|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 87 out of 87 for Brf1

0.032s

Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
2972 | BRF1
Type: gene
Organism: human
•
•
•
•
•
Gene
618161 | BRF1
Type: gene
Organism: cattle
•
•
•
•
•
Gene
709533 | BRF1
Type: gene
Organism: macaque, rhesus
•
•
•
•
•
Gene
490883 | BRF1
Type: gene
Organism: dog, domestic
•
•
•
•
•
Gene
453212 | BRF1
Type: gene
Organism: chimpanzee
•
•
•
•
•
Gene
423503 | BRF1
Type: gene
Organism: chicken
•
•
•
•
•
Gene
100170638 | brf1
Type: gene
Organism: frog, western clawed
•
•
•
•
•
Protein Domain
IPR029529 | Brf1
Type: Family
Description: Transcription by RNA polymerase III (pol III) is a complex molecular process orchestrated by the two main transcription factors, TFIIIB and TFIIIC. The TFIIIB complex can be recruited by TFIIIC to upstream DNA and form an exceptionally kinetically stable TFIIIB-DNA complex, which then recruits the Pol III enzymatic complex and helps maintain it for multiple transcription cycles in a process called facilitated recycling []. Saccharomyces cerevisiae TFIIIB is a complex of three subunits, the TATA box-binding protein TBP, the TFIIB-related factor BRF, and the beta'' protein. This entry represents transcription factor IIIB subunit Brf1, which is a homologue of the functionally analogous pol II initiation factor, TFIIB []. In budding yeast, Brf1 interacts with several initiation-specific subunits of the pol III machinery, TBP, beta", TFC4p and the pol III subunits C34 and C17 [].
•
•
•
•
•
Gene
299347 | Brf1
Type: gene
Organism: rat
•
•
•
•
•
Protein Coding Gene
MGI:1919558 | Brf1
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein
Q6PED6
Organism: Mus musculus/domesticus
Length: 203  
Fragment?: false
•
•
•
•
•
Publication
24733888 | J:233560
First Author: Tan FE
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Brf1 posttranscriptionally regulates pluripotency and differentiation responses downstream of Erk MAP kinase.
Volume: 111
Issue: 17
Pages: E1740-8
•
•
•
•
•
Publication
14976220 | J:88901
First Author: Raineri I
Year: 2004
Journal: Nucleic Acids Res
Title: Roles of AUF1 isoforms, HuR and BRF1 in ARE-dependent mRNA turnover studied by RNA interference.
Volume: 32
Issue: 4
Pages: 1279-88
•
•
•
•
•
Publication
30858608 | J:285667
First Author: Liko D
Year: 2019
Journal: Cell Death Differ
Title: Brf1 loss and not overexpression disrupts tissues homeostasis in the intestine, liver and pancreas.
Volume: 26
Issue: 12
Pages: 2535-2550
•
•
•
•
•
Protein
Q8CFK2
Organism: Mus musculus/domesticus
Length: 676  
Fragment?: false
•
•
•
•
•
Protein
G3X8S2
Organism: Mus musculus/domesticus
Length: 676  
Fragment?: false
•
•
•
•
•
Publication
11433012 | -
First Author: Huang Y
Year: 2001
Journal: Nucleic Acids Res
Title: Comparison of the RNA polymerase III transcription machinery in Schizosaccharomyces pombe, Saccharomyces cerevisiae and human.
Volume: 29
Issue: 13
Pages: 2675-90
•
•
•
•
•
Protein Coding Gene
MGP_CAROLIEiJ_G0018166 | -
Type: protein_coding_gene
Organism: Mus caroli
•
•
•
•
•
Protein Coding Gene
MGP_129S1SvImJ_G0020166 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_AJ_G0020122 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_AKRJ_G0020097 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_BALBcJ_G0020107 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_C3HHeJ_G0019909 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI_C57BL6J_1919558 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_C57BL6NJ_G0020552 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_CASTEiJ_G0019449 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_CBAJ_G0019876 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_DBA2J_G0019993 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_FVBNJ_G0019978 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_LPJ_G0020067 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_NODShiLtJ_G0020016 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_NZOHlLtJ_G0020581 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_PWKPhJ_G0019211 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_WSBEiJ_G0019509 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_PahariEiJ_G0029923 | -
Type: protein_coding_gene
Organism: Mus pahari
•
•
•
•
•
Protein Coding Gene
MGP_SPRETEiJ_G0019015 | -
Type: protein_coding_gene
Organism: Mus spretus
•
•
•
•
•
Publication
15741177 | J:126097
First Author: Cobellis G
Year: 2005
Journal: Nucleic Acids Res
Title: Tagging genes with cassette-exchange sites.
Volume: 33
Issue: 4
Pages: e44
•
•
•
•
•
Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
•
•
•
•
•
Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
•
•
•
•
•
Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
•
•
•
•
•
Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
•
•
•
•
•
Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
•
•
•
•
•
Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
•
•
•
•
•
Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
•
•
•
•
•
Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
•
•
•
•
•
Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
•
•
•
•
•
Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
•
•
•
•
•
Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
•
•
•
•
•
Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
•
•
•
•
•
Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
•
•
•
•
•
Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
•
•
•
•
•
Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
•
•
•
•
•
Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
•
•
•
•
•
Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
•
•
•
•
•
Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
•
•
•
•
•
Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
•
•
•
•
•
Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
•
•
•
•
•
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
•
•
•
•
•
Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
•
•
•
•
•
Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
•
•
•
•
•
Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
•
•
•
•
•
Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
•
•
•
•
•
Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
•
•
•
•
•
Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
•
•
•
•
•
Publication
8595910 | J:30103
First Author: Maclean KN
Year: 1995
Journal: Genomics
Title: The human immediate early gene BRF1 maps to chromosome 14q22-q24.
Volume: 30
Issue: 1
Pages: 89-90
•
•
•
•
•
Gene
334316 | brf1b
Type: gene
Organism: zebrafish
•
•
•
•
•
Gene
334402 | brf1a
Type: gene
Organism: zebrafish
•
•
•
•
•
Publication
24277937 | -
First Author: Khoo SK
Year: 2014
Journal: Mol Cell Biol
Title: Mapping the protein interaction network for TFIIB-related factor Brf1 in the RNA polymerase III preinitiation complex.
Volume: 34
Issue: 3
Pages: 551-9
•
•
•
•
•
Protein
P23950
Organism: Mus musculus/domesticus
Length: 338  
Fragment?: false
•
•
•
•
•
Protein Coding Gene
MGI:107946 | Zfp36l1
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
DO Term
DOID:0080898 | cerebellofaciodental syndrome
•
•
•
•
•
Publication
12660736 | -
First Author: Juo ZS
Year: 2003
Journal: Nature
Title: Crystal structure of a transcription factor IIIB core interface ternary complex.
Volume: 422
Issue: 6931
Pages: 534-9
•
•
•
•
•
Publication
24336746 | -
First Author: Korde A
Year: 2014
Journal: Genetics
Title: Intergenic transcriptional interference is blocked by RNA polymerase III transcription factor TFIIIB in Saccharomyces cerevisiae.
Volume: 196
Issue: 2
Pages: 427-38
•
•
•
•
•
Protein Domain
IPR011665 | BRF1_TBP-bd_dom
Type: Domain
Description: In budding yeasts, Brf1 forms the TFIIIB complex with TATA-binding protein (TBP) and Bdp1 []. The TFIIIB complex can be recruited to the Pol III promoters and form an exceptionally kinetically stable TFIIIB-DNA complex, which then recruits the Pol III enzymatic complex and helps maintain it for multiple transcription cycles in a process called facilitated recycling [].This entry represents the TATA binding protein (TBP) binding domain of Brf1 that covers both the Brf homology II and III regions [].
•
•
•
•
•
Publication
27697617 | J:242096
 
