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Search results 1 to 100 out of 102 for Cc2d1a

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
54862 | CC2D1A
Type: gene
Organism: human
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Gene
100145460 | cc2d1a
Type: gene
Organism: frog, western clawed
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Gene
288908 | Cc2d1a
Type: gene
Organism: rat
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Gene
484911 | CC2D1A
Type: gene
Organism: dog, domestic
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Gene
468744 | CC2D1A
Type: gene
Organism: chimpanzee
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Gene
513078 | CC2D1A
Type: gene
Organism: cattle
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Gene
100001297 | cc2d1a
Type: gene
Organism: zebrafish
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Gene
718483 | CC2D1A
Type: gene
Organism: macaque, rhesus
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Gene
101748080 | CC2D1A
Type: gene
Organism: chicken
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Protein Coding Gene
MGI:2384831 | Cc2d1a
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
31721010 | J:319512
First Author: Dana H
Year: 2020
Journal: Neuromolecular Med
Title: Disregulation of Autophagy in the Transgenerational Cc2d1a Mouse Model of Autism.
Volume: 22
Issue: 2
Pages: 239-249
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Publication
37059290 | J:355534
 
First Author: Sener EF
Year: 2023
Journal: Prog Neuropsychopharmacol Biol Psychiatry
Title: Heterozygous Cc2d1a mice show sex-dependent changes in the Beclin-1/p62 ratio with impaired prefrontal cortex and hippocampal autophagy.
Volume: 125
Pages: 110764
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Publication
26826102 | J:241103
First Author: Oaks AW
Year: 2017
Journal: Cereb Cortex
Title: Cc2d1a Loss of Function Disrupts Functional and Morphological Development in Forebrain Neurons Leading to Cognitive and Social Deficits.
Volume: 27
Issue: 2
Pages: 1670-1685
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Publication
30992372 | J:276133
First Author: Yang CY
Year: 2019
Journal: J Neurosci
Title: Conditional Deletion of CC2D1A Reduces Hippocampal Synaptic Plasticity and Impairs Cognitive Function through Rac1 Hyperactivation.
Volume: 39
Issue: 25
Pages: 4959-4975
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Publication
26720614 | J:236761
First Author: Drusenheimer N
Year: 2015
Journal: PLoS Genet
Title: The Mammalian Orthologs of Drosophila Lgd, CC2D1A and CC2D1B, Function in the Endocytic Pathway, but Their Individual Loss of Function Does Not Affect Notch Signalling.
Volume: 11
Issue: 12
Pages: e1005749
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Publication
29552027 | J:262467
 
First Author: Zamarbide M
Year: 2018
Journal: Front Genet
Title: Loss of the Intellectual Disability and Autism Gene Cc2d1a and Its Homolog Cc2d1b Differentially Affect Spatial Memory, Anxiety, and Hyperactivity.
Volume: 9
Pages: 65
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Publication
16033914 | J:200890
First Author: Basel-Vanagaite L
Year: 2006
Journal: J Med Genet
Title: The CC2D1A, a member of a new gene family with C2 domains, is involved in autosomal recessive non-syndromic mental retardation.
Volume: 43
Issue: 3
Pages: 203-10
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Publication
17535813 | J:124603
First Author: Rogaeva A
Year: 2007
Journal: J Biol Chem
Title: Differential repression by freud-1/CC2D1A at a polymorphic site in the dopamine-D2 receptor gene.
Volume: 282
Issue: 29
Pages: 20897-905
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Publication
21273312 | J:177407
First Author: Zhao M
Year: 2011
Journal: J Neurophysiol
Title: Cc2d1a, a C2 domain containing protein linked to nonsyndromic mental retardation, controls functional maturation of central synapses.
Volume: 105
Issue: 4
Pages: 1506-15
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Publication
34048600 | J:347777
First Author: Pond HL
Year: 2021
Journal: J Neurosci Res
Title: Digging behavior discrimination test to probe burrowing and exploratory digging in male and female mice.
Volume: 99
Issue: 9
Pages: 2046-2058
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Publication
22375002 | J:184920
First Author: Al-Tawashi A
Year: 2012
Journal: J Biol Chem
Title: Protein implicated in nonsyndromic mental retardation regulates protein kinase A (PKA) activity.
Volume: 287
Issue: 18
Pages: 14644-58
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Publication
30732858 | J:280260
First Author: Zamarbide M
Year: 2019
Journal: Biol Psychiatry
Title: Male-Specific cAMP Signaling in the Hippocampus Controls Spatial Memory Deficits in a Mouse Model of Autism and Intellectual Disability.
Volume: 85
Issue: 9
Pages: 760-768
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Protein Coding Gene
MGP_CAROLIEiJ_G0031294 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0033856 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0033839 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0033765 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0033832 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0033542 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2384831 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0034352 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0032872 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0033518 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0033672 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0033619 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0033763 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0033661 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0034369 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0032576 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0032985 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0022900 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0032412 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
32514154 | J:293759
First Author: Ozkul Y
Year: 2020
Journal: Sci Rep
Title: A heritable profile of six miRNAs in autistic patients and mouse models.
Volume: 10
Issue: 1
Pages: 9011
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Publication
22833682 | J:190401
First Author: Chen KR
Year: 2012
Journal: J Biol Chem
Title: TBK1-associated protein in endolysosomes (TAPE)/CC2D1A is a key regulator linking RIG-I-like receptors to antiviral immunity.
Volume: 287
Issue: 38
Pages: 32216-21
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Publication
39504361 | J:359114
First Author: Chen KR
Year: 2024
Journal: Sci Adv
Title: Endosomes serve as signaling platforms for RIG-I ubiquitination and activation.
Volume: 10
Issue: 45
Pages: eadq0660
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Publication
38050173 | J:358827
 
