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Search results 1 to 100 out of 1038 for Brca2

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Type Details Score
Gene
675 | BRCA2
Type: gene
Organism: human
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Gene
507069 | BRCA2
Type: gene
Organism: cattle
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Gene
721981 | BRCA2
Type: gene
Organism: macaque, rhesus
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Gene
566758 | brca2
Type: gene
Organism: zebrafish
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Gene
474180 | BRCA2
Type: gene
Organism: dog, domestic
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Gene
452526 | BRCA2
Type: gene
Organism: chimpanzee
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Gene
374139 | BRCA2
Type: gene
Organism: chicken
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Gene
100038818 | brca2
Type: gene
Organism: frog, western clawed
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Gene
key_31375 | BRCA2
Type: gene
Organism: hamster, Chinese
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Gene
key_31373 | BRCA2
Type: gene
Organism: pig, domestic
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Gene
360254 | Brca2
Type: gene
Organism: rat
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Protein Domain
IPR015525 | BRCA2
Type: Family
Description: The breast cancer type 2 susceptibility protein (BRCA2) is a breast tumour suppressor involved in double-strand break repair and/or homologous recombination []. BRCA2 gene expression is regulated in a cell-cycle dependent manner and peak expression of BRCA2 mRNA occurring in S phase, suggesting BRCA2 may participate in regulating cell proliferation. BRCA2, and related protein BRCA1, have transcriptional activation potential and the two proteins are associated with the activation of double-strand break repair and/or homologous recombination. The two proteins have been shown to coexist and colocalize in a biochemical complex. BRCA2 has a number of 39 amino acid repeats []that are critical for binding to RAD51 (a key protein in DNA recombinational repair) and resistance to methyl methanesulphonate treatment [, , ]. There are eight repeats in BRCA2 designated as BRC1 to BRC8. BRC1, BRC2, BRC3, BRC4, BRC7, and BRC8 have high sequence identity and bind to Rad51, whereas BRC5 and BRC6 are less well conserved and are unable to bind Rad51 []. It has been suggested that BRCA2 plays a role in positioning Rad51 at the site of DNA repair or in removing Rad51 from DNA once repair has been completed.Mutations in BRCA1 and BRCA2 have been linked to an elevated risk of young onset breast cancer and confer a high risk of the disease through a dominantly inherited fashion []. BRCA2 mutations are typically microdeletions.Homologues exist in plants: the BRCA2A and BRCA2B proteins from Arabidopsis thalianaare required for repair of breaks in double-stranded DNA and homologous recombination and in the prophase stage of meiosis are required for formation of RAD51 and DMC1 foci in males [].
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Protein Coding Gene
MGI:109337 | Brca2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q6PB43
Organism: Mus musculus/domesticus
Length: 1180  
Fragment?: false
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Publication
8673099 | -
First Author: Bork P
Year: 1996
Journal: Nat Genet
Title: Internal repeats in the BRCA2 protein sequence.
Volume: 13
Issue: 1
Pages: 22-3
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Publication
9811893 | -
First Author: Marmorstein LY
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: The BRCA2 gene product functionally interacts with p53 and RAD51.
Volume: 95
Issue: 23
Pages: 13869-74
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Publication
9560268 | -
First Author: Chen PL
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment.
Volume: 95
Issue: 9
Pages: 5287-92
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Publication
9405383 | -
First Author: Wong AK
Year: 1997
Journal: J Biol Chem
Title: RAD51 interacts with the evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene brca2.
Volume: 272
Issue: 51
Pages: 31941-4
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Publication
10551859 | -
First Author: Chen CF
Year: 1999
Journal: J Biol Chem
Title: Expression of BRC repeats in breast cancer cells disrupts the BRCA2-Rad51 complex and leads to radiation hypersensitivity and loss of G(2)/M checkpoint control.
