Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
guinea pig |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
CD19 is a component of a cell surface receptor complex that play critical roles as regulators of B cell responses to a variety of stimuli, influencing cell activation, differentiation, and survival [].Mutations in the CD19 gene cause immunodeficiency, common variable, 3 (CVID3), a primary immunodeficiency characterised by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen []. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Knoetig SM |
Year: |
2002 |
Journal: |
J Immunol |
Title: |
CD19 signaling pathways play a major role for murine AIDS induction and progression. |
Volume: |
169 |
Issue: |
10 |
Pages: |
5607-14 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
547
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang Y |
Year: |
2002 |
Journal: |
Immunity |
Title: |
The physiologic role of CD19 cytoplasmic tyrosines. |
Volume: |
17 |
Issue: |
4 |
Pages: |
501-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ishiura N |
Year: |
2010 |
Journal: |
Eur J Immunol |
Title: |
Differential phosphorylation of functional tyrosines in CD19 modulates B-lymphocyte activation. |
Volume: |
40 |
Issue: |
4 |
Pages: |
1192-204 |
|
•
•
•
•
•
|
Publication |
First Author: |
van Zelm MC |
Year: |
2006 |
Journal: |
N Engl J Med |
Title: |
An antibody-deficiency syndrome due to mutations in the CD19 gene. |
Volume: |
354 |
Issue: |
18 |
Pages: |
1901-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Engel P |
Year: |
1995 |
Journal: |
Immunity |
Title: |
Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule. |
Volume: |
3 |
Issue: |
1 |
Pages: |
39-50 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
546
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhou LJ |
Year: |
1992 |
Journal: |
Immunogenetics |
Title: |
Structure of the genes encoding the CD19 antigen of human and mouse B lymphocytes. |
Volume: |
35 |
Issue: |
2 |
Pages: |
102-11 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tedder TF |
Year: |
1989 |
Journal: |
J Immunol |
Title: |
Isolation of cDNAs encoding the CD19 antigen of human and mouse B lymphocytes. A new member of the immunoglobulin superfamily. |
Volume: |
143 |
Issue: |
2 |
Pages: |
712-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhou LJ |
Year: |
1991 |
Journal: |
J Immunol |
Title: |
Structure and domain organization of the CD19 antigen of human, mouse, and guinea pig B lymphocytes. Conservation of the extensive cytoplasmic domain. |
Volume: |
147 |
Issue: |
4 |
Pages: |
1424-32 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kozmik Z |
Year: |
1992 |
Journal: |
Mol Cell Biol |
Title: |
The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP. |
Volume: |
12 |
Issue: |
6 |
Pages: |
2662-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
Buhl AM |
Year: |
1997 |
Journal: |
J Exp Med |
Title: |
Qualitative regulation of B cell antigen receptor signaling by CD19: selective requirement for PI3-kinase activation, inositol-1,4,5-trisphosphate production and Ca2+ mobilization. |
Volume: |
186 |
Issue: |
11 |
Pages: |
1897-910 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sato S |
Year: |
1997 |
Journal: |
J Immunol |
Title: |
Regulation of B lymphocyte development and activation by the CD19/CD21/CD81/Leu 13 complex requires the cytoplasmic domain of CD19. |
Volume: |
159 |
Issue: |
7 |
Pages: |
3278-87 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rickert RC |
Year: |
1995 |
Journal: |
Nature |
Title: |
Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice. |
Volume: |
376 |
Issue: |
6538 |
Pages: |
352-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Otero DC |
Year: |
2003 |
Journal: |
J Immunol |
Title: |
CD19 function in early and late B cell development. II. CD19 facilitates the pro-B/pre-B transition. |
Volume: |
171 |
Issue: |
11 |
Pages: |
5921-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
You Y |
Year: |
2009 |
Journal: |
J Immunol |
Title: |
Cutting edge: Primary and secondary effects of CD19 deficiency on cells of the marginal zone. |
Volume: |
182 |
Issue: |
12 |
Pages: |
7343-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sato S |
Year: |
1997 |
Journal: |
J Immunol |
Title: |
