|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 100 out of 352 for C7

<< First    < Previous  |  Next >    Last >>
0.049s

Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: pig, domestic
HT Sample  
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal week 8
Stage: 28
Structure . Name: lung
Curation Status: Curated
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication  
First Author: Welsh KJ
Year: 2012
Journal: Clin Dev Immunol
Title: Complement factor C7 contributes to lung immunopathology caused by Mycobacterium tuberculosis.
Volume: 2012
Pages: 429675
Gene
Type: gene
Organism: human
Cell Line
Name: C7
Derivation . Parent Cell Line . Name: D3H
Cell Line Type: ES Cell
GXD Expression
Probe: MGI:2148090
Assay Type: Immunohistochemistry
Annotation Date: 2001-09-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757721
Pattern: Single cells
Stage: TS21
Assay Id: MGI:2149089
Age: embryonic day 13.5
Image: 3J - C7
Note: Expression was detected in motor neurons. The specimen was from the level of the cervical vertebra 7.
Specimen Label: 3J - C7
Detected: true
Specimen Num: 3
GXD Expression
Probe: MGI:2148090
Assay Type: Immunohistochemistry
Annotation Date: 2001-09-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757721
Pattern: Single cells
Stage: TS21
Assay Id: MGI:2149089
Age: embryonic day 13.5
Image: 3N - C7
Note: Expression was detected in motor neurons. The specimen was from the level of the cervical vertebra 7.
Specimen Label: 3N - C7
Detected: true
Specimen Num: 7
GXD Expression
Probe: MGI:2148090
Assay Type: Immunohistochemistry
Annotation Date: 2001-09-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757721
Pattern: Single cells
Stage: TS21
Assay Id: MGI:2149091
Age: embryonic day 13.5
Image: 3J - C7
Note: Expression was detected in motor neurons. The specimen was from the level of the cervical vertebra 7.
Specimen Label: 3J - C7
Detected: true
Specimen Num: 3
GXD Expression
Probe: MGI:2148090
Assay Type: Immunohistochemistry
Annotation Date: 2001-09-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757721
Pattern: Single cells
Stage: TS21
Assay Id: MGI:2149091
Age: embryonic day 13.5
Image: 3N - C7
Note: Expression was detected in motor neurons. The specimen was from the level of the cervical vertebra 7.
Specimen Label: 3N - C7
Detected: true
Specimen Num: 7
GXD Expression
Probe: MGI:2148090
Assay Type: Immunohistochemistry
Annotation Date: 2007-03-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757721
Pattern: Single cells
Stage: TS21
Assay Id: MGI:3700202
Age: embryonic day 13.5
Image: 3B - C7
Note: Expression was detected in motor neurons. The specimen was from the level of the cervical vertebra 7.
Specimen Label: 3B - C7
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:2148090
Assay Type: Immunohistochemistry
Annotation Date: 2007-03-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757722
Pattern: Single cells
Stage: TS22
Assay Id: MGI:3700202
Age: embryonic day 14.5
Image: 3F - C7
Note: Expression was detected in motor neurons. The specimen was from the level of the cervical vertebra 7.
Specimen Label: 3F - C7
Detected: true
Specimen Num: 6
GXD Expression
Probe: MGI:2148090
Assay Type: Immunohistochemistry
Annotation Date: 2007-03-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757721
Pattern: Single cells
Stage: TS21
Assay Id: MGI:3700203
Age: embryonic day 13.5
Image: 3B - C7
Note: Expression was detected in motor neurons. The specimen was from the level of the cervical vertebra 7.
Specimen Label: 3B - C7
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:2148090
Assay Type: Immunohistochemistry
Annotation Date: 2007-03-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757722
Pattern: Single cells
Stage: TS22
Assay Id: MGI:3700203
Age: embryonic day 14.5
Image: 3F - C7
Note: Expression was detected in motor neurons. The specimen was from the level of the cervical vertebra 7.