Volume: 274
Issue: 46
Pages: 32931-5
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Gene
106721785 | LOC106721785
Type: gene
Organism: human
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Publication
12228710 | J:114800
First Author: Yang H
Year: 2002
Journal: Science
Title: BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure.
Volume: 297
Issue: 5588
Pages: 1837-48
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Publication
22077663 | -
First Author: Seeliger K
Year: 2012
Journal: New Phytol
Title: BRCA2 is a mediator of RAD51- and DMC1-facilitated homologous recombination in Arabidopsis thaliana.
Volume: 193
Issue: 2
Pages: 364-75
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Publication
27490902 | J:234167
First Author: Hartford SA
Year: 2016
Journal: PLoS Genet
Title: Interaction with PALB2 Is Essential for Maintenance of Genomic Integrity by BRCA2.
Volume: 12
Issue: 8
Pages: e1006236
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Publication
20513136 | -
First Author: Walker LC
Year: 2010
Journal: Hum Mutat
Title: Detection of splicing aberrations caused by BRCA1 and BRCA2 sequence variants encoding missense substitutions: implications for prediction of pathogenicity.
Volume: 31
Issue: 6
Pages: E1484-505
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Protein
Q3TN53
Organism: Mus musculus/domesticus
Length: 747  
Fragment?: true
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Publication
11597317 | J:114008
First Author: Orelli BJ
Year: 2001
Journal: Breast Cancer Res
Title: BRCA2 and homologous recombination.
Volume: 3
Issue: 5
Pages: 294-8
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Protein
Q8VHD0
Organism: Mus musculus/domesticus
Length: 3329  
Fragment?: false
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Protein
P97929
Organism: Mus musculus/domesticus
Length: 3329  
Fragment?: false
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Gene
79728 | PALB2
Type: gene
Organism: human
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Publication
19047179 | J:142088
First Author: Philip S
Year: 2008
Journal: Cancer Res
Title: Degradation of BRCA2 in alkyltransferase-mediated DNA repair and its clinical implications.
Volume: 68
Issue: 23
Pages: 9973-81
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Publication
30760716 | J:273173
First Author: Zhang J
Year: 2019
Journal: Nat Commun
Title: A meiosis-specific BRCA2 binding protein recruits recombinases to DNA double-strand breaks to ensure homologous recombination.
Volume: 10
Issue: 1
Pages: 722
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Publication
9660919 | J:47362
First Author: Patel KJ
Year: 1998
Journal: Mol Cell
Title: Involvement of Brca2 in DNA repair.
Volume: 1
Issue: 3
Pages: 347-57
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Publication
27498558 | J:241267
 
First Author: Ding X
Year: 2016
Journal: Nat Commun
Title: Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies.
Volume: 7
Pages: 12425
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Publication
11343905 | J:114055
First Author: Venkitaraman AR
Year: 2001
Journal: Curr Opin Cell Biol
Title: Chromosome stability, DNA recombination and the BRCA2 tumour suppressor.
Volume: 13
Issue: 3
Pages: 338-43
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Protein
A0A0J9YVI7
Organism: Mus musculus/domesticus
Length: 992  
Fragment?: true
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Publication
14981540 | J:89083
First Author: Yan DH
Year: 2004
Journal: Oncogene
Title: A delayed chemically induced tumorigenesis in Brca2 mutant mice.
Volume: 23
Issue: 10
Pages: 1896-901
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Publication
12410562 | J:141600
First Author: Flores KG
Year: 2002
Journal: Mol Carcinog
Title: Thymic model for examining BRCA2 expression and function.
Volume: 35
Issue: 3
Pages: 103-9
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Publication
12242698 | J:115553
First Author: Daniel DC
Year: 2002
Journal: Microsc Res Tech
Title: Highlight: BRCA1 and BRCA2 proteins in breast cancer.
Volume: 59
Issue: 1
Pages: 68-83
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Publication
16108063 | J:101017
First Author: Henderson BR
Year: 2005
Journal: Bioessays
Title: Regulation of BRCA1, BRCA2 and BARD1 intracellular trafficking.