CD19 expression levels regulate B lymphocyte development: human CD19 restores normal function in mice lacking endogenous CD19. |
Volume: |
158 |
Issue: |
10 |
Pages: |
4662-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yoshizaki A |
Year: |
2008 |
Journal: |
Am J Pathol |
Title: |
CD19 regulates skin and lung fibrosis via Toll-like receptor signaling in a model of bleomycin-induced scleroderma. |
Volume: |
172 |
Issue: |
6 |
Pages: |
1650-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Matsushita T |
Year: |
2006 |
Journal: |
Am J Pathol |
Title: |
Inhibitory role of CD19 in the progression of experimental autoimmune encephalomyelitis by regulating cytokine response. |
Volume: |
168 |
Issue: |
3 |
Pages: |
812-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yanaba K |
Year: |
2013 |
Journal: |
Am J Pathol |
Title: |
CD19 expression in B cells regulates atopic dermatitis in a mouse model. |
Volume: |
182 |
Issue: |
6 |
Pages: |
2214-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Diamant E |
Year: |
2005 |
Journal: |
Blood |
Title: |
CD19 regulates positive selection and maturation in B lymphopoiesis: lack of CD19 imposes developmental arrest of immature B cells and consequential stimulation of receptor editing. |
Volume: |
105 |
Issue: |
8 |
Pages: |
3247-54 |
|
•
•
•
•
•
|
Publication |
First Author: |
Watanabe R |
Year: |
2010 |
Journal: |
J Immunol |
Title: |
Regulatory B cells (B10 cells) have a suppressive role in murine lupus: CD19 and B10 cell deficiency exacerbates systemic autoimmunity. |
Volume: |
184 |
Issue: |
9 |
Pages: |
4801-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sato S |
Year: |
1995 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
The CD19 signal transduction molecule is a response regulator of B-lymphocyte differentiation. |
Volume: |
92 |
Issue: |
25 |
Pages: |
11558-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ziegler AI |
Year: |
2013 |
Journal: |
Diabetologia |
Title: |
The CD19 signalling molecule is elevated in NOD mice and controls type 1 diabetes development. |
Volume: |
56 |
Issue: |
12 |
Pages: |
2659-68 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chung EY |
Year: |
2012 |
Journal: |
J Clin Invest |
Title: |
CD19 is a major B cell receptor-independent activator of MYC-driven B-lymphomagenesis. |
Volume: |
122 |
Issue: |
6 |
Pages: |
2257-66 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
427
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
546
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
545
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Otero DC |
Year: |
2003 |
Journal: |
J Immunol |
Title: |
CD19 function in early and late B cell development: I. Maintenance of follicular and marginal zone B cells requires CD19-dependent survival signals. |
Volume: |
170 |
Issue: |
1 |
Pages: |
73-83 |
|
•
•
•
•
•
|
Publication |
First Author: |
Poe JC |
Year: |
2012 |
Journal: |
J Immunol |
Title: |
A c-Myc and surface CD19 signaling amplification loop promotes B cell lymphoma development and progression in mice. |
Volume: |
189 |
Issue: |
5 |
Pages: |
2318-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fujimoto M |
Year: |
2000 |
Journal: |
Immunity |
Title: |
CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification. |
Volume: |
13 |
Issue: |
1 |
Pages: |
47-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fujimoto M |
Year: |
1999 |
Journal: |
J Immunol |
Title: |
CD19 amplifies B lymphocyte signal transduction by regulating Src-family protein tyrosine kinase activation. |
Volume: |
162 |
Issue: |
12 |
Pages: |
7088-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Anzelon AN |
Year: |
2003 |
Journal: |
Nat Immunol |
Title: |
Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function. |
Volume: |
4 |
Issue: |
3 |
Pages: |
287-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang Y |
Year: |
2005 |
Journal: |
Immunity |
Title: |
CD19 regulates B cell maturation, proliferation, and positive selection in the FDC zone of murine splenic germinal centers. |
Volume: |
22 |
Issue: |
6 |
Pages: |
749-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Aiba Y |
Year: |
2008 |
Journal: |
Blood |
Title: |
Regulation of B-cell development by BCAP and CD19 through their binding to phosphoinositide 3-kinase. |
Volume: |
111 |
Issue: |
3 |
Pages: |
