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Search results 1 to 100 out of 1059 for Casp8

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Hits by Strain

Type Details Score
Gene
841 | CASP8
Type: gene
Organism: human
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Gene
100495471 | casp8
Type: gene
Organism: frog, western clawed
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Gene
64044 | Casp8
Type: gene
Organism: rat
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Gene
746477 | CASP8
Type: gene
Organism: chimpanzee
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Gene
488473 | CASP8
Type: gene
Organism: dog, domestic
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Gene
507481 | CASP8
Type: gene
Organism: cattle
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Gene
395284 | CASP8
Type: gene
Organism: chicken
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Gene
58022 | casp8
Type: gene
Organism: zebrafish
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Gene
702781 | CASP8
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:1261423 | Casp8
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene
8837 | CFLAR
Type: gene
Organism: human
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Publication
9763668 | J:50676
First Author: Kischkel FC
Year: 1998
Journal: Cytogenet Cell Genet
Title: Assignment of CASP8 to human chromosome band 2q33-->q34 and Casp8 to the murine syntenic region on chromosome 1B-proximal C by in situ hybridization.
Volume: 82
Issue: 1-2
Pages: 95-6
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Publication
31411503 | J:293430
First Author: Kaden-Volynets V
Year: 2019
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Deletion of the Casp8 gene in mice results in ileocolitis, gut barrier dysfunction, and malassimilation, which can be partially attenuated by inulin or sodium butyrate.
Volume: 317
Issue: 4
Pages: G493-G507
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Publication
31511692 | J:281456
First Author: Newton K
Year: 2019
Journal: Nature
Title: Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis.
Volume: 574
Issue: 7778
Pages: 428-431
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Publication
24095739 | J:203778
First Author: Weinlich R
Year: 2013
Journal: Cell Rep
Title: Protective roles for caspase-8 and cFLIP in adult homeostasis.
Volume: 5
Issue: 2
Pages: 340-8
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Publication
22095280 | J:203612
First Author: Moujalled DM
Year: 2012
Journal: Cell Death Differ
Title: In mouse embryonic fibroblasts, neither caspase-8 nor cellular FLICE-inhibitory protein (FLIP) is necessary for TNF to activate NF-κB, but caspase-8 is required for TNF to cause cell death, and induction of FLIP by NF-κB is required to prevent it.
Volume: 19
Issue: 5
Pages: 808-15
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Publication
28218919 | J:251277
First Author: Wang PX
Year: 2017
Journal: Nat Med
Title: Targeting CASP8 and FADD-like apoptosis regulator ameliorates nonalcoholic steatohepatitis in mice and nonhuman primates.
Volume: 23
Issue: 4
Pages: 439-449
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Publication
27523270 | J:254600
First Author: Alvarez-Diaz S
Year: 2016
Journal: Immunity
Title: The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis.
Volume: 45
Issue: 3
Pages: 513-526
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Publication
22675671 | J:196028
First Author: Dillon CP
Year: 2012
Journal: Cell Rep
Title: Survival function of the FADD-CASPASE-8-cFLIP(L) complex.
Volume: 1
Issue: 5
Pages: 401-7
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Publication
31519887 | J:279494
First Author: Tang Y
Year: 2019
Journal: Nat Commun
Title: K63-linked ubiquitination regulates RIPK1 kinase activity to prevent cell death during embryogenesis and inflammation.
Volume: 10
Issue: 1
Pages: 4157
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Publication
29596938 | J:309497
First Author: Piao X
Year: 2019
Journal: J Allergy Clin Immunol
Title: Blockade of TNF receptor superfamily 1 (TNFR1)-dependent and TNFR1-independent cell death is crucial for normal epidermal differentiation.
Volume: 143
Issue: 1
Pages: 213-228.e10
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Publication
24813850 | J:214393
First Author: Dillon CP
Year: 2014
Journal: Cell
Title: RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3.
Volume: 157
Issue: 5
Pages: 1189-202
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Publication
9729047 | J:49459
First Author: Varfolomeev EE
Year: 1998
Journal: Immunity
Title: Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.
Volume: 9
Issue: 2
Pages: 267-76
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Publication
15972663 | J:100574
First Author: Dohrman A
Year: 2005
Journal: J Immunol
Title: Cellular FLIP long form augments caspase activity and death of T cells through heterodimerization with and activation of caspase-8.
Volume: 175
Issue: 1
Pages: 311-8
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Publication
16263940 | J:104561
First Author: Giampietri C
Year: 2006
Journal: FASEB J
Title: c-Flip expression and function in fetal mouse gonocytes.
Volume: 20
Issue: 1
Pages: 124-6
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Publication
11247636 | J:68151
First Author: Bergman ML
Year: 2001
Journal: J Autoimmun
Title: CTLA-4-/- mice display T cell-apoptosis resistance resembling that ascribed to autoimmune-prone non-obese diabetic (NOD) mice.