First Author: Shi G
Year: 2017
Journal: Gene
Title: Alcohol-associated cancer and deregulation of Pol III genes.
Volume: 612
Pages: 25-28
•
•
•
•
•
Protein Domain
IPR000812 | TFIIB
Type: Family
Description: In eukaryotes, transcription initiation by polymerase II is modulated by both general and specific transcription factors. The general factors (which include TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIG and TFIIH) operate through common promoter elements, such as the TATA box. Transcription factor IIB (TFIIB) is of central importance in transcription of class II genes. It associates with TFIID-TFIIA bound to DNA (the DA complex) to form a ternary TFIID-IIA-IBB (DAB) complex, which is recognised by RNA polymerase II [, ]. TFIIB comprises ~315-340 residues and contains an imperfect C-terminal repeat of a 75-residue domain that may contribute to the symmetry of the folded protein.Proteins in this entry also include transcription factor IIIB subunit Brf1, which shares protein sequence similarity with TFIIB. In budding yeast, Brf1 interacts with several initiation-specific subunits of the pol III machinery, TBP, beta", TFC4p and the pol III subunits C34 and C17 [].
•
•
•
•
•
Publication
19620725 | J:152018
First Author: Zhong S
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: The JNKs differentially regulate RNA polymerase III transcription by coordinately modulating the expression of all TFIIIB subunits.
Volume: 106
Issue: 31
Pages: 12682-7
•
•
•
•
•
Publication
1876184 | -
First Author: Ha I
Year: 1991
Journal: Nature
Title: Cloning of a human gene encoding the general transcription initiation factor IIB.
Volume: 352
Issue: 6337
Pages: 689-95
•
•
•
•
•
Publication
1949150 | -
First Author: Hawley D
Year: 1991
Journal: Trends Biochem Sci
Title: Transcriptional activation: enter TFIIB.
Volume: 16
Issue: 9
Pages: 317-8
•
•
•
•
•
Protein
A0A1B0GRY1
Organism: Mus musculus/domesticus
Length: 85  
Fragment?: false
•
•
•
•
•
Protein
Q3UAW9
Organism: Mus musculus/domesticus
Length: 420  
Fragment?: false
•
•
•
•
•
Protein
P62915
Organism: Mus musculus/domesticus
Length: 316  
Fragment?: false
•
•
•
•
•
Protein
Q3UNY0
Organism: Mus musculus/domesticus
Length: 316  
Fragment?: false
•
•
•
•
•
Protein
Q3UZJ3
Organism: Mus musculus/domesticus
Length: 316  
Fragment?: false
•
•
•
•
•
Protein
A0A0R4J0C6
Organism: Mus musculus/domesticus
Length: 420  
Fragment?: false
•
•
•
•
•
Protein
Q3ULN2
Organism: Mus musculus/domesticus
Length: 316  
Fragment?: false
•
•
•
•
•
Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom