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Search results 1 to 100 out of 156 for Card11

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
84433 | CARD11
Type: gene
Organism: human
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Gene
105948360 | card11
Type: gene
Organism: frog, western clawed
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Gene
489887 | CARD11
Type: gene
Organism: dog, domestic
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Gene
463235 | CARD11
Type: gene
Organism: chimpanzee
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Gene
515377 | CARD11
Type: gene
Organism: cattle
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Gene
100363332 | Card11
Type: gene
Organism: rat
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Gene
416476 | CARD11
Type: gene
Organism: chicken
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Gene
557072 | card11
Type: gene
Organism: zebrafish
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Gene
714728 | CARD11
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR033538 | CARD11
Type: Family
Description: The caspase recruitment domain (CARD) is a homotypic protein interaction module that participates in apoptosis signalling. This entry represents CARD11, which is a large multidomain scaffold protein that functions as upstream activator of NF-kappaB signalling []. It forms a CBM complex with BCL10 and MALT1. The CBM complex links AgR (antigen receptor) triggering to NF-kappaB activation []. Its activity is controlled by an Inhibitory Domain (ID) [].Mutations in the CARD11 gene cause B-cell expansion with NFKB and T-cell anergy (BENTA) []and Immunodeficiency 11 (IMD11) [].
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Protein Coding Gene
MGI:1916978 | Card11
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene
101927256 | CARD11-AS1
Type: gene
Organism: human
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Publication
23129749 | -
First Author: Snow AL
Year: 2012
Journal: J Exp Med
Title: Congenital B cell lymphocytosis explained by novel germline CARD11 mutations.
Volume: 209
Issue: 12
Pages: 2247-61
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Publication
- | J:198555
     
First Author: Beutler B
Year: 2013
Journal: MGI Direct Data Submission
Title: Direct data submission for a Card11 allele
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Publication
- | J:121682
     
First Author: Sproule TJ
Year: 2007
Journal: MGI Direct Data Submission
Title: Ploymorphism distinguishing Card11 mutant allele um-J
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Publication
12818158 | J:84036
First Author: Hara H
Year: 2003
Journal: Immunity
Title: The MAGUK family protein CARD11 is essential for lymphocyte activation.
Volume: 18
Issue: 6
Pages: 763-75
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Publication
11278692 | -
First Author: Bertin J
Year: 2001
Journal: J Biol Chem
Title: CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B.
Volume: 276
Issue: 15
Pages: 11877-82
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Publication
30127060 | J:266057
First Author: Wray-Dutra MN
Year: 2018
Journal: J Exp Med
Title: Activated CARD11 accelerates germinal center kinetics, promoting mTORC1 and terminal differentiation.
Volume: 215
Issue: 9
Pages: 2445-2461
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Publication
12356734 | J:84961
First Author: Pomerantz JL
Year: 2002
Journal: EMBO J
Title: CARD11 mediates factor-specific activation of NF-kappaB by the T cell receptor complex.
Volume: 21
Issue: 19
Pages: 5184-94
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Publication
31784498 | J:292926
 
First Author: Wei Z
Year: 2019
Journal: Sci Immunol
Title: Pathogenic CARD11 mutations affect B cell development and differentiation through a noncanonical pathway.
Volume: 4
Issue: 41
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Publication
36446869 | J:331703
First Author: Kameda T
Year: 2022
Journal: Commun Biol
Title: CARD11 mutation and HBZ expression induce lymphoproliferative disease and adult T-cell leukemia/lymphoma.
Volume: 5
Issue: 1
Pages: 1309
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Publication
36960072 | J:342748
 
