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Search results 1 to 100 out of 975 for Braf

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
GXD Expression
Probe: MGI:2673435
Assay Type: RNA in situ
Annotation Date: 2003-09-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603923
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:2673449
Age: embryonic day 15.5
Image: Braf
Note: Authors state that there is ubiquitous expression.
Specimen Label: Braf
Detected: true
Specimen Num: 1
Gene
Type: gene
Organism: human
Publication
First Author: Diedrich B
Year: 2017
Journal: EMBO J
Title: Discrete cytosolic macromolecular BRAF complexes exhibit distinct activities and composition.
Volume: 36
Issue: 5
Pages: 646-663
Publication
First Author: Clerk A
Year: 2022
Journal: Biochem J
Title: Cardiomyocyte BRAF and type 1 RAF inhibitors promote cardiomyocyte and cardiac hypertrophy in mice in vivo.
Volume: 479
Issue: 3
Pages: 401-424
Publication
First Author: Chen HC
Year: 2018
Journal: Oncotarget
Title: Activation of Grm1 expression by mutated BRaf (V600E) in vitro and in vivo.
Volume: 9
Issue: 5
Pages: 5861-5875
Publication
First Author: Koh HY
Year: 2018
Journal: Nat Med
Title: BRAF somatic mutation contributes to intrinsic epileptogenicity in pediatric brain tumors.
Volume: 24
Issue: 11
Pages: 1662-1668
Publication
First Author: Kamata T
Year: 2010
Journal: Cancer Res
Title: BRAF inactivation drives aneuploidy by deregulating CRAF.
Volume: 70
Issue: 21
Pages: 8475-86
Publication
First Author: Perna D
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: BRAF inhibitor resistance mediated by the AKT pathway in an oncogenic BRAF mouse melanoma model.
Volume: 112
Issue: 6
Pages: E536-45
Publication
First Author: Nieto P
Year: 2017
Journal: Nature
Title: A Braf kinase-inactive mutant induces lung adenocarcinoma.
Volume: 548
Issue: 7666
Pages: 239-243
Publication
First Author: McNeill RS
Year: 2016
Journal: Am J Pathol
Title: BRAF Mutations Open Doors for N-Ethyl-N-Nitrosourea-Induced Gliomagenesis.
Volume: 186
Issue: 10
Pages: 2551-4
Publication
First Author: Dhomen N
Year: 2009
Journal: Cancer Cell
Title: Oncogenic Braf induces melanocyte senescence and melanoma in mice.
Volume: 15
Issue: 4
Pages: 294-303
Publication
First Author: Brady DC
Year: 2014
Journal: Nature
Title: Copper is required for oncogenic BRAF signalling and tumorigenesis.
Volume: 509
Issue: 7501
Pages: 492-6
Publication
First Author: Nelson DS
Year: 2019
Journal: PLoS One
Title: BRAF V600E and Pten deletion in mice produces a histiocytic disorder with features of Langerhans cell histiocytosis.
Volume: 14
Issue: 9
Pages: e0222400
Publication
First Author: Zhao ZQ
Year: 2013
Journal: J Clin Invest
Title: Chronic itch development in sensory neurons requires BRAF signaling pathways.
Volume: 123
Issue: 11
Pages: 4769-80
Publication
First Author: Tien AC
Year: 2012
Journal: Development
Title: Regulated temporal-spatial astrocyte precursor cell proliferation involves BRAF signalling in mammalian spinal cord.
Volume: 139
Issue: 14
Pages: 2477-87
Publication
First Author: Gronych J
Year: 2011
Journal: J Clin Invest
Title: An activated mutant BRAF kinase domain is sufficient to induce pilocytic astrocytoma in mice.
Volume: 121
Issue: 4
Pages: 1344-8
Publication
First Author: Bond CE
Year: 2018
Journal: Epigenetics
Title: Oncogenic BRAF mutation induces DNA methylation changes in a murine model for human serrated colorectal neoplasia.
Volume: 13
Issue: 1
Pages: 40-48
Publication
First Author: Sievert AJ
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Paradoxical activation and RAF inhibitor resistance of BRAF protein kinase fusions characterizing pediatric astrocytomas.
Volume: 110
Issue: 15
Pages: 5957-62
Publication
First Author: Wojnowski L
Year: 2000
Journal: Mech Dev
Title: Overlapping and specific functions of Braf and Craf-1 proto-oncogenes during mouse embryogenesis.
