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Search results 1 to 96 out of 96 for Cc2d1a

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Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
54862 | CC2D1A
Type: gene
Organism: human
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Gene
513078 | CC2D1A
Type: gene
Organism: cattle
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Gene
100001297 | cc2d1a
Type: gene
Organism: zebrafish
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Gene
718483 | CC2D1A
Type: gene
Organism: macaque, rhesus
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Gene
101748080 | CC2D1A
Type: gene
Organism: chicken
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Gene
100145460 | cc2d1a
Type: gene
Organism: frog, western clawed
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Gene
288908 | Cc2d1a
Type: gene
Organism: rat
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Gene
484911 | CC2D1A
Type: gene
Organism: dog, domestic
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Gene
468744 | CC2D1A
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:2384831 | Cc2d1a
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
31721010 | J:319512
First Author: Dana H
Year: 2020
Journal: Neuromolecular Med
Title: Disregulation of Autophagy in the Transgenerational Cc2d1a Mouse Model of Autism.
Volume: 22
Issue: 2
Pages: 239-249
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Publication
26826102 | J:241103
First Author: Oaks AW
Year: 2017
Journal: Cereb Cortex
Title: Cc2d1a Loss of Function Disrupts Functional and Morphological Development in Forebrain Neurons Leading to Cognitive and Social Deficits.
Volume: 27
Issue: 2
Pages: 1670-1685
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Publication
30992372 | J:276133
First Author: Yang CY
Year: 2019
Journal: J Neurosci
Title: Conditional Deletion of CC2D1A Reduces Hippocampal Synaptic Plasticity and Impairs Cognitive Function through Rac1 Hyperactivation.
Volume: 39
Issue: 25
Pages: 4959-4975
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Publication
26720614 | J:236761
First Author: Drusenheimer N
Year: 2015
Journal: PLoS Genet
Title: The Mammalian Orthologs of Drosophila Lgd, CC2D1A and CC2D1B, Function in the Endocytic Pathway, but Their Individual Loss of Function Does Not Affect Notch Signalling.
Volume: 11
Issue: 12
Pages: e1005749
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Publication
29552027 | J:262467
 
First Author: Zamarbide M
Year: 2018
Journal: Front Genet
Title: Loss of the Intellectual Disability and Autism Gene Cc2d1a and Its Homolog Cc2d1b Differentially Affect Spatial Memory, Anxiety, and Hyperactivity.
Volume: 9
Pages: 65
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Publication
16033914 | J:200890
First Author: Basel-Vanagaite L
Year: 2006
Journal: J Med Genet
Title: The CC2D1A, a member of a new gene family with C2 domains, is involved in autosomal recessive non-syndromic mental retardation.
Volume: 43
Issue: 3
Pages: 203-10
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Publication
17535813 | J:124603
First Author: Rogaeva A
Year: 2007
Journal: J Biol Chem
Title: Differential repression by freud-1/CC2D1A at a polymorphic site in the dopamine-D2 receptor gene.
Volume: 282
Issue: 29
Pages: 20897-905
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Publication
21273312 | J:177407
First Author: Zhao M
Year: 2011
Journal: J Neurophysiol
Title: Cc2d1a, a C2 domain containing protein linked to nonsyndromic mental retardation, controls functional maturation of central synapses.
Volume: 105
Issue: 4
Pages: 1506-15
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Publication
22375002 | J:184920
First Author: Al-Tawashi A
Year: 2012
Journal: J Biol Chem
Title: Protein implicated in nonsyndromic mental retardation regulates protein kinase A (PKA) activity.
Volume: 287
Issue: 18
Pages: 14644-58
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Publication
30732858 | J:280260
First Author: Zamarbide M
Year: 2019
Journal: Biol Psychiatry
Title: Male-Specific cAMP Signaling in the Hippocampus Controls Spatial Memory Deficits in a Mouse Model of Autism and Intellectual Disability.