First Author: Masle-Farquhar E
Year: 2023
Journal: Front Immunol
Title: CARD11 gain-of-function mutation drives cell-autonomous accumulation of PD-1(+) ICOS(high) activated T cells, T-follicular, T-regulatory and T-follicular regulatory cells.
Volume: 14
Pages: 1095257
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Publication
23027925 | J:190942
First Author: Jeelall YS
Year: 2012
Journal: J Exp Med
Title: Human lymphoma mutations reveal CARD11 as the switch between self-antigen-induced B cell death or proliferation and autoantibody production.
Volume: 209
Issue: 11
Pages: 1907-17
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Publication
26884334 | J:233726
First Author: Jattani RP
Year: 2016
Journal: J Biol Chem
Title: Intramolecular Interactions and Regulation of Cofactor Binding by the Four Repressive Elements in the Caspase Recruitment Domain-containing Protein 11 (CARD11) Inhibitory Domain.
Volume: 291
Issue: 16
Pages: 8338-48
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Publication
23374270 | -
First Author: Stepensky P
Year: 2013
Journal: J Allergy Clin Immunol
Title: Deficiency of caspase recruitment domain family, member 11 (CARD11), causes profound combined immunodeficiency in human subjects.
Volume: 131
Issue: 2
Pages: 477-85.e1
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Publication
18625728 | J:140363
First Author: McCully RR
Year: 2008
Journal: Mol Cell Biol
Title: The protein kinase C-responsive inhibitory domain of CARD11 functions in NF-kappaB activation to regulate the association of multiple signaling cofactors that differentially depend on Bcl10 and MALT1 for association.
Volume: 28
Issue: 18
Pages: 5668-86
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Publication
25087226 | -
First Author: Turvey SE
Year: 2014
Journal: J Allergy Clin Immunol
Title: The CARD11-BCL10-MALT1 (CBM) signalosome complex: Stepping into the limelight of human primary immunodeficiency.
Volume: 134
Issue: 2
Pages: 276-84
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Protein
Q8BVX8
Organism: Mus musculus/domesticus
Length: 278  
Fragment?: false
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Protein
Q8CIS0
Organism: Mus musculus/domesticus
Length: 1159  
Fragment?: false
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Publication
34341167 | J:318699
First Author: Hutcherson SM
Year: 2021
Journal: J Immunol
Title: Pathway-Specific Defects in T, B, and NK Cells and Age-Dependent Development of High IgE in Mice Heterozygous for a CADINS-Associated Dominant Negative CARD11 Allele.
Volume: 207
Issue: 4
Pages: 1150-1164
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Publication
- | J:139069
     
First Author: Barnes MJ
Year: 2008
Journal: MGI Direct Data Submission
Title: Record for "king"
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Publication
28362433 | J:268799
First Author: Hu DY
Year: 2017
Journal: Cell Death Differ
Title: IL-2 prevents deletion of developing T-regulatory cells in the thymus.
Volume: 24
Issue: 6
Pages: 1007-1016
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Publication
19260764 | J:149767
First Author: Barnes MJ
Year: 2009
Journal: PLoS Biol
Title: Commitment to the regulatory T cell lineage requires CARMA1 in the thymus but not in the periphery.
Volume: 7
Issue: 3
Pages: e51
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Publication
12867038 | J:89322
First Author: Egawa T
Year: 2003
Journal: Curr Biol
Title: Requirement for CARMA1 in antigen receptor-induced NF-kappa B activation and lymphocyte proliferation.
Volume: 13
Issue: 14
Pages: 1252-8
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Publication
31138793 | J:278509
First Author: Rosenbaum M
Year: 2019
Journal: Nat Commun
Title: Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells.
Volume: 10
Issue: 1
Pages: 2352
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Protein Coding Gene
MGP_CAROLIEiJ_G0027957 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0030308 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0030277 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0030209 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0030294 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0030005 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1916978 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0030739 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0029410 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0029975 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0030125 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0030080 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0030211 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0030111 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0030779 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0029125 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0029484 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0024529 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0028961 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
12154356 | J:304570
First Author: Wang D
Year: 2002
Journal: Nat Immunol
Title: A requirement for CARMA1 in TCR-induced NF-kappa B activation.
Volume: 3
Issue: 9
Pages: 830-5
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Publication
16356855 | J:113308
First Author: Sommer K
Year: 2005
Journal: Immunity
Title: Phosphorylation of the CARMA1 linker controls NF-kappaB activation.
Volume: 23
Issue: 6
Pages: 561-74
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Publication
15520247 | J:94910
First Author: Hara H
Year: 2004
Journal: J Exp Med
Title: The molecular adapter Carma1 controls entry of IkappaB kinase into the central immune synapse.
Volume: 200
Issue: 9
Pages: 1167-77
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Publication
22371397 | J:183102
First Author: Blonska M
Year: 2012
Journal: J Immunol
Title: CARMA1 controls Th2 cell-specific cytokine expression through regulating JunB and GATA3 transcription factors.
Volume: 188
Issue: 7
Pages: 3160-8
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Publication
17048267 | J:117002
First Author: Pappu BP
Year: 2006
Journal: Eur J Immunol
Title: Potential role of CARMA1 in CD40-induced splenic B cell proliferation and marginal zone B cell maturation.
Volume: 36
Issue: 11
Pages: 3033-43
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Publication
25602919 | J:219718
 
First Author: Hara H
Year: 2015
Journal: Nat Commun
Title: Clustering of CARMA1 through SH3-GUK domain interactions is required for its activation of NF-κB signalling.
Volume: 6
Pages: 5555
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Publication
19130560 | J:143725
First Author: Medoff BD
Year: 2009
Journal: Eur J Immunol
Title: Differential requirement for CARMA1 in agonist-selected T-cell development.
Volume: 39
Issue: 1
Pages: 78-84
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Publication
12818157 | J:84042
First Author: Jun JE
Year: 2003
Journal: Immunity
Title: Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis.
Volume: 18
Issue: 6
Pages: 751-62
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Publication
- | J:254856
     