Volume: 91
Issue: 1-2
Pages: 97-104
Publication
First Author: Ruiz R
Year: 2017
Journal: PLoS Genet
Title: The RhoJ-BAD signaling network: An Achilles' heel for BRAF mutant melanomas.
Volume: 13
Issue: 7
Pages: e1006913
Publication
First Author: Charles RP
Year: 2014
Journal: Mol Cancer Res
Title: Activating BRAF and PIK3CA mutations cooperate to promote anaplastic thyroid carcinogenesis.
Volume: 12
Issue: 7
Pages: 979-86
Publication
First Author: Kim H
Year: 2022
Journal: Cell Death Dis
Title: AK2 is an AMP-sensing negative regulator of BRAF in tumorigenesis.
Volume: 13
Issue: 5
Pages: 469
Publication
First Author: Kamata T
Year: 2013
Journal: Mol Cancer Res
Title: Hematopoietic expression of oncogenic BRAF promotes aberrant growth of monocyte-lineage cells resistant to PLX4720.
Volume: 11
Issue: 12
Pages: 1530-41
Publication
First Author: Hernandez MA
Year: 2016
Journal: Cell Signal
Title: Regulation of BRAF protein stability by a negative feedback loop involving the MEK-ERK pathway but not the FBXW7 tumour suppressor.
Volume: 28
Issue: 6
Pages: 561-71
Publication
First Author: Sanchez-Laorden B
Year: 2014
Journal: Sci Signal
Title: BRAF inhibitors induce metastasis in RAS mutant or inhibitor-resistant melanoma cells by reactivating MEK and ERK signaling.
Volume: 7
Issue: 318
Pages: ra30
Publication
First Author: de Keizer PL
Year: 2010
Journal: Cancer Res
Title: Activation of forkhead box O transcription factors by oncogenic BRAF promotes p21cip1-dependent senescence.
Volume: 70
Issue: 21
Pages: 8526-36
Publication
First Author: Köhler C
Year: 2017
Journal: Cell Stem Cell
Title: Mouse Cutaneous Melanoma Induced by Mutant BRaf Arises from Expansion and Dedifferentiation of Mature Pigmented Melanocytes.
Volume: 21
Issue: 5
Pages: 679-693.e6
Publication
First Author: Braun AD
Year: 2020
Journal: J Invest Dermatol
Title: Activated Hgf-Met Signaling Cooperates with Oncogenic BRAF to Drive Primary Cutaneous Melanomas and Angiotropic Lung Metastases in Mice.
Volume: 140
Issue: 7
Pages: 1410-1417.e2
Publication
First Author: Heidorn SJ
Year: 2010
Journal: Cell
Title: Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF.
Volume: 140
Issue: 2
Pages: 209-21
Publication
First Author: Ho PC
Year: 2014
Journal: Cancer Res
Title: Immune-based antitumor effects of BRAF inhibitors rely on signaling by CD40L and IFNγ.
Volume: 74
Issue: 12
Pages: 3205-17
Publication
First Author: Schoultz E
Year: 2023
Journal: iScience
Title: Tissue specificity of oncogenic BRAF targeted to lung and thyroid through a shared lineage factor.
Volume: 26
Issue: 7
Pages: 107071
Publication
First Author: Knight DA
Year: 2013
Journal: J Clin Invest
Title: Host immunity contributes to the anti-melanoma activity of BRAF inhibitors.
Volume: 123
Issue: 3
Pages: 1371-81
Publication
First Author: Yu P
Year: 2023
Journal: Sci Adv
Title: TERT accelerates BRAF mutant-induced thyroid cancer dedifferentiation and progression by regulating ribosome biogenesis.
Volume: 9
Issue: 35
Pages: eadg7125
Publication
First Author: Inoue SI
Year: 2017
Journal: Hum Mol Genet
Title: Activated Braf induces esophageal dilation and gastric epithelial hyperplasia in mice.
Volume: 26
Issue: 23
Pages: 4715-4727
Publication    
First Author: Shin J
Year: 2016
Journal: Elife
Title: BRAF activates PAX3 to control muscle precursor cell migration during forelimb muscle development.
Volume: 5
Publication
First Author: Escuin-Ordinas H
Year: 2014
Journal: Mol Oncol
Title: COX-2 inhibition prevents the appearance of cutaneous squamous cell carcinomas accelerated by BRAF inhibitors.
Volume: 8
Issue: 2
Pages: 250-60
Publication
First Author: Vandal G
Year: 2014
Journal: PLoS One
Title: Ras effector mutant expression suggest a negative regulator inhibits lung tumor formation.
