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Search results 1 to 100 out of 692 for Btk

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
695 | BTK
Type: gene
Organism: human
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Gene
100170477 | btk
Type: gene
Organism: frog, western clawed
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Gene
119868479 | BTK
Type: gene
Organism: dog, domestic
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Gene
367901 | Btk
Type: gene
Organism: rat
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Gene
465759 | BTK
Type: gene
Organism: chimpanzee
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Gene
533459 | BTK
Type: gene
Organism: cattle
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Gene
374075 | BTK
Type: gene
Organism: chicken
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Gene
568653 | btk
Type: gene
Organism: zebrafish
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Gene
703000 | BTK
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:88216 | Btk
Type: protein_coding_gene
Organism: mouse, laboratory
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GXD Expression
GXD Expression
   
Probe: MGI:3160580
Assay Type: RNA in situ
Annotation Date: 2009-01-15
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1750322
Stage: TS22
Assay Id: MGI:3826153
Age: embryonic day 14.5
Image: Additional file 4 Btk
Specimen Label: Additional file 4 Btk
Detected: false
Specimen Num: 1
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Publication
8630736 | J:266154
First Author: Park H
Year: 1996
Journal: Immunity
Title: Regulation of Btk function by a major autophosphorylation site within the SH3 domain.
Volume: 4
Issue: 5
Pages: 515-25
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Publication
10852954 | J:126402
First Author: Kawakami Y
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: Regulation of protein kinase CbetaI by two protein-tyrosine kinases, Btk and Syk.
Volume: 97
Issue: 13
Pages: 7423-8
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GXD Expression
GXD Expression
   
Probe: MGI:1350566
Assay Type: RT-PCR
Annotation Date: 2000-01-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:1351286
Age: postnatal adult
Image: 4
Specimen Label: BTK S
Detected: true
Specimen Num: 2
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Publication
9371815 | J:108696
First Author: Satterthwaite AB
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: Btk dosage determines sensitivity to B cell antigen receptor cross-linking.
Volume: 94
Issue: 24
Pages: 13152-7
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Publication
10811867 | J:110720
First Author: Petro JB
Year: 2000
Journal: J Exp Med
Title: Bruton's tyrosine kinase is required for activation of IkappaB kinase and nuclear factor kappaB in response to B cell receptor engagement.
Volume: 191
Issue: 10
Pages: 1745-54
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Publication
17207856 | J:118704
First Author: Contreras CM
Year: 2007
Journal: Mol Immunol
Title: Btk regulates multiple stages in the development and survival of B-1 cells.
Volume: 44
Issue: 10
Pages: 2719-28
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Publication
8332901 | J:13209
First Author: Rawlings DJ
Year: 1993
Journal: Science
Title: Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice.
Volume: 261
Issue: 5119
Pages: 358-61
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Publication
7989760 | J:21900
First Author: Sideras P
Year: 1994
Journal: J Immunol
Title: Genomic organization of mouse and human Bruton's agammaglobulinemia tyrosine kinase (Btk) loci.
Volume: 153
Issue: 12
Pages: 5607-17
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Publication
17725607 | J:134805
First Author: Hasan M
Year: 2008
Journal: Immunology
Title: Defective Toll-like receptor 9-mediated cytokine production in B cells from Bruton's tyrosine kinase-deficient mice.
Volume: 123
Issue: 2
Pages: 239-49
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Publication
24465735 | J:212337
First Author: Ní Gabhann J
Year: 2014
Journal: PLoS One
Title: Btk regulates macrophage polarization in response to lipopolysaccharide.
Volume: 9
Issue: 1
Pages: e85834
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Publication
25105368 | J:215743
First Author: Bestas B
Year: 2014
Journal: J Clin Invest
Title: Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia model.
Volume: 124
Issue: 9
Pages: 4067-81
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Publication
8425221 | J:14186
First Author: Tsukada S
Year: 1993
Journal: Cell
Title: Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia.
Volume: 72
Issue: 2
Pages: 279-90
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Publication
34554188 | J:331919
 
