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Search results 1 to 100 out of 288 for Capn3

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Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
825 | CAPN3
Type: gene
Organism: human
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Gene
281663 | CAPN3
Type: gene
Organism: cattle
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Gene
100611209 | CAPN3
Type: gene
Organism: chimpanzee
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Gene
100856545 | CAPN3
Type: gene
Organism: dog, domestic
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Gene
423233 | CAPN3
Type: gene
Organism: chicken
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Gene
707913 | CAPN3
Type: gene
Organism: macaque, rhesus
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Gene
100497532 | capn3
Type: gene
Organism: frog, western clawed
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Gene
29155 | Capn3
Type: gene
Organism: rat
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Protein Coding Gene
MGI:107437 | Capn3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR029531 | CAPN3
Type: Family
Description: Calpain-3 (CAPN3) belongs to the calpain family, which consists of a group of Ca2+ dependent cysteine proteases that regulate functions of substrates by proteolysis [, ]. Calpain-3 is a calcium-dependent cysteine protease mainly expressed in skeletal muscle. It is involved in sarcomere maintenance and remodelling []. It interacts with myospryn, which is a muscle-specific protein that functions in vesicular trafficking and protein kinase A signalling []. Mutations of the calpain-3 gene cause limb-girdle muscular dystrophy 2A (LGMD2A), an autosomal recessive degenerative myopathy characterised by progressive symmetrical atrophy and weakness of the proximal limb muscles and elevated serum creatine kinase [, ].
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Publication
35309930 | J:328204
 
First Author: Lasa-Elgarresta J
Year: 2022
Journal: Front Cell Dev Biol
Title: Targeting the Ubiquitin-Proteasome System in Limb-Girdle Muscular Dystrophy With CAPN3 Mutations.
Volume: 10
Pages: 822563
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Publication
20634290 | -
First Author: Sarparanta J
Year: 2010
Journal: J Biol Chem
Title: Interactions with M-band titin and calpain 3 link myospryn (CMYA5) to tibial and limb-girdle muscular dystrophies.
Volume: 285
Issue: 39
Pages: 30304-15
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Protein
Q64691
Organism: Mus musculus/domesticus
Length: 821  
Fragment?: false
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Protein
Q0VGP9
Organism: Mus musculus/domesticus
Length: 709  
Fragment?: false
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Protein
A0A668KLF1
Organism: Mus musculus/domesticus
Length: 815  
Fragment?: false
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Protein
A2AVV6
Organism: Mus musculus/domesticus
Length: 785  
Fragment?: false
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Protein
Q08EM5
Organism: Mus musculus/domesticus
Length: 80  
Fragment?: false
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Protein
A0A668KM80
Organism: Mus musculus/domesticus
Length: 136  
Fragment?: true
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Protein
A0A668KL63
Organism: Mus musculus/domesticus
Length: 178  
Fragment?: true
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Protein
Q762C5
Organism: Mus musculus/domesticus
Length: 653  
Fragment?: false
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Protein
Q920R8
Organism: Mus musculus/domesticus
Length: 44  
Fragment?: true
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Protein
A2AVV5
Organism: Mus musculus/domesticus
Length: 737  
Fragment?: false
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Protein
A0A668KLB3
Organism: Mus musculus/domesticus
Length: 156  
Fragment?: false
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Protein
O88977
Organism: Mus musculus/domesticus
Length: 709  
Fragment?: false
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Protein
A4QPE6
Organism: Mus musculus/domesticus
Length: 821  
Fragment?: false
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Protein
Q762C4
Organism: Mus musculus/domesticus
Length: 421  
Fragment?: false
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Protein
Q8C532
Organism: Mus musculus/domesticus
Length: 139  
Fragment?: true
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Protein
A2AVV7
Organism: Mus musculus/domesticus
Length: 757  
Fragment?: false
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Protein
Q8C7L1
Organism: Mus musculus/domesticus
Length: 156  
Fragment?: false
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Protein
Q8C2H4
Organism: Mus musculus/domesticus
Length: 191  
Fragment?: false
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Publication
12843408 | -
First Author: Goll DE
Year: 2003
Journal: Physiol Rev
Title: The calpain system.
Volume: 83
Issue: 3
Pages: 731-801
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Publication
7720071 | -
First Author: Richard I
Year: 1995
Journal: Cell
Title: Mutations in the proteolytic enzyme calpain 3 cause limb-girdle muscular dystrophy type 2A.
