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Search results 1 to 100 out of 1031 for Casp8

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Type Details Score
Gene
841 | CASP8
Type: gene
Organism: human
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Gene
746477 | CASP8
Type: gene
Organism: chimpanzee
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Gene
488473 | CASP8
Type: gene
Organism: dog, domestic
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Gene
507481 | CASP8
Type: gene
Organism: cattle
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Gene
395284 | CASP8
Type: gene
Organism: chicken
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Gene
58022 | casp8
Type: gene
Organism: zebrafish
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Gene
702781 | CASP8
Type: gene
Organism: macaque, rhesus
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Gene
100495471 | casp8
Type: gene
Organism: frog, western clawed
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Gene
64044 | Casp8
Type: gene
Organism: rat
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Protein Coding Gene
MGI:1261423 | Casp8
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene
8837 | CFLAR
Type: gene
Organism: human
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Publication
9763668 | J:50676
First Author: Kischkel FC
Year: 1998
Journal: Cytogenet Cell Genet
Title: Assignment of CASP8 to human chromosome band 2q33-->q34 and Casp8 to the murine syntenic region on chromosome 1B-proximal C by in situ hybridization.
Volume: 82
Issue: 1-2
Pages: 95-6
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Publication
31411503 | J:293430
First Author: Kaden-Volynets V
Year: 2019
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Deletion of the Casp8 gene in mice results in ileocolitis, gut barrier dysfunction, and malassimilation, which can be partially attenuated by inulin or sodium butyrate.
Volume: 317
Issue: 4
Pages: G493-G507
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Publication
31511692 | J:281456
First Author: Newton K
Year: 2019
Journal: Nature
Title: Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis.
Volume: 574
Issue: 7778
Pages: 428-431
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Publication
24095739 | J:203778
First Author: Weinlich R
Year: 2013
Journal: Cell Rep
Title: Protective roles for caspase-8 and cFLIP in adult homeostasis.
Volume: 5
Issue: 2
Pages: 340-8
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Publication
22095280 | J:203612
First Author: Moujalled DM
Year: 2012
Journal: Cell Death Differ
Title: In mouse embryonic fibroblasts, neither caspase-8 nor cellular FLICE-inhibitory protein (FLIP) is necessary for TNF to activate NF-κB, but caspase-8 is required for TNF to cause cell death, and induction of FLIP by NF-κB is required to prevent it.
Volume: 19
Issue: 5
Pages: 808-15
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Publication
27523270 | J:254600
First Author: Alvarez-Diaz S
Year: 2016
Journal: Immunity
Title: The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis.
Volume: 45
Issue: 3
Pages: 513-526
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Publication
28218919 | J:251277
First Author: Wang PX
Year: 2017
Journal: Nat Med
Title: Targeting CASP8 and FADD-like apoptosis regulator ameliorates nonalcoholic steatohepatitis in mice and nonhuman primates.
Volume: 23
Issue: 4
Pages: 439-449
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Publication
22675671 | J:196028
First Author: Dillon CP
Year: 2012
Journal: Cell Rep
Title: Survival function of the FADD-CASPASE-8-cFLIP(L) complex.
Volume: 1
Issue: 5
Pages: 401-7
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Publication
31519887 | J:279494
First Author: Tang Y
Year: 2019
Journal: Nat Commun
Title: K63-linked ubiquitination regulates RIPK1 kinase activity to prevent cell death during embryogenesis and inflammation.
Volume: 10
Issue: 1
Pages: 4157
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Publication
29596938 | J:309497
First Author: Piao X
Year: 2019
Journal: J Allergy Clin Immunol
Title: Blockade of TNF receptor superfamily 1 (TNFR1)-dependent and TNFR1-independent cell death is crucial for normal epidermal differentiation.
Volume: 143
Issue: 1
Pages: 213-228.e10
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Publication
24813850 | J:214393
First Author: Dillon CP
Year: 2014
Journal: Cell
Title: RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3.
Volume: 157
Issue: 5
Pages: 1189-202
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Publication
9729047 | J:49459
First Author: Varfolomeev EE
Year: 1998
Journal: Immunity
Title: Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.
Volume: 9
Issue: 2
Pages: 267-76
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Publication
15972663 | J:100574
First Author: Dohrman A
Year: 2005
Journal: J Immunol
Title: Cellular FLIP long form augments caspase activity and death of T cells through heterodimerization with and activation of caspase-8.
Volume: 175
Issue: 1
Pages: 311-8
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Publication
16263940 | J:104561
First Author: Giampietri C
Year: 2006
Journal: FASEB J
Title: c-Flip expression and function in fetal mouse gonocytes.
