|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 100 out of 152 for Card11

<< First    < Previous  |  Next >    Last >>
0.046s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: dog, domestic
Protein Domain
Type: Family
Description: The caspase recruitment domain (CARD) is a homotypic protein interaction module that participates in apoptosis signalling. This entry represents CARD11, which is a large multidomain scaffold protein that functions as upstream activator of NF-kappaB signalling []. It forms a CBM complex with BCL10 and MALT1. The CBM complex links AgR (antigen receptor) triggering to NF-kappaB activation []. Its activity is controlled by an Inhibitory Domain (ID) [].Mutations in the CARD11 gene cause B-cell expansion with NFKB and T-cell anergy (BENTA) []and Immunodeficiency 11 (IMD11) [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Gene
Type: gene
Organism: human
Publication
First Author: Snow AL
Year: 2012
Journal: J Exp Med
Title: Congenital B cell lymphocytosis explained by novel germline CARD11 mutations.
Volume: 209
Issue: 12
Pages: 2247-61
Publication      
First Author: Beutler B
Year: 2013
Journal: MGI Direct Data Submission
Title: Direct data submission for a Card11 allele
Publication      
First Author: Sproule TJ
Year: 2007
Journal: MGI Direct Data Submission
Title: Ploymorphism distinguishing Card11 mutant allele um-J
Publication
First Author: Hara H
Year: 2003
Journal: Immunity
Title: The MAGUK family protein CARD11 is essential for lymphocyte activation.
Volume: 18
Issue: 6
Pages: 763-75
Publication
First Author: Bertin J
Year: 2001
Journal: J Biol Chem
Title: CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B.
Volume: 276
Issue: 15
Pages: 11877-82
Publication
First Author: Wray-Dutra MN
Year: 2018
Journal: J Exp Med
Title: Activated CARD11 accelerates germinal center kinetics, promoting mTORC1 and terminal differentiation.
Volume: 215
Issue: 9
Pages: 2445-2461
Publication
First Author: Pomerantz JL
Year: 2002
Journal: EMBO J
Title: CARD11 mediates factor-specific activation of NF-kappaB by the T cell receptor complex.
Volume: 21
Issue: 19
Pages: 5184-94
Publication  
First Author: Wei Z
Year: 2019
Journal: Sci Immunol
Title: Pathogenic CARD11 mutations affect B cell development and differentiation through a noncanonical pathway.
Volume: 4
Issue: 41
Publication
First Author: Kameda T
Year: 2022
Journal: Commun Biol
Title: CARD11 mutation and HBZ expression induce lymphoproliferative disease and adult T-cell leukemia/lymphoma.
Volume: 5
Issue: 1
Pages: 1309
Publication  
First Author: Masle-Farquhar E
Year: 2023
Journal: Front Immunol
Title: CARD11 gain-of-function mutation drives cell-autonomous accumulation of PD-1(+) ICOS(high) activated T cells, T-follicular, T-regulatory and T-follicular regulatory cells.
Volume: 14
Pages: 1095257
Publication
First Author: Jeelall YS
Year: 2012
Journal: J Exp Med
Title: Human lymphoma mutations reveal CARD11 as the switch between self-antigen-induced B cell death or proliferation and autoantibody production.
Volume: 209
Issue: 11
Pages: 1907-17
Publication
First Author: Jattani RP
Year: 2016
Journal: J Biol Chem
Title: Intramolecular Interactions and Regulation of Cofactor Binding by the Four Repressive Elements in the Caspase Recruitment Domain-containing Protein 11 (CARD11) Inhibitory Domain.
Volume: 291
Issue: 16
Pages: 8338-48
Publication
First Author: McCully RR
Year: 2008
Journal: Mol Cell Biol
Title: The protein kinase C-responsive inhibitory domain of CARD11 functions in NF-kappaB activation to regulate the association of multiple signaling cofactors that differentially depend on Bcl10 and MALT1 for association.
Volume: 28
Issue: 18
Pages: 5668-86
Publication
First Author: Stepensky P
Year: 2013
Journal: J Allergy Clin Immunol
Title: Deficiency of caspase recruitment domain family, member 11 (CARD11), causes profound combined immunodeficiency in human subjects.
