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Search results 1 to 100 out of 3902 for Cd2

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Domain
Type: Family
Description: The CD2 adhesion molecule is a cell surface protein expressed by T cells and natural killer cells. CD2's extracellular domain contains immunoglobulin-like domains that are glycosylated at two sites and can mediate homodimerisation []. Ligation of CD2 by CD58 in humans or CD48 in mice helps T cells adhere to antigen-presenting cells, and initiates signal transduction pathways that enhance signalling through the T cell receptor for antigen. CD2 knockout mice exhibit essentially normal immune function [], and it is thought that CD2 is somewhat functionally redundant with other T cell co-stimulatory receptors such as CD28 [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Killeen N
Year: 1992
Journal: EMBO J
Title: Development and function of T cells in mice with a disrupted CD2 gene.
Volume: 11
Issue: 12
Pages: 4329-36
Publication
First Author: Sewell WA
Year: 1987
Journal: Eur J Immunol
Title: The murine homologue of the T lymphocyte CD2 antigen: molecular cloning, chromosome assignment and cell surface expression.
Volume: 17
Issue: 7
Pages: 1015-20
Publication  
First Author: Hashem T
Year: 2020
Journal: Front Immunol
Title: CD2 Regulates Pathogenesis of Asthma Induced by House Dust Mice Extract.
Volume: 11
Pages: 881
Protein
Organism: Mus musculus/domesticus
Length: 344  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 344  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 344  
Fragment?: false
Publication
First Author: Sasada T
Year: 2001
Journal: J Immunol
Title: A critical role for CD2 in both thymic selection events and mature T cell function.
Volume: 166
Issue: 4
Pages: 2394-403
Publication
First Author: Green JM
Year: 2000
Journal: J Immunol
Title: Coordinate regulation of T cell activation by CD2 and CD28.
Volume: 164
Issue: 7
Pages: 3591-5
Publication
First Author: Shimojima M
Year: 2002
Journal: Immunology
Title: A feline CD2 homologue interacts with human red blood cells.
Volume: 105
Issue: 3
Pages: 360-6
Publication
First Author: Yagita H
Year: 1988
Journal: J Immunol
Title: Molecular cloning of the murine homologue of CD2. Homology of the molecule to its human counterpart T11.
Volume: 140
Issue: 4
Pages: 1321-6
Publication
First Author: Clayton LK
Year: 1987
Journal: Eur J Immunol
Title: Murine and human T11 (CD2) cDNA sequences suggest a common signal transduction mechanism.
Volume: 17
Issue: 9
Pages: 1367-70
Publication
First Author: Diamond DJ
Year: 1988
Journal: Proc Natl Acad Sci U S A
Title: Exon-intron organization and sequence comparison of human and murine T11 (CD2) genes.
Volume: 85
Issue: 5
Pages: 1615-9
Publication
First Author: Yagita H
Year: 1989
Journal: Proc Natl Acad Sci U S A
Title: Monoclonal antibodies specific for murine CD2 reveal its presence on B as well as T cells.
Volume: 86
Issue: 2
Pages: 645-9
Publication
First Author: van der Merwe PA
Year: 1999
Journal: J Exp Med
Title: A subtle role for CD2 in T cell antigen recognition.
Volume: 190
Issue: 10
Pages: 1371-4
Publication
First Author: Chen HA
Year: 2002
Journal: Biochemistry
Title: The pH dependence of CD2 domain 1 self-association and 15N chemical exchange broadening is correlated with the anomalous pKa of Glu41.
Volume: 41
Issue: 50
Pages: 14680-8
Publication
First Author: Hutchcroft JE
Year: 1998
Journal: J Immunol
Title: Uncoupling activation-dependent HS1 phosphorylation from nuclear factor of activated T cells transcriptional activation in Jurkat T cells: differential signaling through CD3 and the costimulatory receptors CD2 and CD28.
