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Search results 1 to 81 out of 81 for Cass4

0.047s

Categories

Hits by Category

Hits by Strain

Type Details Score
Gene
57091 | CASS4
Type: gene
Organism: human
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Gene
100490791 | cass4
Type: gene
Organism: frog, western clawed
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Gene
296409 | Cass4
Type: gene
Organism: rat
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Gene
477269 | CASS4
Type: gene
Organism: dog, domestic
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Gene
458350 | CASS4
Type: gene
Organism: chimpanzee
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Gene
512832 | CASS4
Type: gene
Organism: cattle
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Gene
419330 | CASS4
Type: gene
Organism: chicken
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Gene
100000938 | cass4
Type: gene
Organism: zebrafish
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Gene
697924 | CASS4
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:2444482 | Cass4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR035512 | CASS4
Type: Family
Description: CASS4, also known as HEPL, is a Cas family member that regulates FAK and cell spreading [].The CAS (Crk-Associated Substrate) protein family is a group of scaffolding proteins that play important modulatory roles in both normal and pathological cell growth regulation. They contain an N-terminal Src homology 3 (SH3) domain and a substrate domain (SD). The SD contains a large number of YxxP motifs, which when phosphorylated by Src-family kinases provide canonical binding sites for proteins containing SH2 domains such as Crk, Crk-L, CRKII [].
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Publication
18256281 | -
First Author: Singh MK
Year: 2008
Journal: Mol Biol Cell
Title: A novel Cas family member, HEPL, regulates FAK and cell spreading.
Volume: 19
Issue: 4
Pages: 1627-36
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Protein
Q08EC4
Organism: Mus musculus/domesticus
Length: 804  
Fragment?: false
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Protein
A0A0R4J199
Organism: Mus musculus/domesticus
Length: 778  
Fragment?: false
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Publication
19937461 | -
First Author: Tikhmyanova N
Year: 2010
Journal: Cell Mol Life Sci
Title: CAS proteins in normal and pathological cell growth control.
Volume: 67
Issue: 7
Pages: 1025-48
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Protein Coding Gene
MGP_CAROLIEiJ_G0024737 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0026944 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0026911 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0026882 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0026920 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0026662 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2444482 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0027367 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0026120 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0026639 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0026777 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0026743 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0026878 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0026762 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0027424 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0025857 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0026193 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0026178 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0025657 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
   
