Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Publication |
First Author: |
Mishima Y |
Year: |
2015 |
Journal: |
Sci Rep |
Title: |
Lack of stress responses to long-term effects of corticosterone in Caps2 knockout mice. |
Volume: |
5 |
|
Pages: |
8932 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ratai O |
Year: |
2019 |
Journal: |
J Neurosci |
Title: |
An Alternative Exon of CAPS2 Influences Catecholamine Loading into LDCVs of Chromaffin Cells. |
Volume: |
39 |
Issue: |
1 |
Pages: |
18-27 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fujima S |
Year: |
2021 |
Journal: |
J Neurosci |
Title: |
CAPS2 Deficiency Impairs the Release of the Social Peptide Oxytocin, as Well as Oxytocin-Associated Social Behavior. |
Volume: |
41 |
Issue: |
20 |
Pages: |
4524-4535 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yagishita K |
Year: |
2017 |
Journal: |
Neurosci Lett |
Title: |
CAPS2 deficiency affects environmental enrichment-induced adult neurogenesis and differentiation/survival of newborn neurons in the hippocampal dentate gyrus. |
Volume: |
661 |
|
Pages: |
121-125 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sadakata T |
Year: |
2012 |
Journal: |
FEBS J |
Title: |
Calcium-dependent activator protein for secretion 2 interacts with the class II ARF small GTPases and regulates dense-core vesicle trafficking. |
Volume: |
279 |
Issue: |
3 |
Pages: |
384-94 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Sadakata T |
Year: |
2010 |
Journal: |
Neurosci Res |
Title: |
Ca(2+)-dependent activator protein for secretion 2 and autistic-like phenotypes. |
Volume: |
67 |
Issue: |
3 |
Pages: |
197-202 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nguyen Truong CQ |
Year: |
2014 |
Journal: |
Cell Rep |
Title: |
Secretory vesicle priming by CAPS is independent of its SNARE-binding MUN domain. |
Volume: |
9 |
Issue: |
3 |
Pages: |
902-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sadakata T |
Year: |
2007 |
Journal: |
BMC Neurosci |
Title: |
Alternative splicing variations in mouse CAPS2: differential expression and functional properties of splicing variants. |
Volume: |
8 |
|
Pages: |
25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shinoda Y |
Year: |
2011 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Calcium-dependent activator protein for secretion 2 (CAPS2) promotes BDNF secretion and is critical for the development of GABAergic interneuron network. |
Volume: |
108 |
Issue: |
1 |
Pages: |
373-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sadakata T |
Year: |
2014 |
Journal: |
PLoS One |
Title: |
Axonal localization of Ca2+-dependent activator protein for secretion 2 is critical for subcellular locality of brain-derived neurotrophic factor and neurotrophin-3 release affecting proper development of postnatal mouse cerebellum. |
Volume: |
9 |
Issue: |
6 |
Pages: |
e99524 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sadakata T |
Year: |
2009 |
Journal: |
Cerebellum |
Title: |
Developmentally regulated Ca2+-dependent activator protein for secretion 2 (CAPS2) is involved in BDNF secretion and is associated with autism susceptibility. |
Volume: |
8 |
Issue: |
3 |
Pages: |
312-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
University of California, Davis |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by the University of California, Davis |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Function or Process or Component Unknown following Literature Review |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2009 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
DDB, FB, MGI, GOA, ZFIN curators |
Year: |
2001 |
|
Title: |
Gene Ontology annotation through association of InterPro records with GO terms |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Sadakata T |
Year: |
2004 |
Journal: |
J Neurosci |
Title: |
The secretory granule-associated protein CAPS2 regulates neurotrophin release and cell survival. |
Volume: |
24 |
Issue: |
1 |
Pages: |
43-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Speidel D |
Year: |
2008 |
Journal: |
Cell Metab |
Title: |
CAPS1 and CAPS2 regulate stability and recruitment of insulin granules in mouse pancreatic beta cells. |
Volume: |
7 |
Issue: |
1 |
Pages: |
57-67 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fujima S |
Year: |
2020 |
Journal: |
Neurosci Lett |
Title: |
CAPS2 deficiency induces proopiomelanocortin accumulation in pituitary and affects food intake behavior in mice. |
Volume: |
738 |
|
Pages: |
135335 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sadakata T |
Year: |
2012 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Reduced axonal localization of a Caps2 splice variant impairs axonal release of BDNF and causes autistic-like behavior in mice. |
Volume: |
109 |
Issue: |
51 |
Pages: |
21104-9 |
|
•
•
•
•
•
|
Allele |