Volume: 161
Issue: 9
Pages: 4506-12
Publication
First Author: Williams AF
Year: 1987
Journal: J Exp Med
Title: Similarities in sequences and cellular expression between rat CD2 and CD4 antigens.
Volume: 165
Issue: 2
Pages: 368-80
Publication
First Author: Singleton K
Year: 2006
Journal: J Immunol
Title: A large T cell invagination with CD2 enrichment resets receptor engagement in the immunological synapse.
Volume: 177
Issue: 7
Pages: 4402-13
Publication
First Author: Sasada T
Year: 2002
Journal: J Immunol
Title: CD2 facilitates differentiation of CD4 Th cells without affecting Th1/Th2 polarization.
Volume: 168
Issue: 3
Pages: 1113-22
Publication
First Author: Teh SJ
Year: 1997
Journal: Blood
Title: CD2 regulates the positive selection and function of antigen-specific CD4- CD8+ T cells.
Volume: 89
Issue: 4
Pages: 1308-18
Publication
First Author: Kaplan AJ
Year: 1993
Journal: J Immunol
Title: Production and characterization of soluble and transmembrane murine CD2. Demonstration that CD48 is a ligand for CD2 and that CD48 adhesion is regulated by CD2.
Volume: 151
Issue: 8
Pages: 4022-32
Publication
First Author: Altevogt P
Year: 1989
Journal: Eur J Immunol
Title: Antibody 12-15 cross-reacts with mouse Fc gamma receptors and CD2: study of thymus expression, genetic polymorphism and biosynthesis of the CD2 protein.
Volume: 19
Issue: 2
Pages: 341-6
Publication
First Author: Lin J
Year: 1996
Journal: Cell Immunol
Title: Anti-CD2 monoclonal antibody-induced receptor changes. II. Interaction of CD2 and CD3.
Volume: 167
Issue: 2
Pages: 249-58
Publication
First Author: Dustin ML
Year: 1998
Journal: Cell
Title: A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts.
Volume: 94
Issue: 5
Pages: 667-77
Publication
First Author: Ortaldo JR
Year: 2007
Journal: Cell Immunol
Title: Modulation of lymphocyte function with inhibitory CD2: loss of NK and NKT cells.
Volume: 249
Issue: 1
Pages: 8-19
Gene
Type: gene
Organism: human
Publication
First Author: Evans CF
Year: 1993
Journal: J Immunol
Title: CD2-deficient mice generate virus-specific cytotoxic T lymphocytes upon infection with lymphocytic choriomeningitis virus.
Volume: 151
Issue: 11
Pages: 6259-64
Publication
First Author: Kato K
Year: 1992
Journal: J Exp Med
Title: CD48 is a counter-receptor for mouse CD2 and is involved in T cell activation.
Volume: 176
Issue: 5
Pages: 1241-9
Publication
First Author: Clarkson NG
Year: 2009
Journal: J Biol Chem
Title: Inhibition and activation by CD244 depends on CD2 and phospholipase C-gamma1.
Volume: 284
Issue: 37
Pages: 24725-34
Publication
First Author: Kingsmore SF
Year: 1989
Journal: Immunogenetics
Title: Physical linkage of genes encoding the lymphocyte adhesion molecules CD2 and its ligand LFA-3.
Volume: 30
Issue: 2
Pages: 123-5
Protein
Organism: Mus musculus/domesticus
Length: 267  
Fragment?: false
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Publication
First Author: Beck JM
Year: 2003
Journal: J Immunol
Title: T cell costimulatory molecule function determines susceptibility to infection with Pneumocystis carinii in mice.
Volume: 171
Issue: 4
Pages: 1969-77
Publication
First Author: Butler JJ
Year: 2003
Journal: J Cell Biochem
Title: Adenosine inhibits activation-induced T cell expression of CD2 and CD28 co-stimulatory molecules: role of interleukin-2 and cyclic AMP signaling pathways.