Volume: 16
Issue: 2
Pages: 105-13
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Publication
21368763 | J:170814
First Author: Oberst A
Year: 2011
Journal: Nature
Title: Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis.
Volume: 471
Issue: 7338
Pages: 363-7
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Publication
29107687 | J:250982
First Author: Zhuge B
Year: 2017
Journal: Biochem Biophys Res Commun
Title: MiR-150 deficiency ameliorated hepatosteatosis and insulin resistance in nonalcoholic fatty liver disease via targeting CASP8 and FADD-like apoptosis regulator.
Volume: 494
Issue: 3-4
Pages: 687-692
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Publication
18708583 | J:138979
First Author: Schile AJ
Year: 2008
Journal: Genes Dev
Title: Regulation of apoptosis by XIAP ubiquitin-ligase activity.
Volume: 22
Issue: 16
Pages: 2256-66
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Publication
24557836 | J:209137
First Author: Newton K
Year: 2014
Journal: Science
Title: Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis.
Volume: 343
Issue: 6177
Pages: 1357-60
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Publication
11016460 | J:88667
First Author: Hill NJ
Year: 2000
Journal: Diabetes
Title: NOD Idd5 locus controls insulitis and diabetes and overlaps the orthologous CTLA4/IDDM12 and NRAMP1 loci in humans.
Volume: 49
Issue: 10
Pages: 1744-7
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Publication
16469705 | J:114810
First Author: Chang L
Year: 2006
Journal: Cell
Title: The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover.
Volume: 124
Issue: 3
Pages: 601-13
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Publication
32193329 | J:286605
First Author: Muendlein HI
Year: 2020
Journal: Science
Title: cFLIPL protects macrophages from LPS-induced pyroptosis via inhibition of complex II formation.
Volume: 367
Issue: 6484
Pages: 1379-1384
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Publication
22089168 | J:202809
 
First Author: Vanlangenakker N
Year: 2011
Journal: Cell Death Dis
Title: TNF-induced necroptosis in L929 cells is tightly regulated by multiple TNFR1 complex I and II members.
Volume: 2
Pages: e230
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Publication
17462996 | J:123526
First Author: Misra RS
Year: 2007
Journal: J Biol Chem
Title: Caspase-8 and c-FLIPL associate in lipid rafts with NF-kappaB adaptors during T cell activation.
Volume: 282
Issue: 27
Pages: 19365-74
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Publication
24275659 | J:319042
First Author: Koenig A
Year: 2014
Journal: J Biol Chem
Title: The c-FLIPL cleavage product p43FLIP promotes activation of extracellular signal-regulated kinase (ERK), nuclear factor κB (NF-κB), and caspase-8 and T cell survival.
Volume: 289
Issue: 2
Pages: 1183-91
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Publication
23144495 | J:190865
First Author: Bossaller L
Year: 2012
Journal: J Immunol
Title: Cutting edge: FAS (CD95) mediates noncanonical IL-1β and IL-18 maturation via caspase-8 in an RIP3-independent manner.
Volume: 189
Issue: 12
Pages: 5508-12
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Publication
17488888 | J:127224
First Author: Prows DR
Year: 2007
Journal: Physiol Genomics
Title: Genetic analysis of hyperoxic acute lung injury survival in reciprocal intercross mice.
Volume: 30
Issue: 3
Pages: 271-81
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Publication
34531562 | J:320753
First Author: Brusilovsky M
Year: 2021
Journal: Nat Immunol
Title: Environmental allergens trigger type 2 inflammation through ripoptosome activation.
Volume: 22
Issue: 10
Pages: 1316-1326
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Publication
17170703 | J:200418
First Author: Qi W
Year: 2007
Journal: EMBO J
Title: A novel function of caspase-8 in the regulation of androgen-receptor-driven gene expression.
Volume: 26
Issue: 1
Pages: 65-75
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Publication
27819682 | J:242990
First Author: Newton K
Year: 2016
Journal: Nature
Title: RIPK1 inhibits ZBP1-driven necroptosis during development.
Volume: 540
Issue: 7631
Pages: 129-133
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Publication
16148088 | J:116713
First Author: Beisner DR
Year: 2005
Journal: J Immunol
Title: Cutting edge: innate immunity conferred by B cells is regulated by caspase-8.
Volume: 175
Issue: 6
Pages: 3469-73
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Publication
17563067 | J:126586
First Author: Liadis N
Year: 2007
Journal: Diabetes
Title: Distinct in vivo roles of caspase-8 in beta-cells in physiological and diabetes models.
