Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
pig, domestic |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Not Specified |
Age: |
postnatal week 8 |
Stage: |
28 |
Structure . Name: |
lung |
|
Curation Status: |
Curated |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Welsh KJ |
Year: |
2012 |
Journal: |
Clin Dev Immunol |
Title: |
Complement factor C7 contributes to lung immunopathology caused by Mycobacterium tuberculosis. |
Volume: |
2012 |
|
Pages: |
429675 |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Cell Line |
Name: |
C7 |
Derivation . Parent Cell Line . Name: |
D3H |
Cell Line Type: |
ES Cell |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2148090 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2001-09-04 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757721 |
Pattern: |
Single cells |
Stage: |
TS21 |
Assay Id: |
MGI:2149089 |
Age: |
embryonic day 13.5 |
Image: |
3J - C7 |
Note: |
Expression was detected in motor neurons. The specimen was from the level of the cervical vertebra 7. |
Specimen Label: |
3J - C7 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2148090 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2001-09-04 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757721 |
Pattern: |
Single cells |
Stage: |
TS21 |
Assay Id: |
MGI:2149089 |
Age: |
embryonic day 13.5 |
Image: |
3N - C7 |
Note: |
Expression was detected in motor neurons. The specimen was from the level of the cervical vertebra 7. |
Specimen Label: |
3N - C7 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2148090 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2001-09-04 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757721 |
Pattern: |
Single cells |
Stage: |
TS21 |
Assay Id: |
MGI:2149091 |
Age: |
embryonic day 13.5 |
Image: |
3J - C7 |
Note: |
Expression was detected in motor neurons. The specimen was from the level of the cervical vertebra 7. |
Specimen Label: |
3J - C7 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2148090 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2001-09-04 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757721 |
Pattern: |
Single cells |
Stage: |
TS21 |
Assay Id: |
MGI:2149091 |
Age: |
embryonic day 13.5 |
Image: |
3N - C7 |
Note: |
Expression was detected in motor neurons. The specimen was from the level of the cervical vertebra 7. |
Specimen Label: |
3N - C7 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2148090 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2007-03-19 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757721 |
Pattern: |
Single cells |
Stage: |
TS21 |
Assay Id: |
MGI:3700202 |
Age: |
embryonic day 13.5 |
Image: |
3B - C7 |
Note: |
Expression was detected in motor neurons. The specimen was from the level of the cervical vertebra 7. |
Specimen Label: |
3B - C7 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2148090 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2007-03-19 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757722 |
Pattern: |
Single cells |
Stage: |
TS22 |
Assay Id: |
MGI:3700202 |
Age: |
embryonic day 14.5 |
Image: |
3F - C7 |
Note: |
Expression was detected in motor neurons. The specimen was from the level of the cervical vertebra 7. |
Specimen Label: |
3F - C7 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2148090 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2007-03-19 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757721 |
Pattern: |
Single cells |
Stage: |
TS21 |
Assay Id: |
MGI:3700203 |
Age: |
embryonic day 13.5 |
Image: |
3B - C7 |
Note: |
Expression was detected in motor neurons. The specimen was from the level of the cervical vertebra 7. |
Specimen Label: |
3B - C7 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2148090 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2007-03-19 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757722 |
Pattern: |
Single cells |
Stage: |
TS22 |
Assay Id: |
MGI:3700203 |
Age: |
embryonic day 14.5 |
Image: |
3F - C7 |
Note: |
Expression was detected in motor neurons. The specimen was from the level of the cervical vertebra 7. |
Specimen Label: |
3F - C7 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2149027 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2001-09-04 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757721 |
Pattern: |
Single cells |
Stage: |
TS21 |
Assay Id: |
MGI:2149088 |
Age: |
embryonic day 13.5 |
Image: |
3B - C7 |
Note: |
The specimen was from the level of the cervical vertebra 7. At the rostral part of this level, expression was detected in a mosaic population of motor neurons. In the medial and caudal parts of this level, expression was in 100% of the motor neurons. |
Specimen Label: |
3B - C7 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2149027 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2001-09-04 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757722 |
