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Search results 1 to 100 out of 5063 for Casp3

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: hamster, golden
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
GXD Expression
Probe: MGI:6489361
Assay Type: Immunohistochemistry
Annotation Date: 2020-12-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3557822
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:6489368
Age: embryonic day 14.5
Image: 3E Casp3
Note: Authors report apoptosis in myogenic cells.
Specimen Label: 3E Casp3
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:7448595
Assay Type: Immunohistochemistry
Annotation Date: 2023-03-30
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:3284223
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:7448697
Age: embryonic day 15.5
Image: 5A Casp3 Neocortex CNS-ctr
Note: Expression in control was not described.
Specimen Label: 5A Casp3 Neocortex CNS-ctr
Specimen Num: 1
GXD Expression  
Probe: MGI:7448595
Assay Type: Immunohistochemistry
Annotation Date: 2023-03-30
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3284223
Stage: TS23
Assay Id: MGI:7448697
Age: embryonic day 15.5
Image: 5A Casp3 Neocortex CNS-del
Note: No cell death reported in cortex at E15.5
Specimen Label: 5A Casp3 Neocortex CNS-del
Detected: false
Specimen Num: 2
GXD Expression  
Probe: MGI:6285223
Assay Type: Immunohistochemistry
Annotation Date: 2023-11-10
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1754423
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:7547342
Age: embryonic day 15.5
Image: 4D CASP3 Cenpj+/+
Note: Expression in wild type not reported.
Specimen Label: 4D CASP3 Cenpj+/+
Specimen Num: 1
GXD Expression  
Probe: MGI:6285223
Assay Type: Immunohistochemistry
Annotation Date: 2023-11-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754423
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:7547342
Age: embryonic day 15.5
Image: 4D CASP3 CenpjCKO
Specimen Label: 4D CASP3 CenpjCKO
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:2674976
Assay Type: Immunohistochemistry
Annotation Date: 2022-07-13
Strength: Trace
Sex: Not Specified
Emaps: EMAPS:1603917
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:7311707
Age: embryonic day 10.5
Image: S5B Casp3 WT (left)
Specimen Label: S5B Casp3 WT (left)
Detected: true
Specimen Num: 10
GXD Expression  
Probe: MGI:2674976
Assay Type: Immunohistochemistry
Annotation Date: 2022-07-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1603917
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:7311707
Age: embryonic day 10.5
Image: S5B Casp3 WT (right)
Note: Expression in specimen not described.
Specimen Label: S5B Casp3 WT (right)
Specimen Num: 11
GXD Expression  
Probe: MGI:2674976
Assay Type: Immunohistochemistry
Annotation Date: 2022-07-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:7311707
Age: embryonic day 10.5
Image: S5B Casp3 Ptch KO
Specimen Label: S5B Casp3 Ptch KO
Detected: true
Specimen Num: 12
GXD Expression  
Probe: MGI:3820972
Assay Type: RNA in situ
Annotation Date: 2009-01-15
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3564922
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3826201
Age: embryonic day 14.5
Image: Additional file 4 Casp3
Specimen Label: Additional file 4 Casp3
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:2674976
Assay Type: Immunohistochemistry
Annotation Date: 2022-07-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:7311707
Age: embryonic day 10.5
Image: S5B Casp3 Trp53 KO (left)
Specimen Label: S5B Casp3 Trp53 KO (left)
Detected: true
Specimen Num: 15
GXD Expression  
Probe: MGI:7448595
Assay Type: Immunohistochemistry
Annotation Date: 2023-03-30
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1755020
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:7448697
Age: embryonic day 12.5
Image: 5A Casp3 Medulla oblongata CNS-ctr
Note: Expression in control was not described.
Specimen Label: 5A Casp3 Medulla oblongata CNS-ctr
Specimen Num: 3
GXD Expression
Probe: MGI:7448595
Assay Type: Immunohistochemistry
Annotation Date: 2023-03-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1755020
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:7448697
Age: embryonic day 12.5
Image: 5A Casp3 Medulla oblongata CNS-del
Note: Authors report expression in pyknotic cells with fragmented nuclei.