1497-503 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gommerman JL |
Year: |
2000 |
Journal: |
J Immunol |
Title: |
A role for CD21/CD35 and CD19 in responses to acute septic peritonitis: a potential mechanism for mast cell activation. |
Volume: |
165 |
Issue: |
12 |
Pages: |
6915-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yazawa N |
Year: |
2003 |
Journal: |
Blood |
Title: |
CD19 regulates innate immunity by the toll-like receptor RP105 signaling in B lymphocytes. |
Volume: |
102 |
Issue: |
4 |
Pages: |
1374-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yu J |
Year: |
2018 |
Journal: |
Am J Pathol |
Title: |
Induction of the Hajdu-Cheney Syndrome Mutation in CD19 B Cells in Mice Alters B-Cell Allocation but Not Skeletal Homeostasis. |
Volume: |
188 |
Issue: |
6 |
Pages: |
1430-1446 |
|
•
•
•
•
•
|
Publication |
First Author: |
Barrington RA |
Year: |
2009 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Uncoupling CD21 and CD19 of the B-cell coreceptor. |
Volume: |
106 |
Issue: |
34 |
Pages: |
14490-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rolink A |
Year: |
1996 |
Journal: |
J Exp Med |
Title: |
A subpopulation of B220+ cells in murine bone marrow does not express CD19 and contains natural killer cell progenitors. |
Volume: |
183 |
Issue: |
1 |
Pages: |
187-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hasegawa M |
Year: |
2001 |
Journal: |
J Immunol |
Title: |
CD19 can regulate B lymphocyte signal transduction independent of complement activation. |
Volume: |
167 |
Issue: |
6 |
Pages: |
3190-200 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shoham T |
Year: |
2003 |
Journal: |
J Immunol |
Title: |
The tetraspanin CD81 regulates the expression of CD19 during B cell development in a postendoplasmic reticulum compartment. |
Volume: |
171 |
Issue: |
8 |
Pages: |
4062-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xu Y |
Year: |
2002 |
Journal: |
J Immunol |
Title: |
The activation and subsequent regulatory roles of Lyn and CD19 after B cell receptor ligation are independent. |
Volume: |
169 |
Issue: |
12 |
Pages: |
6910-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tsitsikov EN |
Year: |
1997 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Impaired CD19 expression and signaling, enhanced antibody response to type II T independent antigen and reduction of B-1 cells in CD81-deficient mice. |
Volume: |
94 |
Issue: |
20 |
Pages: |
10844-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ghosh A |
Year: |
2017 |
Journal: |
Nat Med |
Title: |
Donor CD19 CAR T cells exert potent graft-versus-lymphoma activity with diminished graft-versus-host activity. |
Volume: |
23 |
Issue: |
2 |
Pages: |
242-249 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ord DC |
Year: |
1994 |
Journal: |
Immunogenetics |
Title: |
CD19 maps to a region of conservation between human chromosome 16 and mouse chromosome 7. |
Volume: |
39 |
Issue: |
5 |
Pages: |
322-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ogura M |
Year: |
2017 |
Journal: |
Eur J Immunol |
Title: |
Mitochondrial reactive oxygen species suppress humoral immune response through reduction of CD19 expression in B cells in mice. |
Volume: |
47 |
Issue: |
2 |
Pages: |
406-418 |
|
•
•
•
•
•
|
Publication |
First Author: |
Baban B |
Year: |
2005 |
Journal: |
Int Immunol |
Title: |
A minor population of splenic dendritic cells expressing CD19 mediates IDO-dependent T cell suppression via type I IFN signaling following B7 ligation. |
Volume: |
17 |
Issue: |
7 |
Pages: |
909-19 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dasu T |
Year: |
2009 |
Journal: |
Mol Immunol |
Title: |
CD19 signaling is impaired in murine peritoneal and splenic B-1 B lymphocytes. |
Volume: |
46 |
Issue: |
13 |
Pages: |
2655-65 |
|
•
•
•
•
•
|
Publication |
First Author: |
Haas KM |
Year: |
2005 |
Journal: |
Immunity |
Title: |
B-1a and B-1b cells exhibit distinct developmental requirements and have unique functional roles in innate and adaptive immunity to S. pneumoniae. |
Volume: |
23 |
Issue: |
1 |
Pages: |
7-18 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hobeika E |
Year: |
2015 |
Journal: |
EMBO J |
Title: |
CD19 and BAFF-R can signal to promote B-cell survival in the absence of Syk. |
Volume: |
34 |
Issue: |
7 |
Pages: |
925-39 |
|
•
•
•
•
•
|
Publication |
First Author: |