Volume: 85
Issue: 9
Pages: 760-768
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Protein Coding Gene
MGP_CAROLIEiJ_G0031294 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0033856 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0033839 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0033765 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0033832 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0033542 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2384831 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0034352 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0032872 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0033518 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0033672 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0033619 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0033763 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0033661 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0034369 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0032576 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0032985 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0022900 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0032412 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
32514154 | J:293759
First Author: Ozkul Y
Year: 2020
Journal: Sci Rep
Title: A heritable profile of six miRNAs in autistic patients and mouse models.
Volume: 10
Issue: 1
Pages: 9011
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Publication
22833682 | J:190401
First Author: Chen KR
Year: 2012
Journal: J Biol Chem
Title: TBK1-associated protein in endolysosomes (TAPE)/CC2D1A is a key regulator linking RIG-I-like receptors to antiviral immunity.
Volume: 287
Issue: 38
Pages: 32216-21
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GXD Expression
GXD Expression
   
Probe: MGI:5615482
Assay Type: RNA in situ
Annotation Date: 2015-02-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271120
Pattern: Widespread
Stage: TS20
Assay Id: MGI:5615481
Age: embryonic day 12.0
Specimen Label: E12
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:5615482
Assay Type: RNA in situ
Annotation Date: 2015-02-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271124
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:5615481
Age: embryonic day 16.0
Note: Expression is particularly prominent in this region.
Specimen Label: E16
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:5615482
Assay Type: RNA in situ
Annotation Date: 2015-02-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284524
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:5615481
Age: embryonic day 16.0
Note: Expression is particularly prominent in this region.
Specimen Label: E16
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:5615482
Assay Type: RNA in situ
Annotation Date: 2015-02-12
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3284527
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:5615481
Age: postnatal day 3
Note: Expression is particularly prominent in this region.
Specimen Label: P3
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:5615482
Assay Type: RNA in situ
Annotation Date: 2015-02-12
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3277027
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:5615481
Age: postnatal day 3
Note: Expression is particularly prominent in this region.
Specimen Label: P3
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:5615482
Assay Type: RNA in situ
Annotation Date: 2015-02-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754720
Pattern: Widespread
Stage: TS20
Assay Id: MGI:5615481
Age: embryonic day 12.0
Specimen Label: E12
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:5615482
Assay Type: RNA in situ
Annotation Date: 2015-02-12
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3521127
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:5615481
Age: postnatal day 3
Note: Expression is particularly prominent in this region.
Specimen Label: P3
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:5615482
Assay Type: RNA in situ
Annotation Date: 2015-02-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3266520
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:5615481
Age: embryonic day 12.0
Specimen Label: E12
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5615482
Assay Type: RNA in situ
Annotation Date: 2015-02-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689424
Pattern: Widespread
Stage: TS24
Assay Id: MGI:5615481
Age: embryonic day 16.0
Specimen Label: E16
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:5615482
Assay Type: RNA in situ
Annotation Date: 2015-02-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Pattern: Widespread
Stage: TS28
Assay Id: MGI:5615481
Age: postnatal adult
Note: Expression appears restricted mostly to neurons.
Specimen Label: Adult
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:5615482
Assay Type: RNA in situ
Annotation Date: 2015-02-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Pattern: Widespread
Stage: TS27
Assay Id: MGI:5615481
Age: postnatal day 3
Specimen Label: P3
Detected: true
Specimen Num: 3
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Publication
29101244 | J:251143
First Author: Vahid-Ansari F
Year: 2017
Journal: J Neurosci
Title: Abrogated Freud-1/Cc2d1a Repression of 5-HT1A Autoreceptors Induces Fluoxetine-Resistant Anxiety/Depression-Like Behavior.
Volume: 37
Issue: 49
Pages: 11967-11978
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Publication
21155902 | J:174464
First Author: Hadjighassem MR
Year: 2011
Journal: Eur J Neurosci
Title: Freud-2/CC2D1B mediates dual repression of the serotonin-1A receptor gene.
Volume: 33
Issue: 2
Pages: 214-23
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Publication
- | J:77000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: MGC Data curation in Mouse Genome Informatics
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Publication
- | J:157064
     
First Author: University of California, Davis
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the University of California, Davis
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:81858
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
27769858 | -
First Author: Deshar R
Year: 2016
Journal: Biochem Biophys Res Commun
Title: CC2D1A and CC2D1B regulate degradation and signaling of EGFR and TLR4.
