Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Acheta J |
Year: |
2022 |
Journal: |
Front Mol Neurosci |
Title: |
Cc2d1b Contributes to the Regulation of Developmental Myelination in the Central Nervous System. |
Volume: |
15 |
|
Pages: |
881571 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zamarbide M |
Year: |
2018 |
Journal: |
Front Genet |
Title: |
Loss of the Intellectual Disability and Autism Gene Cc2d1a and Its Homolog Cc2d1b Differentially Affect Spatial Memory, Anxiety, and Hyperactivity. |
Volume: |
9 |
|
Pages: |
65 |
|
•
•
•
•
•
|
Publication |
First Author: |
Drusenheimer N |
Year: |
2015 |
Journal: |
PLoS Genet |
Title: |
The Mammalian Orthologs of Drosophila Lgd, CC2D1A and CC2D1B, Function in the Endocytic Pathway, but Their Individual Loss of Function Does Not Affect Notch Signalling. |
Volume: |
11 |
Issue: |
12 |
Pages: |
e1005749 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4422968 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1679723 |
Pattern: |
Spotted |
Stage: |
TS23 |
Assay Id: |
MGI:4823660 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_009319_03 |
|
Specimen Label: |
euxassay_009319_03 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4422968 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1679723 |
Pattern: |
Spotted |
Stage: |
TS23 |
Assay Id: |
MGI:4823660 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_009319_04 |
|
Specimen Label: |
euxassay_009319_04 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4422968 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1679723 |
Pattern: |
Spotted |
Stage: |
TS23 |
Assay Id: |
MGI:4823660 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_009319_05 |
|
Specimen Label: |
euxassay_009319_05 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4422968 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1679723 |
Pattern: |
Spotted |
Stage: |
TS23 |
Assay Id: |
MGI:4823660 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_009319_06 |
|
Specimen Label: |
euxassay_009319_06 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4422968 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1679723 |
Pattern: |
Spotted |
Stage: |
TS23 |
Assay Id: |
MGI:4823660 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_009319_07 |
|
Specimen Label: |
euxassay_009319_07 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4422968 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1679723 |
Pattern: |
Spotted |
Stage: |
TS23 |
Assay Id: |
MGI:4823660 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_009319_08 |
|
Specimen Label: |
euxassay_009319_08 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4422968 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1679723 |
Pattern: |
Spotted |
Stage: |
TS23 |
Assay Id: |
MGI:4823660 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_009319_09 |
|
Specimen Label: |
euxassay_009319_09 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4422968 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1679723 |
Pattern: |
Spotted |
Stage: |
TS23 |
Assay Id: |
MGI:4823660 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_009319_17 |
|
Specimen Label: |
euxassay_009319_17 |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4422968 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1679723 |
Pattern: |
Spotted |
Stage: |
TS23 |
Assay Id: |
MGI:4823660 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_009319_18 |
|
Specimen Label: |
euxassay_009319_18 |
Detected: |
true |
Specimen Num: |
9 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4422968 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1679723 |
Pattern: |
Spotted |
Stage: |
TS23 |
Assay Id: |
MGI:4823660 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_009319_19 |
|
Specimen Label: |
euxassay_009319_19 |
Detected: |
true |
Specimen Num: |
10 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4422968 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1679723 |
Pattern: |
Spotted |
Stage: |
TS23 |
Assay Id: |
MGI:4823660 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_009319_20 |
|
Specimen Label: |
euxassay_009319_20 |
Detected: |
true |
Specimen Num: |
11 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4422968 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1679723 |
Pattern: |
Spotted |
Stage: |
TS23 |
Assay Id: |
MGI:4823660 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_009319_21 |
|
Specimen Label: |
euxassay_009319_21 |
Detected: |
true |
Specimen Num: |
12 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4422968 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1679723 |
Pattern: |
Spotted |
Stage: |
TS23 |
Assay Id: |
MGI:4823660 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_009319_22 |
|
Specimen Label: |
euxassay_009319_22 |
Detected: |
true |
Specimen Num: |
13 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4422968 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1756923 |
Pattern: |
Spotted |
Stage: |
TS23 |
Assay Id: |
MGI:4823660 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_009319_04 |
|
Specimen Label: |
euxassay_009319_04 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4422968 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1756923 |
Pattern: |
Spotted |
Stage: |
TS23 |
Assay Id: |
MGI:4823660 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_009319_05 |
|
Specimen Label: |
euxassay_009319_05 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4422968 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1756923 |
Pattern: |
Spotted |
Stage: |
TS23 |
Assay Id: |
MGI:4823660 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_009319_06 |
|
Specimen Label: |
euxassay_009319_06 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4422968 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1756923 |
Pattern: |
Spotted |
Stage: |
TS23 |
Assay Id: |
MGI:4823660 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_009319_07 |
|
Specimen Label: |
euxassay_009319_07 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4422968 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1679523 |
Pattern: |
Spotted |
Stage: |
TS23 |
Assay Id: |
MGI:4823660 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_009319_08 |
|
Specimen Label: |
euxassay_009319_08 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4422968 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1679523 |
Pattern: |
Spotted |
Stage: |
TS23 |
Assay Id: |
MGI:4823660 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_009319_19 |
|
Specimen Label: |
euxassay_009319_19 |
Detected: |
true |
Specimen Num: |
10 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4422968 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1679823 |