Pattern: |
Single cells |
Stage: |
TS22 |
Assay Id: |
MGI:2149088 |
Age: |
embryonic day 14.5 |
Image: |
3F - C7 |
Note: |
The specimen was from the level of the cervical vertebra 7. At the rostral part of this level, expression was detected in a mosaic population of motor neurons. In the medial and caudal parts of this level, expression was in 100% of the motor neurons. |
Specimen Label: |
3F - C7 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2007-03-13 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757721 |
Pattern: |
Single cells |
Stage: |
TS21 |
Assay Id: |
MGI:3699628 |
Age: |
embryonic day 13.5 |
Image: |
3J - C7 |
Note: |
The specimen was from the level of the cervical vertebra 7. At the rostral part of this level, expression was detected in a mosaic population of motor neurons. In the medial and caudal parts of this level, expression was in 100% of the motor neurons. |
Specimen Label: |
3J - C7 |
Detected: |
true |
Specimen Num: |
9 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2007-03-13 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757721 |
Pattern: |
Single cells |
Stage: |
TS21 |
Assay Id: |
MGI:3699628 |
Age: |
embryonic day 13.5 |
Image: |
3N - C7 |
Note: |
The specimen was from the level of the cervical vertebra 7. At the rostral part of this level, expression was detected in a mosaic population of motor neurons. |
Specimen Label: |
3N - C7 |
Detected: |
true |
Specimen Num: |
13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zelek WM |
Year: |
2020 |
Journal: |
Front Immunol |
Title: |
Monoclonal Antibodies Capable of Inhibiting Complement Downstream of C5 in Multiple Species. |
Volume: |
11 |
|
Pages: |
612402 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2681700 |
Assay Type: |
RT-PCR |
Annotation Date: |
2003-12-19 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757726 |
|
Stage: |
TS26 |
Assay Id: |
MGI:2681733 |
Age: |
embryonic day 18.0 |
|
|
Specimen Label: |
c7 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2681703 |
Assay Type: |
RT-PCR |
Annotation Date: |
2003-12-19 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757726 |
|
Stage: |
TS26 |
Assay Id: |
MGI:2681765 |
Age: |
embryonic day 18.0 |
|
|
Specimen Label: |
C7 |
Detected: |
true |
Specimen Num: |
9 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2681702 |
Assay Type: |
RT-PCR |
Annotation Date: |
2003-12-19 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757726 |
|
Stage: |
TS26 |
Assay Id: |
MGI:2681772 |
Age: |
embryonic day 18.0 |
|
|
Specimen Label: |
C7 |
Detected: |
true |
Specimen Num: |
9 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3056517 |
Assay Type: |
RT-PCR |
Annotation Date: |
2004-11-11 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757728 |
|
Stage: |
TS28 |
Assay Id: |
MGI:3056537 |
Age: |
postnatal day 21 |
|
|
Specimen Label: |
C7 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3056515 |
Assay Type: |
RT-PCR |
Annotation Date: |
2004-11-11 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757728 |
|
Stage: |
TS28 |
Assay Id: |
MGI:3056539 |
Age: |
postnatal day 21 |
|
|
Specimen Label: |
C7 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
Publication |
First Author: |
van Oorschot RA |
Year: |
1993 |
Journal: |
Biochem Genet |
Title: |
Linkage between complement components 6 and 7 and glutamic pyruvate transaminase in the marsupial Monodelphis domestica. |
Volume: |
31 |
Issue: |
5-6 |
Pages: |
215-22 |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhou Z |
Year: |
2023 |
Journal: |
Oncogene |
Title: |
Androgen-regulated stromal complement component 7 (C7) suppresses prostate cancer growth. |
Volume: |
42 |
Issue: |
32 |
Pages: |
2428-2438 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zelek WM |
Year: |
2024 |
Journal: |
Brain Behav Immun |
Title: |
Targeting terminal pathway reduces brain complement activation, amyloid load and synapse loss, and improves cognition in a mouse model of dementia. |
Volume: |
118 |
|
Pages: |
355-363 |
|
•
•
•
•
•
|
Publication |
First Author: |
Orren A |
Year: |
1985 |
Journal: |
Immunogenetics |
Title: |
Close linkage between mouse genes determining the two forms of complement component C6 and component C7, and cis action of a C6 regulatory gene. |
Volume: |
21 |
Issue: |
6 |
Pages: |
591-9 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5285271 |
Assay Type: |
Northern blot |
Annotation Date: |
2011-09-14 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1797228 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5285325 |
Age: |
postnatal |
|
|
Specimen Label: |
JSD |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5285271 |
Assay Type: |
Northern blot |
Annotation Date: |
2011-09-14 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1797228 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5285325 |