First Author: Vahid-Ansari F
Year: 2024
Journal: J Neurosci
Title: Chronic Desipramine Reverses Deficits in Cell Activity, Norepinephrine Innervation, and Anxiety-Depression Phenotypes in Fluoxetine-Resistant cF1ko Mice.
Volume: 44
Issue: 3
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Publication
39208980 | J:353955
 
First Author: Vahid-Ansari F
Year: 2024
Journal: Neuropharmacology
Title: Rapid reorganization of serotonin projections and antidepressant response to 5-HT1A-biased agonist NLX-101 in fluoxetine-resistant cF1ko mice.
Volume: 261
Pages: 110132
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GXD Expression
GXD Expression
   
Probe: MGI:5615482
Assay Type: RNA in situ
Annotation Date: 2015-02-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271120
Pattern: Widespread
Stage: TS20
Assay Id: MGI:5615481
Age: embryonic day 12.0
Specimen Label: E12
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:5615482
Assay Type: RNA in situ
Annotation Date: 2015-02-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271124
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:5615481
Age: embryonic day 16.0
Note: Expression is particularly prominent in this region.
Specimen Label: E16
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:5615482
Assay Type: RNA in situ
Annotation Date: 2015-02-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284524
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:5615481
Age: embryonic day 16.0
Note: Expression is particularly prominent in this region.
Specimen Label: E16
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:5615482
Assay Type: RNA in situ
Annotation Date: 2015-02-12
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3284527
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:5615481
Age: postnatal day 3
Note: Expression is particularly prominent in this region.
Specimen Label: P3
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:5615482
Assay Type: RNA in situ
Annotation Date: 2015-02-12
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3277027
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:5615481
Age: postnatal day 3
Note: Expression is particularly prominent in this region.
Specimen Label: P3
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:5615482
Assay Type: RNA in situ
Annotation Date: 2015-02-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754720
Pattern: Widespread
Stage: TS20
Assay Id: MGI:5615481
Age: embryonic day 12.0
Specimen Label: E12
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:5615482
Assay Type: RNA in situ
Annotation Date: 2015-02-12
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3521127
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:5615481
Age: postnatal day 3
Note: Expression is particularly prominent in this region.
Specimen Label: P3
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:5615482
Assay Type: RNA in situ
Annotation Date: 2015-02-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3266520
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:5615481
Age: embryonic day 12.0
Specimen Label: E12
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5615482
Assay Type: RNA in situ
Annotation Date: 2015-02-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689424
Pattern: Widespread
Stage: TS24
Assay Id: MGI:5615481
Age: embryonic day 16.0
Specimen Label: E16
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:5615482
Assay Type: RNA in situ
Annotation Date: 2015-02-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Pattern: Widespread
Stage: TS28
Assay Id: MGI:5615481
Age: postnatal adult
Note: Expression appears restricted mostly to neurons.
Specimen Label: Adult
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:5615482
Assay Type: RNA in situ
Annotation Date: 2015-02-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Pattern: Widespread
Stage: TS27
Assay Id: MGI:5615481
Age: postnatal day 3
Specimen Label: P3
Detected: true
Specimen Num: 3
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Publication
29101244 | J:251143
First Author: Vahid-Ansari F
Year: 2017
Journal: J Neurosci
Title: Abrogated Freud-1/Cc2d1a Repression of 5-HT1A Autoreceptors Induces Fluoxetine-Resistant Anxiety/Depression-Like Behavior.
Volume: 37
Issue: 49
Pages: 11967-11978
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Publication
21155902 | J:174464
First Author: Hadjighassem MR
Year: 2011
Journal: Eur J Neurosci
Title: Freud-2/CC2D1B mediates dual repression of the serotonin-1A receptor gene.
Volume: 33
Issue: 2
Pages: 214-23
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Publication
- | J:77000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: MGC Data curation in Mouse Genome Informatics
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Publication
- | J:157064
     