First Author: Bittner ZA
Year: 2021
Journal: J Exp Med
Title: BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity.
Volume: 218
Issue: 11
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Publication
38696257 | J:349934
 
First Author: Desai JV
Year: 2024
Journal: J Clin Invest
Title: BTK drives neutrophil activation for sterilizing antifungal immunity.
Volume: 134
Issue: 12
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Publication
21659545 | J:174854
First Author: Ormsby T
Year: 2011
Journal: Blood
Title: Btk is a positive regulator in the TREM-1/DAP12 signaling pathway.
Volume: 118
Issue: 4
Pages: 936-45
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Publication
22589540 | J:188371
First Author: Bao Y
Year: 2012
Journal: J Biol Chem
Title: Tyrosine kinase Btk is required for NK cell activation.
Volume: 287
Issue: 28
Pages: 23769-78
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Publication
26777396 | J:259937
First Author: Volmering S
Year: 2016
Journal: Immunity
Title: The Neutrophil Btk Signalosome Regulates Integrin Activation during Sterile Inflammation.
Volume: 44
Issue: 1
Pages: 73-87
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Publication
18281276 | J:136557
First Author: Lee SH
Year: 2008
Journal: J Biol Chem
Title: The tec family tyrosine kinase Btk Regulates RANKL-induced osteoclast maturation.
Volume: 283
Issue: 17
Pages: 11526-34
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Publication
14993283 | J:89059
First Author: Tomlinson MG
Year: 2004
Journal: Mol Cell Biol
Title: Expression and function of Tec, Itk, and Btk in lymphocytes: evidence for a unique role for Tec.
Volume: 24
Issue: 6
Pages: 2455-66
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Publication
23544144 | J:199894
First Author: Köprülü AD
Year: 2013
Journal: PLoS One
Title: The tyrosine kinase Btk regulates the macrophage response to Listeria monocytogenes infection.
Volume: 8
Issue: 3
Pages: e60476
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Publication
22383797 | J:183762
First Author: Kil LP
Year: 2012
Journal: Blood
Title: Btk levels set the threshold for B-cell activation and negative selection of autoreactive B cells in mice.
Volume: 119
Issue: 16
Pages: 3744-56
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Publication
12563258 | J:96704
First Author: Suzuki H
Year: 2003
Journal: Nat Immunol
Title: PI3K and Btk differentially regulate B cell antigen receptor-mediated signal transduction.
Volume: 4
Issue: 3
Pages: 280-6
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Publication
24899507 | J:315513
First Author: Benson MJ
Year: 2014
Journal: J Immunol
Title: Modeling the clinical phenotype of BTK inhibition in the mature murine immune system.
Volume: 193
Issue: 1
Pages: 185-97
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Publication
17372989 | J:120843
First Author: Halcomb KE
Year: 2007
Journal: Eur J Immunol
Title: Btk and phospholipase C gamma 2 can function independently during B cell development.
Volume: 37
Issue: 4
Pages: 1033-42
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Publication
15214046 | J:115493
First Author: Lindvall JM
Year: 2004
Journal: Eur J Immunol
Title: Gene expression profile of B cells from Xid mice and Btk knockout mice.
Volume: 34
Issue: 7
Pages: 1981-91
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Publication
10508272 | J:57737
First Author: Pinschewer DD
Year: 1999
Journal: Eur J Immunol
Title: A Btk transgene restores the antiviral TI-2 antibody responses of xid mice in a dose-dependent fashion.
Volume: 29
Issue: 9
Pages: 2981-7
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Publication
17684099 | J:123766
First Author: Hantschel O
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: The Btk tyrosine kinase is a major target of the Bcr-Abl inhibitor dasatinib.
Volume: 104
Issue: 33
Pages: 13283-8
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Publication
18849077 | J:141113
First Author: Halcomb KE
Year: 2008
Journal: Mol Immunol
Title: Btk regulates localization, in vivo activation, and class switching of anti-DNA B cells.
Volume: 46
Issue: 2
Pages: 233-41
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Publication
30873567 | J:291120
First Author: de Porto APNA
Year: 2019
Journal: Thromb Haemost