First Author: Zhong X
Year: 2018
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for Dealer
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Publication
- | J:254879
     
First Author: Zhong X
Year: 2018
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for Tumnus
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Publication
12867037 | J:95800
First Author: Newton K
Year: 2003
Journal: Curr Biol
Title: Mice lacking the CARD of CARMA1 exhibit defective B lymphocyte development and impaired proliferation of their B and T lymphocytes.
Volume: 13
Issue: 14
Pages: 1247-51
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Publication
- | J:221487
     
First Author: Zeng M
Year: 2015
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for hubei
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Publication
- | J:272116
     
First Author: Zhong X
Year: 2019
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for Sharp.
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Publication
- | J:274940
     
First Author: Choi JH
Year: 2019
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for unmodulated2.
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Publication
- | J:274762
     
First Author: Zhong X
Year: 2019
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for Caravaggio.
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Publication
17428801 | J:122770
First Author: Tanner MJ
Year: 2007
Journal: J Biol Chem
Title: CARMA1 coiled-coil domain is involved in the oligomerization and subcellular localization of CARMA1 and is required for T cell receptor-induced NF-kappaB activation.
Volume: 282
Issue: 23
Pages: 17141-7
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Publication
24383645 | J:250950
First Author: Salisbury EM
Year: 2014
Journal: Immunology
Title: N-Ethyl-N-nitrosourea mutagenesis in the mouse provides strong genetic and in vivo evidence for the role of the Caspase Recruitment Domain (CARD) of CARD-MAGUK1 in T regulatory cell development.
Volume: 141
Issue: 3
Pages: 446-56
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Publication
32401674 | J:298166
First Author: Perlee D
Year: 2020
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Caspase-11 contributes to pulmonary host defense against Klebsiella pneumoniae and local activation of coagulation.
Volume: 319
Issue: 1
Pages: L105-L114
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Publication
22075698 | J:180410
First Author: Ramadas RA
Year: 2011
Journal: J Immunol
Title: CARMA1 is necessary for optimal T cell responses in a murine model of allergic asthma.
Volume: 187
Issue: 12
Pages: 6197-207
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Publication
19118383 | J:146202
First Author: Bidère N
Year: 2009
Journal: Nature
Title: Casein kinase 1alpha governs antigen-receptor-induced NF-kappaB activation and human lymphoma cell survival.
Volume: 458
Issue: 7234
Pages: 92-6
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Publication
21771792 | J:176611
First Author: Rajasekaran K
Year: 2011
Journal: J Biol Chem
Title: Transforming growth factor-beta-activated kinase 1 regulates natural killer cell-mediated cytotoxicity and cytokine production.
Volume: 286
Issue: 36
Pages: 31213-24
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Publication
20233721 | J:163899
First Author: Lee AJ
Year: 2010
Journal: J Biol Chem
Title: CARMA1 regulation of regulatory T cell development involves modulation of interleukin-2 receptor signaling.
Volume: 285
Issue: 21
Pages: 15696-703
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Publication
17189706 | J:118202
First Author: Blonska M
Year: 2007
Journal: Immunity
Title: The CARMA1-Bcl10 signaling complex selectively regulates JNK2 kinase in the T cell receptor-signaling pathway.
Volume: 26
Issue: 1
Pages: 55-66
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Publication
20008554 | J:160499
First Author: Moreno-García ME
Year: 2010
Journal: Mol Cell Biol
Title: MAGUK-controlled ubiquitination of CARMA1 modulates lymphocyte NF-kappaB activity.
Volume: 30
Issue: 4
Pages: 922-34
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Publication
19815501 | J:153751
First Author: Kojo S
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Mechanisms of NKT cell anergy induction involve Cbl-b-promoted monoubiquitination of CARMA1.
Volume: 106
Issue: 42
Pages: 17847-51
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Publication
25648675 | J:360992
First Author: Barnes SE
Year: 2015
Journal: J Immunother Cancer
Title: T cell-NF-κB activation is required for tumor control in vivo.
Volume: 3
Issue: 1
Pages: 1
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Publication
24345681 | J:259782
First Author: Blonska M
Year: 2013
Journal: Sci Signal
Title: Activation of the transcription factor c-Maf in T cells is dependent on the CARMA1-IKKβ signaling cascade.
Volume: 6
Issue: 306
Pages: ra110
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Publication
22547705 | J:188722
First Author: Altin JA
Year: 2012
Journal: J Immunol
Title: IL-10+ CTLA-4+ Th2 inhibitory cells form in a Foxp3-independent, IL-2-dependent manner from Th2 effectors during chronic inflammation.
Volume: 188
Issue: 11