Volume: 81
Issue: 1
Pages: 27-40
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Publication
9771675 | -
First Author: Kawai H
Year: 1998
Journal: Muscle Nerve
Title: Clinical, pathological, and genetic features of limb-girdle muscular dystrophy type 2A with new calpain 3 gene mutations in seven patients from three Japanese families.
Volume: 21
Issue: 11
Pages: 1493-501
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Publication
16884488 | -
First Author: Duguez S
Year: 2006
Journal: FEBS J
Title: Calpain 3: a key regulator of the sarcomere?
Volume: 273
Issue: 15
Pages: 3427-36
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Publication
24085852 | -
First Author: Jeong SY
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Calpain-dependent cytoskeletal rearrangement exploited for anthrax toxin endocytosis.
Volume: 110
Issue: 42
Pages: E4007-15
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Publication
16115818 | J:101746
First Author: Huebsch KA
Year: 2005
Journal: Hum Mol Genet
Title: Mdm muscular dystrophy: interactions with calpain 3 and a novel functional role for titin's N2A domain.
Volume: 14
Issue: 19
Pages: 2801-11
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Publication
14741210 | J:87870
First Author: Witt CC
Year: 2004
Journal: J Mol Biol
Title: Induction and myofibrillar targeting of CARP, and suppression of the Nkx2.5 pathway in the MDM mouse with impaired titin-based signaling.
Volume: 336
Issue: 1
Pages: 145-54
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Publication
32801165 | J:297040
 
First Author: Ojima K
Year: 2020
Journal: Biol Open
Title: Developing fluorescence sensor probe to capture activated muscle-specific calpain-3 (CAPN3) in living muscle cells.
Volume: 9
Issue: 9
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Publication
16982691 | J:114647
First Author: Kramerova I
Year: 2006
Journal: Mol Cell Biol
Title: Regulation of the M-cadherin-beta-catenin complex by calpain 3 during terminal stages of myogenic differentiation.
Volume: 26
Issue: 22
Pages: 8437-47
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Publication
29528394 | J:261418
First Author: Kramerova I
Year: 2018
Journal: Hum Mol Genet
Title: Calpain 3 and CaMKIIβ signaling are required to induce HSP70 necessary for adaptive muscle growth after atrophy.
Volume: 27
Issue: 9
Pages: 1642-1653
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Publication
18073330 | J:180460
First Author: Benayoun B
Year: 2008
Journal: FASEB J
Title: NF-kappaB-dependent expression of the antiapoptotic factor c-FLIP is regulated by calpain 3, the protein involved in limb-girdle muscular dystrophy type 2A.
Volume: 22
Issue: 5
Pages: 1521-9
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Publication
21624972 | J:174978
First Author: Ermolova N
Year: 2011
Journal: Hum Mol Genet
Title: Pathogenity of some limb girdle muscular dystrophy mutations can result from reduced anchorage to myofibrils and altered stability of calpain 3.
Volume: 20
Issue: 17
Pages: 3331-45
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Publication
33205074 | J:328077
First Author: Liu J
Year: 2020
Journal: Cell Rep Med
Title: A Small-Molecule Approach to Restore a Slow-Oxidative Phenotype and Defective CaMKIIβ Signaling in Limb Girdle Muscular Dystrophy.
Volume: 1
Issue: 7
Pages: 100122
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Publication
19924298 | J:282614
First Author: van Haagen HH
Year: 2009
Journal: PLoS One
Title: Novel protein-protein interactions inferred from literature context.
Volume: 4
Issue: 11
Pages: e7894
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Publication
25877298 | J:223343
First Author: Charton K
Year: 2015
Journal: Hum Mol Genet
Title: CAPN3-mediated processing of C-terminal titin replaced by pathological cleavage in titinopathy.
Volume: 24
Issue: 13
Pages: 3718-31
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Publication
17525200 | J:123279
First Author: Tang Y
Year: 2007
Journal: Invest Ophthalmol Vis Sci
Title: Age-related cataracts in alpha3Cx46-knockout mice are dependent on a calpain 3 isoform.
Volume: 48
Issue: 6
Pages: 2685-94
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Publication
20139084 | J:180556
First Author: Stuelsatz P
Year: 2010
Journal: J Biol Chem
Title: Down-regulation of MyoD by calpain 3 promotes generation of reserve cells in C2C12 myoblasts.