Title: Platelet Btk is Required for Maintaining Lung Vascular Integrity during Murine Pneumococcal Pneumosepsis.
Volume: 119
Issue: 6
Pages: 930-940
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Publication
28275136 | J:247793
First Author: de Bruijn MJ
Year: 2017
Journal: J Immunol
Title: Distinct and Overlapping Functions of TEC Kinase and BTK in B Cell Receptor Signaling.
Volume: 198
Issue: 8
Pages: 3058-3068
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Publication
10856225 | J:63082
First Author: Pasquet JM
Year: 2000
Journal: EMBO J
Title: Phosphatidylinositol 3,4,5-trisphosphate regulates Ca(2+) entry via btk in platelets and megakaryocytes without increasing phospholipase C activity.
Volume: 19
Issue: 12
Pages: 2793-802
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Publication
9730885 | J:50288
First Author: Satterthwaite AB
Year: 1998
Journal: J Exp Med
Title: Independent and opposing roles for Btk and lyn in B and myeloid signaling pathways.
Volume: 188
Issue: 5
Pages: 833-44
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Publication
11449370 | J:70406
First Author: Jumaa H
Year: 2001
Journal: Eur J Immunol
Title: The absence of SLP65 and Btk blocks B cell development at the preB cell receptor-positive stage.
Volume: 31
Issue: 7
Pages: 2164-9
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Publication
9620599 | J:47277
First Author: Takeshita H
Year: 1998
Journal: Int Immunol
Title: Abrogation of autoimmune disease in Lyn-deficient mice by the mutation of the Btk gene.
Volume: 10
Issue: 4
Pages: 435-44
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Publication
10903718 | J:120482
First Author: Kawakami Y
Year: 2000
Journal: J Immunol
Title: Redundant and opposing functions of two tyrosine kinases, Btk and Lyn, in mast cell activation.
Volume: 165
Issue: 3
Pages: 1210-9
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Publication
26581914 | J:329775
First Author: Huang W
Year: 2016
Journal: J Allergy Clin Immunol
Title: Nonreceptor tyrosine kinases ITK and BTK negatively regulate mast cell proinflammatory responses to lipopolysaccharide.
Volume: 137
Issue: 4
Pages: 1197-1205
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Publication
19109164 | J:142896
First Author: Sharma S
Year: 2009
Journal: J Immunol
Title: Btk regulates B cell receptor-mediated antigen processing and presentation by controlling actin cytoskeleton dynamics in B cells.
Volume: 182
Issue: 1
Pages: 329-39
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Publication
18329366 | J:135537
First Author: Shinohara M
Year: 2008
Journal: Cell
Title: Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals.
Volume: 132
Issue: 5
Pages: 794-806
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Publication
25213142 | J:222332
First Author: Sakuma C
Year: 2015
Journal: Mol Immunol
Title: Specific binding of the WASP N-terminal domain to Btk is critical for TLR2 signaling in macrophages.
Volume: 63
Issue: 2
Pages: 328-36
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Publication
16176929 | J:132405
First Author: Iwaki S
Year: 2005
Journal: J Biol Chem
Title: Btk plays a crucial role in the amplification of Fc epsilonRI-mediated mast cell activation by kit.
Volume: 280
Issue: 48
Pages: 40261-70
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Publication
8890160 | J:35769
First Author: Hendriks RW
Year: 1996
Journal: EMBO J
Title: Inactivation of Btk by insertion of lacZ reveals defects in B cell development only past the pre-B cell stage.
Volume: 15
Issue: 18
Pages: 4862-72
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Publication
31837347 | J:287915
First Author: Simonowski A
Year: 2020
Journal: Biochim Biophys Acta Mol Cell Res
Title: Differential use of BTK and PLC in FcεRI- and KIT-mediated mast cell activation: A marginal role of BTK upon KIT activation.
Volume: 1867
Issue: 4
Pages: 118622
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Publication
10987665 | J:60402
First Author: Hügin AW
Year: 2000
Journal: Comp Med
Title: Diagnostic immunoglobulin M expression by peripheral blood lymphocytes from tyrosine kinase Btk mutant BTKxid mice.
Volume: 50
Issue: 1
Pages: 36-8
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Publication
28368423 | J:248153
First Author: Moyo TK
Year: 2017
Journal: Oncogene
