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Search results 1 to 87 out of 87 for Cc2d1a

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Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Danio rerio
Gene
Type: gene
Organism: Rattus norvegicus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Oaks AW
Year: 2017
Journal: Cereb Cortex
Title: Cc2d1a Loss of Function Disrupts Functional and Morphological Development in Forebrain Neurons Leading to Cognitive and Social Deficits.
Volume: 27
Issue: 2
Pages: 1670-1685
Publication
First Author: Yang CY
Year: 2019
Journal: J Neurosci
Title: Conditional Deletion of CC2D1A Reduces Hippocampal Synaptic Plasticity and Impairs Cognitive Function through Rac1 Hyperactivation.
Volume: 39
Issue: 25
Pages: 4959-4975
Publication
First Author: Drusenheimer N
Year: 2015
Journal: PLoS Genet
Title: The Mammalian Orthologs of Drosophila Lgd, CC2D1A and CC2D1B, Function in the Endocytic Pathway, but Their Individual Loss of Function Does Not Affect Notch Signalling.
Volume: 11
Issue: 12
Pages: e1005749
Publication  
First Author: Zamarbide M
Year: 2018
Journal: Front Genet
Title: Loss of the Intellectual Disability and Autism Gene Cc2d1a and Its Homolog Cc2d1b Differentially Affect Spatial Memory, Anxiety, and Hyperactivity.
Volume: 9
Pages: 65
Publication
First Author: Basel-Vanagaite L
Year: 2006
Journal: J Med Genet
Title: The CC2D1A, a member of a new gene family with C2 domains, is involved in autosomal recessive non-syndromic mental retardation.
Volume: 43
Issue: 3
Pages: 203-10
Publication
First Author: Rogaeva A
Year: 2007
Journal: J Biol Chem
Title: Differential repression by freud-1/CC2D1A at a polymorphic site in the dopamine-D2 receptor gene.
Volume: 282
Issue: 29
Pages: 20897-905
Publication
First Author: Zhao M
Year: 2011
Journal: J Neurophysiol
Title: Cc2d1a, a C2 domain containing protein linked to nonsyndromic mental retardation, controls functional maturation of central synapses.
Volume: 105
Issue: 4
Pages: 1506-15
Publication
First Author: Al-Tawashi A
Year: 2012
Journal: J Biol Chem
Title: Protein implicated in nonsyndromic mental retardation regulates protein kinase A (PKA) activity.
Volume: 287
Issue: 18
Pages: 14644-58
Publication
First Author: Zamarbide M
Year: 2019
Journal: Biol Psychiatry
Title: Male-Specific cAMP Signaling in the Hippocampus Controls Spatial Memory Deficits in a Mouse Model of Autism and Intellectual Disability.
Volume: 85
Issue: 9
Pages: 760-768
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Chen KR
Year: 2012
Journal: J Biol Chem
Title: TBK1-associated protein in endolysosomes (TAPE)/CC2D1A is a key regulator linking RIG-I-like receptors to antiviral immunity.
Volume: 287
Issue: 38
Pages: 32216-21
Publication
First Author: Ozkul Y
Year: 2020
Journal: Sci Rep
Title: A heritable profile of six miRNAs in autistic patients and mouse models.
Volume: 10
Issue: 1
Pages: 9011
GXD Expression    
Probe: MGI:5615482
Assay Type: RNA in situ
Annotation Date: 2015-02-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271120
Pattern: Widespread
Stage: TS20
Assay Id: MGI:5615481
Age: embryonic day 12.0
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5615482
Assay Type: RNA in situ
Annotation Date: 2015-02-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271124
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:5615481
Age: embryonic day 16.0
Note: Expression is particularly prominent in this region.
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:5615482
Assay Type: RNA in situ
Annotation Date: 2015-02-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284524
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:5615481
Age: embryonic day 16.0
Note: Expression is particularly prominent in this region.
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:5615482
Assay Type: RNA in situ
Annotation Date: 2015-02-12
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3284527
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:5615481
Age: postnatal day 3
Note: Expression is particularly prominent in this region.
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:5615482
Assay Type: RNA in situ
Annotation Date: 2015-02-12
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3277027
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:5615481
Age: postnatal day 3
Note: Expression is particularly prominent in this region.
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:5615482
Assay Type: RNA in situ
Annotation Date: 2015-02-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754720
Pattern: Widespread
Stage: TS20
Assay Id: MGI:5615481
Age: embryonic day 12.0
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5615482
Assay Type: RNA in situ
Annotation Date: 2015-02-12
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3521127
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:5615481
Age: postnatal day 3
Note: Expression is particularly prominent in this region.
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:5615482
Assay Type: RNA in situ
Annotation Date: 2015-02-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3266520
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:5615481
Age: embryonic day 12.0
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5615482
Assay Type: RNA in situ
Annotation Date: 2015-02-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689424
Pattern: Widespread
Stage: TS24
Assay Id: MGI:5615481
Age: embryonic day 16.0
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:5615482
Assay Type: RNA in situ
Annotation Date: 2015-02-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Pattern: Widespread
Stage: TS28
Assay Id: MGI:5615481
Age: postnatal adult
Note: Expression appears restricted mostly to neurons.