Specimen Label: 5A Casp3 Medulla oblongata CNS-del
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:2674976
Assay Type: Immunohistochemistry
Annotation Date: 2022-07-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:7311707
Age: embryonic day 10.5
Image: S5B Casp3 Trp53 Het (left)
Specimen Label: S5B Casp3 Trp53 Het (left)
Detected: true
Specimen Num: 13
GXD Expression  
Probe: MGI:2674976
Assay Type: Immunohistochemistry
Annotation Date: 2022-07-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:7311707
Age: embryonic day 10.5
Image: S5B Casp3 Trp53 Het (right)
Specimen Label: S5B Casp3 Trp53 Het (right)
Detected: true
Specimen Num: 14
GXD Expression  
Probe: MGI:2674976
Assay Type: Immunohistochemistry
Annotation Date: 2022-07-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:7311707
Age: embryonic day 10.5
Image: S5B Casp3 Trp53 KO (right)
Specimen Label: S5B Casp3 Trp53 KO (right)
Detected: true
Specimen Num: 16
GXD Expression      
Probe: MGI:6285223
Assay Type: Immunohistochemistry
Annotation Date: 2023-08-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3284221
Stage: TS21
Assay Id: MGI:7520514
Age: embryonic day 12.5
Specimen Label: 3A Casp3 Control
Detected: false
Specimen Num: 9
GXD Expression  
Probe: MGI:6285223
Assay Type: Immunohistochemistry
Annotation Date: 2023-08-25
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3284220
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:7520514
Age: embryonic day 12.5
Note: Regions with no or limitied apoptosis.
Specimen Label: 3A Casp3 DKO
Detected: true
Specimen Num: 10
GXD Expression  
Probe: MGI:2674976
Assay Type: Immunohistochemistry
Annotation Date: 2018-05-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3187626
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:6154912
Age: embryonic day 18.5
Note: Authors report expression indicating apoptosis in the spongiotrophoblast layer.
Specimen Label: 4C Cleaved Casp3
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3611930
Assay Type: Immunohistochemistry
Annotation Date: 2020-12-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1666820
Pattern: Single cells
Stage: TS20
Assay Id: MGI:6488056
Age: embryonic day 12.0
Note: Quantification of Casp3 activation and apoptosis.
Specimen Label: Table 1 E12 +/+
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3611930
Assay Type: Immunohistochemistry
Annotation Date: 2020-12-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1666820
Pattern: Single cells
Stage: TS20
Assay Id: MGI:6488056
Age: embryonic day 12.0
Note: Quantification of Casp3 activation and apoptosis.
Specimen Label: Table 1E12 +/-
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6169022
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6189917
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Casp3
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6169022
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6189917
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Casp3
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6169022
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6189917
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Casp3
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6169022
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6189917
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Casp3
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6169022
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189917
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Casp3
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6169022
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189917
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Casp3
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6169022
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189917
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Casp3
Detected: true
Specimen Num: 7
GXD Expression
Probe: MGI:2674976
Assay Type: Immunohistochemistry
Annotation Date: 2023-08-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1616413
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:7514664
Age: embryonic day 8.5
Image: 3B Tip55 Neural Tube
Note: Cleaved Casp3 staining was significantly elevated in neural tube of the mutant.
Specimen Label: 3B Tip55 Neural Tube
Detected: true
Specimen Num: 4
GXD Expression
Probe: MGI:2674976
Assay Type: Immunohistochemistry
Annotation Date: 2022-06-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1771322
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:7286342
Age: embryonic day 14.5
Image: 3E 11Prom-Cre; Sox9
Note: Significant apoptosis associated with the expression of cleaved Casp3 was detected in the zone of terminally mature chondrocytes.
Specimen Label: 3E 11Prom-Cre; Sox9
Detected: true
Specimen Num: 4
GXD Expression
Probe: MGI:2674976
Assay Type: Immunohistochemistry
Annotation Date: 2022-06-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1771321
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:7286342
Age: embryonic day 13.5
Image: 1E 11Enh-Cre; Sox9
Note: Cleaved Casp3 was detected in chondrocytes in the epiphyseal region in the disorganized cartilage in the humerus of the conditional mutant.
Specimen Label: 1E 11Enh-Cre; Sox9
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:6400551
Assay Type: Immunohistochemistry
Annotation Date: 2020-03-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284220
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:6400589
Age: embryonic day 12.5
Image: 6D
Note: Immunofluorescence with cleaved Casp3 was used to mark apoptotic cells. TUNEL-positive cells marked cells in late stages of apoptosis. Of the cleaved Casp3+/TUNEL- cells in the E12 mutant pallium, 38% were also EdU+.