Volume: 9
Issue: 1
Pages: e84745
Publication
First Author: Vanden Borre P
Year: 2014
Journal: Thyroid
Title: The next generation of orthotopic thyroid cancer models: immunocompetent orthotopic mouse models of BRAF V600E-positive papillary and anaplastic thyroid carcinoma.
Volume: 24
Issue: 4
Pages: 705-14
Publication
First Author: Dhomen N
Year: 2010
Journal: Pigment Cell Melanoma Res
Title: Inducible expression of (V600E) Braf using tyrosinase-driven Cre recombinase results in embryonic lethality.
Volume: 23
Issue: 1
Pages: 112-20
Publication
First Author: Pritchard C
Year: 2007
Journal: Biochem Soc Trans
Title: Mouse models for BRAF-induced cancers.
Volume: 35
Issue: Pt 5
Pages: 1329-33
Publication
First Author: Moriya M
Year: 2015
Journal: Hum Mol Genet
Title: Adult mice expressing a Braf Q241R mutation on an ICR/CD-1 background exhibit a cardio-facio-cutaneous syndrome phenotype.
Volume: 24
Issue: 25
Pages: 7349-60
Publication
First Author: Pfeiffer V
Year: 2013
Journal: PLoS One
Title: Ablation of BRaf impairs neuronal differentiation in the postnatal hippocampus and cerebellum.
Volume: 8
Issue: 3
Pages: e58259
Publication
First Author: Steinberg SM
Year: 2017
Journal: Cancer Res
Title: Myeloid Cells That Impair Immunotherapy Are Restored in Melanomas with Acquired Resistance to BRAF Inhibitors.
Volume: 77
Issue: 7
Pages: 1599-1610
Publication
First Author: Wu X
Year: 2012
Journal: Mol Cell Biol
Title: Increased BRAF heterodimerization is the common pathogenic mechanism for noonan syndrome-associated RAF1 mutants.
Volume: 32
Issue: 19
Pages: 3872-90
Publication  
First Author: Janardhan HP
Year: 2020
Journal: J Exp Med
Title: KRAS or BRAF mutations cause hepatic vascular cavernomas treatable with MAP2K-MAPK1 inhibition.
Volume: 217
Issue: 7
Publication    
First Author: Ruiz-Vega R
Year: 2020
Journal: Elife
Title: Dynamics of nevus development implicate cell cooperation in the growth arrest of transformed melanocytes.
Volume: 9
Publication
First Author: Inoue SI
Year: 2019
Journal: Hum Mol Genet
Title: C-type natriuretic peptide improves growth retardation in a mouse model of cardio-facio-cutaneous syndrome.
Volume: 28
Issue: 1
Pages: 74-83
Publication
First Author: Shen CH
Year: 2013
Journal: Mol Cell
Title: Phosphorylation of BRAF by AMPK impairs BRAF-KSR1 association and cell proliferation.
Volume: 52
Issue: 2
Pages: 161-72
Publication
First Author: Parhar RS
Year: 2016
Journal: Lab Invest
Title: IL-12 immunotherapy of Braf(V600E)-induced papillary thyroid cancer in a mouse model.
Volume: 96
Issue: 1
Pages: 89-97
Publication  
First Author: Ma R
Year: 2014
Journal: Front Endocrinol (Lausanne)
Title: Stemness is Derived from Thyroid Cancer Cells.
Volume: 5
Pages: 114
Publication  
First Author: Pani F
Year: 2021
Journal: Endocrinology
Title: Pre-existing Thyroiditis Ameliorates Papillary Thyroid Cancer: Insights From a New Mouse Model.
Volume: 162
Issue: 10
Publication
First Author: Wefers B
Year: 2012
Journal: PLoS One
Title: MAPK signaling determines anxiety in the juvenile mouse brain but depression-like behavior in adults.
Volume: 7
Issue: 4
Pages: e35035
Publication
First Author: Inoue S
Year: 2014
Journal: Hum Mol Genet
Title: New BRAF knockin mice provide a pathogenetic mechanism of developmental defects and a therapeutic approach in cardio-facio-cutaneous syndrome.
Volume: 23
Issue: 24
Pages: 6553-66
Publication  
First Author: Schoultz E
Year: 2022
Journal: Dis Model Mech
Title: Tissue architecture delineates field cancerization in BRAFV600E-induced tumor development.
Volume: 15
Issue: 2
Publication
First Author: Sengal A
Year: 2021
Journal: Blood
Title: Overcoming T-cell exhaustion in LCH: PD-1 blockade and targeted MAPK inhibition are synergistic in a mouse model of LCH.