Pattern: |
Spotted |
Stage: |
TS23 |
Assay Id: |
MGI:4823660 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_009319_08 |
|
Specimen Label: |
euxassay_009319_08 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4422968 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1679823 |
Pattern: |
Spotted |
Stage: |
TS23 |
Assay Id: |
MGI:4823660 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_009319_18 |
|
Specimen Label: |
euxassay_009319_18 |
Detected: |
true |
Specimen Num: |
9 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4422968 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1679823 |
Pattern: |
Spotted |
Stage: |
TS23 |
Assay Id: |
MGI:4823660 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_009319_19 |
|
Specimen Label: |
euxassay_009319_19 |
Detected: |
true |
Specimen Num: |
10 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
773
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Zamarbide M |
Year: |
2019 |
Journal: |
Biol Psychiatry |
Title: |
Male-Specific cAMP Signaling in the Hippocampus Controls Spatial Memory Deficits in a Mouse Model of Autism and Intellectual Disability. |
Volume: |
85 |
Issue: |
9 |
Pages: |
760-768 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hadjighassem MR |
Year: |
2011 |
Journal: |
Eur J Neurosci |
Title: |
Freud-2/CC2D1B mediates dual repression of the serotonin-1A receptor gene. |
Volume: |
33 |
Issue: |
2 |
Pages: |
214-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the Europhenome Mouse Phenotyping Resource |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from Europhenome |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the Wellcome Trust Sanger Institute Mouse Genetics Project (MGP) |
Year: |
2011 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the Wellcome Trust Sanger Institute (WTSI) Mouse Resources Portal |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Ingham NJ |
Year: |
2019 |
Journal: |
PLoS Biol |
Title: |
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. |
Volume: |
17 |
Issue: |
4 |
Pages: |
e3000194 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2001 |
|
Title: |
Gene Ontology Annotation by the MGI Curatorial Staff |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen J |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. |
Volume: |
100 |
Issue: |
17 |
Pages: |
9918-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Friedel RH |
Year: |
2007 |
Journal: |
Brief Funct Genomic Proteomic |
Title: |
EUCOMM--the European conditional mouse mutagenesis program. |
Volume: |
6 |
Issue: |
3 |
Pages: |
180-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stryke D |
Year: |
2003 |
Journal: |
Nucleic Acids Res |
Title: |
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. |
Volume: |
31 |
Issue: |
1 |
Pages: |
278-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2009 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen GM |
Year: |
2008 |
Journal: |
Genome Res |
Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
Volume: |
18 |
Issue: |
10 |
Pages: |
1670-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Magdaleno S |
Year: |
2006 |
Journal: |
PLoS Biol |
Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
Volume: |
4 |
Issue: |
4 |
Pages: |
e86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
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CC2D1A and CC2D1B regulate degradation and signaling of EGFR and TLR4. |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
126
 |
Fragment?: |
true |
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Publication |
First Author: |
Hadjighassem MR |
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2009 |
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Biol Psychiatry |
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214-22 |
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Protein Domain |
Type: |
Family |
Description: |
This entry includes coiled-coil and C2 domain-containing protein 1A/B (CC2D1A/B, also known as Freud-1/2). CC2D1A is involved in many pathways, including nuclear factor kappaB, PDK1/Akt, cAMP/PKA, Notch and bone morphogenetic protein []. It is a calcium-regulated repressor of serotonine receptor 5-HT1A and dopamine-D2 receptor expression [, ]. CC2D1B binds to the 5-HT1A DRE and represses the human 5-HT1A receptor gene to regulate its expression in non-serotonergic cells and neurons [].CC2D1A and CC2D1B have also been shown to interact with the CHMP4 family of proteins, the major subunit of the ESCRT-III complex. They may regulate degradation and signaling of EGFR and TLR4 [].CC2D1A and CC2D1B share conserved domains, including several DM14 domains that are specific to this protein family, a C-terminal helix-loop-helix domain, and a C2 domain. The CC2D1A C2 domain is thought to be calcium insensitive and it lacks several acidic residues that mediate calcium binding of the PKC C2 domain. In addition, it contains a poly-basic insert that is not present in calcium-dependent C2 domains and may function as a nuclear localization signal []. The CC2D1B C2 domain appears to be essential for its DNA binding and repressor function; it may mediate protein-protein interactions []. Mutations in the CC2D1A gene has been linked to nonsyndromic mental retardation [, ]. |
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Publication |
First Author: |
Ou XM |
Year: |
2003 |
Journal: |
J Neurosci |
Title: |
Freud-1: A neuronal calcium-regulated repressor of the 5-HT1A receptor gene. |
Volume: |
23 |
Issue: |
19 |
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Publication |
First Author: |
Basel-Vanagaite L |
Year: |
2006 |
Journal: |
J Med Genet |
Title: |
The CC2D1A, a member of a new gene family with C2 domains, is involved in autosomal recessive non-syndromic mental retardation. |
Volume: |
43 |
Issue: |
3 |
Pages: |
203-10 |
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Publication |
First Author: |
Rogaeva A |
Year: |
2007 |
Journal: |
J Biol Chem |
Title: |
Differential repression by freud-1/CC2D1A at a polymorphic site in the dopamine-D2 receptor gene. |
Volume: |
282 |
Issue: |
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Pages: |
20897-905 |
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Publication |
First Author: |
Rogaeva A |
Year: |
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Journal: |
J Neurosci Res |
Title: |
The Freud-1/CC2D1A family: transcriptional regulators implicated in mental retardation. |
Volume: |
85 |
Issue: |
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Pages: |
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