Volume: 89
Issue: 5
Pages: 975-91
Publication
First Author: Fernandez Lahore G
Year: 2021
Journal: Nat Commun
Title: Polymorphic estrogen receptor binding site causes Cd2-dependent sex bias in the susceptibility to autoimmune diseases.
Volume: 12
Issue: 1
Pages: 5565
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Niethammer AG
Year: 2001
Journal: Cancer Res
Title: Targeted interleukin 2 therapy enhances protective immunity induced by an autologous oral DNA vaccine against murine melanoma.
Volume: 61
Issue: 16
Pages: 6178-84
Publication
First Author: Clayton LK
Year: 1988
Journal: J Immunol
Title: The gene for T11 (CD2) maps to chromosome 1 in humans and to chromosome 3 in mice.
Volume: 140
Issue: 10
Pages: 3617-21
Publication
First Author: Grönholm J
Year: 2017
Journal: Diabetologia
Title: Metabolically inactive insulin analogue does not prevent autoimmune diabetes in NOD mice.
Volume: 60
Issue: 8
Pages: 1475-1482
GXD Expression    
Probe: MGI:1204572
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:1204574
Age: postnatal week 6-8
Image: st96_211
Specimen Label: None
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:1204572
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Absent
Sex: Pooled
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:1204574
Age: postnatal week 6-8
Image: st96_211
Specimen Label: None
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:1204572
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Absent
Sex: Pooled
Emaps: EMAPS:3284528
Stage: TS28
Assay Id: MGI:1204574
Age: postnatal week 6-8
Image: st96_211
Specimen Label: None
Detected: false
Specimen Num: 3
GXD Expression    
Probe: MGI:1204572
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1697428
Stage: TS28
Assay Id: MGI:1204574
Age: postnatal week 6-8
Image: st96_211
Specimen Label: None
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:1204572
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1754928
Stage: TS28
Assay Id: MGI:1204574
Age: postnatal week 6-8
Image: st96_211
Specimen Label: None
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:1204572
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Absent
Sex: Pooled
Emaps: EMAPS:3280928
Stage: TS28
Assay Id: MGI:1204574
Age: postnatal week 6-8
Image: st96_211
Specimen Label: None
Detected: false
Specimen Num: 6
GXD Expression    
Probe: MGI:1204572
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:1204574
Age: postnatal week 6-8
Image: st96_211
Specimen Label: None
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:1204572
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1757728
Stage: TS28
Assay Id: MGI:1204574
Age: postnatal week 6-8
Image: st96_211
Specimen Label: None
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:1204572
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:3599828
Stage: TS28
Assay Id: MGI:1204574
Age: postnatal week 6-8
Image: st96_211
Specimen Label: None
Detected: true
Specimen Num: 9
GXD Expression    
Probe: MGI:1204572
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:1204574
Age: postnatal week 6-8
Image: st96_211
Specimen Label: None
Detected: true
Specimen Num: 10
GXD Expression    
Probe: MGI:1204572
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:1204574
Age: postnatal week 6-8
Image: st96_211
Specimen Label: None
Detected: true
Specimen Num: 11
GXD Expression    
Probe: MGI:1204572
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:1204574
Age: postnatal week 6-8
Image: st96_211
Specimen Label: None
Detected: true
Specimen Num: 12
GXD Expression    
Probe: MGI:1204572
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:1204574
Age: postnatal week 6-8
Image: st96_211
Specimen Label: None
Detected: true
Specimen Num: 13
GXD Expression    
Probe: MGI:1204572
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:1204574
Age: postnatal week 6-8
Image: st96_211
Specimen Label: None
Detected: true
Specimen Num: 14
GXD Expression    
Probe: MGI:1204572
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:1204574
Age: postnatal week 6-8
Image: st96_211
Specimen Label: None
