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Search results 1 to 91 out of 91 for Ccar2

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Hits by Category

Hits by Strain

Type Details Score
Gene
57805 | CCAR2
Type: gene
Organism: human
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Gene
306007 | Ccar2
Type: gene
Organism: rat
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Gene
486122 | CCAR2
Type: gene
Organism: dog, domestic
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Gene
464047 | CCAR2
Type: gene
Organism: chimpanzee
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Gene
507114 | CCAR2
Type: gene
Organism: cattle
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Gene
564155 | ccar2
Type: gene
Organism: zebrafish
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Gene
716288 | CCAR2
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:2444228 | Ccar2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR028811 | CCAR2
Type: Family
Description: Cell cycle and apoptosis regulator protein 2 (CCAR2, also known as DBC-1) regulates biological processes such as transcription, heterochromatin formation, metabolism, mRNA splicing, apoptosis, and cell proliferation []. It is a core component of the DBIRD complex, which affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions []. It binds to SIRT1 and is a negative regulator of SIRT1 []. DBC-1 has been implicated in tumorigenesis [].
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Publication
34197713 | J:355672
First Author: Niri F
Year: 2021
Journal: Biochem Cell Biol
Title: Chromatin remodeling factor CECR2 forms tissue-specific complexes with CCAR2 and LUZP1.
Volume: 99
Issue: 6
Pages: 759-765
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Protein
Q8VDP4
Organism: Mus musculus/domesticus
Length: 922  
Fragment?: false
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Publication
18235501 | -
First Author: Kim JE
Year: 2008
Journal: Nature
Title: DBC1 is a negative regulator of SIRT1.
Volume: 451
Issue: 7178
Pages: 583-6
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Publication
23352644 | -
First Author: Kim W
Year: 2013
Journal: Cancer Lett
Title: Deleted in breast cancer 1 (DBC1) deficiency results in apoptosis of breast cancer cells through impaired responses to UV-induced DNA damage.
Volume: 333
Issue: 2
Pages: 180-6
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Publication
19657230 | -
First Author: Kim JE
Year: 2009
Journal: Cell Cycle
Title: p30 DBC is a potential regulator of tumorigenesis.
Volume: 8
Issue: 18
Pages: 2932-5
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Publication
25732823 | J:222111
First Author: Qin B
Year: 2015
Journal: Cell Rep
Title: DBC1 functions as a tumor suppressor by regulating p53 stability.
Volume: 10
Issue: 8
Pages: 1324-34
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Protein Coding Gene
MGP_CAROLIEiJ_G0019474 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0021530 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0021489 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0021465 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0021495 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0021272 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2444228 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0021934 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0020789 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0021239 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0021362 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0021341 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0021433 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0021370 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0021958 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0020533 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0020842 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0030491 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0020366 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
19218236 | J:149260
First Author: Li Z
Year: 2009
Journal: J Biol Chem
Title: Inhibition of SUV39H1 methyltransferase activity by DBC1.
Volume: 284
Issue: 16
Pages: 10361-6
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Publication
24415752 | J:209502
First Author: Nin V
Year: 2014
Journal: J Biol Chem
Title: Deleted in breast cancer 1 (DBC1) protein regulates hepatic gluconeogenesis.
Volume: 289
Issue: 9
Pages: 5518-27
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Publication
32317757 | J:289830
First Author: Colman L
Year: 2020
Journal: Sci Rep
Title: The protein Deleted in Breast Cancer-1 (DBC1) regulates vascular response and formation of aortic dissection during Angiotensin II infusion.
Volume: 10
Issue: 1
Pages: 6772
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Publication
31591441 | J:284242
First Author: Santos L
Year: 2019
Journal: Sci Rep
Title: A novel form of Deleted in breast cancer 1 (DBC1) lacking the N-terminal domain does not bind SIRT1 and is dynamically regulated in vivo.
Volume: 9
Issue: 1
Pages: 14381
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Publication
25053585 | J:230114
First Author: Escande C
Year: 2015
Journal: Diabetes
Title: Deleted in breast cancer 1 limits adipose tissue fat accumulation and plays a key role in the development of metabolic syndrome phenotype.
Volume: 64
Issue: 1
Pages: 12-22
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Publication
24992635 | J:215312
First Author: Escande C
Year: 2014
Journal: Aging Cell
Title: Deleted in Breast Cancer 1 regulates cellular senescence during obesity.
Volume: 13
Issue: 5
Pages: 951-3
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GXD Expression
GXD Expression
 
