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Search results 1 to 100 out of 880 for Brca2

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Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Gene
Type: gene
Organism: Drosophila melanogaster
Protein Domain
Type: Family
Description: The breast cancer type 2 susceptibility protein (BRCA2) is a breast tumour suppressor involved in double-strand break repair and/or homologous recombination [[cite:PUB00027524]]. BRCA2 gene expression is regulated in a cell-cycle dependent manner and peak expression of BRCA2 mRNA occurring in S phase, suggesting BRCA2 may participate in regulating cell proliferation. BRCA2, and related protein BRCA1, have transcriptional activation potential and the two proteins are associated with the activation of double-strandbreak repair and/or homologous recombination. The two proteins have been shown to coexist and colocalize in a biochemical complex. BRCA2 has a number of 39 amino acid repeats [[cite:PUB00003901]]that are critical for binding to RAD51 (a key protein in DNA recombinational repair) and resistance to methyl methanesulphonate treatment [[cite:PUB00005803], [cite:PUB00005815], [cite:PUB00005834]]. There are eight repeats in BRCA2 designated as BRC1 to BRC8. BRC1, BRC2, BRC3, BRC4, BRC7, and BRC8 have high sequence identity and bind to Rad51, whereas BRC5 and BRC6 are less well conserved and are unable to bind Rad51 [[cite:PUB00007172]]. It has been suggested that BRCA2 plays a role in positioning Rad51 at the site of DNA repair or in removing Rad51 from DNA once repair has been completed.Mutations in BRCA1 and BRCA2 have been linked to an elevated risk of young onset breast cancer and confer a high risk of the disease through a dominantly inherited fashion [[cite:PUB00066909]]. BRCA2 mutations are typically microdeletions.Homologues exist in plants: the BRCA2A and BRCA2B proteins from Arabidopsis thalianaare required for repair of breaks in double-stranded DNA and homologous recombination and in the prophase stage of meiosis are required for formation of RAD51 and DMC1 foci in males [[cite:PUB00085103]].
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein
Organism: Mus musculus
Length: 1180  
Fragment?: false
Publication
First Author: Bork P
Year: 1996
Journal: Nat Genet
Title: Internal repeats in the BRCA2 protein sequence.
Volume: 13
Issue: 1
Pages: 22-3
Publication
First Author: Marmorstein LY
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: The BRCA2 gene product functionally interacts with p53 and RAD51.
Volume: 95
Issue: 23
Pages: 13869-74
Publication
First Author: Chen PL
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment.
Volume: 95
Issue: 9
Pages: 5287-92
Gene
Type: gene
Organism: Homo sapiens
Publication
First Author: Wong AK
Year: 1997
Journal: J Biol Chem
Title: RAD51 interacts with the evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene brca2.
Volume: 272
Issue: 51
Pages: 31941-4
Publication
First Author: Chen CF
Year: 1999
Journal: J Biol Chem
Title: Expression of BRC repeats in breast cancer cells disrupts the BRCA2-Rad51 complex and leads to radiation hypersensitivity and loss of G(2)/M checkpoint control.
Volume: 274
Issue: 46
Pages: 32931-5
Publication
First Author: Yang H
Year: 2002
Journal: Science
Title: BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure.
Volume: 297
Issue: 5588
Pages: 1837-48
Publication
First Author: Hartford SA
Year: 2016
Journal: PLoS Genet
Title: Interaction with PALB2 Is Essential for Maintenance of Genomic Integrity by BRCA2.
Volume: 12
Issue: 8
Pages: e1006236
Publication
First Author: Seeliger K
Year: 2012
Journal: New Phytol
Title: BRCA2 is a mediator of RAD51- and DMC1-facilitated homologous recombination in Arabidopsis thaliana.
Volume: 193
Issue: 2
Pages: 364-75
Publication
First Author: Orelli BJ
Year: 2001
Journal: Breast Cancer Res
Title: BRCA2 and homologous recombination.
Volume: 3
Issue: 5
Pages: 294-8
Publication
First Author: Walker LC
Year: 2010
Journal: Hum Mutat
Title: Detection of splicing aberrations caused by BRCA1 and BRCA2 sequence variants encoding missense substitutions: implications for prediction of pathogenicity.
Volume: 31
Issue: 6
Pages: E1484-505
Protein
Organism: Mus musculus
Length: 747  
Fragment?: true
Protein
Organism: Mus musculus
Length: 3329  
Fragment?: false
Protein
Organism: Mus musculus
Length: 3329  
Fragment?: false
Publication
First Author: Philip S
Year: 2008
Journal: Cancer Res
Title: Degradation of BRCA2 in alkyltransferase-mediated DNA repair and its clinical implications.
