Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
PcG proteins form large multiprotein complexes (PcG bodies) which are involved in the stable repression of genes involved in development, signaling or cancer via chromatin-based epigenetic modifications. Mammalian PRC1 includes canonical (cPRC1) and non-canonical complexes; cPRC1, contains four core subunits including one CBX protein (CBX2, CBX4, and CBX6-CBX8) that binds H3K27me3. CBX family members have different affinity for H3K27me3, with CBX7 having the highest binding capability [, ].This entry represents CBX7 []. In pluripotent cells, CBX7 is the main PRC1-associated Cbx protein and plays an important role in the maintenance of pluripotency []. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Cho KW |
Year: |
2020 |
Journal: |
Sci Rep |
Title: |
Mammalian CBX7 isoforms p36 and p22 exhibit differential responses to serum, varying functions for proliferation, and distinct subcellular localization. |
Volume: |
10 |
Issue: |
1 |
Pages: |
8061 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
251
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Gil J |
Year: |
2004 |
Journal: |
Nat Cell Biol |
Title: |
Polycomb CBX7 has a unifying role in cellular lifespan. |
Volume: |
6 |
Issue: |
1 |
Pages: |
67-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
Forzati F |
Year: |
2012 |
Journal: |
J Clin Invest |
Title: |
CBX7 is a tumor suppressor in mice and humans. |
Volume: |
122 |
Issue: |
2 |
Pages: |
612-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Scott CL |
Year: |
2007 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Role of the chromobox protein CBX7 in lymphomagenesis. |
Volume: |
104 |
Issue: |
13 |
Pages: |
5389-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Forzati F |
Year: |
2014 |
Journal: |
Biol Open |
Title: |
CBX7 gene expression plays a negative role in adipocyte cell growth and differentiation. |
Volume: |
3 |
Issue: |
9 |
Pages: |
871-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jiang F |
Year: |
2019 |
Journal: |
J Bone Miner Metab |
Title: |
Effect of CBX7 deficiency on the socket healing after tooth extractions. |
Volume: |
37 |
Issue: |
4 |
Pages: |
584-593 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhou Z |
Year: |
2016 |
Journal: |
J Mol Histol |
Title: |
CBX7 deficiency plays a positive role in dentin and alveolar bone development. |
Volume: |
47 |
Issue: |
4 |
Pages: |
401-11 |
|
•
•
•
•
•
|
Publication |
First Author: |
Morey L |
Year: |
2013 |
Journal: |
Cell Rep |
Title: |
RYBP and Cbx7 define specific biological functions of polycomb complexes in mouse embryonic stem cells. |
Volume: |
3 |
Issue: |
1 |
Pages: |
60-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cho KW |
Year: |
2023 |
Journal: |
Circulation |
Title: |
Polycomb Group Protein CBX7 Represses Cardiomyocyte Proliferation Through Modulation of the TARDBP/RBM38 Axis. |
Volume: |
147 |
Issue: |
24 |
Pages: |
1823-1842 |
|
•
•
•
•
•
|
Publication |
First Author: |
Morey L |
Year: |
2012 |
Journal: |
Cell Stem Cell |
Title: |
Nonoverlapping functions of the Polycomb group Cbx family of proteins in embryonic stem cells. |
Volume: |
10 |
Issue: |
1 |
Pages: |
47-62 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
106
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Kaustov L |
Year: |
2011 |
Journal: |
J Biol Chem |
Title: |
Recognition and specificity determinants of the human cbx chromodomains. |
Volume: |
286 |
Issue: |
1 |
Pages: |
521-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ma RG |
Year: |
2014 |
Journal: |
J Zhejiang Univ Sci B |
Title: |
Epigenetic regulation by polycomb group complexes: focus on roles of CBX proteins. |
Volume: |
15 |
Issue: |
5 |
Pages: |
412-28 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vandamme J |
Year: |
2011 |
Journal: |
Mol Cell Proteomics |
Title: |
Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells. |
Volume: |
10 |
Issue: |
4 |
Pages: |
M110.002642 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
180
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
121
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
158
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
251
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu HA |
Year: |
2013 |
Journal: |
J Biol Chem |
Title: |
Mitogen-activated protein kinase signaling mediates phosphorylation of polycomb ortholog Cbx7. |
Volume: |
288 |
Issue: |
51 |
Pages: |
36398-408 |
|
•
•
•
•
•
|
Publication |
First Author: |
Klauke K |
Year: |
2013 |
Journal: |
Nat Cell Biol |
Title: |
Polycomb Cbx family members mediate the balance between haematopoietic stem cell self-renewal and differentiation. |
Volume: |
15 |
Issue: |
4 |
Pages: |
353-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Maertens GN |
Year: |
2009 |
Journal: |
PLoS One |
Title: |
Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus. |
Volume: |
4 |
Issue: |
7 |
Pages: |
e6380 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bernstein E |
Year: |
2006 |
Journal: |
Mol Cell Biol |
Title: |
Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin. |
Volume: |
26 |
Issue: |
7 |
Pages: |
2560-9 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
El Messaoudi-Aubert S |
Year: |
2010 |
Journal: |
Nat Struct Mol Biol |
Title: |
Role for the MOV10 RNA helicase in polycomb-mediated repression of the INK4a tumor suppressor. |
Volume: |
17 |
Issue: |
7 |
Pages: |
862-8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1901967 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-11-24 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689521 |
Pattern: |
Regionally restricted |
Stage: |
TS21 |
Assay Id: |
MGI:3688569 |
Age: |
embryonic day 13.5 |
|
Note: |
Expression is in the hippocampus. |
Specimen Label: |
Not shown |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1901967 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-11-24 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1697426 |
Pattern: |
Regionally restricted |
Stage: |
TS26 |
Assay Id: |
MGI:3688569 |
Age: |
embryonic day 18.5 |
Image: |
7B |
Note: |
Expression is in the superior and inferior colliculi. |
Specimen Label: |
7B |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1901967 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-11-24 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1903726 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:3688569 |
Age: |
embryonic day 18.5 |