Volume: 27
Issue: 9
Pages: 884-93
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Publication
12442171 | -
First Author: Pellegrini L
Year: 2002
Journal: Nature
Title: Insights into DNA recombination from the structure of a RAD51-BRCA2 complex.
Volume: 420
Issue: 6913
Pages: 287-93
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Publication
12140683 | J:78538
First Author: Callens N
Year: 2002
Journal: Mamm Genome
Title: Genomic organization and expression of the mouse Brca2 gene.
Volume: 13
Issue: 7
Pages: 352-8
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Publication
9002670 | J:38519
First Author: Bignell G
Year: 1997
Journal: Hum Mol Genet
Title: The BRC repeats are conserved in mammalian BRCA2 proteins.
Volume: 6
Issue: 1
Pages: 53-8
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Publication
10819537 | J:62421
First Author: Hakem R
Year: 1998
Journal: J Mammary Gland Biol Neoplasia
Title: Developmental studies of Brca1 and Brca2 knock-out mice.
Volume: 3
Issue: 4
Pages: 431-45
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Publication
25666348 | J:232670
First Author: Jeong JH
Year: 2015
Journal: Mol Cells
Title: Brca2 deficiency leads to T cell loss and immune dysfunction.
Volume: 38
Issue: 3
Pages: 251-8
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Publication
14660434 | J:87231
First Author: Sharan SK
Year: 2004
Journal: Development
Title: BRCA2 deficiency in mice leads to meiotic impairment and infertility.
Volume: 131
Issue: 1
Pages: 131-42
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Publication
22157755 | J:182460
First Author: Singh KK
Year: 2012
Journal: J Biol Chem
Title: BRCA2 protein deficiency exaggerates doxorubicin-induced cardiomyocyte apoptosis and cardiac failure.
Volume: 287
Issue: 9
Pages: 6604-14
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Publication
26338419 | J:238472
First Author: Jiang Q
Year: 2015
Journal: Genes Dev
Title: MERIT40 cooperates with BRCA2 to resolve DNA interstrand cross-links.
Volume: 29
Issue: 18
Pages: 1955-68
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Publication
31242413 | J:294372
First Author: Brandsma I
Year: 2019
Journal: Cell Rep
Title: HSF2BP Interacts with a Conserved Domain of BRCA2 and Is Required for Mouse Spermatogenesis.
Volume: 27
Issue: 13
Pages: 3790-3798.e7
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Publication
25043256 | J:215920
First Author: Xu H
Year: 2014
Journal: J Pathol
Title: Up-regulation of the interferon-related genes in BRCA2 knockout epithelial cells.
Volume: 234
Issue: 3
Pages: 386-97
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Publication
17476307 | J:122559
First Author: Frappart PO
Year: 2007
Journal: EMBO J
Title: BRCA2 is required for neurogenesis and suppression of medulloblastoma.
Volume: 26
Issue: 11
Pages: 2732-42
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Gene
56647 | BCCIP
Type: gene
Organism: human
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Gene
56946 | EMSY
Type: gene
Organism: human
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Publication
9171369 | J:40595
First Author: Suzuki A
Year: 1997
Journal: Genes Dev
Title: Brca2 is required for embryonic cellular proliferation in the mouse.
Volume: 11
Issue: 10
Pages: 1242-52
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Publication
22340495 | J:181473
First Author: Choi E
Year: 2012
Journal: Dev Cell
Title: BRCA2 fine-tunes the spindle assembly checkpoint through reinforcement of BubR1 acetylation.
Volume: 22
Issue: 2
Pages: 295-308
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Publication
11494122 | J:70564
First Author: Ludwig T
Year: 2001
Journal: Oncogene
Title: Development of mammary adenocarcinomas by tissue-specific knockout of Brca2 in mice.