First Author: University of California, Davis
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the University of California, Davis
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:81858
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
27769858 | -
First Author: Deshar R
Year: 2016
Journal: Biochem Biophys Res Commun
Title: CC2D1A and CC2D1B regulate degradation and signaling of EGFR and TLR4.
Volume: 480
Issue: 2
Pages: 280-287
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DO Term
DOID:0081179 | autosomal recessive intellectual developmental disorder 3
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Protein Domain
IPR037772 | C2_Freud
Type: Domain
Description: The cc2d1a gene family consists of two homologues, CC2D1A (Freud-1) and CC2D1B (Freud-2). Freud-1 is a calcium-regulated repressor of serotonine receptor 5-HT1A and dopamine-D2 receptor expression [, ]. Mutations in cc2d1a has been linked to nonsyndromic mental retardation [, ].CC2D1A/freud-1 and CC2D1B/freud-2 share conserved domains, including several DM14 domains that are specific to this protein family, a C-terminal helix-loop-helix domain, and a C2 domain. The Freud-1 C2 domain is thought to be calcium insensitive and it lacks several acidic residues that mediate calcium binding of the PKC C2 domain. In addition, it contains a poly-basic insert that is not present in calcium-dependent C2 domains and may function as a nuclear localization signal []. The Freud-1 C2 domain appears to be essential for its DNA binding and repressor function; it may mediate protein-protein interactions [].
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Publication
12917378 | -
First Author: Ou XM
Year: 2003
Journal: J Neurosci
Title: Freud-1: A neuronal calcium-regulated repressor of the 5-HT1A receptor gene.
Volume: 23
Issue: 19
Pages: 7415-25
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Publication
17394259 | -
First Author: Rogaeva A
Year: 2007
Journal: J Neurosci Res
Title: The Freud-1/CC2D1A family: transcriptional regulators implicated in mental retardation.
Volume: 85
Issue: 13
Pages: 2833-8
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Protein
H3BKI0
Organism: Mus musculus/domesticus
Length: 126  
Fragment?: true
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Publication
19423080 | -
First Author: Hadjighassem MR
Year: 2009
Journal: Biol Psychiatry
Title: Human Freud-2/CC2D1B: a novel repressor of postsynaptic serotonin-1A receptor expression.
Volume: 66
Issue: 3
Pages: 214-22
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Protein Domain
IPR039725 | CC2D1A/B
Type: Family
Description: This entry includes coiled-coil and C2 domain-containing protein 1A/B (CC2D1A/B, also known as Freud-1/2). CC2D1A is involved in many pathways, including nuclear factor kappaB, PDK1/Akt, cAMP/PKA, Notch and bone morphogenetic protein []. It is a calcium-regulated repressor of serotonine receptor 5-HT1A and dopamine-D2 receptor expression [, ]. CC2D1B binds to the 5-HT1A DRE and represses the human 5-HT1A receptor gene to regulate its expression in non-serotonergic cells and neurons [].CC2D1A and CC2D1B have also been shown to interact with the CHMP4 family of proteins, the major subunit of the ESCRT-III complex. They may regulate degradation and signaling of EGFR and TLR4 [].CC2D1A and CC2D1B share conserved domains, including several DM14 domains that are specific to this protein family, a C-terminal helix-loop-helix domain, and a C2 domain. The CC2D1A C2 domain is thought to be calcium insensitive and it lacks several acidic residues that mediate calcium binding of the PKC C2 domain. In addition, it contains a poly-basic insert that is not present in calcium-dependent C2 domains and may function as a nuclear localization signal []. The CC2D1B C2 domain appears to be essential for its DNA binding and repressor function; it may mediate protein-protein interactions []. Mutations in the CC2D1A gene has been linked to nonsyndromic mental retardation [, ].
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Protein
Q8K1A6
Organism: Mus musculus/domesticus
Length: 943  
Fragment?: false
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Protein
Q8BRN9
Organism: Mus musculus/domesticus
Length: 848  
Fragment?: false
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Protein
F6XC25
Organism: Mus musculus/domesticus
Length: 770  
Fragment?: true
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