Specimen Label: 3F - C7
Detected: true
Specimen Num: 6
GXD Expression
Probe: MGI:2149027
Assay Type: Immunohistochemistry
Annotation Date: 2001-09-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757721
Pattern: Single cells
Stage: TS21
Assay Id: MGI:2149088
Age: embryonic day 13.5
Image: 3B - C7
Note: The specimen was from the level of the cervical vertebra 7. At the rostral part of this level, expression was detected in a mosaic population of motor neurons. In the medial and caudal parts of this level, expression was in 100% of the motor neurons.
Specimen Label: 3B - C7
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:2149027
Assay Type: Immunohistochemistry
Annotation Date: 2001-09-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757722
Pattern: Single cells
Stage: TS22
Assay Id: MGI:2149088
Age: embryonic day 14.5
Image: 3F - C7
Note: The specimen was from the level of the cervical vertebra 7. At the rostral part of this level, expression was detected in a mosaic population of motor neurons. In the medial and caudal parts of this level, expression was in 100% of the motor neurons.
Specimen Label: 3F - C7
Detected: true
Specimen Num: 6
GXD Expression  
Assay Type: In situ reporter (knock in)
Annotation Date: 2007-03-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757721
Pattern: Single cells
Stage: TS21
Assay Id: MGI:3699628
Age: embryonic day 13.5
Image: 3J - C7
Note: The specimen was from the level of the cervical vertebra 7. At the rostral part of this level, expression was detected in a mosaic population of motor neurons. In the medial and caudal parts of this level, expression was in 100% of the motor neurons.
Specimen Label: 3J - C7
Detected: true
Specimen Num: 9
GXD Expression  
Assay Type: In situ reporter (knock in)
Annotation Date: 2007-03-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757721
Pattern: Single cells
Stage: TS21
Assay Id: MGI:3699628
Age: embryonic day 13.5
Image: 3N - C7
Note: The specimen was from the level of the cervical vertebra 7. At the rostral part of this level, expression was detected in a mosaic population of motor neurons.
Specimen Label: 3N - C7
Detected: true
Specimen Num: 13
Publication  
First Author: Zelek WM
Year: 2020
Journal: Front Immunol
Title: Monoclonal Antibodies Capable of Inhibiting Complement Downstream of C5 in Multiple Species.
Volume: 11
Pages: 612402
GXD Expression      
Probe: MGI:2681700
Assay Type: RT-PCR
Annotation Date: 2003-12-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757726
Stage: TS26
Assay Id: MGI:2681733
Age: embryonic day 18.0
Specimen Label: c7
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:2681703
Assay Type: RT-PCR
Annotation Date: 2003-12-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757726
Stage: TS26
Assay Id: MGI:2681765
Age: embryonic day 18.0
Specimen Label: C7
Detected: true
Specimen Num: 9
GXD Expression      
Probe: MGI:2681702
Assay Type: RT-PCR
Annotation Date: 2003-12-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757726
Stage: TS26
Assay Id: MGI:2681772
Age: embryonic day 18.0
Specimen Label: C7
Detected: true
Specimen Num: 9
GXD Expression      
Probe: MGI:3056517
Assay Type: RT-PCR
Annotation Date: 2004-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757728
Stage: TS28
Assay Id: MGI:3056537
Age: postnatal day 21
Specimen Label: C7
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3056515
Assay Type: RT-PCR
Annotation Date: 2004-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757728
Stage: TS28
Assay Id: MGI:3056539
Age: postnatal day 21
Specimen Label: C7
Detected: true
Specimen Num: 5
Publication
First Author: van Oorschot RA
Year: 1993
Journal: Biochem Genet
Title: Linkage between complement components 6 and 7 and glutamic pyruvate transaminase in the marsupial Monodelphis domestica.
Volume: 31
Issue: 5-6
Pages: 215-22
Gene
Type: gene
Organism: human
Publication
First Author: Zhou Z
Year: 2023
Journal: Oncogene
Title: Androgen-regulated stromal complement component 7 (C7) suppresses prostate cancer growth.
Volume: 42
Issue: 32
Pages: 2428-2438
Publication  
First Author: Zelek WM
Year: 2024
Journal: Brain Behav Immun
Title: Targeting terminal pathway reduces brain complement activation, amyloid load and synapse loss, and improves cognition in a mouse model of dementia.
Volume: 118
Pages: 355-363
Publication
First Author: Orren A
Year: 1985
Journal: Immunogenetics
Title: Close linkage between mouse genes determining the two forms of complement component C6 and component C7, and cis action of a C6 regulatory gene.
Volume: 21
Issue: 6
Pages: 591-9
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression      
Probe: MGI:5285271
Assay Type: Northern blot
Annotation Date: 2011-09-14
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:5285325
Age: postnatal
Specimen Label: JSD
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5285271
Assay Type: Northern blot
Annotation Date: 2011-09-14
Strength: Absent
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:5285325
Age: postnatal
Specimen Label: W/Wv
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:5285271
Assay Type: Northern blot
Annotation Date: 2011-09-14
Strength: Absent
Sex: Male
Emaps: EMAPS:1797226
Stage: TS26
Assay Id: MGI:5285325
Age: embryonic day 19.5
Specimen Label: 19.5 dpc
Detected: false
Specimen Num: 4
GXD Expression      
Probe: MGI:5285271
Assay Type: Northern blot
Annotation Date: 2011-09-14
Strength: Absent
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:5285325
Age: postnatal day 10
Specimen Label: 10 day
Detected: false
Specimen Num: 5
GXD Expression      
Probe: MGI:5285271
Assay Type: Northern blot
Annotation Date: 2011-09-14
Strength: Absent
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:5285325
Age: postnatal week 3
Specimen Label: 3 week
Detected: false
Specimen Num: 6
GXD Expression      
Probe: MGI:5285271
Assay Type: Northern blot
Annotation Date: 2011-09-14
Strength: Absent
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:5285325
Age: postnatal week 10
Specimen Label: 10 week
Detected: false
Specimen Num: 7
Publication
First Author: Menny A
Year: 2018
Journal: Nat Commun
Title: CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers.
Volume: 9
Issue: 1
Pages: 5316
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Publication
First Author: Schauwecker PE
Year: 2004
Journal: J Comp Neurol
Title: Genetic control of sensitivity to hippocampal cell death induced by kainic acid: a quantitative trait loci analysis.
Volume: 477
Issue: 1
Pages: 96-107
Publication
First Author: Beebe AM
Year: 1997
Journal: Immunity
Title: Serial backcross mapping of multiple loci associated with resistance to Leishmania major in mice.
Volume: 6
Issue: 5
Pages: 551-7
Publication
First Author: Tanaka K
Year: 2002
Journal: Dev Biol
Title: Spermatogonia-dependent expression of testicular genes in mice.
Volume: 246
Issue: 2
Pages: 466-79
Publication
First Author: Queen R
Year: 2023
Journal: PLoS Genet
Title: Spatial transcriptomics reveals novel genes during the remodelling of the embryonic human arterial valves.
Volume: 19
Issue: 11
Pages: e1010777
Publication      
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication      
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Protein
Organism: Mus musculus/domesticus
Length: 190  
Fragment?: false
Gene
Type: gene
Organism: frog, African clawed
Publication
First Author: Phelan MM
Year: 2009
Journal: J Biol Chem
Title: Solution structure of factor I-like modules from complement C7 reveals a pair of follistatin domains in compact pseudosymmetric arrangement.
Volume: 284
Issue: 29
Pages: 19637-49
Publication
First Author: Kuijpers TW
Year: 2010
Journal: Mol Immunol
Title: Complement factor 7 gene mutations in relation to meningococcal infection and clinical recurrence of meningococcal disease.
