Issue: 24
Pages: 6157-6171
Publication
First Author: Gong W
Year: 2015
Journal: J Biol Chem
Title: Kelch Repeat and BTB Domain Containing Protein 5 (Kbtbd5) Regulates Skeletal Muscle Myogenesis through the E2F1-DP1 Complex.
Volume: 290
Issue: 24
Pages: 15350-61
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression      
Probe: MGI:4836255
Assay Type: RT-PCR
Annotation Date: 2010-10-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:4836491
Age: postnatal
Specimen Label: WT
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:4836255
Assay Type: RT-PCR
Annotation Date: 2010-10-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:4836491
Age: postnatal
Specimen Label: FIH KO
Detected: true
Specimen Num: 2
GXD Expression        
Probe: MGI:5825515
Assay Type: RT-PCR
Annotation Date: 2017-03-03
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:5827533
Age: embryonic day 10.5
Specimen Label: +/+
Specimen Num: 1
GXD Expression      
Probe: MGI:5825515
Assay Type: RT-PCR
Annotation Date: 2017-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:5827533
Age: embryonic day 10.5
Specimen Label: -/-
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:5817976
Assay Type: RT-PCR
Annotation Date: 2017-01-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598827
Stage: TS27
Assay Id: MGI:5818009
Age: postnatal day 1
Image: 7
Specimen Label: Kbtbd5+/+
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5817976
Assay Type: RT-PCR
Annotation Date: 2017-01-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598827
Stage: TS27
Assay Id: MGI:5818009
Age: postnatal day 1
Image: 7
Specimen Label: Kbtbd5-/-
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:5817976
Assay Type: RT-PCR
Annotation Date: 2017-01-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598827
Stage: TS27
Assay Id: MGI:5818018
Age: postnatal day 1
Image: 8
Specimen Label: Kbtbd5+/+;E2F1-/-
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5817976
Assay Type: RT-PCR
Annotation Date: 2017-01-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598827
Stage: TS27
Assay Id: MGI:5818018
Age: postnatal day 1
Image: 8
Specimen Label: Kbtbd5-/-;E2F1-/-
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6192461
Assay Type: RT-PCR
Annotation Date: 2018-08-01
Strength: Present
Sex: Female
Emaps: EMAPS:3568928
Stage: TS28
Assay Id: MGI:6192473
Age: postnatal adult
Specimen Label: placenta normoxia
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6192461
Assay Type: RT-PCR
Annotation Date: 2018-08-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:6192473
Age: embryonic day 20.0
Specimen Label: brain normoxia
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6468541
Assay Type: RT-PCR
Annotation Date: 2020-10-23
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:360422
Stage: TS02
Assay Id: MGI:6468542
Age: embryonic day 1.0
Specimen Label: 2-cell
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:6468541
Assay Type: RT-PCR
Annotation Date: 2020-10-23
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:360433
Stage: TS03
Assay Id: MGI:6468542
Age: embryonic day 2.0
Specimen Label: 4-cell
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:6468541
Assay Type: RT-PCR
Annotation Date: 2020-10-23
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:360453
Stage: TS03
Assay Id: MGI:6468542
Age: embryonic day 3.0
Specimen Label: Morula
Detected: false
Specimen Num: 3