Volume: 131
Issue: 2
Pages: 477-85.e1
Publication
First Author: Turvey SE
Year: 2014
Journal: J Allergy Clin Immunol
Title: The CARD11-BCL10-MALT1 (CBM) signalosome complex: Stepping into the limelight of human primary immunodeficiency.
Volume: 134
Issue: 2
Pages: 276-84
Protein
Organism: Mus musculus/domesticus
Length: 278  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1159  
Fragment?: false
Publication
First Author: Hutcherson SM
Year: 2021
Journal: J Immunol
Title: Pathway-Specific Defects in T, B, and NK Cells and Age-Dependent Development of High IgE in Mice Heterozygous for a CADINS-Associated Dominant Negative CARD11 Allele.
Volume: 207
Issue: 4
Pages: 1150-1164
Publication      
First Author: Barnes MJ
Year: 2008
Journal: MGI Direct Data Submission
Title: Record for "king"
Publication
First Author: Barnes MJ
Year: 2009
Journal: PLoS Biol
Title: Commitment to the regulatory T cell lineage requires CARMA1 in the thymus but not in the periphery.
Volume: 7
Issue: 3
Pages: e51
Publication
First Author: Hu DY
Year: 2017
Journal: Cell Death Differ
Title: IL-2 prevents deletion of developing T-regulatory cells in the thymus.
Volume: 24
Issue: 6
Pages: 1007-1016
Publication
First Author: Egawa T
Year: 2003
Journal: Curr Biol
Title: Requirement for CARMA1 in antigen receptor-induced NF-kappa B activation and lymphocyte proliferation.
Volume: 13
Issue: 14
Pages: 1252-8
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Wang D
Year: 2002
Journal: Nat Immunol
Title: A requirement for CARMA1 in TCR-induced NF-kappa B activation.
Volume: 3
Issue: 9
Pages: 830-5
Publication
First Author: Sommer K
Year: 2005
Journal: Immunity
Title: Phosphorylation of the CARMA1 linker controls NF-kappaB activation.
Volume: 23
Issue: 6
Pages: 561-74
Publication
First Author: Medoff BD
Year: 2009
Journal: Eur J Immunol
Title: Differential requirement for CARMA1 in agonist-selected T-cell development.
Volume: 39
Issue: 1
Pages: 78-84
Publication
First Author: Hara H
Year: 2004
Journal: J Exp Med
Title: The molecular adapter Carma1 controls entry of IkappaB kinase into the central immune synapse.
Volume: 200
Issue: 9
Pages: 1167-77
Publication      
First Author: Zhong X
Year: 2019
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for Caravaggio.
Publication      
First Author: Zhong X
Year: 2019
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for Sharp.
Publication      
First Author: Zhong X
Year: 2018
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for Tumnus
Publication      
First Author: Zhong X
Year: 2018
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for Dealer
Publication
First Author: Jun JE
Year: 2003
Journal: Immunity
Title: Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis.
Volume: 18
Issue: 6
Pages: 751-62
Publication      
First Author: Choi JH
Year: 2019
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for unmodulated2.
Publication      
First Author: Zeng M
Year: 2015
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for hubei
Publication
First Author: Newton K
Year: 2003
Journal: Curr Biol
Title: Mice lacking the CARD of CARMA1 exhibit defective B lymphocyte development and impaired proliferation of their B and T lymphocytes.
Volume: 13
Issue: 14
Pages: 1247-51
Publication  
First Author: Hara H
Year: 2015
Journal: Nat Commun
Title: Clustering of CARMA1 through SH3-GUK domain interactions is required for its activation of NF-κB signalling.
Volume: 6
Pages: 5555
Publication
First Author: Pappu BP
Year: 2006
Journal: Eur J Immunol
Title: Potential role of CARMA1 in CD40-induced splenic B cell proliferation and marginal zone B cell maturation.
Volume: 36
Issue: 11
Pages: 3033-43
Publication
First Author: Blonska M
Year: 2012
Journal: J Immunol
Title: CARMA1 controls Th2 cell-specific cytokine expression through regulating JunB and GATA3 transcription factors.