Volume: 68
Issue: 23
Pages: 9973-81
Publication
First Author: Patel KJ
Year: 1998
Journal: Mol Cell
Title: Involvement of Brca2 in DNA repair.
Volume: 1
Issue: 3
Pages: 347-57
Publication  
First Author: Ding X
Year: 2016
Journal: Nat Commun
Title: Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies.
Volume: 7
Pages: 12425
Publication
First Author: Venkitaraman AR
Year: 2001
Journal: Curr Opin Cell Biol
Title: Chromosome stability, DNA recombination and the BRCA2 tumour suppressor.
Volume: 13
Issue: 3
Pages: 338-43
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Homo sapiens
Publication
First Author: Yan DH
Year: 2004
Journal: Oncogene
Title: A delayed chemically induced tumorigenesis in Brca2 mutant mice.
Volume: 23
Issue: 10
Pages: 1896-901
Publication
First Author: Flores KG
Year: 2002
Journal: Mol Carcinog
Title: Thymic model for examining BRCA2 expression and function.
Volume: 35
Issue: 3
Pages: 103-9
Publication
First Author: Daniel DC
Year: 2002
Journal: Microsc Res Tech
Title: Highlight: BRCA1 and BRCA2 proteins in breast cancer.
Volume: 59
Issue: 1
Pages: 68-83
Publication
First Author: Callens N
Year: 2002
Journal: Mamm Genome
Title: Genomic organization and expression of the mouse Brca2 gene.
Volume: 13
Issue: 7
Pages: 352-8
Publication
First Author: Hakem R
Year: 1998
Journal: J Mammary Gland Biol Neoplasia
Title: Developmental studies of Brca1 and Brca2 knock-out mice.
Volume: 3
Issue: 4
Pages: 431-45
Publication
First Author: Bignell G
Year: 1997
Journal: Hum Mol Genet
Title: The BRC repeats are conserved in mammalian BRCA2 proteins.
Volume: 6
Issue: 1
Pages: 53-8
Protein
Organism: Mus musculus
Length: 992  
Fragment?: true
Publication
First Author: Henderson BR
Year: 2005
Journal: Bioessays
Title: Regulation of BRCA1, BRCA2 and BARD1 intracellular trafficking.
Volume: 27
Issue: 9
Pages: 884-93
Publication
First Author: Sharan SK
Year: 2004
Journal: Development
Title: BRCA2 deficiency in mice leads to meiotic impairment and infertility.
Volume: 131
Issue: 1
Pages: 131-42
Publication
First Author: Jeong JH
Year: 2015
Journal: Mol Cells
Title: Brca2 deficiency leads to T cell loss and immune dysfunction.
Volume: 38
Issue: 3
Pages: 251-8
Publication
First Author: Singh KK
Year: 2012
Journal: J Biol Chem
Title: BRCA2 protein deficiency exaggerates doxorubicin-induced cardiomyocyte apoptosis and cardiac failure.
Volume: 287
Issue: 9
Pages: 6604-14
Publication
First Author: Jiang Q
Year: 2015
Journal: Genes Dev
Title: MERIT40 cooperates with BRCA2 to resolve DNA interstrand cross-links.
Volume: 29
Issue: 18
Pages: 1955-68
Publication
First Author: Pellegrini L
Year: 2002
Journal: Nature
Title: Insights into DNA recombination from the structure of a RAD51-BRCA2 complex.
Volume: 420
Issue: 6913
Pages: 287-93
Publication
First Author: Xu H
Year: 2014
Journal: J Pathol
Title: Up-regulation of the interferon-related genes in BRCA2 knockout epithelial cells.
Volume: 234
Issue: 3
Pages: 386-97
Publication
First Author: Frappart PO
Year: 2007
Journal: EMBO J
Title: BRCA2 is required for neurogenesis and suppression of medulloblastoma.
Volume: 26
Issue: 11
Pages: 2732-42
Publication
First Author: Choi E
Year: 2012
Journal: Dev Cell
Title: BRCA2 fine-tunes the spindle assembly checkpoint through reinforcement of BubR1 acetylation.
Volume: 22
Issue: 2
Pages: 295-308
Publication
First Author: Suzuki A
Year: 1997
Journal: Genes Dev
Title: Brca2 is required for embryonic cellular proliferation in the mouse.