Probe: MGI:223581
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716824
Pattern: Uniform
Stage: TS24
Assay Id: MGI:3585600
Age: embryonic day 16.0
Note: Expression was panretinal.
Specimen Label: E16
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:223581
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716826
Pattern: Uniform
Stage: TS26
Assay Id: MGI:3585600
Age: embryonic day 18.0
Note: Expression was panretinal.
Specimen Label: E18
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:223581
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915527
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3585600
Age: postnatal day 0-1
Note: Expression was detected in the inner neuroblastic layer.
Specimen Label: P0/1
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:223581
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915527
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:3585600
Age: postnatal day 2-3
Note: Expression was detected in the scleral inner neuroblastic layer.
Specimen Label: P2/3
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:223581
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:3585600
Age: postnatal day 4-5
Note: Expression was detected in the scleral inner neuroblastic layer.
Specimen Label: P4/5
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:223581
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585600
Age: postnatal day 6-7
Specimen Label: P6/7
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:223581
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Male
Emaps: EMAPS:1915528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585600
Age: postnatal adult
Specimen Label: Adult
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Probe: MGI:223581
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1647028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585600
Age: postnatal day 6
Note: Expression was widespread.
Specimen Label: CNS
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
 
Probe: MGI:223581
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603924
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:3585600
Age: embryonic day 16.0
Note: Expression was widespread.
Specimen Label: Embryo
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
 
Probe: MGI:223581
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915727
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:3585600
Age: postnatal day 0-1
Note: Expression was detected in the vitreal outer neuroblastic layer.
Specimen Label: P0/1
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:223581
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915727
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3585600
Age: postnatal day 2-3
Note: Expression was detected in the outer neuroblastic layer.
Specimen Label: P2/3
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:223581
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585600
Age: postnatal day 4-5
Note: Expression was detected in the outer neuroblastic layer.
Specimen Label: P4/5
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:223581
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585600
Age: postnatal day 6-7
Specimen Label: P6/7
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:223581
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Male
Emaps: EMAPS:1915728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585600
Age: postnatal adult
Specimen Label: Adult
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Probe: MGI:223581
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3574228
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:3585600
Age: postnatal day 6-7
Note: Expression was detected in amacrine cells.
Specimen Label: P6/7
Detected: true
Specimen Num: 6
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Publication
21030595 | J:221556
First Author: Chini CC
Year: 2010
Journal: J Biol Chem
Title: HDAC3 is negatively regulated by the nuclear protein DBC1.
Volume: 285
Issue: 52
Pages: 40830-7
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Publication
26060310 | J:223757
First Author: Gao Y
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Inflammation negatively regulates FOXP3 and regulatory T-cell function via DBC1.
Volume: 112
Issue: 25
Pages: E3246-54
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Publication
20071779 | J:156677
First Author: Escande C
Year: 2010
Journal: J Clin Invest
Title: Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice.
Volume: 120
Issue: 2
Pages: 545-58
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Publication
23398316 | J:198046
First Author: Chini CC
Year: 2013
Journal: Biochem J
Title: DBC1 (Deleted in Breast Cancer 1) modulates the stability and function of the nuclear receptor Rev-erbα.
Volume: 451
Issue: 3
Pages: 453-61
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Publication
30415949 | J:268829
First Author: Krzysiak TC
Year: 2018
Journal: Mol Cell
Title: An Insulin-Responsive Sensor in the SIRT1 Disordered Region Binds DBC1 and PACS-2 to Control Enzyme Activity.
Volume: 72
Issue: 6
Pages: 985-998.e7
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Publication
22863012 | J:187882
First Author: Qiang L
Year: 2012
Journal: Cell
Title: Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparγ.
Volume: 150
Issue: 3
Pages: 620-32
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Publication
26074075 | J:228688
First Author: Qiang L
Year: 2015
Journal: Cell Rep
Title: Hepatic SirT1-Dependent Gain of Function of Stearoyl-CoA Desaturase-1 Conveys Dysmetabolic and Tumor Progression Functions.
Volume: 11
Issue: 11
Pages: 1797-808
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Publication
12693553 | J:83413
First Author: Okazaki N
Year: 2003
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 10
Issue: 1
Pages: 35-48
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Publication
15226823 | J:93300
First Author: Blackshaw S
Year: 2004
Journal: PLoS Biol
Title: Genomic analysis of mouse retinal development.
Volume: 2
Issue: 9
Pages: E247
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Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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Cambridge CB2 3EH, United Kingdom