Depoil D |
Year: |
2008 |
Journal: |
Nat Immunol |
Title: |
CD19 is essential for B cell activation by promoting B cell receptor-antigen microcluster formation in response to membrane-bound ligand. |
Volume: |
9 |
Issue: |
1 |
Pages: |
63-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gärdby E |
Year: |
2000 |
Journal: |
Eur J Immunol |
Title: |
CD19-deficient mice exhibit poor responsiveness to oral immunization despite evidence of unaltered total IgA levels, germinal centers and IgA-isotype switching in Peyer's patches. |
Volume: |
30 |
Issue: |
7 |
Pages: |
1861-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fehr T |
Year: |
1998 |
Journal: |
J Exp Med |
Title: |
Antiviral protection and germinal center formation, but impaired B cell memory in the absence of CD19. |
Volume: |
188 |
Issue: |
1 |
Pages: |
145-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Keren Z |
Year: |
2004 |
Journal: |
J Biol Chem |
Title: |
Modification of ligand-independent B cell receptor tonic signals activates receptor editing in immature B lymphocytes. |
Volume: |
279 |
Issue: |
14 |
Pages: |
13418-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sin SH |
Year: |
2010 |
Journal: |
J Virol |
Title: |
The viral latency-associated nuclear antigen augments the B-cell response to antigen in vivo. |
Volume: |
84 |
Issue: |
20 |
Pages: |
10653-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Atkinson JR |
Year: |
2017 |
Journal: |
J Virol |
Title: |
Protective Humoral Immunity in the Central Nervous System Requires Peripheral CD19-Dependent Germinal Center Formation following Coronavirus Encephalomyelitis. |
Volume: |
91 |
Issue: |
23 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Walter K |
Year: |
2008 |
Journal: |
Blood |
Title: |
Stem cell-specific epigenetic priming and B cell-specific transcriptional activation at the mouse Cd19 locus. |
Volume: |
112 |
Issue: |
5 |
Pages: |
1673-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Benhamou D |
Year: |
2016 |
Journal: |
Cell Rep |
Title: |
A c-Myc/miR17-92/Pten Axis Controls PI3K-Mediated Positive and Negative Selection in B Cell Development and Reconstitutes CD19 Deficiency. |
Volume: |
16 |
Issue: |
2 |
Pages: |
419-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gärdby E |
Year: |
2001 |
Journal: |
Scand J Immunol |
Title: |
Impaired CD40-signalling in CD19-deficient mice selectively affects Th2-dependent isotype switching. |
Volume: |
53 |
Issue: |
1 |
Pages: |
13-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Scotto L |
Year: |
2012 |
Journal: |
Clin Cancer Res |
Title: |
Development and characterization of a novel CD19CherryLuciferase (CD19CL) transgenic mouse for the preclinical study of B-cell lymphomas. |
Volume: |
18 |
Issue: |
14 |
Pages: |
3803-11 |
|
•
•
•
•
•
|
Publication |
First Author: |
Iwata Y |
Year: |
2009 |
Journal: |
Am J Pathol |
Title: |
CD19, a response regulator of B lymphocytes, regulates wound healing through hyaluronan-induced TLR4 signaling. |
Volume: |
175 |
Issue: |
2 |
Pages: |
649-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Keppler SJ |
Year: |
2015 |
Journal: |
Immunity |
Title: |
Wiskott-Aldrich Syndrome Interacting Protein Deficiency Uncovers the Role of the Co-receptor CD19 as a Generic Hub for PI3 Kinase Signaling in B Cells. |
Volume: |
43 |
Issue: |
4 |
Pages: |
660-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen R |
Year: |
2022 |
Journal: |
J Leukoc Biol |
Title: |
B10 cells decrease fibrosis progression following cardiac injury partially by IL-10 production and regulating hyaluronan secretion. |
Volume: |
111 |
Issue: |
2 |
Pages: |
415-425 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kasama Y |
Year: |
2010 |
Journal: |
Blood |
Title: |
Persistent expression of the full genome of hepatitis C virus in B cells induces spontaneous development of B-cell lymphomas in vivo. |
Volume: |
116 |
Issue: |
23 |
Pages: |
4926-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang JY |
Year: |
2011 |
Journal: |
Am J Pathol |
Title: |
Dermatan sulfate interacts with dead cells and regulates CD5(+) B-cell fate: implications for a key role in autoimmunity. |
Volume: |
178 |
Issue: |
5 |
Pages: |
2168-76 |
|
•
•
•
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•
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