Title: Myc enhances B-cell receptor signaling in precancerous B cells and confers resistance to Btk inhibition.
Volume: 36
Issue: 32
Pages: 4653-4661
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Publication
11120822 | J:118397
First Author: Webb CF
Year: 2000
Journal: J Immunol
Title: The transcription factor Bright associates with Bruton's tyrosine kinase, the defective protein in immunodeficiency disease.
Volume: 165
Issue: 12
Pages: 6956-65
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Publication
15007095 | J:90486
First Author: Schmidt U
Year: 2004
Journal: J Exp Med
Title: Btk is required for an efficient response to erythropoietin and for SCF-controlled protection against TRAIL in erythroid progenitors.
Volume: 199
Issue: 6
Pages: 785-95
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Publication
18523268 | J:137240
First Author: Melcher M
Year: 2008
Journal: J Immunol
Title: Essential roles for the Tec family kinases Tec and Btk in M-CSF receptor signaling pathways that regulate macrophage survival.
Volume: 180
Issue: 12
Pages: 8048-56
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Publication
8476425 | J:20701
First Author: Yamada N
Year: 1993
Journal: Biochem Biophys Res Commun
Title: Structure and expression of novel protein-tyrosine kinases, Emb and Emt, in hematopoietic cells.
Volume: 192
Issue: 1
Pages: 231-40
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Publication
19017959 | J:142195
First Author: Kuehn HS
Year: 2008
Journal: J Immunol
Title: The phosphoinositide 3-kinase-dependent activation of Btk is required for optimal eicosanoid production and generation of reactive oxygen species in antigen-stimulated mast cells.
Volume: 181
Issue: 11
Pages: 7706-12
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Publication
20167705 | J:160787
First Author: Mueller H
Year: 2010
Journal: Blood
Title: Tyrosine kinase Btk regulates E-selectin-mediated integrin activation and neutrophil recruitment by controlling phospholipase C (PLC) gamma2 and PI3Kgamma pathways.
Volume: 115
Issue: 15
Pages: 3118-27
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Publication
23754751 | J:204563
First Author: Mohammad DK
Year: 2013
Journal: Mol Cell Biol
Title: Dual phosphorylation of Btk by Akt/protein kinase b provides docking for 14-3-3ζ, regulates shuttling, and attenuates both tonic and induced signaling in B cells.
Volume: 33
Issue: 16
Pages: 3214-26
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Publication
9218782 | -
First Author: Hyvönen M
Year: 1997
Journal: EMBO J
Title: Structure of the PH domain and Btk motif from Bruton's tyrosine kinase: molecular explanations for X-linked agammaglobulinaemia.
Volume: 16
Issue: 12
Pages: 3396-404
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Publication
8629002 | J:266145
First Author: Rawlings DJ
Year: 1996
Journal: Science
Title: Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases.
Volume: 271
Issue: 5250
Pages: 822-5
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Publication
10352268 | J:120990
First Author: Maas A
Year: 1999
Journal: J Immunol
Title: Early arrest in B cell development in transgenic mice that express the E41K Bruton's tyrosine kinase mutant under the control of the CD19 promoter region.
Volume: 162
Issue: 11
Pages: 6526-33
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Publication
20623551 | J:165753
First Author: Kersseboom R
Year: 2010
Journal: Eur J Immunol
Title: Constitutive activation of Bruton's tyrosine kinase induces the formation of autoreactive IgM plasma cells.
Volume: 40
Issue: 9
Pages: 2643-54
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Publication
12618482 | J:82430
First Author: Whyburn LR
Year: 2003
Journal: Int Immunol
Title: Haploinsufficiency of B cell linker protein enhances B cell signaling defects in mice expressing a limiting dosage of Bruton's tyrosine kinase.
Volume: 15
Issue: 3
Pages: 383-92
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Publication
14634110 | J:120989
First Author: Middendorp S
Year: 2003
Journal: J Immunol
Title: Function of Bruton's tyrosine kinase during B cell development is partially independent of its catalytic activity.
Volume: 171
Issue: 11
Pages: 5988-96
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Publication
35537415 | J:339284
   