Volume: 285
Issue: 17
Pages: 12670-83
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Publication
14645524 | J:86865
First Author: Taveau M
Year: 2003
Journal: Mol Cell Biol
Title: Calpain 3 is activated through autolysis within the active site and lyses sarcomeric and sarcolemmal components.
Volume: 23
Issue: 24
Pages: 9127-35
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Publication
22505582 | J:185282
First Author: Kramerova I
Year: 2012
Journal: Hum Mol Genet
Title: Impaired calcium calmodulin kinase signaling and muscle adaptation response in the absence of calpain 3.
Volume: 21
Issue: 14
Pages: 3193-204
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Publication
25389288 | J:218397
First Author: Ermolova N
Year: 2015
Journal: J Biol Chem
Title: Autolytic activation of calpain 3 proteinase is facilitated by calmodulin protein.
Volume: 290
Issue: 2
Pages: 996-1004
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Publication
18676612 | J:140035
First Author: Kramerova I
Year: 2008
Journal: Hum Mol Genet
Title: Novel role of calpain-3 in the triad-associated protein complex regulating calcium release in skeletal muscle.
Volume: 17
Issue: 21
Pages: 3271-80
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Publication
27005420 | J:236707
First Author: Kramerova I
Year: 2016
Journal: Hum Mol Genet
Title: Failure to up-regulate transcription of genes necessary for muscle adaptation underlies limb girdle muscular dystrophy 2A (calpainopathy).
Volume: 25
Issue: 11
Pages: 2194-2207
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Publication
23300487 | J:195085
First Author: Pistoni M
Year: 2013
Journal: PLoS Genet
Title: Rbfox1 downregulation and altered calpain 3 splicing by FRG1 in a mouse model of Facioscapulohumeral muscular dystrophy (FSHD).
Volume: 9
Issue: 1
Pages: e1003186
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Protein Coding Gene
MGP_CAROLIEiJ_G0024168 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0026367 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0026328 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0026307 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0026341 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0026087 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_107437 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0026788 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0025549 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0026063 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0026202 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0026164 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0026303 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0026183 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0026843 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0025285 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0025618 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0025610 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0025084 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
8661728 | J:33167
First Author: Richard I
Year: 1996
Journal: Mamm Genome
Title: Molecular cloning of mouse canp3, the gene associated with limb-girdle muscular dystrophy 2A in human.
Volume: 7
Issue: 5
Pages: 377-9
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Publication
19483197 | J:151336
First Author: Kramerova I
Year: 2009
Journal: Hum Mol Genet
Title: Mitochondrial abnormalities, energy deficit and oxidative stress are features of calpain 3 deficiency in skeletal muscle.
Volume: 18
Issue: 17
Pages: 3194-205
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Publication
15961411 | J:100387
First Author: Kramerova I
Year: 2005
Journal: Hum Mol Genet
Title: Calpain 3 participates in sarcomere remodeling by acting upstream of the ubiquitin-proteasome pathway.
Volume: 14
Issue: 15
Pages: 2125-34
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Publication
20592470 | J:163711
First Author: Ojima K
Year: 2010
Journal: J Clin Invest
Title: Dynamic distribution of muscle-specific calpain in mice has a key role in physical-stress adaptation and is impaired in muscular dystrophy.
Volume: 120
Issue: 8
Pages: 2672-83
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Publication
20460380 | J:165998
First Author: Ono Y
Year: 2010
Journal: J Biol Chem
Title: Skeletal muscle-specific calpain is an intracellular Na+-dependent protease.
Volume: 285
Issue: 30
Pages: 22986-98
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Publication
12084932 | J:77348
First Author: Spencer MJ
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Stable expression of calpain 3 from a muscle transgene in vivo: immature muscle in transgenic mice suggests a role for calpain 3 in muscle maturation.
Volume: 99
Issue: 13
Pages: 8874-9
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Publication
11134085 | J:66862
First Author: Richard I
Year: 2000
Journal: J Cell Biol
Title: Loss of calpain 3 proteolytic activity leads to muscular dystrophy and to apoptosis-associated IkappaBalpha/nuclear factor kappaB pathway perturbation in mice.
Volume: 151
Issue: 7
Pages: 1583-90
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Publication
12707983 | J:105529
First Author: Fougerousse F
Year: 2003
Journal: Muscle Nerve
Title: Force impairment in calpain 3-deficient mice is not correlated with mechanical disruption.