Volume: 20
Issue: 1
Pages: 124-6
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Publication
11247636 | J:68151
First Author: Bergman ML
Year: 2001
Journal: J Autoimmun
Title: CTLA-4-/- mice display T cell-apoptosis resistance resembling that ascribed to autoimmune-prone non-obese diabetic (NOD) mice.
Volume: 16
Issue: 2
Pages: 105-13
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Publication
21368763 | J:170814
First Author: Oberst A
Year: 2011
Journal: Nature
Title: Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis.
Volume: 471
Issue: 7338
Pages: 363-7
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Publication
18708583 | J:138979
First Author: Schile AJ
Year: 2008
Journal: Genes Dev
Title: Regulation of apoptosis by XIAP ubiquitin-ligase activity.
Volume: 22
Issue: 16
Pages: 2256-66
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Publication
24557836 | J:209137
First Author: Newton K
Year: 2014
Journal: Science
Title: Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis.
Volume: 343
Issue: 6177
Pages: 1357-60
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Publication
29107687 | J:250982
First Author: Zhuge B
Year: 2017
Journal: Biochem Biophys Res Commun
Title: MiR-150 deficiency ameliorated hepatosteatosis and insulin resistance in nonalcoholic fatty liver disease via targeting CASP8 and FADD-like apoptosis regulator.
Volume: 494
Issue: 3-4
Pages: 687-692
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Publication
11016460 | J:88667
First Author: Hill NJ
Year: 2000
Journal: Diabetes
Title: NOD Idd5 locus controls insulitis and diabetes and overlaps the orthologous CTLA4/IDDM12 and NRAMP1 loci in humans.
Volume: 49
Issue: 10
Pages: 1744-7
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Publication
32193329 | J:286605
First Author: Muendlein HI
Year: 2020
Journal: Science
Title: cFLIPL protects macrophages from LPS-induced pyroptosis via inhibition of complex II formation.
Volume: 367
Issue: 6484
Pages: 1379-1384
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Publication
16469705 | J:114810
First Author: Chang L
Year: 2006
Journal: Cell
Title: The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover.
Volume: 124
Issue: 3
Pages: 601-13
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Publication
22089168 | J:202809
 
First Author: Vanlangenakker N
Year: 2011
Journal: Cell Death Dis
Title: TNF-induced necroptosis in L929 cells is tightly regulated by multiple TNFR1 complex I and II members.
Volume: 2
Pages: e230
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Publication
17462996 | J:123526
First Author: Misra RS
Year: 2007
Journal: J Biol Chem
Title: Caspase-8 and c-FLIPL associate in lipid rafts with NF-kappaB adaptors during T cell activation.
Volume: 282
Issue: 27
Pages: 19365-74
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Publication
24275659 | J:319042
First Author: Koenig A
Year: 2014
Journal: J Biol Chem
Title: The c-FLIPL cleavage product p43FLIP promotes activation of extracellular signal-regulated kinase (ERK), nuclear factor κB (NF-κB), and caspase-8 and T cell survival.
Volume: 289
Issue: 2
Pages: 1183-91
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Publication
17488888 | J:127224
First Author: Prows DR
Year: 2007
Journal: Physiol Genomics
Title: Genetic analysis of hyperoxic acute lung injury survival in reciprocal intercross mice.
Volume: 30
Issue: 3
Pages: 271-81
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Publication
23144495 | J:190865
First Author: Bossaller L
Year: 2012
Journal: J Immunol
Title: Cutting edge: FAS (CD95) mediates noncanonical IL-1β and IL-18 maturation via caspase-8 in an RIP3-independent manner.
Volume: 189
Issue: 12
Pages: 5508-12
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Publication
34531562 | J:320753
First Author: Brusilovsky M
Year: 2021
Journal: Nat Immunol
Title: Environmental allergens trigger type 2 inflammation through ripoptosome activation.
Volume: 22
Issue: 10
Pages: 1316-1326
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Publication
17170703 | J:200418
First Author: Qi W
Year: 2007
Journal: EMBO J
Title: A novel function of caspase-8 in the regulation of androgen-receptor-driven gene expression.
Volume: 26
Issue: 1
Pages: 65-75
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Publication
16148088 | J:116713
First Author: Beisner DR
Year: 2005
Journal: J Immunol
Title: Cutting edge: innate immunity conferred by B cells is regulated by caspase-8.
Volume: 175
Issue: 6
Pages: 3469-73
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Publication
27819682 | J:242990
First Author: Newton K
Year: 2016
Journal: Nature
Title: RIPK1 inhibits ZBP1-driven necroptosis during development.
Volume: 540
Issue: 7631
Pages: 129-133
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Publication
26405176 | J:315563
First Author: Kavanagh E
Year: 2015
Journal: Aging (Albany NY)
Title: Deletion of caspase-8 in mouse myeloid cells blocks microglia pro-inflammatory activation and confers protection in MPTP neurodegeneration model.