Volume: 137
Issue: 13
Pages: 1777-1791
Publication
First Author: Hogstad B
Year: 2018
Journal: J Exp Med
Title: RAF/MEK/extracellular signal-related kinase pathway suppresses dendritic cell migration and traps dendritic cells in Langerhans cell histiocytosis lesions.
Volume: 215
Issue: 1
Pages: 319-336
Publication
First Author: Montero-Conde C
Year: 2013
Journal: Cancer Discov
Title: Relief of feedback inhibition of HER3 transcription by RAF and MEK inhibitors attenuates their antitumor effects in BRAF-mutant thyroid carcinomas.
Volume: 3
Issue: 5
Pages: 520-33
Publication
First Author: Nagarajah J
Year: 2016
Journal: J Clin Invest
Title: Sustained ERK inhibition maximizes responses of BrafV600E thyroid cancers to radioiodine.
Volume: 126
Issue: 11
Pages: 4119-4124
Publication  
First Author: Liu H
Year: 2020
Journal: JCI Insight
Title: MAPK mutations and cigarette smoke promote the pathogenesis of pulmonary Langerhans cell histiocytosis.
Volume: 5
Issue: 4
Publication
First Author: Maeda Y
Year: 2021
Journal: Dev Dyn
Title: Ras/MAPK dysregulation in development causes a skeletal myopathy in an activating BrafL597V mouse model for cardio-facio-cutaneous syndrome.
Volume: 250
Issue: 8
Pages: 1074-1095
Publication
First Author: Kamata T
Year: 2005
Journal: Blood
Title: A critical function for B-Raf at multiple stages of myelopoiesis.
Volume: 106
Issue: 3
Pages: 833-40
Publication
First Author: Galvani E
Year: 2020
Journal: Nat Commun
Title: Stroma remodeling and reduced cell division define durable response to PD-1 blockade in melanoma.
Volume: 11
Issue: 1
Pages: 853
Publication
First Author: Trucco LD
Year: 2021
Journal: J Invest Dermatol
Title: Map3k1 Loss Cooperates with BrafV600E to Drive Melanomagenesis.
Volume: 141
Issue: 1
Pages: 221-225.e6
Publication
First Author: Trucco LD
Year: 2019
Journal: Nat Med
Title: Ultraviolet radiation-induced DNA damage is prognostic for outcome in melanoma.
Volume: 25
Issue: 2
Pages: 221-224
Publication
First Author: Kane AM
Year: 2020
Journal: Neoplasia
Title: Alterations in signaling pathways that accompany spontaneous transition to malignancy in a mouse model of BRAF mutant microsatellite stable colorectal cancer.
Volume: 22
Issue: 2
Pages: 120-128
Publication
First Author: Sobczak I
Year: 2008
Journal: Oncogene
Title: B-Raf is required for ERK activation and tumor progression in a mouse model of pancreatic beta-cell carcinogenesis.
Volume: 27
Issue: 35
Pages: 4779-87
Publication
First Author: Chen S
Year: 2019
Journal: Nat Commun
Title: Targeting MC1R depalmitoylation to prevent melanomagenesis in redheads.
Volume: 10
Issue: 1
Pages: 877
Publication
First Author: Köhler M
Year: 2019
Journal: Oncogene
Title: B-Raf deficiency impairs tumor initiation and progression in a murine breast cancer model.
Volume: 38
Issue: 8
Pages: 1324-1339
Publication
First Author: Rae J
Year: 2012
Journal: J Invest Dermatol
Title: (V600E)Braf::Tyr-CreERT2::K14-Kitl mice do not develop superficial spreading-like melanoma: keratinocyte Kit ligand is insufficient to "translocate" (V600E)Braf-driven melanoma to the epidermis.
Volume: 132
Issue: 2
Pages: 488-91
Publication
First Author: Mass E
Year: 2017
Journal: Nature
Title: A somatic mutation in erythro-myeloid progenitors causes neurodegenerative disease.
Volume: 549
Issue: 7672
Pages: 389-393
Publication
First Author: Maertens O
Year: 2013
Journal: Cancer Discov
Title: Elucidating distinct roles for NF1 in melanomagenesis.
Volume: 3
Issue: 3
Pages: 338-49
Publication
First Author: Viros A
Year: 2014
Journal: Nature
Title: Ultraviolet radiation accelerates BRAF-driven melanomagenesis by targeting TP53.
