Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Burkhardt AM |
Year: |
2019 |
Journal: |
J Interferon Cytokine Res |
Title: |
CCL28 Is Involved in Mucosal IgA Responses, Olfaction, and Resistance to Enteric Infections. |
Volume: |
39 |
Issue: |
4 |
Pages: |
214-223 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lin D |
Year: |
2020 |
Journal: |
Acta Biochim Biophys Sin (Shanghai) |
Title: |
Dispensable role of CCL28 in Kras-mutated non-small cell lung cancer mouse models. |
Volume: |
52 |
Issue: |
6 |
Pages: |
691-694 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wilson E |
Year: |
2004 |
Journal: |
J Exp Med |
Title: |
CCL28 controls immunoglobulin (Ig)A plasma cell accumulation in the lactating mammary gland and IgA antibody transfer to the neonate. |
Volume: |
200 |
Issue: |
6 |
Pages: |
805-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hieshima K |
Year: |
2003 |
Journal: |
J Immunol |
Title: |
CCL28 has dual roles in mucosal immunity as a chemokine with broad-spectrum antimicrobial activity. |
Volume: |
170 |
Issue: |
3 |
Pages: |
1452-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu B |
Year: |
2010 |
Journal: |
Eur J Immunol |
Title: |
The antimicrobial activity of CCL28 is dependent on C-terminal positively-charged amino acids. |
Volume: |
40 |
Issue: |
1 |
Pages: |
186-96 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang W |
Year: |
2000 |
Journal: |
J Biol Chem |
Title: |
Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2). |
Volume: |
275 |
Issue: |
29 |
Pages: |
22313-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Matsuo K |
Year: |
2018 |
Journal: |
J Immunol |
Title: |
CCL28-Deficient Mice Have Reduced IgA Antibody-Secreting Cells and an Altered Microbiota in the Colon. |
Volume: |
200 |
Issue: |
2 |
Pages: |
800-809 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hieshima K |
Year: |
2004 |
Journal: |
J Immunol |
Title: |
CC chemokine ligands 25 and 28 play essential roles in intestinal extravasation of IgA antibody-secreting cells. |
Volume: |
173 |
Issue: |
6 |
Pages: |
3668-75 |
|
•
•
•
•
•
|
Publication |
First Author: |
Feng N |
Year: |
2006 |
Journal: |
J Immunol |
Title: |
Redundant role of chemokines CCL25/TECK and CCL28/MEC in IgA+ plasmablast recruitment to the intestinal lamina propria after rotavirus infection. |
Volume: |
176 |
Issue: |
10 |
Pages: |
5749-59 |
|
•
•
•
•
•
|
Publication |
First Author: |
Grayson MH |
Year: |
2007 |
Journal: |
J Exp Med |
Title: |
Induction of high-affinity IgE receptor on lung dendritic cells during viral infection leads to mucous cell metaplasia. |
Volume: |
204 |
Issue: |
11 |
Pages: |
2759-69 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Publication |
First Author: |
Pan J |
Year: |
2000 |
Journal: |
J Immunol |
Title: |
A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial cells in mucosal tissues. |
Volume: |
165 |
Issue: |
6 |
Pages: |
2943-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
IUIS/WHO Subcommittee on Chemokine Nomenclature. |
Year: |
2002 |
Journal: |
J Immunol Methods |
Title: |
Chemokine/chemokine receptor nomenclature. |
Volume: |
262 |
Issue: |
1-2 |
Pages: |
1-3 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shanghai Model Organisms Center |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI and IMPC |
Year: |
2018 |
Journal: |
Database Release |
Title: |
MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2016 |
|
Title: |
Automatic assignment of GO terms using logical inference, based on on inter-ontology links |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
International Mouse Strain Resource |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of germline transmission data for alleles from IMSR strain data |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
DDB, FB, MGI, GOA, ZFIN curators |
Year: |
2001 |
|
Title: |
Gene Ontology annotation through association of InterPro records with GO terms |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Magdaleno S |
Year: |
2006 |
Journal: |
PLoS Biol |
Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
Volume: |
4 |
Issue: |
4 |
Pages: |
e86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
|
Title: |
Cyagen Biosciences Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Chen Z |
Year: |
2023 |
Journal: |
Front Pharmacol |
Title: |
Neutralization of excessive CCL28 improves wound healing in diabetic mice. |
Volume: |
14 |
|
Pages: |
1087924 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ji L |
Year: |
2020 |
Journal: |
Cancer Res |
Title: |
Blockade of β-Catenin-Induced CCL28 Suppresses Gastric Cancer Progression via Inhibition of Treg Cell Infiltration. |
Volume: |
80 |
Issue: |
10 |
Pages: |
2004-2016 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen J |
Year: |
2023 |
Journal: |
Nat Commun |
Title: |
Inhibition of ALKBH5 attenuates I/R-induced renal injury in male mice by promoting Ccl28 m6A modification and increasing Treg recruitment. |
Volume: |
14 |
Issue: |
1 |
Pages: |
1161 |
|
•
•
•
•
•
|
Allele |
Name: |
C-C motif chemokine ligand 28; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
Allele |
Name: |
C-C motif chemokine ligand 28; endonuclease-mediated mutation 1, Zhigao Xu |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Publication |
First Author: |
Morteau O |
Year: |
2008 |
Journal: |
J Immunol |
Title: |
An indispensable role for the chemokine receptor CCR10 in IgA antibody-secreting cell accumulation. |
Volume: |