First Author: Liu Z
Year: 2022
Journal: J Innate Immun
Title: Bruton's Tyrosine Kinase in Neutrophils Is Crucial for Host Defense against Klebsiella pneumoniae.
Pages: 1-15
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Protein
P35991
Organism: Mus musculus/domesticus
Length: 659  
Fragment?: false
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Publication
34323286 | J:309482
First Author: Rip J
Year: 2021
Journal: Eur J Immunol
Title: Bruton's tyrosine kinase inhibition induces rewiring of proximal and distal B-cell receptor signaling in mice.
Volume: 51
Issue: 9
Pages: 2251-2265
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Publication
15331445 | J:94768
First Author: Middendorp S
Year: 2005
Journal: Blood
Title: Tumor suppressor function of Bruton tyrosine kinase is independent of its catalytic activity.
Volume: 105
Issue: 1
Pages: 259-65
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Publication
8332900 | J:13210
First Author: Thomas JD
Year: 1993
Journal: Science
Title: Colocalization of X-linked agammaglobulinemia and X-linked immunodeficiency genes.
Volume: 261
Issue: 5119
Pages: 355-8
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Publication
30761150 | J:284474
 
First Author: Rip J
Year: 2019
Journal: Front Immunol
Title: Toll-Like Receptor Signaling Drives Btk-Mediated Autoimmune Disease.
Volume: 10
Pages: 95
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Publication
34552589 | J:311429
 
First Author: de Porto AP
Year: 2021
Journal: Front Immunol
Title: Bruton's Tyrosine Kinase-Mediated Signaling in Myeloid Cells Is Required for Protective Innate Immunity During Pneumococcal Pneumonia.
Volume: 12
Pages: 723967
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Publication
30237801 | J:315931
 
First Author: Roman-Garcia S
Year: 2018
Journal: Front Immunol
Title: Distinct Roles for Bruton's Tyrosine Kinase in B Cell Immune Synapse Formation.
Volume: 9
Pages: 2027
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Publication
16371463 | J:104554
First Author: Kawakami Y
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Regulation of dendritic cell maturation and function by Bruton's tyrosine kinase via IL-10 and Stat3.
Volume: 103
Issue: 1
Pages: 153-8
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Publication
16764821 | J:110533
First Author: Lindvall JM
Year: 2006
Journal: Biochem Biophys Res Commun
Title: Distinct gene expression signature in Btk-defective T1 B-cells.
Volume: 346
Issue: 2
Pages: 461-9
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Publication
7552994 | J:28968
First Author: Khan WN
Year: 1995
Journal: Immunity
Title: Defective B cell development and function in Btk-deficient mice.
Volume: 3
Issue: 3
Pages: 283-99
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Publication
17239630 | J:118200
First Author: de Gorter DJ
Year: 2007
Journal: Immunity
Title: Bruton's tyrosine kinase and phospholipase Cgamma2 mediate chemokine-controlled B cell migration and homing.
Volume: 26
Issue: 1
Pages: 93-104
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Publication
9240435 | -
First Author: Kojima T
Year: 1997
Journal: Biochem Biophys Res Commun
Title: Characterization of the pleckstrin homology domain of Btk as an inositol polyphosphate and phosphoinositide binding domain.
Volume: 236
Issue: 2
Pages: 333-9
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Publication
9888854 | J:52228
First Author: Suzuki H
Year: 1999
Journal: Science
Title: Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase.
Volume: 283
Issue: 5400
Pages: 390-2
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Publication
25704810 | J:324776
First Author: Lee KG
Year: 2015
Journal: Cell Rep
Title: Bruton's tyrosine kinase phosphorylates DDX41 and activates its binding of dsDNA and STING to initiate type 1 interferon response.
Volume: 10
Issue: 7
Pages: 1055-65
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Publication
7734414 | J:23927
First Author: Santos-Argumedo L
Year: 1995
Journal: Int Immunol
Title: CD38 unresponsiveness of xid B cells implicates Bruton's tyrosine kinase (btk) as a regular of CD38 induced signal transduction.
Volume: 7
Issue: 2
Pages: 163-70
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Publication
11104803 | J:66080
First Author: Ellmeier W
Year: 2000
Journal: J Exp Med
Title: Severe B cell deficiency in mice lacking the tec kinase family members Tec and Btk.
Volume: 192
Issue: 11
Pages: 1611-24
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Publication
8935990 | J:32578
First Author: Shanmugam V
Year: 1996
Journal: Biochem Genet
Title: A novel Tth111I restriction fragment length polymorphism (RFLP) allows tracing of X-chromosome inactivation in the (Xid) heterozygote.
Volume: 34
Issue: 1-2
Pages: 17-29
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Publication
21063022 | J:168508
First Author: Fiedler K
Year: 2011
Journal: Blood
Title: Neutrophil development and function critically depend on Bruton tyrosine kinase in a mouse model of X-linked agammaglobulinemia.
Volume: 117
Issue: 4
Pages: 1329-39
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Publication
23378429 | J:193615
First Author: Crane DD
Year: 2013
Journal: J Immunol
Title: B1a cells enhance susceptibility to infection with virulent Francisella tularensis via modulation of NK/NKT cell responses.
Volume: 190
Issue: 6
Pages: 2756-66
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Publication
33162995 | J:308316
 