Image: |
5F |
Note: |
Higher magnification was shown in the inset. |
Specimen Label: |
5F |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1901967 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-11-24 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1903728 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:3688569 |
Age: |
postnatal adult |
Image: |
9E |
|
Specimen Label: |
9E |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1901967 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-11-24 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271121 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:3688569 |
Age: |
embryonic day 13.5 |
|
|
Specimen Label: |
Not shown |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1901967 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-11-24 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271126 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:3688569 |
Age: |
embryonic day 18.5 |
Image: |
4E |
|
Specimen Label: |
4E |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1901967 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-11-24 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3276728 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:3688569 |
Age: |
postnatal adult |
Image: |
9H |
|
Specimen Label: |
9H |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1901967 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-11-24 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3276828 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:3688569 |
Age: |
postnatal adult |
Image: |
9B |
|
Specimen Label: |
9B |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1901967 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-11-24 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1778726 |
Pattern: |
Regionally restricted |
Stage: |
TS26 |
Assay Id: |
MGI:3688569 |
Age: |
embryonic day 18.5 |
Image: |
7B |
Note: |
Expression is in the purkinje cell layer (more strongly) and the external granule cell layer and is absent in the molecular layer. |
Specimen Label: |
7B |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1901967 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-11-24 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754426 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:3688569 |
Age: |
embryonic day 18.5 |
Image: |
4E |
|
Specimen Label: |
4E |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1901967 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-11-24 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3284526 |
Pattern: |
Regionally restricted |
Stage: |
TS26 |
Assay Id: |
MGI:3688569 |
Age: |
embryonic day 18.5 |
Image: |
5F |
Note: |
Expression is in CA1-3. Higher magnification was shown in the inset. |
Specimen Label: |
5F |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1901967 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-11-24 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3276928 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:3688569 |
Age: |
postnatal adult |
Image: |
9B |
|
Specimen Label: |
9B |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1901967 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-11-24 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3277028 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:3688569 |
Age: |
postnatal adult |
Image: |
9B |
|
Specimen Label: |
9B |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1901967 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-11-24 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754721 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:3688569 |
Age: |
embryonic day 13.5 |
|
|
Specimen Label: |
Not shown |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1901967 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-11-24 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3280926 |
Pattern: |
Regionally restricted |
Stage: |
TS26 |
Assay Id: |
MGI:3688569 |
Age: |
embryonic day 18.5 |
Image: |
6E |
Note: |
Higher magnification was shown in the inset. Expression is in the differentiated mitral layer and is weak in the ventricular zone and granular layer. |
Specimen Label: |
6E |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cheng B |
Year: |
2014 |
Journal: |
Mol Cell Biol |
Title: |
KAP1 represses differentiation-inducible genes in embryonic stem cells through cooperative binding with PRC1 and derepresses pluripotency-associated genes. |
Volume: |
34 |
Issue: |
11 |
Pages: |
2075-91 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ning B |
Year: |
2017 |
Journal: |
Nat Commun |
Title: |
USP26 functions as a negative regulator of cellular reprogramming by stabilising PRC1 complex components. |
Volume: |
8 |
Issue: |
1 |
Pages: |
349 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu X |
Year: |
2013 |
Journal: |
Mol Cell |
Title: |
Fbxl10/Kdm2b recruits polycomb repressive complex 1 to CpG islands and regulates H2A ubiquitylation. |
Volume: |
49 |
Issue: |
6 |
Pages: |
1134-46 |
|
•
•
•
•
•
|
Publication |
First Author: |
Frangini A |
Year: |
2013 |
Journal: |
Mol Cell |
Title: |
The aurora B kinase and the polycomb protein ring1B combine to regulate active promoters in quiescent lymphocytes. |
Volume: |
51 |
Issue: |
5 |
Pages: |
647-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tavares L |
Year: |
2012 |
Journal: |
Cell |
Title: |
RYBP-PRC1 complexes mediate H2A ubiquitylation at polycomb target sites independently of PRC2 and H3K27me3. |
Volume: |
148 |
Issue: |
4 |
Pages: |
664-78 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vogel T |
Year: |
2006 |
Journal: |
Dev Dyn |
Title: |
Differential expression of polycomb repression complex 1 (PRC1) members in the developing mouse brain reveals multiple complexes. |
Volume: |
235 |
Issue: |
9 |
Pages: |
2574-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lynch MD |
Year: |
2012 |
Journal: |
EMBO J |
Title: |
An interspecies analysis reveals a key role for unmethylated CpG dinucleotides in vertebrate Polycomb complex recruitment. |
Volume: |
31 |
Issue: |
2 |
Pages: |
317-29 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li H |
Year: |
2017 |
Journal: |
Cell Stem Cell |
Title: |
RNA Helicase DDX5 Inhibits Reprogramming to Pluripotency by miRNA-Based Repression of RYBP and its PRC1-Dependent and -Independent Functions. |
Volume: |
20 |
Issue: |
4 |
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