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Search results 1 to 97 out of 97 for Bst2

0.029s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Domain
Type: Family
Description: Bone marrow stromal antigen 2, also known as tetherin, is an antiretroviral defence protein, that blocks release of enveloped virus from the cell surface [, , ]. Bst2/tetherin contains two membrane anchors which are employed to retain some enveloped viruses, including HIV-1, tethered to the plasma membrane in the absence of virus encoded antagonists []. Its expression is induced by interferon-alpha []and was originally linked to B cell development [].
Publication
First Author: Radoshitzky SR
Year: 2010
Journal: J Virol
Title: Infectious Lassa virus, but not filoviruses, is restricted by BST-2/tetherin.
Volume: 84
Issue: 20
Pages: 10569-80
Gene
Type: gene
Organism: human
Protein
Organism: Mus musculus/domesticus
Length: 172  
Fragment?: false
Publication
First Author: Yang H
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Structural insight into the mechanisms of enveloped virus tethering by tetherin.
Volume: 107
Issue: 43
Pages: 18428-32
Publication
First Author: Ishikawa J
Year: 1995
Journal: Genomics
Title: Molecular cloning and chromosomal mapping of a bone marrow stromal cell surface gene, BST2, that may be involved in pre-B-cell growth.
Volume: 26
Issue: 3
Pages: 527-34
Publication
First Author: Neil SJ
Year: 2008
Journal: Nature
Title: Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu.
Volume: 451
Issue: 7177
Pages: 425-30
Publication
First Author: Hinz A
Year: 2010
Journal: Cell Host Microbe
Title: Structural basis of HIV-1 tethering to membranes by the BST-2/tetherin ectodomain.
Volume: 7
Issue: 4
Pages: 314-23
Publication
First Author: Kawai S
Year: 2008
Journal: Cancer Sci
Title: Interferon-alpha enhances CD317 expression and the antitumor activity of anti-CD317 monoclonal antibody in renal cell carcinoma xenograft models.
Volume: 99
Issue: 12
Pages: 2461-6
Publication
First Author: Swiecki M
Year: 2012
Journal: J Immunol
Title: Cutting edge: paradoxical roles of BST2/tetherin in promoting type I IFN response and viral infection.
Volume: 188
Issue: 6
Pages: 2488-92
Publication  
First Author: Miller KD
Year: 2021
Journal: Virology
Title: Murine BST2/tetherin promotes measles virus infection of neurons.
Volume: 563
Pages: 38-43
Publication
First Author: Blasius AL
Year: 2006
Journal: J Immunol
Title: Bone marrow stromal cell antigen 2 is a specific marker of type I IFN-producing cells in the naive mouse, but a promiscuous cell surface antigen following IFN stimulation.
Volume: 177
Issue: 5
Pages: 3260-5
Publication
First Author: Florez MA
Year: 2020
Journal: Cell Rep
Title: Interferon Gamma Mediates Hematopoietic Stem Cell Activation and Niche Relocalization through BST2.
Volume: 33
Issue: 12
Pages: 108530
Publication
First Author: Holmgren AM
Year: 2015
Journal: J Virol
Title: Bst2/Tetherin Is Induced in Neurons by Type I Interferon and Viral Infection but Is Dispensable for Protection against Neurotropic Viral Challenge.
Volume: 89
Issue: 21
Pages: 11011-8
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Sarojini S
Year: 2011
Journal: DNA Cell Biol
Title: Interferon-induced tetherin restricts vesicular stomatitis virus release in neurons.
Volume: 30
Issue: 12
Pages: 965-74
Publication
First Author: Liberatore RA
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Tetherin is a key effector of the antiretroviral activity of type I interferon in vitro and in vivo.
Volume: 108
Issue: 44
Pages: 18097-101
Publication  
First Author: Jones PH
Year: 2012
Journal: Retrovirology
Title: Bone marrow stromal cell antigen 2 (BST-2) restricts mouse mammary tumor virus (MMTV) replication in vivo.