181 |
Issue: |
9 |
Pages: |
6309-15 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bonnavion R |
Year: |
2023 |
Journal: |
Front Pharmacol |
Title: |
Large chemokine binding spectrum of human and mouse atypical chemokine receptor GPR182 (ACKR5). |
Volume: |
14 |
|
Pages: |
1297596 |
|
•
•
•
•
•
|
Publication |
First Author: |
Karnezis T |
Year: |
2019 |
Journal: |
Cancer Res |
Title: |
CCL27/CCL28-CCR10 Chemokine Signaling Mediates Migration of Lymphatic Endothelial Cells. |
Volume: |
79 |
Issue: |
7 |
Pages: |
1558-1572 |
|
•
•
•
•
•
|
Publication |
First Author: |
Homey B |
Year: |
2000 |
Journal: |
J Immunol |
Title: |
Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC). |
Volume: |
164 |
Issue: |
7 |
Pages: |
3465-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Homey B |
Year: |
2002 |
Journal: |
Nat Med |
Title: |
CCL27-CCR10 interactions regulate T cell-mediated skin inflammation. |
Volume: |
8 |
Issue: |
2 |
Pages: |
157-65 |
|
•
•
•
•
•
|
Publication |
First Author: |
Murakami T |
Year: |
2003 |
Journal: |
J Exp Med |
Title: |
Immune evasion by murine melanoma mediated through CC chemokine receptor-10. |
Volume: |
198 |
Issue: |
9 |
Pages: |
1337-47 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Chemokines (chemotactic cytokines) are a family of chemoattractant molecules. They attract leukocytes to areas of inflammation and lesions, and play a key role in leukocyte activation. Originally defined as host defense proteins, chemokines are now known to playa much broader biological role []. They have a wide range of effects in many different cell types beyond the immune system, including, for example, various cells of the central nervous system [], and endothelial cells, where they may act as either angiogenic or angiostatic factors [].The chemokine family is divided into four classes based on the number and spacing of their conserved cysteines: 2 Cys residues may be adjacent (the CC family); separated by an intervening residue (the CXC family); have only one of the first two Cys residues (C chemokines); or contain both cysteines, separated by three intervening residues (CX3C chemokines).Chemokines exert their effects by binding to rhodopsin-like G protein-coupled receptors on the surface of cells. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium ions, which cause a cellular response, including the onset of chemotaxis. There are over fifty distinct chemokines and least 18 human chemokine receptors []. Although the receptors bind only a single class of chemokines, they often bind several members of the same class with high affinity. Chemokine receptors are preferentially expressed on important functional subsets of dendritic cells, monocytes and lymphocytes, including Langerhans cells and T helper cells [, ]. Chemokines and their receptors can also be subclassified into homeostatic leukocyte homing molecules (CXCR4, CXCR5, CCR7, CCR9) versus inflammatory/inducible molecules (CXCR1, CXCR2, CXCR3, CCR1-6, CX3CR1).CC chemokine receptors are a subfamily of the chemokine receptors that specifically bind and respond to cytokines of the CC chemokine family. There are currently ten membersof the CC chemokine receptor subfamily, named CCR1 to 10. The receptors receptors are found in monocytes, lymphocytes, basophils and eosinophils.This entry represents CC chemokine receptor 10 (CCR10), previously known as G protein-coupled receptor 2 (GPR2) []. CCR10 is a receptor for CCL27 [], and CCL28 []. CCR10 is found in melanocytes [], dermal fibroblasts, dermal micro-vascular endothelial cells and has also been detected in T-cells []. It is involved in T cell-mediated skin inflammation, having been shown to recruit regulatory T cells to mucosal layers []. The receptor may also play a role in directing metastasis []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Jodeleit H |
Year: |
2020 |
Journal: |
PLoS One |
Title: |
Autoantibodies as diagnostic markers and potential drivers of inflammation in ulcerative colitis. |
Volume: |
15 |
Issue: |
2 |
Pages: |
e0228615 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
362
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Ma Q |
Year: |
1998 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice. |
Volume: |
95 |
Issue: |
16 |
Pages: |
9448-53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Horuk R |
Year: |
2001 |
Journal: |
Cytokine Growth Factor Rev |
Title: |
Chemokine receptors. |
Volume: |
12 |
Issue: |
4 |
Pages: |
313-35 |
|
•
•
•
•
•
|
Publication |
First Author: |
Charbonnier AS |
Year: |
1999 |
Journal: |
J Exp Med |
Title: |
Macrophage inflammatory protein 3alpha is involved in the constitutive trafficking of epidermal langerhans cells. |
Volume: |
190 |
Issue: |
12 |
Pages: |
1755-68 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sallusto F |
Year: |
1998 |
Journal: |
J Exp Med |
Title: |
Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes. |
Volume: |
187 |
Issue: |
6 |
Pages: |
875-83 |
|
•
•
•
•
•
|
Publication |
First Author: |
Strieter RM |
Year: |
1995 |
Journal: |
J Biol Chem |
Title: |
The functional role of the ELR motif in CXC chemokine-mediated angiogenesis. |
Volume: |
270 |
Issue: |
45 |
Pages: |
27348-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zlotnik A |
Year: |
2000 |
Journal: |
Immunity |
Title: |
Chemokines: a new classification system and their role in immunity. |
Volume: |
12 |
Issue: |
2 |
Pages: |
121-7 |
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