Volume: 27
Issue: 5
Pages: 616-23
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Publication
12672459 | J:102531
First Author: Combaret L
Year: 2003
Journal: Int J Biochem Cell Biol
Title: Down-regulation of genes in the lysosomal and ubiquitin-proteasome proteolytic pathways in calpain-3-deficient muscle.
Volume: 35
Issue: 5
Pages: 676-84
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Publication
10814721 | J:62545
First Author: Tagawa K
Year: 2000
Journal: Hum Mol Genet
Title: Myopathy phenotype of transgenic mice expressing active site-mutated inactive p94 skeletal muscle-specific calpain, the gene product responsible for limb girdle muscular dystrophy type 2A.
Volume: 9
Issue: 9
Pages: 1393-402
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Publication
16627476 | J:114363
First Author: Ono Y
Year: 2006
Journal: J Biol Chem
Title: Suppressed disassembly of autolyzing p94/CAPN3 by N2A connectin/titin in a genetic reporter system.
Volume: 281
Issue: 27
Pages: 18519-31
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Publication
17371879 | J:122571
First Author: Ojima K
Year: 2007
Journal: J Biol Chem
Title: Myogenic stage, sarcomere length, and protease activity modulate localization of muscle-specific calpain.
Volume: 282
Issue: 19
Pages: 14493-504
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GXD Expression
GXD Expression
     
Probe: MGI:3767294
Assay Type: RT-PCR
Annotation Date: 2008-01-13
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603919
Stage: TS19
Assay Id: MGI:3767308
Age: embryonic day 11.5
Specimen Label: E11.5
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:3767294
Assay Type: RT-PCR
Annotation Date: 2008-01-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:3767308
Age: embryonic day 12.5
Specimen Label: E12.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:3767294
Assay Type: RT-PCR
Annotation Date: 2008-01-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603921
Stage: TS21
Assay Id: MGI:3767308
Age: embryonic day 13.5
Specimen Label: E13.5
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:3767294
Assay Type: RT-PCR
Annotation Date: 2008-01-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603922
Stage: TS22
Assay Id: MGI:3767308
Age: embryonic day 14.5
Specimen Label: E14.5
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:3767294
Assay Type: RT-PCR
Annotation Date: 2008-01-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:3767308
Age: embryonic day 15.5
Specimen Label: E15.5
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:3767294
Assay Type: RT-PCR
Annotation Date: 2008-01-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603924
Stage: TS24
Assay Id: MGI:3767308
Age: embryonic day 16.5
Specimen Label: E16.5
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:3767294
Assay Type: RT-PCR
Annotation Date: 2008-01-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603925
Stage: TS25
Assay Id: MGI:3767308
Age: embryonic day 17.5
Specimen Label: E17.5
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
     
Probe: MGI:3767294
Assay Type: RT-PCR
Annotation Date: 2008-01-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603926
Stage: TS26
Assay Id: MGI:3767308
Age: embryonic day 18.5
Specimen Label: E18.5
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
     
Probe: MGI:3767294
Assay Type: RT-PCR
Annotation Date: 2008-01-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1783823
Stage: TS23
Assay Id: MGI:3767309
Age: embryonic day 15.5
Specimen Label: embryonic lens
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:3767294
Assay Type: RT-PCR
Annotation Date: 2008-01-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1783828
Stage: TS28
Assay Id: MGI:3767309
Age: postnatal month 6
Specimen Label: adult lens
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:3767294
Assay Type: RT-PCR
Annotation Date: 2008-01-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:3767309
Age: postnatal week 9-11
Specimen Label: skeletal muscle
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:3767294
Assay Type: RT-PCR
Annotation Date: 2008-01-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271728
Stage: TS28
Assay Id: MGI:3767309
Age: postnatal week 9-11
Specimen Label: smooth muscle
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:3767294
Assay Type: RT-PCR
Annotation Date: 2008-01-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3767309
Age: postnatal week 9-11
Specimen Label: heart
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:3767294
Assay Type: RT-PCR
Annotation Date: 2008-01-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3767309
Age: postnatal week 9-11
Specimen Label: brain
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:3767295
Assay Type: RT-PCR
Annotation Date: 2008-01-13
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603919
Stage: TS19
Assay Id: MGI:3767310
Age: embryonic day 11.5
Specimen Label: E11.5
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:3767295
Assay Type: RT-PCR
Annotation Date: 2008-01-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:3767310
Age: embryonic day 12.5
Specimen Label: E12.5
Detected: true
Specimen Num: 2
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