Age: |
postnatal |
|
|
Specimen Label: |
W/Wv |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5285271 |
Assay Type: |
Northern blot |
Annotation Date: |
2011-09-14 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1797226 |
|
Stage: |
TS26 |
Assay Id: |
MGI:5285325 |
Age: |
embryonic day 19.5 |
|
|
Specimen Label: |
19.5 dpc |
Detected: |
false |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5285271 |
Assay Type: |
Northern blot |
Annotation Date: |
2011-09-14 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1797228 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5285325 |
Age: |
postnatal day 10 |
|
|
Specimen Label: |
10 day |
Detected: |
false |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5285271 |
Assay Type: |
Northern blot |
Annotation Date: |
2011-09-14 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1797228 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5285325 |
Age: |
postnatal week 3 |
|
|
Specimen Label: |
3 week |
Detected: |
false |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5285271 |
Assay Type: |
Northern blot |
Annotation Date: |
2011-09-14 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1797228 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5285325 |
Age: |
postnatal week 10 |
|
|
Specimen Label: |
10 week |
Detected: |
false |
Specimen Num: |
7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Menny A |
Year: |
2018 |
Journal: |
Nat Commun |
Title: |
CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers. |
Volume: |
9 |
Issue: |
1 |
Pages: |
5316 |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Publication |
First Author: |
Schauwecker PE |
Year: |
2004 |
Journal: |
J Comp Neurol |
Title: |
Genetic control of sensitivity to hippocampal cell death induced by kainic acid: a quantitative trait loci analysis. |
Volume: |
477 |
Issue: |
1 |
Pages: |
96-107 |
|
•
•
•
•
•
|
Publication |
First Author: |
Beebe AM |
Year: |
1997 |
Journal: |
Immunity |
Title: |
Serial backcross mapping of multiple loci associated with resistance to Leishmania major in mice. |
Volume: |
6 |
Issue: |
5 |
Pages: |
551-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tanaka K |
Year: |
2002 |
Journal: |
Dev Biol |
Title: |
Spermatogonia-dependent expression of testicular genes in mice. |
Volume: |
246 |
Issue: |
2 |
Pages: |
466-79 |
|
•
•
•
•
•
|
Publication |
First Author: |
Queen R |
Year: |
2023 |
Journal: |
PLoS Genet |
Title: |
Spatial transcriptomics reveals novel genes during the remodelling of the embryonic human arterial valves. |
Volume: |
19 |
Issue: |
11 |
Pages: |
e1010777 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory |
Year: |
2012 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by The Jackson Laboratory |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
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Publication |
First Author: |
Shanghai Model Organisms Center |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
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Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
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Title: |
GemPharmatech Website. |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
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Title: |
Human to Mouse ISO GO annotation transfer |
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
Journal: |
Database Download |
Title: |
Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
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Title: |
Rat to Mouse ISO GO annotation transfer |
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Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
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Title: |
Nomenclature Committee Use |
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Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
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Title: |
Annotation inferences using phylogenetic trees |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
190
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Fragment?: |
false |
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Gene |
Type: |
gene |
Organism: |
frog, African clawed |
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Publication |
First Author: |
Phelan MM |
Year: |
2009 |
Journal: |
J Biol Chem |
Title: |
Solution structure of factor I-like modules from complement C7 reveals a pair of follistatin domains in compact pseudosymmetric arrangement. |
Volume: |
284 |
Issue: |
29 |
Pages: |
19637-49 |
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Publication |
First Author: |
Kuijpers TW |
Year: |
2010 |
Journal: |
Mol Immunol |
Title: |
Complement factor 7 gene mutations in relation to meningococcal infection and clinical recurrence of meningococcal disease. |