Volume: 511
Issue: 7510
Pages: 478-482
Publication
First Author: Mercer K
Year: 2005
Journal: Cancer Res
Title: Expression of endogenous oncogenic V600EB-raf induces proliferation and developmental defects in mice and transformation of primary fibroblasts.
Volume: 65
Issue: 24
Pages: 11493-500
Publication
First Author: Tanaka H
Year: 2019
Journal: Cancer Sci
Title: Overproduction of thrombopoietin by BRAFV600E-mutated mouse hepatocytes and contribution of thrombopoietin to hepatocarcinogenesis.
Volume: 110
Issue: 9
Pages: 2748-2759
Publication
First Author: Dorard C
Year: 2019
Journal: FEBS J
Title: RAF dimers control vascular permeability and cytoskeletal rearrangements at endothelial cell-cell junctions.
Volume: 286
Issue: 12
Pages: 2277-2294
Publication
First Author: Chen AP
Year: 2006
Journal: J Neurosci Res
Title: Forebrain-specific knockout of B-raf kinase leads to deficits in hippocampal long-term potentiation, learning, and memory.
Volume: 83
Issue: 1
Pages: 28-38
Publication
First Author: Tabor V
Year: 2014
Journal: Cancer Res
Title: MYC synergizes with activated BRAFV600E in mouse lung tumor development by suppressing senescence.
Volume: 74
Issue: 16
Pages: 4222-9
Publication    
First Author: Sakamoto N
Year: 2017
Journal: Elife
Title: BRAFV600E cooperates with CDX2 inactivation to promote serrated colorectal tumorigenesis.
Volume: 6
Publication
First Author: González-Sánchez E
Year: 2013
Journal: PLoS One
Title: Lkb1 loss promotes tumor progression of BRAF(V600E)-induced lung adenomas.
Volume: 8
Issue: 6
Pages: e66933
Publication
First Author: Kim SH
Year: 2017
Journal: J Invest Dermatol
Title: Phenformin Inhibits Myeloid-Derived Suppressor Cells and Enhances the Anti-Tumor Activity of PD-1 Blockade in Melanoma.
Volume: 137
Issue: 8
Pages: 1740-1748
Publication
First Author: Strohecker AM
Year: 2013
Journal: Cancer Discov
Title: Autophagy sustains mitochondrial glutamine metabolism and growth of BrafV600E-driven lung tumors.
Volume: 3
Issue: 11
Pages: 1272-85
Publication
First Author: Valluet A
Year: 2010
Journal: PLoS One
Title: B-raf alternative splicing is dispensable for development but required for learning and memory associated with the hippocampus in the adult mouse.
Volume: 5
Issue: 12
Pages: e15272
Publication
First Author: Dillon TJ
Year: 2013
Journal: Int Immunol
Title: B-Raf is required for positive selection and survival of DP cells, but not for negative selection of SP cells.
Volume: 25
Issue: 4
Pages: 259-69
Publication
First Author: Cisowski J
Year: 2016
Journal: Oncogene
Title: Oncogene-induced senescence underlies the mutual exclusive nature of oncogenic KRAS and BRAF.
Volume: 35
Issue: 10
Pages: 1328-33
Publication
First Author: Ishak Gabra MB
Year: 2020
Journal: Nat Commun
Title: Dietary glutamine supplementation suppresses epigenetically-activated oncogenic pathways to inhibit melanoma tumour growth.
Volume: 11
Issue: 1
Pages: 3326
Publication
First Author: Jahid S
Year: 2022
Journal: Cell Rep
Title: Structure-based design of CDC42 effector interaction inhibitors for the treatment of cancer.
Volume: 39
Issue: 1
Pages: 110641
Publication
First Author: Blackshear PJ
Year: 1992
Journal: Genomics
Title: Chromosomal mapping of the human (MACS) and mouse (Macs) genes encoding the MARCKS protein.
Volume: 14
Issue: 1
Pages: 168-74
DO Term
Publication      
First Author: DeStefano Shields CE
Year: 2021
Journal: Cancer Discov
Title: Bacterial-Driven Inflammation and Mutant BRAF Expression Combine to Promote Murine Colon Tumorigenesis That Is Sensitive to Immune Checkpoint Therapy.
Publication
First Author: Jolly LA
Year: 2016
Journal: Cancer Res
Title: Fibroblast-Mediated Collagen Remodeling Within the Tumor Microenvironment Facilitates Progression of Thyroid Cancers Driven by BrafV600E and Pten Loss.
Volume: 76
Issue: 7
Pages: 1804-13