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Search results 1 to 100 out of 253 for Cbx2

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Domain
Type: Family
Description: Chromobox protein homolog 2 (CBX2) is a polycomb protein, responsible for polycomb-repressive complex 1 (PRC1) targeting to chromatin via recognition of the repressive mark H3K27me3 []. CBX2 is required during sex determination to stabilize the testis fate by blocking the upregulation of bivalent ovary pathway genes []. It is overexpressed in breast cancer and plays an essential role in tumour progression [, ].
Publication
First Author: Garcia-Moreno SA
Year: 2019
Journal: PLoS Genet
Title: CBX2 is required to stabilize the testis pathway by repressing Wnt signaling.
Volume: 15
Issue: 5
Pages: e1007895
Publication
First Author: Jangal M
Year: 2019
Journal: Expert Opin Ther Targets
Title: Beyond EZH2: is the polycomb protein CBX2 an emerging target for anti-cancer therapy?
Volume: 23
Issue: 7
Pages: 565-578
Publication
First Author: Zheng S
Year: 2019
Journal: Am J Transl Res
Title: Overexpression of CBX2 in breast cancer promotes tumor progression through the PI3K/AKT signaling pathway.
Volume: 11
Issue: 3
Pages: 1668-1682
Publication
First Author: Piqué DG
Year: 2019
Journal: Br J Cancer
Title: A novel approach to modelling transcriptional heterogeneity identifies the oncogene candidate CBX2 in invasive breast carcinoma.
Volume: 120
Issue: 7
Pages: 746-753
Publication  
First Author: Baumann C
Year: 2020
Journal: J Cell Biol
Title: Loss of CBX2 induces genome instability and senescence-associated chromosomal rearrangements.
Volume: 219
Issue: 11
Publication
First Author: Kim JJ
Year: 2023
Journal: Genes Dev
Title: Cell type-specific role of CBX2 and its disordered region in spermatogenesis.
Volume: 37
Issue: 13-14
Pages: 640-660
Publication  
First Author: Katoh-Fukui Y
Year: 2019
Journal: Bone
Title: Mouse polycomb group gene Cbx2 promotes osteoblastic but suppresses adipogenic differentiation in postnatal long bones.
Volume: 120
Pages: 219-231
Publication
First Author: Tardat M
Year: 2015
Journal: Mol Cell
Title: Cbx2 targets PRC1 to constitutive heterochromatin in mouse zygotes in a parent-of-origin-dependent manner.
Volume: 58
Issue: 1
Pages: 157-71
Publication
First Author: Hatano A
Year: 2010
Journal: Biochem Biophys Res Commun
Title: Phosphorylation of the chromodomain changes the binding specificity of Cbx2 for methylated histone H3.
Volume: 397
Issue: 1
Pages: 93-9
Protein
Organism: Mus musculus/domesticus
Length: 136  
Fragment?: true
Publication
First Author: Fisher CL
Year: 2010
Journal: Dev Biol
Title: Additional sex combs-like 1 belongs to the enhancer of trithorax and polycomb group and genetically interacts with Cbx2 in mice.
Volume: 337
Issue: 1
Pages: 9-15
Protein
Organism: Mus musculus/domesticus
Length: 519  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 519  
Fragment?: false
Publication
First Author: Plys AJ
Year: 2019
Journal: Genes Dev
Title: Phase separation of Polycomb-repressive complex 1 is governed by a charged disordered region of CBX2.
Volume: 33
Issue: 13-14
Pages: 799-813
Publication
First Author: Wang D
Year: 2022
Journal: Cell Rep
Title: Developmental maturation of the hematopoietic system controlled by a Lin28b-let-7-Cbx2 axis.
Volume: 39
Issue: 1
Pages: 110587
Publication
First Author: Katoh-Fukui Y
Year: 2012
Journal: Endocrinology
Title: Cbx2, a polycomb group gene, is required for Sry gene expression in mice.
Volume: 153
Issue: 2
Pages: 913-24
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Pearce JJ
Year: 1992
Journal: Development
Title: The mouse has a Polycomb-like chromobox gene.
Volume: 114
Issue: 4
Pages: 921-9
Publication
First Author: Katoh-Fukui Y
Year: 1998
Journal: Nature
Title: Male-to-female sex reversal in M33 mutant mice.
Volume: 393
Issue: 6686
Pages: 688-92
Publication
First Author: Raaphorst FM
Year: 2001
Journal: Trends Immunol
Title: Polycomb-group genes as regulators of mammalian lymphopoiesis.
Volume: 22
Issue: 12
Pages: 682-90
Publication
First Author: Gecz J
Year: 1995
Journal: Genomics
Title: Assignment of a Polycomb-like chromobox gene (CBX2) to human chromosome 17q25.