Volume: 480
Issue: 2
Pages: 280-287
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DO Term
DOID:0081179 | autosomal recessive intellectual developmental disorder 3
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Protein Domain
IPR037772 | C2_Freud
Type: Domain
Description: The cc2d1a gene family consists of two homologues, CC2D1A (Freud-1) and CC2D1B (Freud-2). Freud-1 is a calcium-regulated repressor of serotonine receptor 5-HT1A and dopamine-D2 receptor expression [, ]. Mutations in cc2d1a has been linked to nonsyndromic mental retardation [, ].CC2D1A/freud-1 and CC2D1B/freud-2 share conserved domains, including several DM14 domains that are specific to this protein family, a C-terminal helix-loop-helix domain, and a C2 domain. The Freud-1 C2 domain is thought to be calcium insensitive and it lacks several acidic residues that mediate calcium binding of the PKC C2 domain. In addition, it contains a poly-basic insert that is not present in calcium-dependent C2 domains and may function as a nuclear localization signal []. The Freud-1 C2 domain appears to be essential for its DNA binding and repressor function; it may mediate protein-protein interactions [].
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Publication
12917378 | -
First Author: Ou XM
Year: 2003
Journal: J Neurosci
Title: Freud-1: A neuronal calcium-regulated repressor of the 5-HT1A receptor gene.
Volume: 23
Issue: 19
Pages: 7415-25
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Publication
17394259 | -
First Author: Rogaeva A
Year: 2007
Journal: J Neurosci Res
Title: The Freud-1/CC2D1A family: transcriptional regulators implicated in mental retardation.
Volume: 85
Issue: 13
Pages: 2833-8
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Protein
H3BKI0
Organism: Mus musculus/domesticus
Length: 126  
Fragment?: true
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Publication
19423080 | -
First Author: Hadjighassem MR
Year: 2009
Journal: Biol Psychiatry
Title: Human Freud-2/CC2D1B: a novel repressor of postsynaptic serotonin-1A receptor expression.
Volume: 66
Issue: 3
Pages: 214-22
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Protein Domain
IPR039725 | CC2D1A/B
Type: Family
Description: This entry includes coiled-coil and C2 domain-containing protein 1A/B (CC2D1A/B, also known as Freud-1/2). CC2D1A is involved in many pathways, including nuclear factor kappaB, PDK1/Akt, cAMP/PKA, Notch and bone morphogenetic protein []. It is a calcium-regulated repressor of serotonine receptor 5-HT1A and dopamine-D2 receptor expression [, ]. CC2D1B binds to the 5-HT1A DRE and represses the human 5-HT1A receptor gene to regulate its expression in non-serotonergic cells and neurons [].CC2D1A and CC2D1B have also been shown to interact with the CHMP4 family of proteins, the major subunit of the ESCRT-III complex. They may regulate degradation and signaling of EGFR and TLR4 [].CC2D1A and CC2D1B share conserved domains, including several DM14 domains that are specific to this protein family, a C-terminal helix-loop-helix domain, and a C2 domain. The CC2D1A C2 domain is thought to be calcium insensitive and it lacks several acidic residues that mediate calcium binding of the PKC C2 domain. In addition, it contains a poly-basic insert that is not present in calcium-dependent C2 domains and may function as a nuclear localization signal []. The CC2D1B C2 domain appears to be essential for its DNA binding and repressor function; it may mediate protein-protein interactions []. Mutations in the CC2D1A gene has been linked to nonsyndromic mental retardation [, ].
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Protein
Q8K1A6
Organism: Mus musculus/domesticus
Length: 943  
Fragment?: false
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Protein
Q8BRN9
Organism: Mus musculus/domesticus
Length: 848  
Fragment?: false
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Protein
F6XC25
Organism: Mus musculus/domesticus
Length: 770  
Fragment?: true
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Protein
E9PX94
Organism: Mus musculus/domesticus
Length: 897  
Fragment?: false
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Protein
Q7TPN1
Organism: Mus musculus/domesticus
Length: 773  
Fragment?: true
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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