Detected: true
Specimen Num: 15
GXD Expression    
Probe: MGI:1204572
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1720228
Stage: TS28
Assay Id: MGI:1204574
Age: postnatal week 6-8
Image: st96_211
Specimen Label: None
Detected: true
Specimen Num: 16
GXD Expression    
Probe: MGI:1204572
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1750328
Stage: TS28
Assay Id: MGI:1204574
Age: postnatal week 6-8
Image: st96_211
Specimen Label: None
Detected: true
Specimen Num: 17
GXD Expression    
Probe: MGI:1204572
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:1204574
Age: postnatal week 6-8
Image: st96_211
Specimen Label: None
Detected: true
Specimen Num: 18
GXD Expression    
Probe: MGI:1204572
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1832128
Stage: TS28
Assay Id: MGI:1204574
Age: postnatal week 6-8
Image: st96_211
Specimen Label: None
Detected: true
Specimen Num: 19
GXD Expression    
Probe: MGI:1204572
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1842628
Stage: TS28
Assay Id: MGI:1204574
Age: postnatal week 6-8
Image: st96_211
Specimen Label: None
Detected: true
Specimen Num: 20
GXD Expression    
Probe: MGI:1204572
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1752528
Stage: TS28
Assay Id: MGI:1204574
Age: postnatal week 6-8
Image: st96_211
Specimen Label: None
Detected: true
Specimen Num: 21
GXD Expression    
Probe: MGI:1204572
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:3511228
Stage: TS28
Assay Id: MGI:1204574
Age: postnatal week 6-8
Image: st96_211
Specimen Label: None
Detected: true
Specimen Num: 22
GXD Expression    
Probe: MGI:1204572
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1914328
Stage: TS28
Assay Id: MGI:1204574
Age: postnatal week 6-8
Image: st96_211
Specimen Label: None
Detected: true
Specimen Num: 23
GXD Expression    
Probe: MGI:1204572
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1742828
Stage: TS28
Assay Id: MGI:1204574
Age: postnatal week 6-8
Image: st96_211
Specimen Label: None
Detected: true
Specimen Num: 24
GXD Expression    
Probe: MGI:1204572
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:3288928
Stage: TS28
Assay Id: MGI:1204574
Age: postnatal week 6-8
Image: st96_211
Specimen Label: None
Detected: true
Specimen Num: 25
GXD Expression    
Probe: MGI:1204572
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1718528
Stage: TS28
Assay Id: MGI:1204574
Age: postnatal week 6-8
Image: st96_211
Specimen Label: None
Detected: true
Specimen Num: 26
GXD Expression    
Probe: MGI:1204572
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1775128
Stage: TS28
Assay Id: MGI:1204574
Age: postnatal week 6-8
Image: st96_211
Specimen Label: None
Detected: true
Specimen Num: 27
GXD Expression    
Probe: MGI:1204572
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1683328
Stage: TS28
Assay Id: MGI:1204574
Age: postnatal week 6-8
Image: st96_211
Specimen Label: None
Detected: true
Specimen Num: 28
GXD Expression    
Probe: MGI:1204572
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1788628
Stage: TS28
Assay Id: MGI:1204574
Age: postnatal week 6-8
Image: st96_211
Specimen Label: None
Detected: true
Specimen Num: 29
GXD Expression    
Probe: MGI:1204572
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1789128
Stage: TS28
Assay Id: MGI:1204574
Age: postnatal week 6-8
Image: st96_211
Specimen Label: None
Detected: true
Specimen Num: 30
GXD Expression    
Probe: MGI:1204572
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1885228
Stage: TS28
Assay Id: MGI:1204574
Age: postnatal week 6-8
Image: st96_211
Specimen Label: None
Detected: true
Specimen Num: 31
GXD Expression    
Probe: MGI:1204572
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1866628
Stage: TS28
Assay Id: MGI:1204574
Age: postnatal week 6-8
Image: st96_211
Specimen Label: None
Detected: true
Specimen Num: 32
GXD Expression    
Probe: MGI:1204572
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:3276428
Stage: TS28
Assay Id: MGI:1204574
Age: postnatal week 6-8
Image: st96_211
Specimen Label: None
Detected: true
Specimen Num: 33