Volume: 9
Pages: 10
Publication
First Author: Jones PH
Year: 2013
Journal: Virology
Title: BST-2/tetherin is overexpressed in mammary gland and tumor tissues in MMTV-induced mammary cancer.
Volume: 444
Issue: 1-2
Pages: 124-39
Publication
First Author: Londrigan SL
Year: 2015
Journal: PLoS One
Title: Endogenous Murine BST-2/Tetherin Is Not a Major Restriction Factor of Influenza A Virus Infection.
Volume: 10
Issue: 11
Pages: e0142925
Publication
First Author: Li X
Year: 2007
Journal: Mol Biol Cell
Title: Involvement of a Golgi-resident GPI-anchored protein in maintenance of the Golgi structure.
Volume: 18
Issue: 4
Pages: 1261-71
Publication
First Author: Barrett BS
Year: 2012
Journal: PLoS Pathog
Title: A single nucleotide polymorphism in tetherin promotes retrovirus restriction in vivo.
Volume: 8
Issue: 3
Pages: e1002596
GXD Expression      
Probe: MGI:6444257
Assay Type: RT-PCR
Annotation Date: 2020-07-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Stage: TS28
Assay Id: MGI:6444874
Age: postnatal week 5
Specimen Label: wild type control
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6444257
Assay Type: RT-PCR
Annotation Date: 2020-07-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Stage: TS28
Assay Id: MGI:6444874
Age: postnatal week 5
Specimen Label: miR-183C
Detected: true
Specimen Num: 2
Publication  
First Author: Li SX
Year: 2016
Journal: Sci Rep
Title: Tetherin/BST-2 promotes dendritic cell activation and function during acute retrovirus infection.
Volume: 6
Pages: 20425
Publication
First Author: Fu J
Year: 2021
Journal: Exp Cell Res
Title: BST-2/Tetherin is involved in BAFF-enhanced proliferation and survival via canonical NF-κB signaling in neoplastic B-lymphoid cells.
Volume: 398
Issue: 1
Pages: 112399
Publication
First Author: Jones PH
Year: 2013
Journal: Cell Signal
Title: Phosphatidylinositol 3-kinase is involved in Toll-like receptor 4-mediated BST-2/tetherin regulation.
Volume: 25
Issue: 12
Pages: 2752-61
Publication
First Author: Liu H
Year: 2024
Journal: iScience
Title: Epigenetic repression of Cend1 by lysine-specific demethylase 1 is essential for murine heart development.
Volume: 27
Issue: 1
Pages: 108722
Publication
First Author: Vezzali R
Year: 2016
Journal: Oncotarget
Title: The FOXG1/FOXO/SMAD network balances proliferation and differentiation of cortical progenitors and activates Kcnh3 expression in mature neurons.
Volume: 7
Issue: 25
Pages: 37436-37455
Publication
First Author: Lumayag S
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration.
Volume: 110
Issue: 6
Pages: E507-16
Publication      
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
Publication
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
Publication      
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
Publication      
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
Publication
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication  
First Author: Jia X
Year: 2014
Journal: Elife
Title: Structural basis of HIV-1 Vpu-mediated BST2 antagonism via hijacking of the clathrin adaptor protein complex 1.
Volume: 3
Pages: e02362
Allele
Name: bone marrow stromal cell antigen 2; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Allele
Name: bone marrow stromal cell antigen 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
Ontology Term
Publication  
First Author: Manouchehri N
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: CD11c+CD88+CD317+ myeloid cells are critical mediators of persistent CNS autoimmunity.
Volume: 118
Issue: 14
Publication
First Author: Yamamoto A
Year: 2021
Journal: FASEB J
Title: Transcription factor old astrocyte specifically induced substance is a novel regulator of kidney fibrosis.
