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Search results 1 to 18 out of 18 for Casc1

0.018s

Type

Details

Score

Publication

16862160 | J:111629

First Author:	Liu P
Year:	2006
Journal:	Nat Genet
Title:	Candidate lung tumor susceptibility genes identified through whole-genome association analyses in inbred mice.
Volume:	38
Issue:	8
Pages:	888-95

•

Protein

Q6TDU8

Organism:	Mus musculus/domesticus
Length:	730
Fragment?:	false

•

Protein Coding Gene

MGI:2444480 | Dnai7

Type:	protein_coding_gene
Organism:	mouse, laboratory

•

Protein

Q6TDU8-3

Organism:	Mus musculus/domesticus
Length:	153
Fragment?:	false

•

Protein

Q6TDU8-2

Organism:	Mus musculus/domesticus
Length:	679
Fragment?:	false

•

Allele

Dnai7<Gt(VICTR21)709Lex> | MGI:3664581

Name:	dynein axonemal intermediate chain 7; gene trap 709, Lexicon Genetics
Allele Type:	Gene trapped
Attribute String:	Null/knockout

•

Protein Domain

IPR023247 | IC97/Dnai7-like

Type:

Family

Description:

Dynein-f, also known as dynein I1, is an inner-arm dynein complex comprising two different heavy chains together with a number of intermediate and light chains. In Chlamydomonas, IC97 is the intermediate chain of the Dynein-f complex. This entry includes IC97 () and its homologues, including CASC1 (also known as Dnai7) from humans []. The CAncer Susceptibility Candidate 1 (CASC1) gene is expressed in lung tissues, and is a strong candidate for the pulmonary adenoma susceptibility 1 (Pas1) locus, the major determinant of strain variation in lung tumour susceptibility []. There appears to be a strong correlation between functional polymorphism of CASC1 and lung tumour suspectibility in mice [].Different mouse strains fall into two genotype groups (susceptible and intermediate) according to differences in the 60th codon of the CASC1 gene []. The mouse CASC1 gene shares 81% similarity with the human equivalent; the role of CASC1 in human lung-cancer risk may nevertheless differ from that in mice [, ].

•

Protein Domain

IPR022110 | CASC1_C

Type:

Domain

Description:

This domain can be found at the C terminus of CASC1.The CAncer Susceptibility Candidate 1 (CASC1) gene is expressed in lung tissues, and is a strong candidate for the pulmonary adenoma susceptibility 1 (Pas1) locus, the major determinant of strain variation in lung tumour susceptibility []. There appears to be a strong correlation between functional polymorphism of CASC1 and lung tumour suspectibility in mice [].Different mouse strains fall into two genotype groups (susceptible and intermediate) according to differences in the 60th codon of the CASC1 gene []. The mouse CASC1 gene shares 81% similarity with the human equivalent; the role of CASC1 in human lung-cancer risk may nevertheless differ from that in mice [, ].

•

Publication

30060180 | J:289069

First Author:	Zhang Y
Year:	2019
Journal:	J Mol Cell Biol
Title:	Vertebrate Dynein-f depends on Wdr78 for axonemal localization and is essential for ciliary beat.
Volume:	11
Issue:	5
Pages:	383-394

•

Protein

A0A0N4SUQ9

Organism:	Mus musculus/domesticus
Length:	644
Fragment?:	false

•

Protein

A0A0R4J1G3

Organism:	Mus musculus/domesticus
Length:	679
Fragment?:	false

•

Protein

A0A0R4J0S9

Organism:	Mus musculus/domesticus
Length:	730
Fragment?:	false

•

Protein Domain

IPR031826 | IC97/Casc1_N

Type:

Domain

Description:

This domain is found in CASC1 (cancer susceptibility candidate gene 1 protein) from humans and IC97 from Chlamydomonas []. There are two completely conserved residues (N and W) that may be functionally important.Dynein-f, also known as dynein I1, is an inner-arm dynein complex comprising two different heavy chains together with a number of intermediate and light chains. In Chlamydomonas, IC97 is the intermediate chain of the Dynein-f complex. This entry includes IC97 () and its homologues, including CASC1 (also known as Dnai7) from humans []. The CAncer Susceptibility Candidate 1 (CASC1) gene is expressed in lung tissues, and is a strong candidate for the pulmonary adenoma susceptibility 1 (Pas1) locus, the major determinant of strain variation in lung tumour susceptibility []. There appears to be a strong correlation between functional polymorphism of CASC1 and lung tumour suspectibility in mice [].Different mouse strains fall into two genotype groups (susceptible and intermediate) according to differences in the 60th codon of the CASC1 gene []. The mouse CASC1 gene shares 81% similarity with the human equivalent; the role of CASC1 in human lung-cancer risk may nevertheless differ from that in mice [, ].

•

Publication

14583591 | J:86399

First Author:	Zhang Z
Year:	2003
Journal:	Proc Natl Acad Sci U S A
Title:	Positional cloning of the major quantitative trait locus underlying lung tumor susceptibility in mice.
Volume:	100
Issue:	22
Pages:	12642-7

•

Publication

16410263 | -

First Author:	Manenti G
Year:	2006
Journal:	Carcinogenesis
Title:	A V141L polymorphism of the human LRMP gene is associated with survival of lung cancer patients.
Volume:	27
Issue:	7
Pages:	1386-90

•

Genotype

Symbol:	Dnai7/Dnai7
Background:	involves: 129S5/SvEvBrd
Zygosity:	hm
Has Mutant Allele:	true

•

Genotype

Symbol:	Dnai7/Dnai7<+>
Background:	involves: 129S5/SvEvBrd
Zygosity:	ht
Has Mutant Allele:	true

•

Publication

16458428 | J:108212

First Author:	Galbiati F
Year:	2006
Journal:	Cancer Lett
Title:	Allelic effects of mouse Pas1 candidate genes in human lung cancer cell lines.
Volume:	244
Issue:	2
Pages:	176-81

•

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