Volume: 56
Issue: 9
Pages: 2302-11
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Publication
26405176 | J:315563
First Author: Kavanagh E
Year: 2015
Journal: Aging (Albany NY)
Title: Deletion of caspase-8 in mouse myeloid cells blocks microglia pro-inflammatory activation and confers protection in MPTP neurodegeneration model.
Volume: 7
Issue: 9
Pages: 673-89
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Publication
35871233 | J:344598
First Author: Bader SM
Year: 2023
Journal: Cell Death Differ
Title: Endothelial Caspase-8 prevents fatal necroptotic hemorrhage caused by commensal bacteria.
Volume: 30
Issue: 1
Pages: 27-36
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Publication
31723262 | J:285940
First Author: Newton K
Year: 2019
Journal: Nature
Title: Activity of caspase-8 determines plasticity between cell death pathways.
Volume: 575
Issue: 7784
Pages: 679-682
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Publication
18684943 | J:140185
First Author: Kang TB
Year: 2008
Journal: J Immunol
Title: Mutation of a self-processing site in caspase-8 compromises its apoptotic but not its nonapoptotic functions in bacterial artificial chromosome-transgenic mice.
Volume: 181
Issue: 4
Pages: 2522-32
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Publication
31251782 | J:324736
First Author: Gonçalves AV
Year: 2019
Journal: PLoS Pathog
Title: Gasdermin-D and Caspase-7 are the key Caspase-1/8 substrates downstream of the NAIP5/NLRC4 inflammasome required for restriction of Legionella pneumophila.
Volume: 15
Issue: 6
Pages: e1007886
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Publication
20523353 | J:186349
First Author: Leverrier S
Year: 2011
Journal: Cell Death Differ
Title: Enzymatically active single chain caspase-8 maintains T-cell survival during clonal expansion.
Volume: 18
Issue: 1
Pages: 90-8
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Publication
31285326 | J:277762
First Author: Feng Y
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Caspase-8 restricts antiviral CD8 T cell hyperaccumulation.
Volume: 116
Issue: 30
Pages: 15170-15177
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Publication
30194111 | J:266638
First Author: Feng Y
Year: 2018
Journal: J Immunol
Title: Remarkably Robust Antiviral Immune Response despite Combined Deficiency in Caspase-8 and RIPK3.
Volume: 201
Issue: 8
Pages: 2244-2255
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Publication
31141691 | J:281881
First Author: Zhang J
Year: 2019
Journal: Cell Rep
Title: Ubiquitin Ligases cIAP1 and cIAP2 Limit Cell Death to Prevent Inflammation.
Volume: 27
Issue: 9
Pages: 2679-2689.e3
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Publication
32979304 | J:297236
First Author: Yang ZH
Year: 2020
Journal: Mol Cell
Title: A Non-canonical PDK1-RSK Signal Diminishes Pro-caspase-8-Mediated Necroptosis Blockade.
Volume: 80
Issue: 2
Pages: 296-310.e6
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Publication
38637559 | J:348949
First Author: Liu S
Year: 2024
Journal: Cell Death Dis
Title: Caspase 8 deletion causes infection/inflammation-induced bone marrow failure and MDS-like disease in mice.
Volume: 15
Issue: 4
Pages: 278
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Publication
24442508 | J:209495
First Author: Park YJ
Year: 2014
Journal: Diabetologia
Title: The role of caspase-8 in amyloid-induced beta cell death in human and mouse islets.
Volume: 57
Issue: 4
Pages: 765-75
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Publication
31115653 | J:295768
First Author: Feng Y
Year: 2019
Journal: Med Microbiol Immunol
Title: Caspase-8 restricts natural killer cell accumulation during MCMV Infection.
Volume: 208
Issue: 3-4
Pages: 543-554
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Publication
10894163 | J:63049
First Author: Yeh WC
Year: 2000
Journal: Immunity
Title: Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development.
Volume: 12
Issue: 6
Pages: 633-42
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Publication
21878202 | J:218665
First Author: Liedtke C
Year: 2011
Journal: Gastroenterology
Title: Loss of caspase-8 protects mice against inflammation-related hepatocarcinogenesis but induces non-apoptotic liver injury.
Volume: 141
Issue: 6
Pages: 2176-87
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Publication
30185824 | J:281201
First Author: Anderton H
Year: 2019
Journal: Cell Death Differ
Title: RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development.
Volume: 26
Issue: 5
Pages: 877-889
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Publication
29921154 | J:271942
First Author: Yu Z
Year: 2018
Journal: J Int Med Res
Title: Lens-specific deletion of the Msx2 gene increased apoptosis by enhancing the caspase-3/caspase-8 signaling pathway.