Specimen Label: 6D
Detected: true
Specimen Num: 7
Publication
First Author: Armstrong PA
Year: 2015
Journal: Exp Brain Res
Title: Preserved otolith organ function in caspase-3-deficient mice with impaired horizontal semicircular canal function.
Volume: 233
Issue: 6
Pages: 1825-35
UniProt Feature
Begin: 105
Description: Cleavage; by CASP3
Type: site
End: 106
UniProt Feature
Begin: 88
Description: Cleavage; by CASP3
Type: site
End: 89
UniProt Feature
Begin: 457
Description: Cleavage; by CASP3
Type: site
End: 458
UniProt Feature
Begin: 493
Description: Cleavage; by CASP3
Type: site
End: 494
UniProt Feature
Begin: 445
Description: Cleavage; by CASP3
Type: site
End: 446
UniProt Feature
Begin: 63
Description: Cleavage; by CASP3
Type: site
End: 64
UniProt Feature
Begin: 405
Description: Cleavage; by CASP3
Type: site
End: 406
UniProt Feature
Begin: 307
Description: Cleavage; by CASP3
Type: site
End: 308
UniProt Feature
Begin: 125
Description: Cleavage; by CASP3
Type: site
End: 126
UniProt Feature
Begin: 121
Description: Cleavage; by CASP3
Type: site
End: 122
UniProt Feature
Begin: 94
Description: Cleavage; by CASP3
Type: site
End: 95
UniProt Feature
Begin: 1023
Description: Cleavage; by CASP3
Type: site
End: 1024
Publication
First Author: Yamaguchi Y
Year: 2011
Journal: J Cell Biol
Title: Live imaging of apoptosis in a novel transgenic mouse highlights its role in neural tube closure.
Volume: 195
Issue: 6
Pages: 1047-60
Publication
First Author: Nagasaka A
Year: 2010
Journal: Cell Death Differ
Title: Apaf-1-independent programmed cell death in mouse development.
Volume: 17
Issue: 6
Pages: 931-41
Publication
First Author: Ohsawa S
Year: 2008
Journal: Cell Death Differ
Title: Caspase-mediated changes in histone H1 in early apoptosis: prolonged caspase activation in developing olfactory sensory neurons.
Volume: 15
Issue: 9
Pages: 1429-39
Publication    
First Author: Fogel JL
Year: 2017
Journal: Elife
Title: A minimally sufficient model for rib proximal-distal patterning based on genetic analysis and agent-based simulations.
Volume: 6
Publication
First Author: Ohsawa S
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Maturation of the olfactory sensory neurons by Apaf-1/caspase-9-mediated caspase activity.
Volume: 107
Issue: 30
Pages: 13366-71
Publication
First Author: Nonomura K
Year: 2013
Journal: Dev Cell
Title: Local apoptosis modulates early mammalian brain development through the elimination of morphogen-producing cells.
Volume: 27
Issue: 6
Pages: 621-34
Publication
First Author: Puga I
Year: 2008
Journal: Immunity
Title: Targeted cleavage of signaling proteins by caspase 3 inhibits T cell receptor signaling in anergic T cells.
Volume: 29
Issue: 2
Pages: 193-204
Publication
First Author: Wang YJ
Year: 2020
Journal: Cell Rep
Title: Restoration of Cingulate Long-Term Depression by Enhancing Non-apoptotic Caspase 3 Alleviates Peripheral Pain Hypersensitivity.
Volume: 33
Issue: 6
Pages: 108369
Publication
First Author: Fujita J
Year: 2008
Journal: Cell Stem Cell
Title: Caspase activity mediates the differentiation of embryonic stem cells.
Volume: 2
Issue: 6
Pages: 595-601
Publication
First Author: Rongvaux A
Year: 2014
Journal: Cell
Title: Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA.
Volume: 159
Issue: 7
Pages: 1563-77
Publication
First Author: Cecconi F
Year: 1998
Journal: Cell
Title: Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development.
Volume: 94
Issue: 6
Pages: 727-37
Publication  
First Author: Awazu M
Year: 2021
Journal: Biochem Biophys Res Commun
Title: Caspase-3 regulates ureteric branching in mice via cell migration.