Volume: 7
Issue: 9
Pages: 673-89
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Publication
17563067 | J:126586
First Author: Liadis N
Year: 2007
Journal: Diabetes
Title: Distinct in vivo roles of caspase-8 in beta-cells in physiological and diabetes models.
Volume: 56
Issue: 9
Pages: 2302-11
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Publication
35871233 | J:344598
First Author: Bader SM
Year: 2023
Journal: Cell Death Differ
Title: Endothelial Caspase-8 prevents fatal necroptotic hemorrhage caused by commensal bacteria.
Volume: 30
Issue: 1
Pages: 27-36
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Publication
31723262 | J:285940
First Author: Newton K
Year: 2019
Journal: Nature
Title: Activity of caspase-8 determines plasticity between cell death pathways.
Volume: 575
Issue: 7784
Pages: 679-682
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Publication
18684943 | J:140185
First Author: Kang TB
Year: 2008
Journal: J Immunol
Title: Mutation of a self-processing site in caspase-8 compromises its apoptotic but not its nonapoptotic functions in bacterial artificial chromosome-transgenic mice.
Volume: 181
Issue: 4
Pages: 2522-32
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Publication
31251782 | J:324736
First Author: Gonçalves AV
Year: 2019
Journal: PLoS Pathog
Title: Gasdermin-D and Caspase-7 are the key Caspase-1/8 substrates downstream of the NAIP5/NLRC4 inflammasome required for restriction of Legionella pneumophila.
Volume: 15
Issue: 6
Pages: e1007886
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Publication
31285326 | J:277762
First Author: Feng Y
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Caspase-8 restricts antiviral CD8 T cell hyperaccumulation.
Volume: 116
Issue: 30
Pages: 15170-15177
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Publication
30194111 | J:266638
First Author: Feng Y
Year: 2018
Journal: J Immunol
Title: Remarkably Robust Antiviral Immune Response despite Combined Deficiency in Caspase-8 and RIPK3.
Volume: 201
Issue: 8
Pages: 2244-2255
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Publication
20523353 | J:186349
First Author: Leverrier S
Year: 2011
Journal: Cell Death Differ
Title: Enzymatically active single chain caspase-8 maintains T-cell survival during clonal expansion.
Volume: 18
Issue: 1
Pages: 90-8
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Publication
31141691 | J:281881
First Author: Zhang J
Year: 2019
Journal: Cell Rep
Title: Ubiquitin Ligases cIAP1 and cIAP2 Limit Cell Death to Prevent Inflammation.
Volume: 27
Issue: 9
Pages: 2679-2689.e3
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Publication
32979304 | J:297236
First Author: Yang ZH
Year: 2020
Journal: Mol Cell
Title: A Non-canonical PDK1-RSK Signal Diminishes Pro-caspase-8-Mediated Necroptosis Blockade.
Volume: 80
Issue: 2
Pages: 296-310.e6
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Publication
24442508 | J:209495
First Author: Park YJ
Year: 2014
Journal: Diabetologia
Title: The role of caspase-8 in amyloid-induced beta cell death in human and mouse islets.
Volume: 57
Issue: 4
Pages: 765-75
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Publication
31115653 | J:295768
First Author: Feng Y
Year: 2019
Journal: Med Microbiol Immunol
Title: Caspase-8 restricts natural killer cell accumulation during MCMV Infection.
Volume: 208
Issue: 3-4
Pages: 543-554
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Publication
21878202 | J:218665
First Author: Liedtke C
Year: 2011
Journal: Gastroenterology
Title: Loss of caspase-8 protects mice against inflammation-related hepatocarcinogenesis but induces non-apoptotic liver injury.
Volume: 141
Issue: 6
Pages: 2176-87
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Publication
10894163 | J:63049
First Author: Yeh WC
Year: 2000
Journal: Immunity
Title: Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development.
Volume: 12
Issue: 6
Pages: 633-42
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Publication
29921154 | J:271942
First Author: Yu Z
Year: 2018
Journal: J Int Med Res
Title: Lens-specific deletion of the Msx2 gene increased apoptosis by enhancing the caspase-3/caspase-8 signaling pathway.
Volume: 46
Issue: 7
Pages: 2843-2855
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Publication
30185824 | J:281201
First Author: Anderton H
Year: 2019
Journal: Cell Death Differ
Title: RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development.
Volume: 26
Issue: 5
Pages: 877-889
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Publication
31748744 | J:285930
First Author: Fritsch M
Year: 2019
Journal: Nature
Title: Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis.
Volume: 575
Issue: 7784
Pages: 683-687
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Publication
31827281 | J:285926
First Author: Lalaoui N
Year: 2020
Journal: Nature
Title: Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease.