Volume: 26
Issue: 1
Pages: 130-3
Publication
First Author: Müller J
Year: 1995
Journal: Development
Title: Function of the Polycomb protein is conserved in mice and flies.
Volume: 121
Issue: 9
Pages: 2847-52
Publication
First Author: Noguchi K
Year: 2002
Journal: Biochem Biophys Res Commun
Title: Nuclear translocation of mouse polycomb m33 protein in regenerating liver.
Volume: 291
Issue: 3
Pages: 508-15
Publication
First Author: Grau DJ
Year: 2011
Journal: Genes Dev
Title: Compaction of chromatin by diverse Polycomb group proteins requires localized regions of high charge.
Volume: 25
Issue: 20
Pages: 2210-21
GXD Expression    
Probe: MGI:1339024
Assay Type: RT-PCR
Annotation Date: 1999-07-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:1339667
Age: postnatal adult
Image: 1
Specimen Label: +/+
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:1339024
Assay Type: RT-PCR
Annotation Date: 1999-07-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:1339667
Age: postnatal adult
Image: 1
Specimen Label: +/-
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:1339024
Assay Type: RT-PCR
Annotation Date: 1999-07-13
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:1339667
Age: postnatal adult
Image: 1
Specimen Label: -/-
Detected: false
Specimen Num: 3
GXD Expression      
Probe: MGI:2678077
Assay Type: Western blot
Annotation Date: 2003-11-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:2678093
Age: embryonic day 8.5
Specimen Label: 8.5
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:2678077
Assay Type: Western blot
Annotation Date: 2003-11-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:2678093
Age: embryonic day 9.5
Specimen Label: 9.5
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:2678077
Assay Type: Western blot
Annotation Date: 2003-11-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:2678093
Age: embryonic day 10.5
Specimen Label: 10.5
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:2678077
Assay Type: Western blot
Annotation Date: 2003-11-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:2678093
Age: embryonic day 12.5
Specimen Label: 12.5
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:2678077
Assay Type: Western blot
Annotation Date: 2003-11-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603922
Stage: TS22
Assay Id: MGI:2678093
Age: embryonic day 14.5
Specimen Label: 14.5
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:2678077
Assay Type: Western blot
Annotation Date: 2003-11-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603924
Stage: TS24
Assay Id: MGI:2678093
Age: embryonic day 16.5
Specimen Label: 16.5
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:2678077
Assay Type: Western blot
Annotation Date: 2003-11-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603926
Stage: TS26
Assay Id: MGI:2678093
Age: embryonic day 18.5
Specimen Label: 18.5
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:2678077
Assay Type: Western blot
Annotation Date: 2003-11-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3276028
Stage: TS28
Assay Id: MGI:2678099
Age: postnatal adult
Specimen Label: Bone Marrow
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:2678077
Assay Type: Western blot
Annotation Date: 2003-11-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2678099
Age: postnatal adult
Specimen Label: Brain
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:2678077
Assay Type: Western blot
Annotation Date: 2003-11-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:2678099
Age: postnatal adult
Specimen Label: Heart
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:2678077
Assay Type: Western blot
Annotation Date: 2003-11-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3287428
Stage: TS28
Assay Id: MGI:2678099
Age: postnatal adult
Specimen Label: Intestine
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:2678077
Assay Type: Western blot
Annotation Date: 2003-11-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:2678099
Age: postnatal adult
Specimen Label: Kidney
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:2678077
Assay Type: Western blot
Annotation Date: 2003-11-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:2678099
Age: postnatal adult
Specimen Label: Liver
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:2678077
Assay Type: Western blot
Annotation Date: 2003-11-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:2678099
Age: postnatal adult
Specimen Label: Lung
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:2678077
Assay Type: Western blot
Annotation Date: 2003-11-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3557728
Stage: TS28
Assay Id: MGI:2678099
Age: postnatal adult
Specimen Label: Muscle
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:2678077
Assay Type: Western blot
Annotation Date: 2003-11-03
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:2678099
Age: postnatal adult
Specimen Label: Ovary
Detected: true
Specimen Num: 9
GXD Expression        
Probe: MGI:2678077
Assay Type: Western blot
Annotation Date: 2003-11-03
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1752528
Stage: TS28
Assay Id: MGI:2678099
Age: postnatal adult
Specimen Label: Skin
Specimen Num: 10
GXD Expression      
Probe: MGI:2678077
Assay Type: Western blot
Annotation Date: 2003-11-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:2678099
Age: postnatal adult
Specimen Label: Spleen
Detected: true
Specimen Num: 11
GXD Expression      
Probe: MGI:2678077
Assay Type: Western blot
Annotation Date: 2003-11-03
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:2678099
Age: postnatal adult
Specimen Label: Testis
Detected: true
Specimen Num: 12
GXD Expression      
Probe: MGI:2678077
Assay Type: Western blot
Annotation Date: 2003-11-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:2678099
Age: postnatal adult
Specimen Label: Thymus
Detected: true
Specimen Num: 13