Volume: 559
Pages: 28-34
Publication
First Author: Kuida K
Year: 1998
Journal: Cell
Title: Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9.
Volume: 94
Issue: 3
Pages: 325-37
Publication
First Author: Hertz NT
Year: 2019
Journal: Neuron
Title: Neuronally Enriched RUFY3 Is Required for Caspase-Mediated Axon Degeneration.
Volume: 103
Issue: 3
Pages: 412-422.e4
Publication
First Author: Sohn EJ
Year: 2010
Journal: Cancer Res
Title: EWS/FLI1 oncogene activates caspase 3 transcription and triggers apoptosis in vivo.
Volume: 70
Issue: 3
Pages: 1154-63
Publication
First Author: Liadis N
Year: 2005
Journal: Mol Cell Biol
Title: Caspase-3-dependent beta-cell apoptosis in the initiation of autoimmune diabetes mellitus.
Volume: 25
Issue: 9
Pages: 3620-9
Publication
First Author: Suzuki T
Year: 2020
Journal: Cell Tissue Res
Title: Immune-associated renal disease found in caspase 3-deficient mice.
Volume: 379
Issue: 2
Pages: 323-335
Publication
First Author: Thapaliya S
Year: 2014
Journal: Dig Dis Sci
Title: Caspase 3 inactivation protects against hepatic cell death and ameliorates fibrogenesis in a diet-induced NASH model.
Volume: 59
Issue: 6
Pages: 1197-206
Publication
First Author: Oppenheim RW
Year: 2008
Journal: J Neurosci
Title: Developing postmitotic mammalian neurons in vivo lacking Apaf-1 undergo programmed cell death by a caspase-independent, nonapoptotic pathway involving autophagy.
Volume: 28
Issue: 6
Pages: 1490-7
Publication
First Author: Massa V
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Apoptosis is not required for mammalian neural tube closure.
Volume: 106
Issue: 20
Pages: 8233-8
Publication
First Author: Kyathanahalli C
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Uterine endoplasmic reticulum stress-unfolded protein response regulation of gestational length is caspase-3 and -7-dependent.
Volume: 112
Issue: 45
Pages: 14090-5
Publication
First Author: Kuo WT
Year: 2019
Journal: Gastroenterology
Title: Inflammation-induced Occludin Downregulation Limits Epithelial Apoptosis by Suppressing Caspase-3 Expression.
Volume: 157
Issue: 5
Pages: 1323-1337
Publication
First Author: Yu Z
Year: 2018
Journal: J Int Med Res
Title: Lens-specific deletion of the Msx2 gene increased apoptosis by enhancing the caspase-3/caspase-8 signaling pathway.
Volume: 46
Issue: 7
Pages: 2843-2855
Publication
First Author: Wang Y
Year: 2017
Journal: Nature
Title: Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin.
Volume: 547
Issue: 7661
Pages: 99-103
UniProt Feature
Begin: 52
Description: Cleavage; by CASP3 and CASP7
Type: site
End: 53
UniProt Feature
Begin: 481
Description: Cleavage; by CASP3 and CASP7
Type: site
End: 482
UniProt Feature
Begin: 478
Description: Cleavage; by CASP3 in vitro
Type: site
End: 479
Publication  
First Author: Josefsson EC
Year: 2014
Journal: Nat Commun
Title: Platelet production proceeds independently of the intrinsic and extrinsic apoptosis pathways.
Volume: 5
Pages: 3455
Publication
First Author: Wikenheiser-Brokamp KA
Year: 2006
Journal: Cell Mol Life Sci
Title: Retinoblastoma family proteins: insights gained through genetic manipulation of mice.
Volume: 63
Issue: 7-8
Pages: 767-80
Publication
First Author: Mantela J
Year: 2005
Journal: Development
Title: The retinoblastoma gene pathway regulates the postmitotic state of hair cells of the mouse inner ear.
Volume: 132
Issue: 10
Pages: 2377-88
Publication
First Author: Bisson JA
Year: 2015
Journal: Dev Biol
Title: Wnt5a and Wnt11 inhibit the canonical Wnt pathway and promote cardiac progenitor development via the Caspase-dependent degradation of AKT.
Volume: 398
Issue: 1
Pages: 80-96
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory