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Search results 1 to 100 out of 224 for Capn1

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0.021s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Domain
Type: Family
Description: Calpain-1 catalytic subunit (CAPN1, also known as mu-calpain) belongs to the calpain family, which consists of a group of Ca2+ dependent cysteine proteases that regulate functions of substrates by proteolysis [, ]. The most abundant members of the calpain familiy are CAPN1 and CAPN2. They form heterodimers, which are regulated by a small regulatory subunit (28kDa) encoded by the gene Capn4 []. Calpain-1 plays a role in regulating IgE-mediated mast cell activation []. Calpain-1 is also involved in mammary gland remodelling [].
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Arnandis T
Year: 2014
Journal: Biochem J
Title: Differential functions of calpain 1 during epithelial cell death and adipocyte differentiation in mammary gland involution.
Volume: 459
Issue: 2
Pages: 355-68
Publication
First Author: Wang Y
Year: 2016
Journal: Cell Rep
Title: Defects in the CAPN1 Gene Result in Alterations in Cerebellar Development and Cerebellar Ataxia in Mice and Humans.
Volume: 16
Issue: 1
Pages: 79-91
Publication
First Author: Wu Z
Year: 2014
Journal: J Immunol
Title: Calpain-1 contributes to IgE-mediated mast cell activation.
Volume: 192
Issue: 11
Pages: 5130-9
Protein
Organism: Mus musculus
Length: 79  
Fragment?: true
Publication
First Author: Shimada M
Year: 2008
Journal: J Biol Chem
Title: In vivo targeted deletion of calpain small subunit, Capn4, in cells of the osteoblast lineage impairs cell proliferation, differentiation, and bone formation.
Volume: 283
Issue: 30
Pages: 21002-10
Publication
First Author: Jeong SY
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Calpain-dependent cytoskeletal rearrangement exploited for anthrax toxin endocytosis.
Volume: 110
Issue: 42
Pages: E4007-15
Publication
First Author: Goll DE
Year: 2003
Journal: Physiol Rev
Title: The calpain system.
Volume: 83
Issue: 3
Pages: 731-801
Protein
Organism: Mus musculus
Length: 79  
Fragment?: true
Protein
Organism: Mus musculus
Length: 196  
Fragment?: true
Protein
Organism: Mus musculus
Length: 543  
Fragment?: true
Protein
Organism: Mus musculus
Length: 713  
Fragment?: false
Protein
Organism: Mus musculus
Length: 713  
Fragment?: false
Protein
Organism: Mus musculus
Length: 713  
Fragment?: false
Protein
Organism: Mus musculus
Length: 713  
Fragment?: false
Protein
Organism: Mus musculus
Length: 699  
Fragment?: true
Protein
Organism: Mus musculus
Length: 713  
Fragment?: false
Publication
First Author: Cao T
Year: 2019
Journal: Basic Res Cardiol
Title: Increased calpain-1 in mitochondria induces dilated heart failure in mice: role of mitochondrial superoxide anion.
Volume: 114
Issue: 3
Pages: 17
Publication  
First Author: Dutt P
Year: 2006
Journal: BMC Dev Biol
Title: m-Calpain is required for preimplantation embryonic development in mice.
Volume: 6
Pages: 3
Publication
First Author: Mellgren RL
Year: 2009
Journal: Biochim Biophys Acta
Title: Calcium-dependent plasma membrane repair requires m- or mu-calpain, but not calpain-3, the proteasome, or caspases.
Volume: 1793
Issue: 12
Pages: 1886-93
Publication
First Author: Arthur JS
Year: 2000
Journal: Mol Cell Biol
Title: Disruption of the murine calpain small subunit gene, Capn4: calpain is essential for embryonic development but not for cell growth and division.
Volume: 20
Issue: 12
Pages: 4474-81
Publication  
First Author: Chelko SP
Year: 2021
Journal: Sci Transl Med
Title: Exercise triggers CAPN1-mediated AIF truncation, inducing myocyte cell death in arrhythmogenic cardiomyopathy.
Volume: 13
Issue: 581
Publication
First Author: Arnandis T
Year: 2012
Journal: Cell Death Differ
Title: Calpains mediate epithelial-cell death during mammary gland involution: mitochondria and lysosomal destabilization.