Volume: 188
Issue: 7
Pages: 3160-8
Publication
First Author: Tanner MJ
Year: 2007
Journal: J Biol Chem
Title: CARMA1 coiled-coil domain is involved in the oligomerization and subcellular localization of CARMA1 and is required for T cell receptor-induced NF-kappaB activation.
Volume: 282
Issue: 23
Pages: 17141-7
Publication
First Author: Salisbury EM
Year: 2014
Journal: Immunology
Title: N-Ethyl-N-nitrosourea mutagenesis in the mouse provides strong genetic and in vivo evidence for the role of the Caspase Recruitment Domain (CARD) of CARD-MAGUK1 in T regulatory cell development.
Volume: 141
Issue: 3
Pages: 446-56
Publication
First Author: Rosenbaum M
Year: 2019
Journal: Nat Commun
Title: Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells.
Volume: 10
Issue: 1
Pages: 2352
Publication
First Author: Ramadas RA
Year: 2011
Journal: J Immunol
Title: CARMA1 is necessary for optimal T cell responses in a murine model of allergic asthma.
Volume: 187
Issue: 12
Pages: 6197-207
Publication
First Author: Perlee D
Year: 2020
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Caspase-11 contributes to pulmonary host defense against Klebsiella pneumoniae and local activation of coagulation.
Volume: 319
Issue: 1
Pages: L105-L114
Publication
First Author: Bidère N
Year: 2009
Journal: Nature
Title: Casein kinase 1alpha governs antigen-receptor-induced NF-kappaB activation and human lymphoma cell survival.
Volume: 458
Issue: 7234
Pages: 92-6
Publication
First Author: Lee AJ
Year: 2010
Journal: J Biol Chem
Title: CARMA1 regulation of regulatory T cell development involves modulation of interleukin-2 receptor signaling.
Volume: 285
Issue: 21
Pages: 15696-703
Publication
First Author: Rajasekaran K
Year: 2011
Journal: J Biol Chem
Title: Transforming growth factor-beta-activated kinase 1 regulates natural killer cell-mediated cytotoxicity and cytokine production.
Volume: 286
Issue: 36
Pages: 31213-24
Publication
First Author: Blonska M
Year: 2007
Journal: Immunity
Title: The CARMA1-Bcl10 signaling complex selectively regulates JNK2 kinase in the T cell receptor-signaling pathway.
Volume: 26
Issue: 1
Pages: 55-66
Publication
First Author: Moreno-García ME
Year: 2010
Journal: Mol Cell Biol
Title: MAGUK-controlled ubiquitination of CARMA1 modulates lymphocyte NF-kappaB activity.
Volume: 30
Issue: 4
Pages: 922-34
Publication
First Author: Kojo S
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Mechanisms of NKT cell anergy induction involve Cbl-b-promoted monoubiquitination of CARMA1.
Volume: 106
Issue: 42
Pages: 17847-51
Publication
First Author: Zhang JX
Year: 2008
Journal: PLoS One
Title: Relief of preintegration inhibition and characterization of additional blocks for HIV replication in primary mouse T cells.
Volume: 3
Issue: 4
Pages: e2035
Publication
First Author: Lin Q
Year: 2012
Journal: J Immunol
Title: Cutting edge: the "death" adaptor CRADD/RAIDD targets BCL10 and suppresses agonist-induced cytokine expression in T lymphocytes.
Volume: 188
Issue: 6
Pages: 2493-7
Publication
First Author: Molinero LL
Year: 2011
Journal: J Immunol
Title: High TCR stimuli prevent induced regulatory T cell differentiation in a NF-κB-dependent manner.
Volume: 186
Issue: 8
Pages: 4609-17
Publication
First Author: Blonska M
Year: 2013
Journal: Sci Signal
Title: Activation of the transcription factor c-Maf in T cells is dependent on the CARMA1-IKKβ signaling cascade.