Volume: 20
Issue: 30
Pages: 3937-48
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Publication
31209201 | J:324078
First Author: Miao Y
Year: 2019
Journal: Cell Death Dis
Title: BRCA2 deficiency is a potential driver for human primary ovarian insufficiency.
Volume: 10
Issue: 7
Pages: 474
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Publication
30811824 | J:292589
First Author: Kwon MS
Year: 2019
Journal: FEBS J
Title: Brca2 abrogation engages with the alternative lengthening of telomeres via break-induced replication.
Volume: 286
Issue: 10
Pages: 1841-1858
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Publication
28904335 | J:252453
First Author: Feng W
Year: 2017
Journal: Nat Commun
Title: BRCA2 suppresses replication stress-induced mitotic and G1 abnormalities through homologous recombination.
Volume: 8
Issue: 1
Pages: 525
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Publication
12483515 | J:81094
First Author: Moynahan ME
Year: 2002
Journal: Oncogene
Title: The cancer connection: BRCA1 and BRCA2 tumor suppression in mice and humans.
Volume: 21
Issue: 58
Pages: 8994-9007
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Publication
9242436 | J:41969
First Author: McAllister KA
Year: 1997
Journal: Cancer Res
Title: Characterization of the rat and mouse homologues of the BRCA2 breast cancer susceptibility gene.
Volume: 57
Issue: 15
Pages: 3121-5
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Publication
9699678 | J:49518
First Author: Morimatsu M
Year: 1998
Journal: Cancer Res
Title: Cells deleted for Brca2 COOH terminus exhibit hypersensitivity to gamma-radiation and premature senescence.
Volume: 58
Issue: 15
Pages: 3441-7
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Publication
31877165 | J:283370
First Author: Park D
Year: 2019
Journal: PLoS One
Title: Murine models for familial pancreatic cancer: Histopathology, latency and drug sensitivity among cancers of Palb2, Brca1 and Brca2 mutant mouse strains.
Volume: 14
Issue: 12
Pages: e0226714
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Publication
20585617 | J:161511
First Author: Francis JC
Year: 2010
Journal: PLoS Genet
Title: Brca2 and Trp53 deficiency cooperate in the progression of mouse prostate tumourigenesis.
Volume: 6
Issue: 6
Pages: e1000995
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Publication
18587272 | J:140433
First Author: Park PG
Year: 2008
Journal: Exp Mol Med
Title: Development of thymic lymphomas in mice disrupted of Brca2 allele in the thymus.
Volume: 40
Issue: 3
Pages: 339-44
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Publication
14681210 | J:87195
First Author: Lomonosov M
Year: 2003
Journal: Genes Dev
Title: Stabilization of stalled DNA replication forks by the BRCA2 breast cancer susceptibility protein.
Volume: 17
Issue: 24
Pages: 3017-22
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Publication
34326328 | J:322962
First Author: Ghouil R
Year: 2021
Journal: Nat Commun
Title: BRCA2 binding through a cryptic repeated motif to HSF2BP oligomers does not impact meiotic recombination.
Volume: 12
Issue: 1
Pages: 4605
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Publication
11861370 | J:75026
First Author: McAllister KA
Year: 2002
Journal: Cancer Res
Title: Cancer susceptibility of mice with a homozygous deletion in the COOH-terminal domain of the Brca2 gene.
Volume: 62
Issue: 4
Pages: 990-4
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Publication
9398843 | J:44386
First Author: Connor F
Year: 1997
Journal: Nat Genet
Title: Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation.
Volume: 17
Issue: 4
Pages: 423-30
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Publication
9063750 | J:38616
First Author: Connor F
Year: 1997
Journal: Hum Mol Genet
Title: Cloning, chromosomal mapping and expression pattern of the mouse Brca2 gene.
Volume: 6
Issue: 2
Pages: 291-300
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Publication
11172592 | J:74101
First Author: Bernard-Gallon DJ
Year: 2001
Journal: Int J Oncol
Title: Brca1 and Brca2 protein expression patterns in different tissues of murine origin.