Volume: |
47 |
Issue: |
4 |
Pages: |
671-7 |
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Protein Domain |
Type: |
Family |
Description: |
This entry represents complement component C7, a subunit of the membrane attack complex (MAC) which forms pores in the membranes of cells of invading organisms. C7 anchors the MAC to the membrane. MAC forms when C5 is cleaved into C5a and C5b, and C5b binds sequentially C6, C7, C8 and multiple copies of the pore-forming subunit C9 []. The structure of C7 has been solved and C7 contains a several domains, which from N to C terminus are: TSP type-1, LDL-receptor class A, MACPF, EGF-like, another TSP type-1 and two sushi domains []. Variants of C7 are associated with immunodeficiency diseases and susceptibility to infection such as meningococcal disease caused by Neisseria meningitidis []. |
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Publication |
First Author: |
Jeremiah SJ |
Year: |
1990 |
Journal: |
Ann Hum Genet |
Title: |
The assignment of the genes coding for human complement components C6 and C7 to chromosome 5. |
Volume: |
54 |
Issue: |
Pt 2 |
Pages: |
141-7 |
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Publication |
First Author: |
Suzuki N |
Year: |
2003 |
Journal: |
J Virol |
Title: |
Hypovirus papain-like protease p29 functions in trans to enhance viral double-stranded RNA accumulation and vertical transmission. |
Volume: |
77 |
Issue: |
21 |
Pages: |
11697-707 |
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Publication |
First Author: |
Craven MG |
Year: |
1993 |
Journal: |
J Virol |
Title: |
Papain-like protease p29 as a symptom determinant encoded by a hypovirulence-associated virus of the chestnut blight fungus. |
Volume: |
67 |
Issue: |
11 |
Pages: |
6513-21 |
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Publication |
First Author: |
Choi GH |
Year: |
1991 |
Journal: |
Virology |
Title: |
The autocatalytic protease p29 encoded by a hypovirulence-associated virus of the chestnut blight fungus resembles the potyvirus-encoded protease HC-Pro. |
Volume: |
183 |
Issue: |
2 |
Pages: |
747-52 |
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Publication |
First Author: |
Jensen KS |
Year: |
2014 |
Journal: |
J Virol |
Title: |
Mutagenesis of the catalytic and cleavage site residues of the hypovirus papain-like proteases p29 and p48 reveals alternative processing and contributions to optimal viral RNA accumulation. |
Volume: |
88 |
Issue: |
20 |
Pages: |
11946-54 |
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Publication |
First Author: |
Shapira R |
Year: |
1991 |
Journal: |
J Biol Chem |
Title: |
Gene expression by a hypovirulence-associated virus of the chestnut blight fungus involves two papain-like protease activities. Essential residues and cleavage site requirements for p48 autoproteolysis. |
Volume: |
266 |
Issue: |
29 |
Pages: |
19419-25 |
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Publication |
First Author: |
Deng F |
Year: |
2008 |
Journal: |
J Virol |
Title: |
Hypovirus papain-like protease p48 is required for initiation but not for maintenance of virus RNA propagation in the chestnut blight fungus Cryphonectria parasitica. |
Volume: |
82 |
Issue: |
13 |
Pages: |
6369-78 |
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Protein Domain |
Type: |
Domain |
Description: |
This entry represents a peptidase C7 domain, which is found in HAV papain-like proteases p48 and p29 [, ].Hypoviruses are positive-strand RNA mycoviruses that attenuate virulence of their pathogenic fungal hosts [E1]. They employ a gene expression strategy that involves the autocatalytic processing of the N-terminal portion of encoded polyproteins by papain-like protease domains. The prototypic hypovirus CHV-1/EP713, responsible for virulence attenuation (hypovirulence) of the chestnut blight fungus Cryphonectria parasitica, encodes two contiguous open reading frames (ORFs) designated ORF A and ORF B, which contain N-terminal proteases p29 and p48, respectively. Protease p29 functions as a suppressor of the RNA silencing defense response, while p48 is required for viral RNA replication [, , ]. The HAV papain-like protease p29 is a cysteine protease, which forms the peptidase family C7 [E2]. A Cys and a His catalytic residue are essential for autocatalytic cleavage at a glycine dipeptide clevage site located at the C- terminus of the domain [, , ]. The HAV papain-like protease p48 is a cysteine protease, which forms the peptidase family C8 [E3]. A Cys anda His catalytic residue are essential for autocatalytic cleavage between the cleavage site residues Gly and Ala located at the C terminus of the domain [, , ]. |
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EMAPA Term |
Starts At: |
23 |
Ends At: |
28 |
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