Volume: 11
Issue: 10
Pages: 1242-52
Publication
First Author: Feng W
Year: 2017
Journal: Nat Commun
Title: BRCA2 suppresses replication stress-induced mitotic and G1 abnormalities through homologous recombination.
Volume: 8
Issue: 1
Pages: 525
Publication
First Author: Ludwig T
Year: 2001
Journal: Oncogene
Title: Development of mammary adenocarcinomas by tissue-specific knockout of Brca2 in mice.
Volume: 20
Issue: 30
Pages: 3937-48
Publication
First Author: McAllister KA
Year: 1997
Journal: Cancer Res
Title: Characterization of the rat and mouse homologues of the BRCA2 breast cancer susceptibility gene.
Volume: 57
Issue: 15
Pages: 3121-5
Publication
First Author: Morimatsu M
Year: 1998
Journal: Cancer Res
Title: Cells deleted for Brca2 COOH terminus exhibit hypersensitivity to gamma-radiation and premature senescence.
Volume: 58
Issue: 15
Pages: 3441-7
Publication
First Author: Moynahan ME
Year: 2002
Journal: Oncogene
Title: The cancer connection: BRCA1 and BRCA2 tumor suppression in mice and humans.
Volume: 21
Issue: 58
Pages: 8994-9007
Publication
First Author: Lomonosov M
Year: 2003
Journal: Genes Dev
Title: Stabilization of stalled DNA replication forks by the BRCA2 breast cancer susceptibility protein.
Volume: 17
Issue: 24
Pages: 3017-22
Publication
First Author: Park PG
Year: 2008
Journal: Exp Mol Med
Title: Development of thymic lymphomas in mice disrupted of Brca2 allele in the thymus.
Volume: 40
Issue: 3
Pages: 339-44
Publication
First Author: Connor F
Year: 1997
Journal: Nat Genet
Title: Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation.
Volume: 17
Issue: 4
Pages: 423-30
Publication
First Author: McAllister KA
Year: 2002
Journal: Cancer Res
Title: Cancer susceptibility of mice with a homozygous deletion in the COOH-terminal domain of the Brca2 gene.
Volume: 62
Issue: 4
Pages: 990-4
Publication
First Author: Francis JC
Year: 2010
Journal: PLoS Genet
Title: Brca2 and Trp53 deficiency cooperate in the progression of mouse prostate tumourigenesis.
Volume: 6
Issue: 6
Pages: e1000995
Publication
First Author: Bernard-Gallon DJ
Year: 2001
Journal: Int J Oncol
Title: Brca1 and Brca2 protein expression patterns in different tissues of murine origin.
Volume: 18
Issue: 2
Pages: 271-80
Publication
First Author: Min J
Year: 2012
Journal: J Biol Chem
Title: The breast cancer susceptibility gene BRCA2 is required for the maintenance of telomere homeostasis.
Volume: 287
Issue: 7
Pages: 5091-101
Publication
First Author: Biswas K
Year: 2011
Journal: Blood
Title: A comprehensive functional characterization of BRCA2 variants associated with Fanconi anemia using mouse ES cell-based assay.
Volume: 118
Issue: 9
Pages: 2430-42
Publication
First Author: Blackshear PE
Year: 1998
Journal: Oncogene
Title: Brca1 and Brca2 expression patterns in mitotic and meiotic cells of mice.
Volume: 16
Issue: 1
Pages: 61-8
Publication  
First Author: Kass EM
Year: 2016
Journal: Nat Commun
Title: Robust homology-directed repair within mouse mammary tissue is not specifically affected by Brca2 mutation.
Volume: 7
Pages: 13241
Publication
First Author: Marmorstein LY
Year: 2001
Journal: Cell
Title: A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression.
Volume: 104
Issue: 2
Pages: 247-57
Publication
First Author: Connor F
Year: 1997
Journal: Hum Mol Genet
Title: Cloning, chromosomal mapping and expression pattern of the mouse Brca2 gene.
Volume: 6
Issue: 2
Pages: 291-300
Publication
First Author: Rajan JV
Year: 1996
Journal: Proc Natl Acad Sci U S A
Title: Brca2 is coordinately regulated with Brca1 during proliferation and differentiation in mammary epithelial cells.
Volume: 93
Issue: 23
Pages: 13078-83
Publication
First Author: Jonkers J
Year: 2001
Journal: Nat Genet
Title: Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.
Volume: 29
Issue: 4
Pages: 418-25
Publication
First Author: Sarkisian CJ
Year: 2001
Journal: J Biol Chem
Title: Analysis of murine Brca2 reveals conservation of protein-protein interactions but differences in nuclear localization signals.