Name: |
Ca2+-dependent activator protein for secretion 2; targeted mutation 1, Teiichi Furuichi |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1297
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1275
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
768
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
173
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1304
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1259
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1264
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Sadakata T |
Year: |
2013 |
Journal: |
FEBS Lett |
Title: |
Autistic-like behavioral phenotypes in a mouse model with copy number variation of the CAPS2/CADPS2 gene. |
Volume: |
587 |
Issue: |
1 |
Pages: |
54-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu Y |
Year: |
2010 |
Journal: |
J Cell Biol |
Title: |
Two distinct secretory vesicle-priming steps in adrenal chromaffin cells. |
Volume: |
190 |
Issue: |
6 |
Pages: |
1067-77 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
303
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Renden R |
Year: |
2001 |
Journal: |
Neuron |
Title: |
Drosophila CAPS is an essential gene that regulates dense-core vesicle release and synaptic vesicle fusion. |
Volume: |
31 |
Issue: |
3 |
Pages: |
421-37 |
|
•
•
•
•
•
|
Publication |
First Author: |
Charlie NK |
Year: |
2006 |
Journal: |
Genetics |
Title: |
Presynaptic UNC-31 (CAPS) is required to activate the G alpha(s) pathway of the Caenorhabditis elegans synaptic signaling network. |
Volume: |
172 |
Issue: |
2 |
Pages: |
943-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
You YJ |
Year: |
2008 |
Journal: |
Cell Metab |
Title: |
Insulin, cGMP, and TGF-beta signals regulate food intake and quiescence in C. elegans: a model for satiety. |
Volume: |
7 |
Issue: |
3 |
Pages: |
249-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mills H |
Year: |
2012 |
Journal: |
EMBO J |
Title: |
Monoamines and neuropeptides interact to inhibit aversive behaviour in Caenorhabditis elegans. |
Volume: |
31 |
Issue: |
3 |
Pages: |
667-78 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lin XG |
Year: |
2010 |
Journal: |
Biochem Biophys Res Commun |
Title: |
UNC-31/CAPS docks and primes dense core vesicles in C. elegans neurons. |
Volume: |
397 |
Issue: |
3 |
Pages: |
526-31 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry includes calcium-dependent secretion activators (CAPS) from animals, including CAPS1/2 from humans and unc-31 from worms. Mammalian CAPS1 and CAPS2 regulate the exocytosis of catecholamine-containing or neuropeptide-containing dense-core vesicles (DCVs) at secretion sites such as nerve terminals []. Like its mammalian homologues, unc-31/CAPS from C. elegans and CAPS from Drosophila are indispensable for exocytosis of dense core vesicle (DCV) and synaptic vesicle (SV) [, ]. In C. elegans unc-31 functions with G-alpha proteins from the same motor neurons to regulate locomotion []. It is involved in regulating entry into quiescence triggered by satiety []and plays a role in octopamine signaling and specifically, the octopamine inhibition of aversion responses in olfactory sensory neurons []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Brunk I |
Year: |
2009 |
Journal: |
J Biol Chem |
Title: |
Ca2+-dependent activator proteins of secretion promote vesicular monoamine uptake. |
Volume: |
284 |
Issue: |
2 |
Pages: |
1050-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sadakata T |
Year: |
2007 |
Journal: |
J Neurosci |
Title: |
Impaired cerebellar development and function in mice lacking CAPS2, a protein involved in neurotrophin release. |
Volume: |
27 |
Issue: |
10 |
Pages: |
2472-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sadakata T |
Year: |
2006 |
Journal: |
J Comp Neurol |
Title: |
Differential distributions of the Ca2+ -dependent activator protein for secretion family proteins (CAPS2 and CAPS1) in the mouse brain. |
Volume: |
495 |
Issue: |
6 |
Pages: |
735-53 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
402
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
867
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
768
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
627
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1355
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1304
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1304
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1354
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
899
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1275
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1202
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1275
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1356
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1297
 |
Fragment?: |
false |
|
•
•
•
•
•
|