Volume: 19
Issue: 9
Pages: 1536-48
Publication
First Author: Undyala VV
Year: 2008
Journal: J Cell Sci
Title: The calpain small subunit regulates cell-substrate mechanical interactions during fibroblast migration.
Volume: 121
Issue: Pt 21
Pages: 3581-8
Publication
First Author: Dunnwald M
Year: 2003
Journal: Exp Dermatol
Title: The ichq mutant mouse, a model for the human skin disorder harlequin ichthyosis: mapping, keratinocyte culture, and consideration of candidate genes involved in epidermal growth regulation.
Volume: 12
Issue: 3
Pages: 245-54
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Rao MV
Year: 2014
Journal: J Neurosci
Title: Specific calpain inhibition by calpastatin prevents tauopathy and neurodegeneration and restores normal lifespan in tau P301L mice.
Volume: 34
Issue: 28
Pages: 9222-34
Publication  
First Author: Nwankwo JO
Year: 2017
Journal: Thromb Res
Title: Calpain-1 regulates platelet function in a humanized mouse model of sickle cell disease.
Volume: 160
Pages: 58-65
Publication
First Author: Galvez AS
Year: 2007
Journal: Circ Res
Title: Cardiomyocyte degeneration with calpain deficiency reveals a critical role in protein homeostasis.
Volume: 100
Issue: 7
Pages: 1071-8
Publication
First Author: Kang MY
Year: 2010
Journal: Circ Res
Title: Receptor-independent cardiac protein kinase Calpha activation by calpain-mediated truncation of regulatory domains.
Volume: 107
Issue: 7
Pages: 903-12
Publication
First Author: Li X
Year: 2014
Journal: Am J Physiol Heart Circ Physiol
Title: Cleavage of IκBα by calpain induces myocardial NF-κB activation, TNF-α expression, and cardiac dysfunction in septic mice.
Volume: 306
Issue: 6
Pages: H833-43
Publication
First Author: Letavernier B
Year: 2012
Journal: Arterioscler Thromb Vasc Biol
Title: Calpains contribute to vascular repair in rapidly progressive form of glomerulonephritis: potential role of their externalization.
Volume: 32
Issue: 2
Pages: 335-42
Publication
First Author: Randriamboavonjy V
Year: 2012
Journal: Blood
Title: Calpain inhibition stabilizes the platelet proteome and reactivity in diabetes.
Volume: 120
Issue: 2
Pages: 415-23
Publication
First Author: Azam M
Year: 2001
Journal: Mol Cell Biol
Title: Disruption of the mouse mu-calpain gene reveals an essential role in platelet function.
Volume: 21
Issue: 6
Pages: 2213-20
Publication
First Author: Ishak R
Year: 2018
Journal: Biochem Biophys Res Commun
Title: Defective rapid cell shape and transendothelial migration by calpain-1 null neutrophils.
Volume: 506
Issue: 4
Pages: 1065-1070
Publication
First Author: Zhu G
Year: 2015
Journal: J Neurosci
Title: Different patterns of electrical activity lead to long-term potentiation by activating different intracellular pathways.
Volume: 35
Issue: 2
Pages: 621-33
Publication
First Author: Wieschhaus A
Year: 2012
Journal: Biochem J
Title: Calpain-1 knockout reveals broad effects on erythrocyte deformability and physiology.
Volume: 448
Issue: 1
Pages: 141-52
Publication
First Author: Marzia M
Year: 2006
Journal: J Biol Chem
Title: Calpain is required for normal osteoclast function and is down-regulated by calcitonin.
Volume: 281
Issue: 14
Pages: 9745-54
Publication
First Author: Yamada KH
Year: 2012
Journal: J Biol Chem
Title: Targeted gene inactivation of calpain-1 suppresses cortical degeneration due to traumatic brain injury and neuronal apoptosis induced by oxidative stress.
Volume: 287
Issue: 16
Pages: 13182-93
Publication  
First Author: Zhu G
Year: 2017
Journal: Sci Rep
Title: Calpain-1 deletion impairs mGluR-dependent LTD and fear memory extinction.
Volume: 7
Pages: 42788
Publication
First Author: Grammer M
Year: 2005
Journal: Neurobiol Learn Mem
Title: Lack of phenotype for LTP and fear conditioning learning in calpain 1 knock-out mice.