Volume: 35
Issue: 2
Pages: e21158
Publication  
First Author: Liu DX
Year: 2014
Journal: Antiviral Res
Title: Accessory proteins of SARS-CoV and other coronaviruses.
Volume: 109
Pages: 97-109
Publication
First Author: Martin-Sancho L
Year: 2021
Journal: Mol Cell
Title: Functional landscape of SARS-CoV-2 cellular restriction.
Volume: 81
Issue: 12
Pages: 2656-2668.e8
Protein Domain
Type: Family
Description: This entry represents the structural accessory protein ORF7a from SARS-CoV-like virus, including SARS-CoV, SARS-CoV-2 and bat SARS-like coronavirus.This entry includes the structural accessory protein ORF7a, also called NS7a, X4 and U122, of Severe Acute Respiratory Syndrome Coronaviruses (SARS-CoV) from betacoronavirus subgenera Sarbecovirus (lineage B), including SARS-CoV-2. ORF7a/NS7a from betacoronavirus in the subgenera Sarbecovirus (B lineage) are not related to NS7a proteins from other coronavirus lineages. The structure of the structural accessory protein ORF7a, shows similarities to the immunoglobulin-like fold with some features resembling those of the Dl domain of ICAM-1 and suggests a binding activity to integrin I domains []. In SARS-CoV-infected cells, ORF7a is expressed and retained intracellularly within the Golgi network []. ORF7a is thought to play an important role during the SARS-CoV replication cycle []. Expression studies of ORF7a have shown that biological functions include induction of apoptosis through a caspase-dependent pathway, activation of the p38 mitogen-activated protein kinase signaling pathway, inhibition of host protein translation, and suppression of cell growth progression. These results collectively suggested that ORF7a protein may be involved in virus-host interactions []. Studies in SARS-CoV-2 revealed that ORF7a plays a role as antagonist of host tetherin (BST2), disrupting its antiviral effect. ORF7a binds to BST2 and sequesters it to the perinuclear region, thereby preventing its antiviral function at cell membrane [].
Protein Domain
Type: Homologous_superfamily
Description: This entry includes the structural accessory protein ORF7a, also called NS7a, X4 and U122, of Severe Acute Respiratory Syndrome Coronaviruses (SARS-CoV) from betacoronavirus subgenera Sarbecovirus (lineage B), including SARS-CoV-2. ORF7a/NS7a from betacoronavirus in the subgenera Sarbecovirus (B lineage) are not related to NS7a proteins from other coronavirus lineages. The structure of the structural accessory protein ORF7a, shows similarities to the immunoglobulin-like fold with some features resembling those of the Dl domain of ICAM-1 and suggests a binding activity to integrin I domains []. In SARS-CoV-infected cells, ORF7a is expressed and retained intracellularly within the Golgi network []. ORF7a is thought to play an important role during the SARS-CoV replication cycle []. Expression studies of ORF7a have shown that biological functions include induction of apoptosis through a caspase-dependent pathway, activation of the p38 mitogen-activated protein kinase signaling pathway, inhibition of host protein translation, and suppression of cell growth progression. These results collectively suggested that ORF7a protein may be involved in virus-host interactions []. Studies in SARS-CoV-2 revealed that ORF7a plays a role as antagonist of host tetherin (BST2), disrupting its antiviral effect. ORF7a binds to BST2 and sequesters it to the perinuclear region, thereby preventing its antiviral function at cell membrane [].