Probe: MGI:3720462
Assay Type: RNA in situ
Annotation Date: 2007-09-05
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1737319
Stage: TS19
Assay Id: MGI:3720476
Age: embryonic day 11.5
Image: S2 right
Specimen Label: S2 right
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:3720462
Assay Type: RNA in situ
Annotation Date: 2007-09-05
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1636717
Stage: TS17
Assay Id: MGI:3720476
Age: embryonic day 10.5
Image: S2 left
Note: Expression was not detected in kidney.
Specimen Label: S2 left
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:3720462
Assay Type: RNA in situ
Annotation Date: 2007-09-05
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1609217
Stage: TS17
Assay Id: MGI:3720476
Age: embryonic day 10.5
Image: S2 left
Specimen Label: S2 left
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:3720462
Assay Type: RNA in situ
Annotation Date: 2007-09-05
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1609219
Stage: TS19
Assay Id: MGI:3720476
Age: embryonic day 11.5
Image: S2 right
Specimen Label: S2 right
Detected: false
Specimen Num: 2
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Publication
17530927 | J:122749
First Author: Lu W
Year: 2007
Journal: PLoS Genet
Title: NFIA haploinsufficiency is associated with a CNS malformation syndrome and urinary tract defects.
Volume: 3
Issue: 5
Pages: e80
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Allele
Cass4<em1Smoc> | MGI:7288657
Name: Cas scaffolding protein family member 4; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Strain
MGI:6770617 | C57BL/6JSmoc-Cass4<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
24962474 | -
First Author: Nikonova AS
Year: 2014
Journal: IUBMB Life
Title: CAS proteins in health and disease: an update.
Volume: 66
Issue: 6
Pages: 387-95
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Publication
26119091 | -
First Author: Deneka A
Year: 2015
Journal: Gene
Title: Embryonal Fyn-associated substrate (EFS) and CASS4: The lesser-known CAS protein family members.
Volume: 570
Issue: 1
Pages: 25-35
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Publication
25139996 | J:216403
First Author: Nikonova AS
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Nedd9 restrains renal cystogenesis in Pkd1-/- mice.
Volume: 111
Issue: 35
Pages: 12859-64
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Protein Domain
IPR035744 | CASS4_SH3
Type: Domain
Description: CASS4, also called HEPL (HEF1-EFS-p130Cas-like), is a member of the CAS family. It localizes to focal adhesions and plays a role in regulating FAK activity, focal adhesion integrity, and cell spreading []. CAS (Crk-associated substrate) family members are adaptor proteins that contain a highly conserved N-terminal SH3 domain, an adjacent unstructured domain (substrate domain) containing multiple tyrosine phosphorylation sites that enable binding by SH2-domain containing proteins, a serine-rich four-helix bundle, and a FAT-like C-terminal domain. Most of these domains mediate protein-protein interactions. Through these interactions, they assemble larger signaling complexes that are essential for cell proliferation, survival, migration, and other processes []. The CAS family consists of four members: BCAR1, HEF1, EFS, and CASS4 [].
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Protein Domain
IPR035746 | NEDD9_SH3
Type: Domain
Description: Enhancer of filamentation 1 (also known as NEDD9 or Cas-L) is a member of the CAS family. It is a scaffolding protein that assembles signaling complexes regulating multiple cellular processes, such as cell adhesion, migration, invasion, and metastasis. It is commonly dysregulated during cancer progression. It interacts with Aurora-A kinase to control ciliary resorption, and with Src and other partners to influence proliferative signaling pathways often activated in autosomal dominant polycystic kidney disease [].CAS (Crk-associated substrate) family members are adaptor proteins that contain a highly conserved N-terminal SH3 domain, an adjacent unstructured domain (substrate domain) containing multiple tyrosine phosphorylation sites that enable binding by SH2-domain containing proteins, a serine-rich four-helix bundle, and a FAT-like C-terminal domain. Most of these domains mediate protein-protein interactions. Through these interactions, they assemble larger signaling complexes that are essential for cell proliferation, survival, migration, and other processes []. The CAS family consists of four members: BCAR1, HEF1, EFS, and CASS4 [].
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Protein Domain
IPR035747 | EFS_SH3
Type: Domain
Description: EFS (also known as SIN) is a member of the CAS family. It is involved in T lymphocyte development and immune system maturation. It has also been linked to several disorders, such as cancers and Chediak-Higashi syndrome []. CAS (Crk-associated substrate) family members are adaptor proteins that contain a highly conserved N-terminal SH3 domain, an adjacent unstructured domain (substrate domain) containing multiple tyrosine phosphorylation sites that enable binding by SH2-domain containing proteins, a serine-rich four-helix bundle, and a FAT-like C-terminal domain. Most of these domains mediate protein-protein interactions. Through these interactions, they assemble larger signaling complexes that are essential for cell proliferation, survival, migration, and other processes []. The CAS family consists of four members: BCAR1, HEF1, EFS, and CASS4 [].
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Protein
Q64355
Organism: Mus musculus/domesticus
Length: 560  
Fragment?: false
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Protein
A0A286YCE4
Organism: Mus musculus/domesticus
Length: 194  
Fragment?: true
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Protein
Q8K0F6
Organism: Mus musculus/domesticus
Length: 560  
Fragment?: false
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Protein
O35177
Organism: Mus musculus/domesticus
Length: 833  
Fragment?: false
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Protein
A0A0R4J212
Organism: Mus musculus/domesticus
Length: 833  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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