Volume: 46
Issue: 7
Pages: 2843-2855
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Publication
35671429 | J:359811
First Author: Kim S
Year: 2022
Journal: Proc Natl Acad Sci U S A
Title: Myeloid caspase-8 restricts RIPK3-dependent proinflammatory IL-1β production and CD4 T cell activation in autoimmune demyelination.
Volume: 119
Issue: 24
Pages: e2117636119
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Publication
31748744 | J:285930
First Author: Fritsch M
Year: 2019
Journal: Nature
Title: Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis.
Volume: 575
Issue: 7784
Pages: 683-687
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Publication
31827281 | J:285926
First Author: Lalaoui N
Year: 2020
Journal: Nature
Title: Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease.
Volume: 577
Issue: 7788
Pages: 103-108
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Publication
31147458 | J:276568
First Author: DeLaney AA
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Caspase-8 promotes c-Rel-dependent inflammatory cytokine expression and resistance against Toxoplasma gondii.
Volume: 116
Issue: 24
Pages: 11926-11935
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Publication
25186904 | J:217308
First Author: Takahashi N
Year: 2014
Journal: Nature
Title: RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis.
Volume: 513
Issue: 7516
Pages: 95-9
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Publication
24821786 | J:211029
First Author: Kaiser WJ
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition.
Volume: 111
Issue: 21
Pages: 7753-8
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Publication
21368762 | J:170815
First Author: Kaiser WJ
Year: 2011
Journal: Nature
Title: RIP3 mediates the embryonic lethality of caspase-8-deficient mice.
Volume: 471
Issue: 7338
Pages: 368-72
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Publication
29666472 | J:269295
First Author: Kang TB
Year: 2018
Journal: Cell Death Differ
Title: Caspase-8 deficiency in mouse embryos triggers chronic RIPK1-dependent activation of inflammatory genes, independently of RIPK3.
Volume: 25
Issue: 6
Pages: 1107-1117
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Publication
18946037 | J:248272
First Author: Bell BD
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells.
Volume: 105
Issue: 43
Pages: 16677-82
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Publication
26471282 | J:256711
 
First Author: Cuda CM
Year: 2015
Journal: Arthritis Res Ther
Title: Conditional deletion of caspase-8 in macrophages alters macrophage activation in a RIPK-dependent manner.
Volume: 17
Pages: 291
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Publication
28978351 | J:359761
First Author: Dominguez S
Year: 2017
Journal: Arthritis Res Ther
Title: The caspase-8/RIPK3 signaling axis in antigen presenting cells controls the inflammatory arthritic response.
Volume: 19
Issue: 1
Pages: 224
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Publication
34437534 | J:309361
First Author: Zhang Y
Year: 2021
Journal: PLoS Biol
Title: A unique death pathway keeps RIPK1 D325A mutant mice in check at embryonic day 10.5.
Volume: 19
Issue: 8
Pages: e3001304
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Publication
23982205 | J:260330
First Author: Yang P
Year: 2013
Journal: Sci Signal
Title: Maternal hyperglycemia activates an ASK1-FoxO3a-caspase 8 pathway that leads to embryonic neural tube defects.
Volume: 6
Issue: 290
Pages: ra74
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Publication
17699753 | J:123909
First Author: Breitwieser W
Year: 2007
Journal: Genes Dev
Title: Feedback regulation of p38 activity via ATF2 is essential for survival of embryonic liver cells.
Volume: 21
Issue: 16
Pages: 2069-82
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Gene
117279 | Cflar
Type: gene
Organism: rat
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Gene
100332177 | LOC100332177
Type: gene
Organism: zebrafish
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Gene
114675503 | LOC114675503
Type: gene
Organism: macaque, rhesus
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Publication
28898696 | J:245569
First Author: Boege Y
Year: 2017
Journal: Cancer Cell
Title: A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development.
Volume: 32
Issue: 3
Pages: 342-359.e10
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Publication
37813816 | J:358134
First Author: Soma S
Year: 2024
Journal: Stem Cells
Title: O-Linked N-Acetylglucosamine Transferase Ensures Survival of Mouse Fetal Liver Hematopoietic Progenitors Partly by Regulating Bcl-xL and Oxidative Phosphorylation.
Volume: 42
Issue: 1
Pages: 55-63
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Protein
Q4FK85
Organism: Mus musculus/domesticus
Length: 480  
Fragment?: false
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Protein Coding Gene
MGP_CAROLIEiJ_G0014170 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0016058 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0016041 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0015997 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0015996 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0015828 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1261423 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0016449 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0015410 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0015800 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0015901 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0015903 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0015973 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0015923 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0016496 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0015197 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0015473 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0027408 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0014976 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
11717445 | J:320292
First Author: Wang J
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Caspase-10 is an initiator caspase in death receptor signaling.
Volume: 98
Issue: 24
Pages: 13884-8
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