Volume: 18
Issue: 2
Pages: 271-80
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Publication
9467943 | J:45456
First Author: Blackshear PE
Year: 1998
Journal: Oncogene
Title: Brca1 and Brca2 expression patterns in mitotic and meiotic cells of mice.
Volume: 16
Issue: 1
Pages: 61-8
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Publication
27779185 | J:242647
 
First Author: Kass EM
Year: 2016
Journal: Nat Commun
Title: Robust homology-directed repair within mouse mammary tissue is not specifically affected by Brca2 mutation.
Volume: 7
Pages: 13241
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Publication
11207365 | J:67272
First Author: Marmorstein LY
Year: 2001
Journal: Cell
Title: A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression.
Volume: 104
Issue: 2
Pages: 247-57
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Strain
MGI:5562378 | B6.129P2-Brca2<tm2Mak>/Cnbc
Attribute String: congenic, mutant strain, targeted mutation
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Publication
22187435 | J:182445
First Author: Min J
Year: 2012
Journal: J Biol Chem
Title: The breast cancer susceptibility gene BRCA2 is required for the maintenance of telomere homeostasis.
Volume: 287
Issue: 7
Pages: 5091-101
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Publication
37980415 | J:342841
First Author: Mishra AP
Year: 2023
Journal: Cell Death Dis
Title: Characterization of BRCA2 R3052Q variant in mice supports its functional impact as a low-risk variant.
Volume: 14
Issue: 11
Pages: 753
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Publication
21719596 | J:176900
First Author: Biswas K
Year: 2011
Journal: Blood
Title: A comprehensive functional characterization of BRCA2 variants associated with Fanconi anemia using mouse ES cell-based assay.
Volume: 118
Issue: 9
Pages: 2430-42
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Publication
8917547 | J:36562
First Author: Rajan JV
Year: 1996
Journal: Proc Natl Acad Sci U S A
Title: Brca2 is coordinately regulated with Brca1 during proliferation and differentiation in mammary epithelial cells.
Volume: 93
Issue: 23
Pages: 13078-83
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Publication
11694875 | J:73028
First Author: Jonkers J
Year: 2001
Journal: Nat Genet
Title: Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.
Volume: 29
Issue: 4
Pages: 418-25
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Publication
32980867 | J:305816
First Author: Chen X
Year: 2020
Journal: Cell Death Dis
Title: Brca2 deficiency drives gastrointestinal tumor formation and is selectively inhibited by mitomycin C.
Volume: 11
Issue: 9
Pages: 812
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Publication
11477095 | J:72374
First Author: Sarkisian CJ
Year: 2001
Journal: J Biol Chem
Title: Analysis of murine Brca2 reveals conservation of protein-protein interactions but differences in nuclear localization signals.
Volume: 276
Issue: 40
Pages: 37640-8
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Publication
21056012 | J:166678
First Author: Skoulidis F
Year: 2010
Journal: Cancer Cell
Title: Germline Brca2 heterozygosity promotes Kras(G12D) -driven carcinogenesis in a murine model of familial pancreatic cancer.
Volume: 18
Issue: 5
Pages: 499-509
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Publication
11215675 | J:67445
First Author: Bennett LM
Year: 2001
Journal: Toxicol Pathol
Title: Mammary tumor induction and premature ovarian failure in ApcMin mice are not enhanced by Brca2 deficiency.
Volume: 29
Issue: 1
Pages: 117-25
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Publication
21076401 | J:228560
First Author: Badie S
Year: 2010
Journal: Nat Struct Mol Biol
Title: BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping.
Volume: 17
Issue: 12
Pages: 1461-9
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Publication
12414647 | J:79697
First Author: Cheung AM
Year: 2002
Journal: Cancer Res
Title: Loss of Brca2 and p53 synergistically promotes genomic instability and deregulation of T-cell apoptosis.