Volume: 276
Issue: 40
Pages: 37640-8
Publication
First Author: Bennett LM
Year: 2001
Journal: Toxicol Pathol
Title: Mammary tumor induction and premature ovarian failure in ApcMin mice are not enhanced by Brca2 deficiency.
Volume: 29
Issue: 1
Pages: 117-25
Publication
First Author: Sharan SK
Year: 1997
Journal: Mamm Genome
Title: Identification and characterization of a microsatellite marker within murine Brca2 gene.
Volume: 8
Issue: 1
Pages: 79
Publication
First Author: Skoulidis F
Year: 2010
Journal: Cancer Cell
Title: Germline Brca2 heterozygosity promotes Kras(G12D) -driven carcinogenesis in a murine model of familial pancreatic cancer.
Volume: 18
Issue: 5
Pages: 499-509
Publication
First Author: Hay T
Year: 2005
Journal: Oncogene
Title: Brca2 deficiency in the murine small intestine sensitizes to p53-dependent apoptosis and leads to the spontaneous deletion of stem cells.
Volume: 24
Issue: 23
Pages: 3842-6
Publication
First Author: Donoho G
Year: 2003
Journal: Genes Chromosomes Cancer
Title: Deletion of Brca2 exon 27 causes hypersensitivity to DNA crosslinks, chromosomal instability, and reduced life span in mice.
Volume: 36
Issue: 4
Pages: 317-31
Strain
Attribute String: congenic, mutant strain, targeted mutation
Publication
First Author: Cheung AM
Year: 2002
Journal: Cancer Res
Title: Loss of Brca2 and p53 synergistically promotes genomic instability and deregulation of T-cell apoptosis.
Volume: 62
Issue: 21
Pages: 6194-204
Publication
First Author: Badie S
Year: 2010
Journal: Nat Struct Mol Biol
Title: BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping.
Volume: 17
Issue: 12
Pages: 1461-9
Publication
First Author: Zhang J
Year: 2019
Journal: Nat Commun
Title: A meiosis-specific BRCA2 binding protein recruits recombinases to DNA double-strand breaks to ensure homologous recombination.
Volume: 10
Issue: 1
Pages: 722
Publication
First Author: Biswas K
Year: 2012
Journal: Hum Mol Genet
Title: Functional evaluation of BRCA2 variants mapping to the PALB2-binding and C-terminal DNA-binding domains using a mouse ES cell-based assay.
Volume: 21
Issue: 18
Pages: 3993-4006
Publication
First Author: McAllister KA
Year: 2006
Journal: Toxicol Pathol
Title: Spontaneous and irradiation-induced tumor susceptibility in BRCA2 germline mutant mice and cooperative effects with a p53 germline mutation.
Volume: 34
Issue: 2
Pages: 187-98
Publication
First Author: Cheung AM
Year: 2004
Journal: Cancer Res
Title: Brca2 deficiency does not impair mammary epithelium development but promotes mammary adenocarcinoma formation in p53(+/-) mutant mice.
Volume: 64
Issue: 6
Pages: 1959-65
Publication
First Author: Chen J
Year: 1998
Journal: Mol Cell
Title: Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells.
Volume: 2
Issue: 3
Pages: 317-28
Publication
First Author: Kitami K
Year: 2018
Journal: PLoS Genet
Title: BRCA1 and BRCA2 tumor suppressors in neural crest cells are essential for craniofacial bone development.
Volume: 14
Issue: 5
Pages: e1007340
Publication
First Author: Bennett LM
Year: 2000
Journal: Cancer Res
Title: Mice heterozygous for a Brca1 or Brca2 mutation display distinct mammary gland and ovarian phenotypes in response to diethylstilbestrol.
Volume: 60
Issue: 13
Pages: 3461-9
Publication
First Author: Rajan JV
Year: 1997
Journal: Dev Biol
Title: Developmental expression of Brca2 colocalizes with Brca1 and is associated with proliferation and differentiation in multiple tissues.
Volume: 184
Issue: 2
Pages: 385-401
Publication
First Author: McAllister KA
Year: 1997
Journal: Mamm Genome
Title: Genetic mapping of the Brca2 breast cancer susceptibility gene on mouse chromosome 5.
Volume: 8
Issue: 7
Pages: 540-1
Publication
First Author: Szabova L
Year: 2012
Journal: Cancer Res
Title: Perturbation of Rb, p53, and Brca1 or Brca2 cooperate in inducing metastatic serous epithelial ovarian cancer.