Protein Domain
Type: Family
Description: SARS-CoV contains a number of open reading frames that code for a total of eight accessory proteins, namely ORFs 3a, 3b, 6, 7a, 7b, 8a, 8b, and 9b. These ORFs are specific for SARS-CoV and do not show significant homology to accessory proteins of other coronaviruses. This entry represents the structural accessory protein ORF7a, also called NS7a, of Severe Acute Respiratory Syndrome Coronaviruses (SARS-CoV) from betacoronavirus subgenera Sarbecovirus (lineage B), including SARS-CoV-2. ORF7a/NS7a from betacoronavirus in the subgenera Sarbecovirus (B lineage) are not related to NS7a proteins from other coronavirus lineages.Structurally, ORF7a possesses a distinctive immunoglobulin (Ig)-like domain which is related to extracellular metazoan Ig domains that are involved in adhesion, such as ICAM; it also contains a 15-aa signal peptide sequence at its N terminus, an 81-aa luminal domain, a 21-aa transmembrane domain, and a short C-terminal tail. Coexpression of SARS-CoV ORF7a with S, M, N, and E proteins resulted in production of virus-like particles (VLPs) carrying ORF7a protein, indicating that ORF7a is a viral structural protein. Expression studies of ORF7a have shown that biological functions include induction of apoptosis through a caspase-dependent pathway, activation of the p38 mitogen-activated protein kinase signaling pathway, inhibition of host protein translation, and suppression of cell growth progression. These results collectively suggested that ORF7a protein may be involved in virus-host interactions []. Studies in SARS-CoV-2 revealed that ORF7a plays a role as antagonist of host tetherin (BST2), disrupting its antiviral effect. ORF7a binds to BST2 and sequesters it to the perinuclear region, thereby preventing its antiviral function at cell membrane [].
Protein Domain
Type: Domain
Description: This entry includes the structural accessory protein ORF7a, also called NS7a, X4 and U122, of Severe Acute Respiratory Syndrome Coronaviruses (SARS-CoV) from betacoronavirus subgenera Sarbecovirus (lineage B), including SARS-CoV-2. ORF7a/NS7a from betacoronavirus in the subgenera Sarbecovirus (B lineage) are not related to NS7a proteins from other coronavirus lineages. The structure of the structural accessory protein ORF7a, shows similarities to the immunoglobulin-like fold with some features resembling those of the Dl domain of ICAM-1 and suggests a binding activity to integrin I domains []. In SARS-CoV-infected cells, ORF7a is expressed and retained intracellularly within the Golgi network []. ORF7a is thought to play an important role during the SARS-CoV replication cycle []. Expression studies of ORF7a have shown that biological functions include induction of apoptosis through a caspase-dependent pathway, activation of the p38 mitogen-activated protein kinase signaling pathway, inhibition of host protein translation, and suppression of cell growth progression. These results collectively suggested that ORF7a protein may be involved in virus-host interactions []. Studies in SARS-CoV-2 revealed that ORF7a plays a role as antagonist of host tetherin (BST2), disrupting its antiviral effect. ORF7a binds to BST2 and sequesters it to the perinuclear region, thereby preventing its antiviral function at cell membrane [].This entry represents the X4 ectodomain from ORF7a (X4e), which forms a well defined β-sandwich fold. It is built up from seven β-strands, four strands form one β-sheet and the other three strands form a second sheet. The sheets are closely packed or 'sandwiched' against each other. Each sheet is amphipathic with the hydrophobic side facing inward. Two disulfide bonds link both sheets on opposite edges therefore stabilizing the β-sandwich structure [, ].
Publication
First Author: Nelson CA
Year: 2005
Journal: Structure
Title: Structure and intracellular targeting of the SARS-coronavirus Orf7a accessory protein.
Volume: 13
Issue: 1
Pages: 75-85
Publication
First Author: Hänel K
Year: 2006
Journal: J Biomed Sci
Title: Solution structure of the X4 protein coded by the SARS related coronavirus reveals an immunoglobulin like fold and suggests a binding activity to integrin I domains.
Volume: 13
Issue: 3
Pages: 281-93
Publication
First Author: Akerström S
Year: 2007
Journal: Antiviral Res
Title: Inhibition of SARS-CoV replication cycle by small interference RNAs silencing specific SARS proteins, 7a/7b, 3a/3b and S.
Volume: 73
Issue: 3
Pages: 219-27