First Author: O'Riordan CE
Year: 2020
Journal: Front Immunol
Title: X-Linked Immunodeficient Mice With No Functional Bruton's Tyrosine Kinase Are Protected From Sepsis-Induced Multiple Organ Failure.
Volume: 11
Pages: 581758
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Publication
26880800 | J:231616
First Author: Stiff A
Year: 2016
Journal: Cancer Res
Title: Myeloid-Derived Suppressor Cells Express Bruton's Tyrosine Kinase and Can Be Depleted in Tumor-Bearing Hosts by Ibrutinib Treatment.
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First Author: Clarke SH
Year: 1998
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Title: B-1 cell development: evidence for an uncommitted immunoglobulin (Ig)M+ B cell precursor in B-1 cell differentiation.
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15117762 | J:92639
First Author: Mangla A
Year: 2004
Journal: Blood
Title: Pleiotropic consequences of Bruton tyrosine kinase deficiency in myeloid lineages lead to poor inflammatory responses.
Volume: 104
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11717191 | J:109858
First Author: Cancro MP
Year: 2001
Journal: Int Immunol
Title: xid mice reveal the interplay of homeostasis and Bruton's tyrosine kinase-mediated selection at multiple stages of B cell development.
Volume: 13
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9547335 | J:111179
First Author: Hata D
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Journal: J Exp Med
Title: Involvement of Bruton's tyrosine kinase in FcepsilonRI-dependent mast cell degranulation and cytokine production.
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Title: xid affects events leading to B cell cycle entry.
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Year: 1999
Journal: J Immunol
Title: Delayed clearance of filarial infection and enhanced Th1 immunity due to modulation of macrophage APC functions in xid mice.
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35422819 | J:323998
 
First Author: Bonami RH
Year: 2022
Journal: Front Immunol
Title: Bruton's Tyrosine Kinase Supports Gut Mucosal Immunity and Commensal Microbiome Recognition in Autoimmune Arthritis.
Volume: 13
Pages: 748284
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17082638 | J:140621
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Journal: J Immunol
Title: Bruton's tyrosine kinase is required for TLR-induced IL-10 production.
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First Author: Merchant M
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Journal: Virology
Title: LMP2A survival and developmental signals are transmitted through Btk-dependent and Btk-independent pathways.
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Title: The effects of dasatinib on IgE receptor-dependent activation and histamine release in human basophils.
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