Volume: 577
Issue: 7788
Pages: 103-108
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Publication
24821786 | J:211029
First Author: Kaiser WJ
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition.
Volume: 111
Issue: 21
Pages: 7753-8
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Publication
21368762 | J:170815
First Author: Kaiser WJ
Year: 2011
Journal: Nature
Title: RIP3 mediates the embryonic lethality of caspase-8-deficient mice.
Volume: 471
Issue: 7338
Pages: 368-72
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Publication
31147458 | J:276568
First Author: DeLaney AA
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Caspase-8 promotes c-Rel-dependent inflammatory cytokine expression and resistance against Toxoplasma gondii.
Volume: 116
Issue: 24
Pages: 11926-11935
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Publication
25186904 | J:217308
First Author: Takahashi N
Year: 2014
Journal: Nature
Title: RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis.
Volume: 513
Issue: 7516
Pages: 95-9
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Publication
18946037 | J:248272
First Author: Bell BD
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells.
Volume: 105
Issue: 43
Pages: 16677-82
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Publication
29666472 | J:269295
First Author: Kang TB
Year: 2018
Journal: Cell Death Differ
Title: Caspase-8 deficiency in mouse embryos triggers chronic RIPK1-dependent activation of inflammatory genes, independently of RIPK3.
Volume: 25
Issue: 6
Pages: 1107-1117
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Publication
26471282 | J:256711
 
First Author: Cuda CM
Year: 2015
Journal: Arthritis Res Ther
Title: Conditional deletion of caspase-8 in macrophages alters macrophage activation in a RIPK-dependent manner.
Volume: 17
Pages: 291
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Publication
34437534 | J:309361
First Author: Zhang Y
Year: 2021
Journal: PLoS Biol
Title: A unique death pathway keeps RIPK1 D325A mutant mice in check at embryonic day 10.5.
Volume: 19
Issue: 8
Pages: e3001304
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Publication
23982205 | J:260330
First Author: Yang P
Year: 2013
Journal: Sci Signal
Title: Maternal hyperglycemia activates an ASK1-FoxO3a-caspase 8 pathway that leads to embryonic neural tube defects.
Volume: 6
Issue: 290
Pages: ra74
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Publication
17699753 | J:123909
First Author: Breitwieser W
Year: 2007
Journal: Genes Dev
Title: Feedback regulation of p38 activity via ATF2 is essential for survival of embryonic liver cells.
Volume: 21
Issue: 16
Pages: 2069-82
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Gene
117279 | Cflar
Type: gene
Organism: rat
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Gene
100332177 | LOC100332177
Type: gene
Organism: zebrafish
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Gene
114675503 | LOC114675503
Type: gene
Organism: macaque, rhesus
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Publication
28898696 | J:245569
First Author: Boege Y
Year: 2017
Journal: Cancer Cell
Title: A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development.
Volume: 32
Issue: 3
Pages: 342-359.e10
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Protein
Q4FK85
Organism: Mus musculus/domesticus
Length: 480  
Fragment?: false
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Protein Coding Gene
MGP_CAROLIEiJ_G0014170 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0016058 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0016041 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0015997 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0015996 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0015828 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1261423 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0016449 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0015410 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0015800 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0015901 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0015903 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0015973 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0015923 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0016496 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0015197 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0015473 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0027408 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0014976 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
11717445 | J:320292
First Author: Wang J
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Caspase-10 is an initiator caspase in death receptor signaling.
Volume: 98
Issue: 24
Pages: 13884-8
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Publication
23536557 | J:198365
First Author: Teitz T
Year: 2013
Journal: Cancer Res
Title: Th-MYCN mice with caspase-8 deficiency develop advanced neuroblastoma with bone marrow metastasis.
Volume: 73
Issue: 13
Pages: 4086-97
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Publication
28476895 | J:243778
First Author: He GW
Year: 2017
Journal: J Exp Med
Title: Regression of apoptosis-resistant colorectal tumors by induction of necroptosis in mice.
Volume: 214
Issue: 6
Pages: 1655-1662
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Publication
16157684 | J:107455
First Author: Salmena L
Year: 2005
Journal: J Exp Med
Title: Caspase-8 deficiency in T cells leads to a lethal lymphoinfiltrative immune disorder.
Volume: 202
Issue: 6
Pages: 727-32
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Publication
20671745 | J:186338
First Author: Delfino DV
Year: 2011
Journal: Cell Death Differ
Title: Glucocorticoid-induced activation of caspase-8 protects the glucocorticoid-induced protein Gilz from proteasomal degradation and induces its binding to SUMO-1 in murine thymocytes.
Volume: 18
Issue: 1
Pages: 183-90
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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