Volume: 84
Issue: 3
Pages: 222-7
Publication
First Author: Tidball JG
Year: 2000
Journal: Int J Biochem Cell Biol
Title: Calpains and muscular dystrophies.
Volume: 32
Issue: 1
Pages: 1-5
Publication
First Author: Moens PB
Year: 1990
Journal: Cytogenet Cell Genet
Title: In situ DNA sequence mapping with surface-spread mouse pachytene chromosomes.
Volume: 53
Issue: 4
Pages: 219-20
Publication
First Author: Salazar JJ
Year: 2010
Journal: J Appl Physiol (1985)
Title: Inhibition of calpain prevents muscle weakness and disruption of sarcomere structure during hindlimb suspension.
Volume: 108
Issue: 1
Pages: 120-7
GXD Expression        
Probe: MGI:4361645
Assay Type: RT-PCR
Annotation Date: 2009-10-20
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:3287822
Stage: TS22
Assay Id: MGI:4361686
Age: embryonic day 14.0
Specimen Num: 1
GXD Expression        
Probe: MGI:4361645
Assay Type: RT-PCR
Annotation Date: 2009-10-20
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:3287824
Stage: TS24
Assay Id: MGI:4361686
Age: embryonic day 16.0
Specimen Num: 2
GXD Expression      
Probe: MGI:4361645
Assay Type: RT-PCR
Annotation Date: 2009-10-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3287826
Stage: TS26
Assay Id: MGI:4361686
Age: embryonic day 18.0
Detected: true
Specimen Num: 3
GXD Expression        
Probe: MGI:4361645
Assay Type: RT-PCR
Annotation Date: 2009-10-20
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:3288022
Stage: TS22
Assay Id: MGI:4361682
Age: embryonic day 14.0
Specimen Num: 1
GXD Expression        
Probe: MGI:4361645
Assay Type: RT-PCR
Annotation Date: 2009-10-20
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:3288024
Stage: TS24
Assay Id: MGI:4361682
Age: embryonic day 16.0
Specimen Num: 2
GXD Expression      
Probe: MGI:4361645
Assay Type: RT-PCR
Annotation Date: 2009-10-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3288026
Stage: TS26
Assay Id: MGI:4361682
Age: embryonic day 18.0
Detected: true
Specimen Num: 3
GXD Expression        
Probe: MGI:4361645
Assay Type: RT-PCR
Annotation Date: 2009-10-20
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:3288022
Stage: TS22
Assay Id: MGI:4361687
Age: embryonic day 14.0
Specimen Num: 1
GXD Expression        
Probe: MGI:4361645
Assay Type: RT-PCR
Annotation Date: 2009-10-20
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:3288024
Stage: TS24
Assay Id: MGI:4361687
Age: embryonic day 16.0
Specimen Num: 2
GXD Expression      
Probe: MGI:4361645
Assay Type: RT-PCR
Annotation Date: 2009-10-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3288026
Stage: TS26
Assay Id: MGI:4361687
Age: embryonic day 18.0
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:4361645
Assay Type: RT-PCR
Annotation Date: 2009-10-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3289727
Stage: TS27
Assay Id: MGI:4361682
Age: postnatal day 1
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:4361645
Assay Type: RT-PCR
Annotation Date: 2009-10-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3289728
Stage: TS28
Assay Id: MGI:4361682
Age: postnatal day 7
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:4361645
Assay Type: RT-PCR
Annotation Date: 2009-10-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3289727
Stage: TS27
Assay Id: MGI:4361686
Age: postnatal day 1
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:4361645
Assay Type: RT-PCR
Annotation Date: 2009-10-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3289728
Stage: TS28
Assay Id: MGI:4361686
Age: postnatal day 7
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:4361645
Assay Type: RT-PCR
Annotation Date: 2009-10-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3289727
Stage: TS27
Assay Id: MGI:4361687
Age: postnatal day 1
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:4361645
Assay Type: RT-PCR
Annotation Date: 2009-10-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3289728
Stage: TS28
Assay Id: MGI:4361687
Age: postnatal day 7
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:4361649
Assay Type: Immunohistochemistry
Annotation Date: 2009-10-20
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3287822
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:4361694
Age: embryonic day 14.0
Note: Expression was weak in outer enamel epithelium.
Detected: true
Specimen Num: 11
GXD Expression  
Probe: MGI:4361649
Assay Type: Immunohistochemistry
Annotation Date: 2009-10-20
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3287824
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:4361694
Age: embryonic day 16.0
Note: Expression was weak in the outer enamel epithelium.