Volume: 6
Issue: 306
Pages: ra110
Publication
First Author: Long M
Year: 2009
Journal: Immunity
Title: Nuclear factor-kappaB modulates regulatory T cell development by directly regulating expression of Foxp3 transcription factor.
Volume: 31
Issue: 6
Pages: 921-31
Publication
First Author: Altin JA
Year: 2012
Journal: J Immunol
Title: IL-10+ CTLA-4+ Th2 inhibitory cells form in a Foxp3-independent, IL-2-dependent manner from Th2 effectors during chronic inflammation.
Volume: 188
Issue: 11
Pages: 5478-88
Publication
First Author: Letendre K
Year: 2015
Journal: PLoS One
Title: Bringing statistics up to speed with data in analysis of lymphocyte motility.
Volume: 10
Issue: 5
Pages: e0126333
Publication
First Author: Medeiros RB
Year: 2007
Journal: Science
Title: Regulation of NF-kappaB activation in T cells via association of the adapter proteins ADAP and CARMA1.
Volume: 316
Issue: 5825
Pages: 754-8
Publication
First Author: Eitelhuber AC
Year: 2011
Journal: EMBO J
Title: Dephosphorylation of Carma1 by PP2A negatively regulates T-cell activation.
Volume: 30
Issue: 3
Pages: 594-605
Publication
First Author: Rajasekaran K
Year: 2013
Journal: Nat Immunol
Title: Signaling by Fyn-ADAP via the Carma1-Bcl-10-MAP3K7 signalosome exclusively regulates inflammatory cytokine production in NK cells.
Volume: 14
Issue: 11
Pages: 1127-36
Publication
First Author: So T
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Antigen-independent signalosome of CARMA1, PKCθ, and TNF receptor-associated factor 2 (TRAF2) determines NF-κB signaling in T cells.
Volume: 108
Issue: 7
Pages: 2903-8
Publication
First Author: Medoff BD
Year: 2006
Journal: J Immunol
Title: CARMA1 is critical for the development of allergic airway inflammation in a murine model of asthma.
Volume: 176
Issue: 12
Pages: 7272-7
Publication
First Author: Molinero LL
Year: 2009
Journal: J Immunol
Title: CARMA1 controls an early checkpoint in the thymic development of FoxP3+ regulatory T cells.
Volume: 182
Issue: 11
Pages: 6736-43
Publication
First Author: Molinero LL
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: T cell receptor/CARMA1/NF-κB signaling controls T-helper (Th) 17 differentiation.
Volume: 109
Issue: 45
Pages: 18529-34
Publication
First Author: Takeda K
Year: 2008
Journal: Int Immunol
Title: CD28 stimulation triggers NF-kappaB activation through the CARMA1-PKCtheta-Grb2/Gads axis.
Volume: 20
Issue: 12
Pages: 1507-15
Publication
First Author: Hamilton KS
Year: 2014
Journal: Sci Signal
Title: T cell receptor-dependent activation of mTOR signaling in T cells is mediated by Carma1 and MALT1, but not Bcl10.
Volume: 7
Issue: 329
Pages: ra55
Publication
First Author: Hara H
Year: 2007
Journal: Nat Immunol
Title: The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors.
Volume: 8
Issue: 6
Pages: 619-29
Publication
First Author: Shinohara H
Year: 2005
Journal: J Exp Med
Title: PKC beta regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1.
Volume: 202
Issue: 10
Pages: 1423-31
Publication
First Author: Qiao G
Year: 2008
Journal: Mol Cell Biol
Title: T-cell receptor-induced NF-kappaB activation is negatively regulated by E3 ubiquitin ligase Cbl-b.
Volume: 28
Issue: 7
Pages: 2470-80
Publication
First Author: Gross O
Year: 2008
Journal: Blood
Title: Multiple ITAM-coupled NK-cell receptors engage the Bcl10/Malt1 complex via Carma1 for NF-kappaB and MAPK activation to selectively control cytokine production.
Volume: 112
Issue: 6
Pages: 2421-8
Publication
First Author: Nakaya M
Year: 2014
Journal: Immunity
Title: Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation.
Volume: 40
Issue: 5
Pages: 692-705