GXD Expression      
Probe: MGI:2678077
Assay Type: Western blot
Annotation Date: 2003-11-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:2678232
Age: embryonic day 12.5
Specimen Label: NE
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:2678077
Assay Type: Western blot
Annotation Date: 2003-11-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:2678232
Age: embryonic day 12.5
Specimen Label: Bmi-1 Ab
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:3815648
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Female
Emaps: EMAPS:3102528
Stage: TS28
Assay Id: MGI:3816452
Age: postnatal
Specimen Label: Metaphase II
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3815648
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360422
Stage: TS02
Assay Id: MGI:3816452
Age: embryonic day 1.5
Specimen Label: 2-cell embryo
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3815648
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360433
Stage: TS03
Assay Id: MGI:3816452
Age: embryonic day 2.0
Specimen Label: 4-cell embryo
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3815648
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360443
Stage: TS03
Assay Id: MGI:3816452
Age: embryonic day 2.5
Specimen Label: 8-cell embryo
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3815648
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360453
Stage: TS03
Assay Id: MGI:3816452
Age: embryonic day 3.0
Specimen Label: Morula
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3815648
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360464
Stage: TS04
Assay Id: MGI:3816452
Age: embryonic day 3.5
Specimen Label: E3.5 blastocyst
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:3815648
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360465
Stage: TS05
Assay Id: MGI:3816452
Age: embryonic day 4.5
Specimen Label: E4.5 blastocyst
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:3815648
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160415
Stage: TS05
Assay Id: MGI:3816452
Age: embryonic day 4.5
Specimen Label: E4.5 inner cell mass
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:5775372
Assay Type: Western blot
Annotation Date: 2016-06-08
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876724
Stage: TS24
Assay Id: MGI:5775404
Age: embryonic day 16.5
Specimen Label: M33-/-
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5775372
Assay Type: Western blot
Annotation Date: 2016-06-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876724
Stage: TS24
Assay Id: MGI:5775404
Age: embryonic day 16.5
Specimen Label: M33+/-
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:5775372
Assay Type: Western blot
Annotation Date: 2016-06-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876724
Stage: TS24
Assay Id: MGI:5775404
Age: embryonic day 16.5
Specimen Label: M33+/+
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6394120
Assay Type: Western blot
Annotation Date: 2020-03-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:6394123
Age: embryonic day 10.5
Specimen Label: 23KRA/23KRA
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6394120
Assay Type: Western blot
Annotation Date: 2020-03-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:6394123
Age: embryonic day 10.5
Specimen Label: 23KRA/23KRA
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6394120
Assay Type: Western blot
Annotation Date: 2020-03-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:6394123
Age: embryonic day 10.5
Specimen Label: +/+
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6394120
Assay Type: Western blot
Annotation Date: 2020-03-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:6394123
Age: embryonic day 10.5
Specimen Label: 13KRA/13KRA
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:6394120
Assay Type: Western blot
Annotation Date: 2020-03-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:6394123
Age: embryonic day 10.5
Specimen Label: 13KRA/13KRA
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:6394120
Assay Type: Western blot
Annotation Date: 2020-03-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:6394123
Age: embryonic day 10.5
Specimen Label: +/+
Detected: true
Specimen Num: 6
GXD Expression
Probe: MGI:3688538
Assay Type: RNA in situ
Annotation Date: 2006-11-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1698121
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:3688560
Age: embryonic day 13.5
Image: 1C
Note: Expression is in the tectum.
Specimen Label: 1C
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:1755873
Assay Type: RNA in situ
Annotation Date: 2024-01-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3270422
Pattern: Non-Uniform
Stage: TS22
Assay Id: MGI:7575835
Age: embryonic day 14.5
Note: Caudal expression was greater than rostral.
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5775372
Assay Type: Immunohistochemistry
Annotation Date: 2016-06-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876724
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:5775425
Age: embryonic day 16.5
Note: Immunoreactive cells were detected in hematopoietic cells and vascular structures in the spleen.
Specimen Label: 5D Ad4BP/SF-1 -/-
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5775372
Assay Type: Immunohistochemistry
Annotation Date: 2016-06-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876724
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:5775425
Age: embryonic day 16.5
Note: As in wild type, immunoreactive cells were detected in hematopoietic cells and vascular structures in the spleen.
Specimen Label: 5D Ad4BP/SF-1 +/+
Detected: true
Specimen Num: 2
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1777828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692989
Age: postnatal adult
Image: MRC Harwell_891385
Specimen Label: MRC Harwell_891385
Detected: true
Specimen Num: 1