Volume: 72
Issue: 16
Pages: 4141-53
Publication
First Author: Thirthagiri E
Year: 2016
Journal: Hum Mol Genet
Title: BRCA2 minor transcript lacking exons 4-7 supports viability in mice and may account for survival of humans with a pathogenic biallelic mutation.
Volume: 25
Issue: 10
Pages: 1934-1945
Publication
First Author: Sharan SK
Year: 1997
Journal: Nature
Title: Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2.
Volume: 386
Issue: 6627
Pages: 804-10
Publication
First Author: Huhn SC
Year: 2017
Journal: Oncogene
Title: Regulation of spindle integrity and mitotic fidelity by BCCIP.
Volume: 36
Issue: 33
Pages: 4750-4766
Publication
First Author: Bouwman P
Year: 2011
Journal: J Pathol
Title: Loss of p53 partially rescues embryonic development of Palb2 knockout mice but does not foster haploinsufficiency of Palb2 in tumour suppression.
Volume: 224
Issue: 1
Pages: 10-21
Protein
Organism: Mus musculus
Length: 1030  
Fragment?: false
Publication
First Author: Bowman-Colin C
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer.
Volume: 110
Issue: 21
Pages: 8632-7
Publication
First Author: Zong D
Year: 2019
Journal: Mol Cell
Title: BRCA1 Haploinsufficiency Is Masked by RNF168-Mediated Chromatin Ubiquitylation.
Volume: 73
Issue: 6
Pages: 1267-1281.e7
Publication
First Author: Rantakari P
Year: 2010
Journal: Hum Mol Genet
Title: Inactivation of Palb2 gene leads to mesoderm differentiation defect and early embryonic lethality in mice.
Volume: 19
Issue: 15
Pages: 3021-9
Protein Domain
Type: Repeat
Description: The breast cancer type 2 susceptibility protein has a number of 39 amino acid repeats [[cite:PUB00003901]]that are critical for binding to RAD51 (a key protein in DNA recombinational repair) and resistance to methyl methanesulphonate treatment [[cite:PUB00005803], [cite:PUB00005815], [cite:PUB00005834]]. BRCA2 is a breast tumour suppressor with a potential function in the cellular response to DNA damage. At the cellular level, expressionis regulated in a cell-cycle dependent manner and peak expression of BRCA2 mRNA is found in S phase, suggesting BRCA2 may participate in regulating cell proliferation. There areeight repeats in BRCA2 designated as BRC1 to BRC8. BRC1, BRC2, BRC3, BRC4, BRC7, and BRC8 are highly conserved and bind to Rad51, whereas BRC5 and BRC6 are less well conserved and do not bind to Rad51 [[cite:PUB00007172]]. It has been suggested that BRCA2 plays a role in positioning Rad51 at the site of DNA repair or in removing Rad51 from DNA once repair has been completed.
Publication
First Author: Friedman LS
Year: 1998
Journal: Cancer Res
Title: Thymic lymphomas in mice with a truncating mutation in Brca2.
Volume: 58
Issue: 7
Pages: 1338-43
Protein
Organism: Mus musculus
Length: 1104  
Fragment?: false
Publication
First Author: Venkitaraman AR
Year: 2002
Journal: Cell
Title: Cancer susceptibility and the functions of BRCA1 and BRCA2.
Volume: 108
Issue: 2
Pages: 171-82
Publication
First Author: Daniels MJ
Year: 2004
Journal: Science
Title: Abnormal cytokinesis in cells deficient in the breast cancer susceptibility protein BRCA2.
Volume: 306
Issue: 5697
Pages: 876-9
Publication
First Author: Michl J
Year: 2016
Journal: EMBO J
Title: Interplay between Fanconi anemia and homologous recombination pathways in genome integrity.
Volume: 35
Issue: 9
Pages: 909-23
Publication
First Author: Rajagopalan S
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Mapping the physical and functional interactions between the tumor suppressors p53 and BRCA2.
Volume: 107
Issue: 19
Pages: 8587-92
Publication
First Author: Hay T
Year: 2005
Journal: Cancer Res
Title: Efficient deletion of normal Brca2-deficient intestinal epithelium by poly(ADP-ribose) polymerase inhibition models potential prophylactic therapy.
Volume: 65
Issue: 22
Pages: 10145-8
Publication
First Author: Río P
Year: 2008
Journal: Blood
Title: In vivo proliferation advantage of genetically corrected hematopoietic stem cells in a mouse model of Fanconi anemia FA-D1.
Volume: 112
Issue: 13
Pages: 4853-61