Detected: true
Specimen Num: 12
GXD Expression  
Probe: MGI:4361649
Assay Type: Immunohistochemistry
Annotation Date: 2009-10-20
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3287826
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:4361694
Age: embryonic day 18.0
Note: Expression was weak in outer enamel epithelium and inner enamel epithelium.
Detected: true
Specimen Num: 13
GXD Expression    
Probe: MGI:4361649
Assay Type: Immunohistochemistry
Annotation Date: 2009-10-20
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3287922
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4361694
Age: embryonic day 14.0
Detected: true
Specimen Num: 11
GXD Expression    
Probe: MGI:4361649
Assay Type: Immunohistochemistry
Annotation Date: 2009-10-20
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3287924
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:4361694
Age: embryonic day 16.0
Detected: true
Specimen Num: 12
GXD Expression    
Probe: MGI:4361649
Assay Type: Immunohistochemistry
Annotation Date: 2009-10-20
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3287926
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:4361694
Age: embryonic day 18.0
Detected: true
Specimen Num: 13
GXD Expression    
Probe: MGI:4361649
Assay Type: Immunohistochemistry
Annotation Date: 2009-10-20
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:2694222
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4361694
Age: embryonic day 14.0
Detected: true
Specimen Num: 11
GXD Expression    
Probe: MGI:4361649
Assay Type: Immunohistochemistry
Annotation Date: 2009-10-20
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:2694224
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:4361694
Age: embryonic day 16.0
Detected: true
Specimen Num: 12
GXD Expression    
Probe: MGI:4361649
Assay Type: Immunohistochemistry
Annotation Date: 2009-10-20
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:2694226
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:4361694
Age: embryonic day 18.0
Detected: true
Specimen Num: 13
GXD Expression    
Probe: MGI:4361649
Assay Type: Immunohistochemistry
Annotation Date: 2009-10-20
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:2694227
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:4361694
Age: postnatal day 1
Detected: true
Specimen Num: 14
GXD Expression    
Probe: MGI:4361649
Assay Type: Immunohistochemistry
Annotation Date: 2009-10-20
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:2694228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:4361694
Age: postnatal day 7
Detected: true
Specimen Num: 15
GXD Expression    
Probe: MGI:4361649
Assay Type: Immunohistochemistry
Annotation Date: 2009-10-20
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3288022
Pattern: Diffuse
Stage: TS22
Assay Id: MGI:4361694
Age: embryonic day 14.0
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:4361649
Assay Type: Immunohistochemistry
Annotation Date: 2009-10-20
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3288024
Pattern: Diffuse
Stage: TS24
Assay Id: MGI:4361694
Age: embryonic day 16.0
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:4361649
Assay Type: Immunohistochemistry
Annotation Date: 2009-10-20
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3288026
Pattern: Diffuse
Stage: TS26
Assay Id: MGI:4361694
Age: embryonic day 18.0
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4361649
Assay Type: Immunohistochemistry
Annotation Date: 2009-10-20
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3288026
Pattern: Diffuse
Stage: TS26
Assay Id: MGI:4361694
Age: embryonic day 18.0
Note: Expression was light and diffuse in the enamel epithelium.
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:4361649
Assay Type: Immunohistochemistry
Annotation Date: 2009-10-20
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3290227
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:4361694
Age: postnatal day 1
Detected: true
Specimen Num: 14
GXD Expression    
Probe: MGI:4361649
Assay Type: Immunohistochemistry
Annotation Date: 2009-10-20
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3290228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:4361694
Age: postnatal day 7
Detected: true
Specimen Num: 15
GXD Expression  
Probe: MGI:4361649
Assay Type: Immunohistochemistry
Annotation Date: 2009-10-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3288827
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:4361694
Age: postnatal day 1
Note: Expression was detected in the enamel protein on the secretory side of the ameloblasts.
Detected: true
Specimen Num: 8
GXD Expression  
Probe: MGI:4361649
Assay Type: Immunohistochemistry
Annotation Date: 2009-10-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752526
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:4361694
Age: embryonic day 18.0
Note: Expression was detected in the skin. Staining was moderate in the basal layer, and weak in the peridermal layer.
Detected: true
Specimen Num: 6