Volume: 47
Issue: 4
Pages: 671-7
Protein Domain
Type: Family
Description: This entry represents complement component C7, a subunit of the membrane attack complex (MAC) which forms pores in the membranes of cells of invading organisms. C7 anchors the MAC to the membrane. MAC forms when C5 is cleaved into C5a and C5b, and C5b binds sequentially C6, C7, C8 and multiple copies of the pore-forming subunit C9 []. The structure of C7 has been solved and C7 contains a several domains, which from N to C terminus are: TSP type-1, LDL-receptor class A, MACPF, EGF-like, another TSP type-1 and two sushi domains []. Variants of C7 are associated with immunodeficiency diseases and susceptibility to infection such as meningococcal disease caused by Neisseria meningitidis [].
Publication
First Author: Jeremiah SJ
Year: 1990
Journal: Ann Hum Genet
Title: The assignment of the genes coding for human complement components C6 and C7 to chromosome 5.
Volume: 54
Issue: Pt 2
Pages: 141-7
Publication
First Author: Suzuki N
Year: 2003
Journal: J Virol
Title: Hypovirus papain-like protease p29 functions in trans to enhance viral double-stranded RNA accumulation and vertical transmission.
Volume: 77
Issue: 21
Pages: 11697-707
Publication
First Author: Craven MG
Year: 1993
Journal: J Virol
Title: Papain-like protease p29 as a symptom determinant encoded by a hypovirulence-associated virus of the chestnut blight fungus.
Volume: 67
Issue: 11
Pages: 6513-21
Publication
First Author: Choi GH
Year: 1991
Journal: Virology
Title: The autocatalytic protease p29 encoded by a hypovirulence-associated virus of the chestnut blight fungus resembles the potyvirus-encoded protease HC-Pro.
Volume: 183
Issue: 2
Pages: 747-52
Publication
First Author: Jensen KS
Year: 2014
Journal: J Virol
Title: Mutagenesis of the catalytic and cleavage site residues of the hypovirus papain-like proteases p29 and p48 reveals alternative processing and contributions to optimal viral RNA accumulation.
Volume: 88
Issue: 20
Pages: 11946-54
Publication
First Author: Shapira R
Year: 1991
Journal: J Biol Chem
Title: Gene expression by a hypovirulence-associated virus of the chestnut blight fungus involves two papain-like protease activities. Essential residues and cleavage site requirements for p48 autoproteolysis.
Volume: 266
Issue: 29
Pages: 19419-25
Publication
First Author: Deng F
Year: 2008
Journal: J Virol
Title: Hypovirus papain-like protease p48 is required for initiation but not for maintenance of virus RNA propagation in the chestnut blight fungus Cryphonectria parasitica.
Volume: 82
Issue: 13
Pages: 6369-78
Protein Domain
Type: Domain
Description: This entry represents a peptidase C7 domain, which is found in HAV papain-like proteases p48 and p29 [, ].Hypoviruses are positive-strand RNA mycoviruses that attenuate virulence of their pathogenic fungal hosts [E1]. They employ a gene expression strategy that involves the autocatalytic processing of the N-terminal portion of encoded polyproteins by papain-like protease domains. The prototypic hypovirus CHV-1/EP713, responsible for virulence attenuation (hypovirulence) of the chestnut blight fungus Cryphonectria parasitica, encodes two contiguous open reading frames (ORFs) designated ORF A and ORF B, which contain N-terminal proteases p29 and p48, respectively. Protease p29 functions as a suppressor of the RNA silencing defense response, while p48 is required for viral RNA replication [, , ]. The HAV papain-like protease p29 is a cysteine protease, which forms the peptidase family C7 [E2]. A Cys and a His catalytic residue are essential for autocatalytic cleavage at a glycine dipeptide clevage site located at the C- terminus of the domain [, , ]. The HAV papain-like protease p48 is a cysteine protease, which forms the peptidase family C8 [E3]. A Cys anda His catalytic residue are essential for autocatalytic cleavage between the cleavage site residues Gly and Ala located at the C terminus of the domain [, , ].
EMAPA Term
Starts At: 23
Ends At: 28