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:5615482
Assay Type: RNA in situ
Annotation Date: 2015-02-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Pattern: Widespread
Stage: TS27
Assay Id: MGI:5615481
Age: postnatal day 3
Detected: true
Specimen Num: 3
Publication
First Author: Vahid-Ansari F
Year: 2017
Journal: J Neurosci
Title: Abrogated Freud-1/Cc2d1a Repression of 5-HT1A Autoreceptors Induces Fluoxetine-Resistant Anxiety/Depression-Like Behavior.
Volume: 37
Issue: 49
Pages: 11967-11978
Publication
First Author: Hadjighassem MR
Year: 2011
Journal: Eur J Neurosci
Title: Freud-2/CC2D1B mediates dual repression of the serotonin-1A receptor gene.
Volume: 33
Issue: 2
Pages: 214-23
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: MGC Data curation in Mouse Genome Informatics
Publication      
First Author: University of California, Davis
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the University of California, Davis
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
Publication
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
Publication      
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication
First Author: Deshar R
Year: 2016
Journal: Biochem Biophys Res Commun
Title: CC2D1A and CC2D1B regulate degradation and signaling of EGFR and TLR4.
Volume: 480
Issue: 2
Pages: 280-287
Protein Domain
Type: Domain
Description: The cc2d1a gene family consists of two homologues, CC2D1A (Freud-1) and CC2D1B (Freud-2). Freud-1 is a calcium-regulated repressor of serotonine receptor 5-HT1A and dopamine-D2 receptor expression [, ]. Mutations in cc2d1a has been linked to nonsyndromic mental retardation [, ].CC2D1A/freud-1 and CC2D1B/freud-2 share conserved domains, including several DM14 domains that are specific to this protein family, a C-terminal helix-loop-helix domain, and a C2 domain. The Freud-1 C2 domain is thought to be calcium insensitive and it lacks several acidic residues that mediate calcium binding of the PKC C2 domain. In addition, it contains a poly-basic insert that is not present in calcium-dependent C2 domains and may function as a nuclear localization signal []. The Freud-1 C2 domain appears to be essential for its DNA binding and repressor function; it may mediate protein-protein interactions [].
Publication
First Author: Ou XM
Year: 2003
Journal: J Neurosci
Title: Freud-1: A neuronal calcium-regulated repressor of the 5-HT1A receptor gene.
Volume: 23
Issue: 19
Pages: 7415-25
Publication
First Author: Rogaeva A
Year: 2007
Journal: J Neurosci Res
Title: The Freud-1/CC2D1A family: transcriptional regulators implicated in mental retardation.
Volume: 85
Issue: 13
Pages: 2833-8
Protein
Organism: Mus musculus
Length: 126  
Fragment?: true
Publication
First Author: Hadjighassem MR
Year: 2009
Journal: Biol Psychiatry
Title: Human Freud-2/CC2D1B: a novel repressor of postsynaptic serotonin-1A receptor expression.
Volume: 66
Issue: 3
Pages: 214-22
Protein Domain
Type: Family
Description: This entry includes coiled-coil and C2 domain-containing protein 1A/B (CC2D1A/B, also known as Freud-1/2). CC2D1A is involved in many pathways, including nuclear factor kappaB, PDK1/Akt, cAMP/PKA, Notch and bone morphogenetic protein []. It is a calcium-regulated repressor of serotonine receptor 5-HT1A and dopamine-D2 receptor expression [, ]. CC2D1B binds to the 5-HT1A DRE and represses the human 5-HT1A receptor gene to regulate its expression in non-serotonergic cells and neurons [].CC2D1A and CC2D1B have also been shown to interact with the CHMP4 family of proteins, the major subunit of the ESCRT-III complex. They may regulate degradation and signaling of EGFR and TLR4 [].CC2D1A and CC2D1B share conserved domains, including several DM14 domains that are specific to this protein family, a C-terminal helix-loop-helix domain, and a C2 domain. The CC2D1A C2 domain is thought to be calcium insensitive and it lacks several acidic residues that mediate calcium binding of the PKC C2 domain. In addition, it contains a poly-basic insert that is not present in calcium-dependent C2 domains and may function as a nuclear localization signal []. The CC2D1B C2 domain appears to be essential for its DNA binding and repressor function; it may mediate protein-protein interactions []. Mutations in the CC2D1A gene has been linked to nonsyndromic mental retardation [, ].
Protein
Organism: Mus musculus
Length: 943  
Fragment?: false
Protein
Organism: Mus musculus
Length: 848  
Fragment?: false
Protein
Organism: Mus musculus
Length: 773  
Fragment?: true
Protein
Organism: Mus musculus
Length: 770  
Fragment?: true
Protein
Organism: Mus musculus
Length: 897  
Fragment?: false