Volume: 62
Issue: 21
Pages: 6194-204
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Publication
9021166 | J:38230
First Author: Sharan SK
Year: 1997
Journal: Mamm Genome
Title: Identification and characterization of a microsatellite marker within murine Brca2 gene.
Volume: 8
Issue: 1
Pages: 79
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Publication
12619154 | J:82434
First Author: Donoho G
Year: 2003
Journal: Genes Chromosomes Cancer
Title: Deletion of Brca2 exon 27 causes hypersensitivity to DNA crosslinks, chromosomal instability, and reduced life span in mice.
Volume: 36
Issue: 4
Pages: 317-31
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Publication
15735671 | J:98772
First Author: Hay T
Year: 2005
Journal: Oncogene
Title: Brca2 deficiency in the murine small intestine sensitizes to p53-dependent apoptosis and leads to the spontaneous deletion of stem cells.
Volume: 24
Issue: 23
Pages: 3842-6
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Publication
22678057 | J:187434
First Author: Biswas K
Year: 2012
Journal: Hum Mol Genet
Title: Functional evaluation of BRCA2 variants mapping to the PALB2-binding and C-terminal DNA-binding domains using a mouse ES cell-based assay.
Volume: 21
Issue: 18
Pages: 3993-4006
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Publication
16546942 | J:109193
First Author: McAllister KA
Year: 2006
Journal: Toxicol Pathol
Title: Spontaneous and irradiation-induced tumor susceptibility in BRCA2 germline mutant mice and cooperative effects with a p53 germline mutation.
Volume: 34
Issue: 2
Pages: 187-98
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Publication
15026330 | J:89150
First Author: Cheung AM
Year: 2004
Journal: Cancer Res
Title: Brca2 deficiency does not impair mammary epithelium development but promotes mammary adenocarcinoma formation in p53(+/-) mutant mice.
Volume: 64
Issue: 6
Pages: 1959-65
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Publication
29718910 | J:263685
First Author: Kitami K
Year: 2018
Journal: PLoS Genet
Title: BRCA1 and BRCA2 tumor suppressors in neural crest cells are essential for craniofacial bone development.
Volume: 14
Issue: 5
Pages: e1007340
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Publication
9774970 | J:113839
First Author: Chen J
Year: 1998
Journal: Mol Cell
Title: Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells.
Volume: 2
Issue: 3
Pages: 317-28
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Publication
10910057 | J:206999
First Author: Bennett LM
Year: 2000
Journal: Cancer Res
Title: Mice heterozygous for a Brca1 or Brca2 mutation display distinct mammary gland and ovarian phenotypes in response to diethylstilbestrol.
Volume: 60
Issue: 13
Pages: 3461-9
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Publication
36906610 | J:334068
First Author: Tomaszowski KH
Year: 2023
Journal: Nat Commun
Title: Hypomorphic Brca2 and Rad51c double mutant mice display Fanconi anemia, cancer and polygenic replication stress.
Volume: 14
Issue: 1
Pages: 1333
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Publication
9133444 | J:40064
First Author: Rajan JV
Year: 1997
Journal: Dev Biol
Title: Developmental expression of Brca2 colocalizes with Brca1 and is associated with proliferation and differentiation in multiple tissues.
Volume: 184
Issue: 2
Pages: 385-401
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Publication
9196008 | J:41357
First Author: McAllister KA
Year: 1997
Journal: Mamm Genome
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Year: 2012
Journal: Cancer Res
Title: Perturbation of Rb, p53, and Brca1 or Brca2 cooperate in inducing metastatic serous epithelial ovarian cancer.
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First Author: Thirthagiri E
Year: 2016
Journal: Hum Mol Genet
Title: BRCA2 minor transcript lacking exons 4-7 supports viability in mice and may account for survival of humans with a pathogenic biallelic mutation.
Volume: 25
Issue: 10
Pages: 1934-1945
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First Author: Sharan SK
Year: 1997
Journal: Nature
Title: Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2.
Volume: 386
Issue: 6627
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