Pages: 5478-88
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Publication
25973755 | J:235323
First Author: Letendre K
Year: 2015
Journal: PLoS One
Title: Bringing statistics up to speed with data in analysis of lymphocyte motility.
Volume: 10
Issue: 5
Pages: e0126333
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Publication
18446227 | J:134637
First Author: Zhang JX
Year: 2008
Journal: PLoS One
Title: Relief of preintegration inhibition and characterization of additional blocks for HIV replication in primary mouse T cells.
Volume: 3
Issue: 4
Pages: e2035
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Publication
20064449 | J:156178
First Author: Long M
Year: 2009
Journal: Immunity
Title: Nuclear factor-kappaB modulates regulatory T cell development by directly regulating expression of Foxp3 transcription factor.
Volume: 31
Issue: 6
Pages: 921-31
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Publication
22323537 | J:181859
First Author: Lin Q
Year: 2012
Journal: J Immunol
Title: Cutting edge: the "death" adaptor CRADD/RAIDD targets BCL10 and suppresses agonist-induced cytokine expression in T lymphocytes.
Volume: 188
Issue: 6
Pages: 2493-7
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Publication
17478723 | J:121348
First Author: Medeiros RB
Year: 2007
Journal: Science
Title: Regulation of NF-kappaB activation in T cells via association of the adapter proteins ADAP and CARMA1.
Volume: 316
Issue: 5825
Pages: 754-8
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Publication
21157432 | J:169250
First Author: Eitelhuber AC
Year: 2011
Journal: EMBO J
Title: Dephosphorylation of Carma1 by PP2A negatively regulates T-cell activation.
Volume: 30
Issue: 3
Pages: 594-605
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Publication
24036998 | J:208208
First Author: Rajasekaran K
Year: 2013
Journal: Nat Immunol
Title: Signaling by Fyn-ADAP via the Carma1-Bcl-10-MAP3K7 signalosome exclusively regulates inflammatory cytokine production in NK cells.
Volume: 14
Issue: 11
Pages: 1127-36
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Publication
21282629 | J:169068
First Author: So T
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Antigen-independent signalosome of CARMA1, PKCθ, and TNF receptor-associated factor 2 (TRAF2) determines NF-κB signaling in T cells.
Volume: 108
Issue: 7
Pages: 2903-8
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Publication
23091043 | J:191230
First Author: Molinero LL
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: T cell receptor/CARMA1/NF-κB signaling controls T-helper (Th) 17 differentiation.
Volume: 109
Issue: 45
Pages: 18529-34
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Publication
21411734 | J:172516
First Author: Molinero LL
Year: 2011
Journal: J Immunol
Title: High TCR stimuli prevent induced regulatory T cell differentiation in a NF-κB-dependent manner.
Volume: 186
Issue: 8
Pages: 4609-17
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Publication
19454668 | J:148869
First Author: Molinero LL
Year: 2009
Journal: J Immunol
Title: CARMA1 controls an early checkpoint in the thymic development of FoxP3+ regulatory T cells.
Volume: 182
Issue: 11
Pages: 6736-43
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Publication
16751370 | J:132226
First Author: Medoff BD
Year: 2006
Journal: J Immunol
Title: CARMA1 is critical for the development of allergic airway inflammation in a murine model of asthma.
Volume: 176
Issue: 12
Pages: 7272-7
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Publication
18829987 | J:143461
First Author: Takeda K
Year: 2008
Journal: Int Immunol
Title: CD28 stimulation triggers NF-kappaB activation through the CARMA1-PKCtheta-Grb2/Gads axis.
Volume: 20
Issue: 12
Pages: 1507-15
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Publication
24917592 | J:259187
First Author: Hamilton KS
Year: 2014
Journal: Sci Signal
Title: T cell receptor-dependent activation of mTOR signaling in T cells is mediated by Carma1 and MALT1, but not Bcl10.
Volume: 7
Issue: 329
Pages: ra55
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Publication
17486093 | J:122394
First Author: Hara H
Year: 2007
Journal: Nat Immunol
Title: The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors.
Volume: 8
Issue: 6
Pages: 619-29
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Publication
16301747 | J:118843
First Author: Shinohara H
Year: 2005
Journal: J Exp Med
Title: PKC beta regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1.
Volume: 202
Issue: 10
Pages: 1423-31
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Publication
18227156 | J:134206
First Author: Qiao G
Year: 2008
Journal: Mol Cell Biol
Title: T-cell receptor-induced NF-kappaB activation is negatively regulated by E3 ubiquitin ligase Cbl-b.
Volume: 28
Issue: 7
Pages: 2470-80
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Publication
20668237 | J:163595
First Author: Teh CE
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: T-cell regulation by casitas B-lineage lymphoma (Cblb) is a critical failsafe against autoimmune disease due to autoimmune regulator (Aire) deficiency.
Volume: 107
Issue: 33
Pages: 14709-14
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom